Clinical trials: Perioperative Pain
Hysterectomy, Myomectomy
Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery
Postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. Opioids remain the mainstay for postoperative analgesia.
- Trial name
- NCT03363425
- Testing
- Lidocaine Iv, Dexmedetomidine, Normal saline
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Laparoscopic Gastric Bypass Surgery, Ketamine
Perioperative Ketamine for Pain With Gastric Bypass
Opioid medications such as morphine, hydrocodone and oxycodone are standard for treating pain after surgery, however there are disadvantages.
- Trial name
- NCT03448068
- Testing
- Ketamine, Standard therapy
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Feasibility, Anxiety State
Virtual Reality for Urological Procedures
It is standard practice for most cystoscopies and vasectomies in an office or outpatient setting to be performed under local anesthesia while the patient is awake and conscious.
- Conditions
- Feasibility, Anxiety State, Pain, Satisfaction, Patient
- Trial name
- NCT06534086
- Testing
- Virtual reality (VR) guided meditation therapy, Treatment as usual
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Pain, Postoperative
Analgesic Efficacy of Plan Blocks in Laparoscopic Hysterectomies
Hysterectomy is the most common major intervention in gynecology after cesarean section. Indications include myoma uteri, abnormal uterine bleeding, cervical intraepithelial neoplasia, chronic pelvic pain, uterine uteri, operated…
- Trial name
- NCT05925972
- Testing
- Plane block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Balikesir University
Pain, Post-operative Pain Control
Effect of Lidocaine in Reducing Opioids Requirement in Day Care Surgery
1. *Reduced opioid consumption 2. *Decreased pain scores 3. *Fewer opioid-related side effects 4. *Improved patient satisfaction
- Conditions
- Pain, Post-operative Pain Control, Post-operative Pain
- Trial name
- NCT06717672
- Testing
- Lidocaine 2% without vessel constrictor, Normal Saline
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Liaquat National Hospital & Medical College
Laparoscopic Cholecystectomy
ERAS (Enhanced Recovery After Surgery) and Multimodal Analgesia in Laparoscopic Cholecystectomy
This clinical study aims to evaluate the effects of multimodal analgesia management administered within an ERAS (Enhanced Recovery After Surgery) protocol on postoperative pain, length of hospital stay, early complications, and…
- Trial name
- ERAS (NCT06885086)
- Testing
- Control group - 1, Observation group -2
- Where
- Turkey (Türkiye)
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Vasectomy, Pain
Perioperative Virtual Reality Intervention for Pain and Anxiety During Vasectomies
The goal of this clinical trial is to learn if a virtual reality (VR) program (TRIPP) can reduce pain, anxiety, and distress in adult men (aged 18+) undergoing a vasectomy under local anesthesia.
- Conditions
- Vasectomy, Pain, Anxiety, Virtual Reality
- Trial name
- NCT07055178
- Testing
- Virtual reality (VR) guided meditation therapy, Treatment as usual
- Where
- Canada
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Uterine Pain
Propacetamol to Reduce Post Cesarean Section Uterine Contraction Pain
To evaluate that perioperative regular usage of propacetamol to reduce post cesarean section uterine contraction pain and opioid consumption
- Trial name
- NCT03878082
- Testing
- Propacetamol 1g, Propacetamol 2g, IVPCA
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mackay Memorial Hospital
Invasive Bladder Cancer
Intravenous Lidocaine for Cystectomy Procedures
Patients scheduled for a cystectomy at Charleston Area Medical Center (CAMC) will be enrolled into a randomized, double blinded clinical trial to assess if postoperative pain and ileus are reduced by perioperative intravenous…
- Trial name
- Lidocaine (NCT02924480)
- Testing
- Cystectomy, Lidocaine, Saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CAMC Health System
Lumbar Posterior Decompression
Thoracolumbal Interfascial Plane Block Versus Erector Spinae Plane Block for Lumbar Posterior Decompression Stabilization
This study aimed to found out The Comparison Of Perioperative Analgesia Effectiveness Between Thoracolumbal Interfascial Plane Block with Erector Spinae Plane Block In Lumbar Posterior Decompression and Stabilization.
- Trial name
- NCT04951024
- Testing
- Thoracolumbar interfacial plane (TLIP) Block, Erector Spinae Plane (ESP) Block
- Where
- Indonesia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Postoperative Pain
Effect of Perioperative Hypothermia on Postoperative Pain
This study aims to observe the impact of perioperative body temperature on postoperative pain and pain sensitization for the patients with laparoscopic surgery.
- Trial name
- NCT05681091
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
Regional Anesthesia, Pain
Nociception Index Level (NOL) Perioperative Monitoring During Regional Anesthesia
This prospective observational study was conducted to assess pain using NOL index under locoregional anesthesia for orthopedic surgery of the upper limb.
- Conditions
- Regional Anesthesia, Pain, Intraoperative Monitoring
- Trial name
- NOL and LRA (NCT06300606)
- Testing
- NOL monitoring
- Where
- France
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- American Hospital of Paris
Perioperative Pain
Effect of Bupivacaine Concentration on Ultrasound Guided Pericapsular Group Nerve Block Efficacy in Hip Surgery Patients
Fractures in and around the hip are quite common irrespective of both the young and elderly population groups and are associated with extreme pain.The anterior hip capsule is innervated by articular branches of femoral nerve…
- Trial name
- NCT05788458
- Testing
- Bupivacain
- Where
- Egypt
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Benha University
Pain Management, Postoperative Pain
Effects of S-ketamine on Perioperative Opioid Consumption
This study is a triple-blind randomized controlled trial conducted at a tertiary care hospital in Brussels. It investigates whether a single dose of S-ketamine can reduce opioid (morphine) consumption in the first 24 hours after…
- Conditions
- Pain Management, Postoperative Pain, Opioid Consumption, Postoperative, Opioid Analgesia
- Trial name
- NCT07528651
- Testing
- Esketamine at low dose, Saline (0.9% NaCl)
- Where
- Belgium
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Music Therapy, Anxiety
Therapy on Perioperative Anxiety and Pain in Patients
This study aims to explore the effects of preoperative education combined with intraoperative music therapy on perioperative anxiety and pain in patients undergoing elective cesarean section.
- Conditions
- Music Therapy, Anxiety, Health Education
- Trial name
- NCT06970431
- Testing
- eoperative Education + Intraoperative Music Therapy Arm, Preoperative Education Alone Arm
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Anesthesia
Fentanyl Versus Morphine in Spinal Anesthesia for Caesarian Section - Study on Analgesia, Side Effects and Patient 's Satisfaction
Intrathecal morphine and fentanyl are used for anesthesia and perioperative pain management in caesarian section. Despite the fact that spinal Fentanyl is better tolerated, might not be enough for postoperative pain control.
- Trial name
- FvMinSA (NCT05533229)
- Testing
- Fentanyl, Morphine
- Where
- Romania
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Dr. Mihai Octavian Botea
Pain
Evaluating VR Therapy Using Cold Pressor Test
This study is testing whether or not low-cost, virtual reality (VR) headsets for mobile phones can be used as a potential distractor from pain and thus would have clinical applications as a low-cost, non-pharmaceutical method to…
- Trial name
- NCT03268863
- Testing
- Virtual Reality, Cold Pressor
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Janet Vittone
Perioperative Anxiety, Perioperative Pain Management
Evaluation of the Effectiveness of Virtual Reality as an Adjunct to Standard Care in Managing Perioperative Anxiety and Pain in Patients Undergoing Lower Limb Orthopedic Surgery Under Spinal Anesthesia
The goal of this clinical trial is to evaluate whether virtual reality (VR) can effectively reduce perioperative anxiety and pain in patients undergoing lower limb orthopedic surgery under spinal anesthesia.
- Conditions
- Perioperative Anxiety, Perioperative Pain Management, Hemodynamic Stability, Satisfaction
- Trial name
- NCT07134764
- Testing
- Virtual reality session
- Where
- Tunisia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Fusion of Spine, Lumbar Region
The Effectiveness of IV/PO Acetaminophen in the Perioperative Period in Reducing Opiate Use After Lumbar Spine Fusion
Simple explanation and rationale: Recovery after spine surgery is usually accompanied by severe pain which has traditionally been managed with opioids.
- Trial name
- NCT03104816
- Testing
- Acetaminophen IV Soln 10 MG/ML, Acetaminophen, Hydromorphone
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Knee Osteoarthritis
Comparison of Postoperative Pain Score Between Perioperative Intravenous Ketamine and Placebo in Patients Undergoing Unilateral Total Knee Arthroplasty Under General Anesthesia
The goal of this clinical trial is to compare postoperative pain score between perioperative intravenous ketamine and placebo in patients undergoing unilateral total knee arthroplasty under general anesthesia.
- Trial name
- NCT06267638
- Testing
- Ketamine group
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Thailand