Clinical trials: Periodontal Disease Stage 2
Periodontitis Stage II
Melatonin Loaded in Injectable Platelet-Rich Fibrin in the Management Periodontitis
melatonin loaded in injectible platelet rich fibrin in treatment of periodontitis
- Trial name
- NCT07316582
- Testing
- Melatonin-Loaded Injectable Platelet-Rich Fibrin, injectible platelet rich fibrin (i-PRF )
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Healthy
Clinical Efficacy of Single-Use of Peroxyl Mouthwash for Reducing Bacteria Saliva and Bioaerosol Contamination Phase 2
To evaluate the antibacterial efficacy of a commercial mouthwash containing 1.5% hydrogen peroxide in reducing the levels of bacteria in bioaerosols generated by dental prophylaxis.
- Trial name
- NCT04717063
- Testing
- Peroxyl Oral Product
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Periodontal Diseases
Locally Delivered Melatonin Gel in Management of Stage II Grade B Periodontitis
Background: Periodontitis is a chronic inflammatory disease characterized by the destruction of tooth-supporting tissues, driven by an imbalance between bacterial pathogens and the host immune response.
- Trial name
- NCT07813936
- Testing
- 2% Melatonin gel
- Where
- Egypt
- Volunteers
- 23 people
- Sponsor
- Alexandria University
Type 2 Diabetes Mellitus, Prediabetic State
Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus
With this design, this study hypothesizes that; (i) ICG-PDT would produce superior clinical, microbiological, and immune-inflammatory outcomes as compared to RSD and (ii) ICG-PDT would produce equal efficacy among different forms…
- Conditions
- Type 2 Diabetes Mellitus, Prediabetic State, Chronic Periodontitis
- Trial name
- NCT04857346
- Testing
- Indocyanine green
- Where
- Saudi Arabia
- Volunteers
- 80 people
- Sponsor
- King Saud University
Periodontal Disease, Periodontal Disease Stage 2
Probiotics And Ozonated Olive Oil To Maintain Oral Eubiosis In Stage I And II Periodontitis Patients
The goal of this clinical trial is to investigate the clinical benefits of the combined use of ozonized olive oil products (mouthwash and toothpaste) and probiotics on the health status of patients with Stage I and II…
- Trial name
- NCT06955546
- Testing
- Toothpaste Product, Mouthwash Product, Probiotic
- Where
- Italy
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Massimo Corsalini
Periodontitis
Nd:YAG Laser Versus Diode Laser Assisted New Attachment Procedure (Lanap) in the Management of Stage II Periodontitis
Aim of the study was to assess and compare the clinical and microbiological changes following Laser assisted new attachment procedure (LANAP®) using diode 940 nm versus ND:YAG 1064 nm, and to compare the outcome to conventional…
- Trial name
- NCT06509412
- Testing
- LANAP surgical protocol using ND:YAG 1064 laser, LANAP surgical protocol using diode 940 laser, Scaling and root planing (SRP)
- Where
- Egypt
- Volunteers
- 33 people
- Sponsor
- Nada Shaban
Stage II Periodontitis
Virgin Coconut Oil Versus Chlorhexidine Mouthwash in Non-Surgical Periodontal Therapy of Periodontitis Patients. A Randomized Controlled Clinical Trial With Biochemical Assessment.
This randomized controlled clinical trial will evaluate the effect of virgin coconut oil mouthwash compared with chlorhexidine mouthwash as an adjunct to non-surgical periodontal therapy in patients with stage II periodontitis.
- Trial name
- NCT07706387
- Testing
- Non-surgical periodontal therapy, Chlorhexidine mouthwash, Virgin coconut oil mouthwash
- Where
- Egypt
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Periodontitis and Diabetes, Periodontitis
Clinical Efficacy of Local Delivery of Minocycline and Hyaluronan Gel to Treat Periodontitis in Diabetic Patients
The goal of this clinical trial is to investigate the local delivery of minocycline gel 2% and 0.2% hyaluronan gel to treat periodontitis in diabetic patients as adjunctive to subgingival instrumentation.
- Trial name
- NCT06997731
- Testing
- Non -surgical treatment and oral hygiene instruction, Application of minocycline and hyaluronic acid gel.
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Kafrelsheikh University
Periodontitis, Periodontitis Stage II
Surfactant Protein D Levels in GCF Before and After MINST in Periodontitis
This study will evaluate changes in Surfactant Protein D (SP-D) levels in gingival crevicular fluid (GCF) of patients with periodontitis before and after minimally invasive non-surgical periodontal therapy (MINST).
- Conditions
- Periodontitis, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT07599657
- Testing
- Minimally Invasive Non-Surgical Periodontal Therapy
- Where
- Egypt
- Volunteers
- 18 people
- Sponsor
- Cairo University
Periodontitis
Human Dental Pulp Mesenchymal Stem Cells for the Treatment of Chronic Periodontitis Patients
The primary objective:To evaluate the efficacy of different administration protocols of human dental pulp mesenchymal stem cells for the treatment of chronic periodontitis patients.
- Trial name
- NCT05924373
- Testing
- Human Dental Fulp Stem Cells
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Peking University Third Hospital
Intrabony Periodontal Defect
Injectable Platelet Rich Fibrin With Demineralized Freeze-dried Bone Allograft in Treatment of Intraosseous Defects
Clinical and radiographic evaluation of injectable platelet rich fibrin (i-PRF) and demineralized freeze-dried bone allograft (DFDBA) compared to demineralized freeze-dried bone allograft (DFDBA) alone in management of…
- Trial name
- NCT03900013
- Testing
- Injectable platelet rich fibrin combined with DFDBA, Demineralized Freeze Dried Bone Allograft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Aneurysmal Bone Cysts, Giant Cell Granuloma
Denosumab in Subjects With Giant Cell Rich Tumors of Bone
An open-label, multi-center, phase 2 study of the efficacy of denosumab in subjects with giant cell rich tumors of bone. The population will consist of subjects with the following tumor types: aneurysmal bone cysts (ABC), giant…
- Conditions
- Aneurysmal Bone Cysts, Giant Cell Granuloma, Osteoblastoma, Chondroblastoma
- Trial name
- NCT03605199
- Testing
- Denosumab
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 60 people
- Sponsor
- Leiden University Medical Center
Periodontal Pocket
Comparing Photodisinfection of Chitosan NP Enriched ICG Over ICG as Adjunct to OFD: RCT
The current study is a prospective randomised study-Comparison of photodisinfection with chitosan nanoparticles enriched indocyanine green over indocyanine green as an adjunct to open flap debridement in the management of stage…
- Trial name
- NCT06523244
- Testing
- PHOTODYNAMIC THERAPY
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Krishnadevaraya College of Dental Sciences & Hospital
Periodontitis
Effect of Menstrual Cycle Phase on Pain Perception and Anxiety During Non-Surgical Periodontal Treatment
This study evaluates the effect of menstrual cycle phases on pain perception and dental anxiety during non-surgical periodontal therapy in premenopausal women with Stage II and III periodontitis.
- Trial name
- MAPP (NCT07719686)
- Testing
- Non Surgical Periodontal Treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Karadeniz Technical University
Periodontitis, Periodontitis Stage I
Hypochlorous Acid in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease associated with dental plaque and characterized by the progressive destruction of the tooth-supporting tissues.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II
- Trial name
- NCT07712627
- Testing
- Hypochlorous Acid Application, Scaling and Root Planing (SRP) with Purified Water
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ataturk University
Periodontitis, Periodontitis Stage II
Comparative Effects of Two Oral Antiseptics Used as an Adjuvant in the Treatment of Periodontitis
The focus of this study is on two types of mouthwashes - one containing a chlorhexidine (CHX) at 0.2% (CHX), and the other one containing CHX at a lower concentration of 0.12% with cetylpyridinium chloride (CPC).
- Conditions
- Periodontitis, Periodontitis Stage II, Periodontitis Stage III
- Trial name
- NCT06967402
- Testing
- Experimental (chlorhexidine), Control (chlorhexidine with cetylpyridinium chloride)
- Where
- Hong Kong
- Volunteers
- 60 people
- Sponsor
- The University of Hong Kong
Periodontitis
Evaluation of Metronidazole Hydrogel 25% in Stage II and III Periodontitis
A randomized clinical trial will be performed single-blind to evaluate the effectiveness of sublingual metronidazole hydrogel 25 % in periodontitis.
- Trial name
- NCT04983849
- Testing
- metronidazole hydrogel, scaling and root planning
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of L'Aquila
Periodontitis, Subgingival Plaque
Comparative Evaluation of Minimally Invasive Nonsurgical Periodontal Therapy Versus Conventional Subgingival Instrumentation
Background- The use of minimally invasive procedures has recently been advocated for the treatment of periodontitis, to minimize patient discomfort and maximize the healing potential.
- Trial name
- NCT05876455
- Testing
- Conventional Subgingival Instrumentation, minimally invasive non-surgical periodontal therapy
- Where
- India
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Periodontitis, Periodontitis Stage I
Chlorhexidine and Zinc in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease affecting the supporting structures of the teeth and is associated with both local tissue destruction and systemic inflammatory responses.
- Conditions
- Periodontitis, Periodontitis Stage I, Periodontitis Stage II
- Trial name
- CHX-Zn (NCT07517991)
- Testing
- Chlorhexidine and zinc application, Scaling and root planing with distilled water
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ataturk University
Chronic Periodontitis
Evaluation of Acacia Catechu and Low-Level Laser in the Treatmentof Stage II Periodontitis
Evaluation of Acacia catechu and Low-Level Laser in the Treatment of Stage 2 Periodontitis.
- Trial name
- LLLvsAgel (NCT06805292)
- Testing
- Acacia catechu, Low Level Laser Therapy, phase 1 therapy chronic periodontitis
- Where
- 2 sites in Egypt
- Volunteers
- 60 people
- Sponsor
- Faculty of Dental Medicine for Girls