Clinical trials: Perioperative Hemodynamic
Pain, Constipation
Effect of Lidocaine and Esmolol to Improve the Quality of Recovery
The purpose of this prospective, randomized, double-blinded, active-controlled study is: To assess the effectiveness of systemic administration of lidocaine and esmolol in combination (vs.
- Conditions
- Pain, Constipation, Nausea, Vomiting
- Trial name
- NCT01114997
- Testing
- Lidocaine, Esmolol, Lidocaine + Esmolol (Combo)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Cedars-Sinai Medical Center
Perioperative Hemodynamic Optimization, Cardiac Surgery
Goal-directed Resuscitation in High-risk Patients Undergoing Cardiac Surgery
The primary aim of the study is to investigate whether a goal-directed resuscitation therapy in high-risk patients through cardiac index optimization using the LiDCO Rapid device reduces complications after cardiac surgery.
- Trial name
- GRICS (NCT01470976)
- Testing
- Goal-directed Resuscitation Therapy (GDT), Standard protocol
- Where
- Brazil
- Volunteers
- 126 people
- Sponsor
- University of Sao Paulo
Perioperative Care, Fluid Therapy
Paired Comparison of SVV and PVI Accuracy
This study will compare two operating-room monitors-stroke volume variation (SVV, from the arterial line) and the Pleth Variability Index (PVI, from the pulse oximeter)-to see which one more accurately predicts whether giving a…
- Conditions
- Perioperative Care, Fluid Therapy, Monitoring, Physiologic, Hemodynamics
- Trial name
- NCT07260890
- Testing
- Stroke Volume Variation (SVV) monitoring, Pleth Variability Index (PVI) monitoring
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Wonkwang University Hospital
Postoperative Complications
Personalized Hemodynamic Therapy in Patients Undergoing High-risk Surgery
The purpose of this study is to evaluate the effectiveness of using the personal preoperatively assessed cardiac output in high-risk patients to guide perioperative administration of fluids and vasoactive drugs on predefined…
- Trial name
- TAPIR (NCT02834377)
- Testing
- Treatment algorithm targeting individual cardiac output
- Where
- Germany
- Volunteers
- 188 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
High-risk Surgery
Association of Intraoperative Hemodynamic Characteristics to Postoperative Complications and Mortality
Worldwide, about 400 million major surgeries are performed annually. The scarce data available in the literature still suggest high postoperative morbidity and mortality, even in Europe.
- Trial name
- HeCoMo (NCT06355362)
- Volunteers
- 1,000 people
- Sponsor
- Kliniken Essen-Mitte
Prostate Cancer, Robotic Radical Prostatectomy
Hemodynamic Monitoring-Guided Goal-Directed Fluid Therapy in Robotic Radical Prostatectomy
This prospective observational cohort study evaluated goal-directed fluid therapy guided by minimally invasive hemodynamic monitoring in adult male patients undergoing elective robotic radical prostatectomy.
- Trial name
- NCT07806539
- Testing
- LiDCO-guided goal-directed fluid therapy, Conventional fluid therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Antalya Training and Research Hospital
Valve Heart Disease, Elective Cesarean Delivery
Perioperative Ketorolac-lidocaine in the Patients With Valvular Heart Diseases During Cesarean Delivery
Rheumatic heart valve diseases are prevalent among the young people in Egypt secondary to the socioeconomic conditions. The goal of anesthetic management of these patients is maintenance of sinus rhythm, systemic blood pressure…
- Trial name
- NCT01571791
- Testing
- Ketorolac-Lidocaine
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Mansoura University
Anxiety, Hypotension
Impact of Music on Satisfaction, Anxiety, and Hemodynamics During Spinal Anesthesia for Cesarean Delivery
The aim of this study is to evaluate the effect of perioperative music on maternal anxiety, hemodynamic response to spinal anesthesia, postoperative pain medication requirement, and overall maternal satisfaction.
- Trial name
- NCT02732964
- Testing
- Pandora Music, Mozart Music
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Postoperative Wound Infection, Postoperative Outcome
Effect of Perioperative Hemodynamic Optimization on the Immune Function Parameters of Peripheral Blood Monocytes After Cardiac Surgery
Cardiac surgery patients have a high risk to suffer from postoperative infections. Some studies have shown, that humoral and cellular factors are associated with perioperative immunodysfunction and can increase the risk of…
- Trial name
- Algebra (NCT01184430)
- Testing
- Pulse contour cardiac output device
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Charite University, Berlin, Germany
Post Operative Pain, Hemodynamic Instability
Intra-abdominal Pressure and Insufflator Effects in Robotic Surgery
The main aim of this study is to compare the perioperative effects of different intra-abdominal pressures and different insufflators in patients undergoing robotic surgery at a 30-45 degree trendelenburg position.
- Conditions
- Post Operative Pain, Hemodynamic Instability, Hypercapnia, Complication,Postoperative
- Trial name
- NCT06132490
- Testing
- Valveless Insufflator with 12 mmHg intra-abdominal pressure, Valveless Insufflator with 8 mmHg intra-abdominal pressure
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Koç University
Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold.
- Conditions
- Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion, Hemodynamic and Respiratory Stability
- Trial name
- ReTSEACS (NCT02761564)
- Testing
- Red blood cell tranfusion, ScvO2 measure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Intraoperative Hypotension, Perioperative Care
Machine Learning-Assisted Management of Intraoperative Hypotension for Personalized Treatment
Intraoperative hypotension, defined as a drop in blood pressure during surgery, is a frequent event in patients undergoing general anesthesia.
- Conditions
- Intraoperative Hypotension, Perioperative Care, Hemodynamic Monitoring, Blood Pressure
- Trial name
- HYPOGUARD (NCT07396636)
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Nevsehir Public Hospital
Laparoscopic Surgery
Labetalol and Esmolol: Vital Signs and Post Operative Pain Management
This study proposes to investigate the effects of labetalol or esmolol on managing the vital signs (like blood pressure and heart rate) during surgery, on pain management, and on the later recovery after surgery.
- Trial name
- NCT01114971
- Testing
- Fentanyl, Labetalol, Esmolol
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Cedars-Sinai Medical Center
Coronary Artery Bypass Graft
Prospective Data Analysis of a Quality Improvement Initiative in High Risk Cardiac Surgery Patients
This project is designed to assess the impact of implementing a hemodynamic optimization protocol, utilizing flow guided parameters that is provided by technology from Edwards Lifesciences, for patients undergoing high risk…
- Trial name
- NCT04458701
- Testing
- Hemodynamic monitoring
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- Loma Linda University
Fluid Volume Disorder
Risk Stratification and Goal-directed Volume Therapy
It is difficulte to evaluate risk patients and to find the ideal intraoperative volume management. It seems to be that ill patients benefit of a goal directed volume management.
- Trial name
- NCT01456702
- Testing
- risk stratification group
- Where
- Germany
- Volunteers
- 300 people
- Sponsor
- Charite University, Berlin, Germany
Hemodynamic Monitoring, Perioperative Care
Using the "Edwards" EV1000 Clinical Platform NI in Lymphatic Venous Anastomosis
Lymphatic venous anastomosis could be applied on patients suffering from limb lymphedema after surgery or radiotherapy. The particular pathophysiology leads unconventional fluid treatment strategy and changes in urine output.
- Conditions
- Hemodynamic Monitoring, Perioperative Care, Outcome Assessment
- Trial name
- NCT03553667
- Testing
- Standard group, ClearSight
- Volunteers
- 200 people
- Sponsor
- Chang Gung Memorial Hospital
Prostate Hypertrophy, Renal Disease
Effect of Deep BLock on Intraoperative Surgical Conditions
Rationale: A deep neuromuscular block is often associated with improved surgical conditions especially in laparoscopic surgery. However, a deep block comes at the expense of a variety of items that may conflict with the use of a…
- Trial name
- BLISS (NCT01631149)
- Testing
- Surgical block (rocuronium; atracurium/mivacurium)
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- Leiden University Medical Center
Intraoperative Fluid Management
Advanced Monitoring to Inform and Guide Perioperative Hemodynamic Optimization 1 (AMIGO-1) Study
Serious complications occur in about 16% of major surgeries. Episode of hypotension during surgery may be a leading cause of these complications.
- Trial name
- AMIGO-1 (NCT03477617)
- Testing
- Intraoperative Hemodynamic Algorithm, Usual hemodynamic management
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Hemodynamic Instability, Cardiac Output, High
Individualized Perioperative Hemodynamic Goal-directed Therapy in Major Abdominal Surgery (iPEGASUS-trial)
To evaluate the impact of perioperative, algorithm driven, hemodynamic therapy based on individualized fluid and cardiac output optimization on postoperative moderate and severe complications in patients undergoing major…
- Conditions
- Hemodynamic Instability, Cardiac Output, High, Peroperative Complication
- Trial name
- iPEGASUS (NCT03021525)
- Testing
- Individualized Goal Directed Therapy, Control Group
- Where
- 7 sites in Germany, Italy and 1 more
- Volunteers
- 380 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Hypertension, Hemodynamic Instability
Perioperative Baroreflex Sensitivity
Impaired baroreflex sensitivity (BRS) is a marker of autonomous dysfunction, which may play an important role in the long-term development of hypertension.
- Conditions
- Hypertension, Hemodynamic Instability, Surgery
- Trial name
- NCT02435875
- Testing
- no intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital