Clinical trials: Perioperative/Postoperative Complications
Chronic Postsurgical Pain, Chronic Opioid Users
Prevention of Chronic Postsurgical Pain in Chronic Opioid Users:
Chronic opioid users undergoing surgery are at increased risk of CPSP, contributing to long-term disability, decreased quality of life, and prolonged opioid exposure.
- Conditions
- Chronic Postsurgical Pain, Chronic Opioid Users, Transitional Pain Service, Postoperative Pain
- Trial name
- PRE-OPIOID (NCT07717151)
- Testing
- standard institutional perioperative management, specialized teleconsultation
- Where
- France
- Volunteers
- 354 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Surgery--Complications, Perioperative/Postoperative Complications
Telemedicine Notifications With Machine Learning for Postoperative Care
The ODIN-Report study will be a randomized controlled trial of the effect of providing machine learning risk forecasts to providers caring for patients immediately after surgery on serious complications.
- Conditions
- Surgery--Complications, Perioperative/Postoperative Complications, Acute Kidney Injury, Hospital Mortality
- Trial name
- ODIN-Report (NCT03974828)
- Testing
- Anesthesia Control Tower Notification
- Sponsor
- Washington University School of Medicine
Pain, Perioperative
Study To Investigate The Effectiveness Of Pregabalin For Management Of Patients Undergoing Total Hip Replacement
The purpose of this study is the investigate if pregabalin started a day before surgery and continued for 14 days post-operatively can reduce post-operative pain, relieve pre- and post-operative anxiety and sleep disturbances.
- Trial name
- NCT00905437
- Testing
- Pregabalin
- Where
- 7 sites in India
- Volunteers
- 72 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Cognitive Dysfunction, Postoperative
Effect of Targeted Fluid Therapy on Postoperative Cognitive Dysfunction.
Postoperative cognitive dysfunction (POCD) describes a decline in cognitive function as measured by pre- and postoperative neuropsychological testing.
- Trial name
- NCT06797713
- Testing
- Esophageal doppler, Conventional method
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- TC Erciyes University
Atelectasis, Postoperative, Pulmonary Complication
Evaluation of Perioperative Lung Ultrasound Scores (LUS) in Living Donor Nephrectomy Surgeries
Living donor nephrectomy surgeries can be performed in lateral position with laparoscopic technique which necessitates pneumoperitoneum. Considering the position and the pneumoperitoneum, lungs can be affected macroscopically.
- Trial name
- NCT05815888
- Testing
- Lung Ultrasound Score
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Postoperative Pain
Thoracic Paravertebral Block Versus IV Fentanyl Infusion
High-quality analgesia during and following cardiac surgery is infrequently obtained, Sternotomy and thoracotomy is associated with significant pain that resulte in hypoventilation, atelectasis, and hypoxemia,Pain management is…
- Trial name
- NCT03903367
- Testing
- Fentanyl Citrate
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Beni-Suef University
ERAS, Compliance
Pre-habilitation Within ERAS Protocol for Gynecologic Oncology Surgery: The Pre_ERAS Study
ERAS (Enhanced Recovery After Surgery) protocols are step-by-step care plans that help patients recover faster after surgery. They focus on keeping the body's normal functions, lowering stress from surgery, and supporting a…
- Conditions
- ERAS, Compliance, Quality of Life (QOL), Excercise
- Trial name
- Pre_ERAS (NCT07210164)
- Testing
- Ocoxin, Structured self-guided exercise
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Pain, Postoperative, Postoperative Nausea and Vomiting
Anesthetic Premedication With a Cannabis Extract (Cannapremed)
Clinical evidence about the effects of cannabis in a perioperative setting or for the management of acute pain is rather scarce, mostly consisting of case report-based opinions on adverse events during or after general anesthesia…
- Conditions
- Pain, Postoperative, Postoperative Nausea and Vomiting, Anxiety
- Trial name
- Cannapremed (NCT02283281)
- Testing
- Tetrahydrocannabinol, Dummy oromucosal
- Where
- Israel
- Volunteers
- 200 people
- Sponsor
- Hadassah Medical Organization
Anesthesia, Analgesia
Genetic Variants and Perioperative Morbidity and Mortality
Prospective association study to analyse perioperative patients' outcome. Outcome comprises intraoperative and postoperative complications e.g.
- Conditions
- Anesthesia, Analgesia, Surgical Procedure, Operative
- Trial name
- NCT02124499
- Where
- Switzerland
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hip Fractures, Malnutrition
Postoperative Dietary Intake of Hip Fracture Patients
The goal of this observational study is to observe the postoperative dietary intake in older adult hip fracture patients from their day of surgery (day zero) until day three inclusive.
- Conditions
- Hip Fractures, Malnutrition, Comorbidities and Coexisting Conditions, Postoperative Complications
- Trial name
- NCT06451679
- Testing
- Observational
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Teesside University
Anxiety, Postoperative Pain
Evaluation of the Postoperative Agitation Prevention and Analgesic Efficacy of Perioperative Dexmedetomidine Infusion in a Pediatric Patient Group to Undergo Dental Treatment
Dexmedetomidine is a drug known for its pain-relieving and restlessness-reducing effects. The purpose of this run is to use the association between this use during surgery and the attrition of post-operative pain and discomfort.
- Conditions
- Anxiety, Postoperative Pain, Nausea
- Trial name
- NCT06097169
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Medipol University
Intraoperative Hypotension, Pulmonary Complication
Perioperative Goal Directed Therapy (PGDT) in Spinal Surgery in the Prone Position
This study aims at evaluating if a specific protocol, that can be framed in the innovative concept of Perioperative Goal Directed Therapy (PGDT), based on the evaluation of the Stroke Volume Variation (SVV) - a parameter deriving…
- Conditions
- Intraoperative Hypotension, Pulmonary Complication, Cardiovascular Complication
- Trial name
- PGDT (NCT04025086)
- Where
- Italy
- Volunteers
- 88 people
- Sponsor
- University of Catania
Postoperative Pulmonary Complications, Postoperative Pulmonary Atelectasis
Evaluation of the Effect of Perioperative Recruitment Maneuver Practice on Lung Ultrasound Score and Mechanical Power in Pediatric Patients
Pulmonary atelectasis is common during general anesthesia and increases the risk of hypoxemia, especially in pediatric patients. PEEP and recruitment maneuvers (RM) are effective in preventing atelectasis.
- Conditions
- Postoperative Pulmonary Complications, Postoperative Pulmonary Atelectasis, Pediatric Surgery
- Trial name
- LUS RM PEEP (NCT07294560)
- Testing
- recruitment maneuver, right and left lateral decubitus position recruitment maneuvers
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Istanbul University - Cerrahpasa
Hyperoxia, Postoperative Complication
Individualized Perioperative Open-lung Ventilatory Strategy With High Versus Conventional Inspiratory Oxygen Fraction (iPROVE-O2).
The iPROVE-O2 trial aims at comparing the efficacy of high and conventional FiO2 within a perioperative individualized ventilatory strategy to reduce the overall incidence of SSI.
- Conditions
- Hyperoxia, Postoperative Complication, Surgical Site Infection
- Trial name
- iPROVE-O2 (NCT02776046)
- Testing
- High FiO2, Conventional FiO2
- Where
- Spain
- Volunteers
- 756 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Surgical Site Infection, Antibiotic Prophylaxis
The Role of Guideline-adherent Perioperative Antibiotic Administration and the Risk of Surgical Site Infections After Non-cardiac Surgery.
This study will seek to describe current practice of antibiotic prophylaxis to identify the effect of appropriate perioperative antimicrobial coverage - specifically regarding timing, dose adjustments, and redosing - on surgical…
- Trial name
- NCT03982810
- Testing
- Antibiotics
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Postoperative Complications (Cardiopulmonary)
Preoperative Exercise Testing and Perioperative Outcomes
The goal of this observational study is to learn whether results from a brief exercise test done before surgery can help identify adults who may be more likely to have problems after moderate- to high-risk noncardiac surgery.
- Trial name
- SAMPO (NCT07519733)
- Testing
- Recruited participants receive preoperative rapid submaximal cardiopulmonary exercise testing within the current risk assessment framework of the pre-surgical evaluation clinic
- Where
- United States
- Volunteers
- 992 people, healthy volunteers welcome
- Sponsor
- Yale University
Postoperative Delirium (POD)
Perioperative Dezocine Administration and Postoperative Delirium in Elderly Cardiac Surgery Patients
Postoperative delirium (POD) is a common complication in elderly patients undergoing cardiac surgery and is associated with prolonged hospitalization, increased morbidity, and poor recovery.
- Trial name
- NCT07768150
- Testing
- Dezocine, Normal Saline (NS)
- Where
- 2 sites in China
- Volunteers
- 640 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Hysterectomy, Myomectomy
Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery
Postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. Opioids remain the mainstay for postoperative analgesia.
- Trial name
- NCT03363425
- Testing
- Lidocaine Iv, Dexmedetomidine, Normal saline
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Cervical Cancer Stage IB2, Cervical Cancer Stage IIa
Minimally Invasive Radical Hysterectomy Using Endoscopic Stapler in Stage IB2 or IIA1 Cervical Cancer
This study is a multicenter, open-label, non-inferiority, randomized controlled, investigator-initiated clinical trial comparing the efficacy and safety of open radical hysterectomy versus minimally invasive radical hysterectomy…
- Trial name
- SOLUTION2 (NCT07256977)
- Testing
- Open radical hysterectomy, Minimally invasive radical hysterectomy
- Where
- South Korea
- Volunteers
- 494 people
- Sponsor
- Seoul National University Hospital
Esophageal Cancer, Drainage/Methods
Comparison of Drainage Methods in Minimally Invasive Esophagectomy (DEMURE）
This RCT compares three drainage approaches after minimally invasive esophagectomy (chest tube + thoracic mediastinal drainage tube, thoracic, and abdominal mediastinal drainage tube) to evaluate perioperative outcomes…
- Conditions
- Esophageal Cancer, Drainage/Methods, Postoperative Pain
- Trial name
- NCT07004634
- Testing
- Chest mediastinal tube, Abdominal mediastinal tube, Chest tube + chest mediastinal tube
- Where
- China
- Volunteers
- 75 people
- Sponsor
- Ruijin Hospital