Clinical trials: Periodontal Diseases
Periodontal Disease
Study on Biomarkers of Periodontitis and Type 2 Diabetes Mellitus in Males and Females 30 - 70 Years of Age
The purpose of this study is to learn about the interactions of markers of type 2 diabetes (T2DM) and periodontitis (PD). Study VPE00001 is a multi-center cross-sectional study.
- Trial name
- NCT06582056
- Testing
- Investigational Procedure
- Where
- 4 sites in United States
- Volunteers
- 226 people, healthy volunteers welcome
- Sponsor
- Sanofi Pasteur, a Sanofi Company
Periodontal Diseases
Evaluation of Galectin-3 Levels in GCF And Saliva of Patients With Different Periodontal Diseases
The aim of this study is to assess the levels of galectin-3 in the GCF and saliva in patient with gingivitis and patient with stage III periodontitis.
- Trial name
- NCT05281796
- Testing
- GCF obtaining, saliva obtaining
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Cairo University
Polycystic Ovary Syndrome, Inflammation Gum
Endocan Levels at Polycystic Ovary Syndrome and Periodontal Inflammation
Periodontal diseases are chronic inflammatory disease occurred by the interaction between pathogenic microorganism and the host defense.
- Conditions
- Polycystic Ovary Syndrome, Inflammation Gum, Cytokines
- Trial name
- NCT03264846
- Testing
- Collection of Serum and Saliva Samples
- Where
- Turkey (Türkiye)
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Ebru Saglam
GINGIVAL RECESSION
Growth Factor Enhanced Matrix With Subepithelial Connective Tissue Graft or Collagen Membrane in Treatment of Gingival Recession
The study aimed to compare, the effectiveness of Growth Factor Enhanced Matrix (GEM 21s) ® combined either with free connective tissue graft or collagen membrane in the treatment of Miller class II gingival recession.
- Trial name
- NCT05782751
- Testing
- GROUPI, GROUP II
- Where
- 2 sites in Egypt
- Volunteers
- 10 people
- Sponsor
- Tanta University
Gingivitis
Atlas of Experimental Gingivitis in Humans
Pilot case series with a split-mouth design to track subjects with known exposure (dental biofilm accumulation) over 21 days. Descriptive design, using single cell RNA sequencing as a "digital biopsy" to catalog and contrast…
- Trial name
- ATL (NCT04105569)
- Testing
- Stent-Induced Biofilm Overgrowth
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Chlorhexidine, Gingivitis
Clinical and Microbiological Comparison of 0.12% CHX and 0.05% CHX+0.05%CPC Mouthwashes in TPS Patients
The present study compares the effectiveness of two mouthwash formulations (0.12% CHX and 0.05% CHX+0.05%CPC) in reducing gingival inflammation and microbial colonization in individuals with gingivitis and in preventing…
- Conditions
- Chlorhexidine, Gingivitis, Periodontitis, Cetylpyridinium Chloride
- Trial name
- NCT06411522
- Testing
- Mouthwash containing 0.12% CHX (Chlorhexidine), Mouthwash containing 0.05% CHX (Chlorhexidine) and 0.05% CPC (Cetylpyridinium Chloride)
- Where
- Italy
- Volunteers
- 72 people
- Sponsor
- University of Siena
Recession, Gingival, Tissue Grafts
Topical Hyaluronic Acid Adjunctive Effects on Healing After Free Gingival Grafting in Smokers and Non-Smokers
Comparison of the healing of free gingival grafts applied to smokers and non-smokers and evaluation of the effect of hyaluronic acid gel on healing of the donor site.
- Trial name
- NCT07143760
- Testing
- Gengigel
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Istanbul University
Alveolar Bone Loss
Soft Tissue Width and Abutment Height Influence Peri-implant Bone Resorption
The purpose of this clinical and radiographic study will be to determine what influence on marginal bone loss has the thickness of soft tissues and the height of the prosthetic abutment and eventually determine which of the two…
- Trial name
- i-RES (NCT03229005)
- Testing
- implant insertion, operculectomy, prosthetic rehabilitation
- Where
- Italy
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- International Piezosurgery Academy
Tooth Loss, Vitamin D3 Deficiency
Dental Implants Rehabilitation in Patients With Vitamin D3 Imbalance
Interventional retrospective prospective randomized clinical trial (RCT) in parallel groups. The sample size is 384 patients with loss of teeth and vitamin D imbalance.
- Conditions
- Tooth Loss, Vitamin D3 Deficiency, Osteomalacia
- Trial name
- NCT04841213
- Testing
- Dental implantation
- Where
- 2 sites in Russia
- Volunteers
- 384 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Impacted Mandibular Third Molar, Alveolar Bone Loss
Healing of Mandibular Third Molar Extraction Sockets Using Platelet Concentrates and Photobiomodulation
Surgical removal of impacted mandibular third molars is a common procedure that may be associated with postoperative pain, swelling, limited mouth opening, and delayed bone healing.
- Conditions
- Impacted Mandibular Third Molar, Alveolar Bone Loss, Impacted Mandibular Third Molar Extraction
- Trial name
- NCT07324213
- Testing
- Mandibular Third Molar Extraction With Primary Wound Closure, Autologous Platelet Concentrates, Photobiomodulation
- Where
- Poland
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Medical Innovation Center Wroclaw
Periodontitis, Dental Implants
Marginal Bone Level Around Dental Implants in Periodontitis Patients
This study evaluates and compares marginal bone level changes around dental implants with two different surface characteristics in patients with a history of periodontitis.
- Conditions
- Periodontitis, Dental Implants, Marginal Bone Loss, Periodontal Probing Depth
- Trial name
- (MBL) (NCT07608523)
- Testing
- SLA Dental Implant, Plasma Spraying Dental Implant
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Faculty of Dental Medicine for Girls
Periodontitis
The Efficacy and Safety of Flurbiprofen Chip Versus Chlorhexidine Chip (Periochip®) in Therapy of Adult Chronic Periodontitis
The purpose of the study is to assess efficacy and safety of Flurbiprofen Chip versus Chlorhexidine chip (Periochip®) in therapy of adult chronic periodontitis.
- Trial name
- NCT01040286
- Testing
- Flurbiprofen, Chlorhexidine
- Where
- Israel
- Sponsor
- Dexcel Pharma Technologies Ltd.
Alveolar Bone Loss
Vitamin D and Periodontitis
Vitamin D has become important for periodontal disease due to play a role in autoimmunity, bone mineral metabolism and inflammation.
- Trial name
- NCT03088488
- Testing
- fasting venous blood samples
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ordu University
Periodontitis, Acute-Phase Response
Relationship Between LRG and Periodontal Disease
This study aimed to investigate gingival crevicular fluid (GCF) and serum levels of LRG, interleukin (IL)-6 and tumor necrosis factor (TNF)-α in patients with periodontitis before and after non-surgical periodontal treatment.
- Conditions
- Periodontitis, Acute-Phase Response, Inflammation
- Trial name
- NCT04383561
- Testing
- Non-surgical periodontal treatment, Oral hygiene instructions
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Diabetes Mellitus, Periodontal Disease
Changes in Salivary Asprosin, IL-39, IL-40 and IL-1β Levels in Diabetic Patients with Periodontitis
The aim of this study is to determine the relationships between asprosin, IL-39, IL-40 and IL-1β in saliva between individuals with and without diabetes and between individuals with periodontitis and healthy individuals and to…
- Conditions
- Diabetes Mellitus, Periodontal Disease, Asprosin, Interleukin 1-beta
- Trial name
- NCT06735313
- Testing
- Periodontal examination and saliva collection
- Where
- Turkey (Türkiye)
- Volunteers
- 176 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Plaque Accumulation, Gingival Inflammation
Triphila Mouthwash Effect as Anti-plaque and Anti-gingivitis in Children
The study aim to to assess the antiplaque and antigingivitis efficacy of Triphala mouthwash versus chlorhexidine mouthwash among children.
- Trial name
- NCT07016659
- Testing
- 0.12% Chlorhexidine Mouthwash ( Hexitol ), Triphila mouthwash
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gingivitis
Comparison of Two Interdental Cleaners
Comparison of Two interdental cleaning devices on plaque removal, gingivitis and bleeding.
- Trial name
- NCT03047759
- Testing
- water flosser, air floss
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- All Sum Research Center Ltd.
Metabolic Syndrome, Periodontal Disease
Metabolic Syndrome and Periodontitis
The aim of this study is to evaluate the effect of periodontal treatment on systemic inflammation and quality of life of individuals with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Periodontal Disease, Inflammatory Response
- Trial name
- NCT02012842
- Testing
- Non surgical periodontal treatment
- Where
- 2 sites in Brazil
- Volunteers
- 158 people
- Sponsor
- Federal University of Rio Grande do Sul
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Inflammatory Bowel Diseases, Periodontitis
Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
IBD patients have a higher risk of oral diseases that affect the oral mucosa, the teeth and the tooth supporting tissues. These conditions are often associated with pain, bleeding and impaired masticatory function which may have…
- Conditions
- Inflammatory Bowel Diseases, Periodontitis, Dental Caries, Tooth Loss
- Trial name
- OQal-MICI (NCT05096897)
- Testing
- Self-administrated questionnaires
- Where
- France
- Volunteers
- 138 people
- Sponsor
- University Hospital, Lille