Clinical trials: Peripheral Arterial
Peripheral Artery Disease
Telehealth to Improve Functional Status and Quality of Life in Veterans With PAD
The present study aims to increase Veteran access to supervised exercise therapy and expand its role in improving functional status, quality of life, and cardiovascular risk profile of Veterans with PAD.
- Trial name
- MOVE-IT (NCT05048979)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- VA Office of Research and Development
Peripheral Vascular Disease
Drug-Coated Chocolate PTA Balloon in Patients With Peripheral Arterial Disease - The ENDURE Trial
This first-in-man study is to evaluate the Drug-Coated Chocolate (DCC) Balloon for percutaneous arterial angioplasty in patients with symptomatic peripheral arterial disease.
- Trial name
- ENDURE (NCT02129127)
- Testing
- Paclitaxel Coated Chocolate Balloon Angioplasty
- Where
- 2 sites in Germany, New Zealand
- Volunteers
- 67 people
- Sponsor
- TriReme Medical, LLC
Acute Myocardial Infarction, Ischemic Stroke
Alpha-linolenic Acid and the Risk of ASCVD
Background: The plant-derived omega-3 fatty acid alpha-linolenic acid (ALA, 18:3-n-3) may reduce the risk of atherosclerotic cardiovascular disease, including incident myocardial infarction, ischemic stroke and peripheral artery…
- Conditions
- Acute Myocardial Infarction, Ischemic Stroke, Peripheral Artery Disease
- Trial name
- NCT03258983
- Testing
- Alpha-linolenic acid
- Volunteers
- 57,053 people
- Sponsor
- Aalborg University Hospital
Peripheral Arterial Disease
Study to Evaluate the Effect of Simvastatin, Losartan and Pioglitazone on Patients With Peripheral Arterial Disease.
Part A. The purpose of this study is to assess the effects of 6 weeks of treatment with, simvastatin, losartan or pioglitazone compared to placebo on the RNA expression profile of lower extremity peripheral arterial…
- Trial name
- LEAP (NCT00720577)
- Testing
- Simvastatin, Losartan, Pioglitazone
- Volunteers
- 164 people
- Sponsor
- Medtronic Endovascular
Peripheral Arterial Disease, Femoropopliteal Lesions
BATTLE Trial: Bare Metal Stent Versus Paclitaxel Eluting Stent in the Setting of Primary Stenting of Intermediate Length Femoropopliteal Lesions
Over the past years, endovascular interventions have become an important part of treatment in patients with peripheral arterial disease.1 Indication for endovascular repair of femoropopliteal lesions has been considerably…
- Trial name
- BATTLE (NCT02004951)
- Testing
- Misago RX, Zilver PTX
- Where
- 11 sites in France
- Volunteers
- 186 people
- Sponsor
- Nantes University Hospital
Peripheral Arterial Disease
The Vascular Biology of Dipyridamole in Peripheral Arterial Disease (PAD)
This research study will evaluate the effects of aspirin and dipyridamole alone and in combination on the blood flow in the vessels of the legs.
- Trial name
- NCT00906035
- Testing
- Dipyridamole 200mg and Aspirin 25mg bid:, Dipyridamole 200 mg bid, Aspirin 25 mg bid
- Where
- 3 sites in United States
- Volunteers
- 25 people
- Sponsor
- University of Pennsylvania
Intermittent Claudication, Peripheral Vascular Disease
Safety and Efficacy Study of Ad2/Hypoxia Inducible Factor (HIF)-1α/VP16 Gene Transfer in Patients With Intermittent Claudication
The purpose of this Phase 2 clinical research study is to examine the safety of an experimental gene transfer agent, Ad2/HIF-1α/VP16, and its ability to stimulate the growth of new blood vessels from existing blood vessels (a…
- Conditions
- Intermittent Claudication, Peripheral Vascular Disease, Atherosclerosis
- Trial name
- WALK (NCT00117650)
- Testing
- Ad2/HIF-1α/VP16
- Where
- 47 sites in United States, Germany and 1 more
- Volunteers
- 289 people
- Sponsor
- Genzyme, a Sanofi Company
Superficial Femoral Artery Stenosis
CONTINuous Infra-Inguinal Stenting Using the Bard® LifeStent® VascUlar Stent SysteMs ("CONTINUUM")
The objectives of this study are to collect post-market confirmatory evidence of the safety and effectiveness of the Bard® LifeStent® Vascular Stent System and LifeStent® XL Vascular Stent System (together the "LifeStent®…
- Trial name
- CONTINUUM (NCT00908947)
- Testing
- PTA followed by placement of LifeStent® Vascular Stent
- Where
- 29 sites in United States
- Volunteers
- 173 people
- Sponsor
- C. R. Bard
Vascular Disease, Intermittent Claudication
Optimising the Efficacy, Patient Perception and Uptake of an Exercise Programme in People in Intermittent Claudication
Background: Peripheral arterial disease is a result of atherosclerotic occlusion in the major arteries supplying the lower limbs and is associated with an increased risk of mortality and morbidity.
- Trial name
- SEIC (NCT02641418)
- Testing
- Supervised exercise programme
- Where
- United Kingdom
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Hull University Teaching Hospitals NHS Trust
Peripheral Arterial Disease, Clopidogrel, Poor Metabolism of
Aspirin and Thienopyridine Resistance in Peripheral Arterial Disease
This study evaluates the effects of Aspirin and thienopyridine resistance in relation to clinical cardiovascular outcomes as the genetic predictors of, and outcomes associated with aspirin and thienopyridine resistance in…
- Trial name
- NCT03174990
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
PAD - Peripheral Arterial Disease, PAD
Distrupt Stiffness Trial
Typical symptoms of PAD include exercise-induced pain in the legs (known as intermittent claudication), which can significantly limit pain-free walking. In more advanced stages, pain may also occur at rest.
- Trial name
- NCT07130526
- Testing
- Intravascular Lithotripsy (IVL) plus DCB, POBA plus DCB
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- University Hospital, Essen
Peripheral Artery Disease (PAD), Dysfunctional AV Fistula
Serranator POINT FORCE Registry
The objective of this registry is to collect observational data under local standard of care and evaluate safety and performance of the Serranator® in treatment of peripheral artery disease (PAD), or dysfunctional native or…
- Conditions
- Peripheral Artery Disease (PAD), Dysfunctional AV Fistula, Dysfunctional AV Graft
- Trial name
- POINT FORCE (NCT06687590)
- Testing
- Peripheral balloon angioplasty
- Where
- 19 sites in United States
- Volunteers
- 500 people
- Sponsor
- Cagent Vascular LLC
Chronic Ulcer of Lower Extremity, Wound
Effect of Blood Flow by Botulinum Toxin Injection for Severe Peripheral Artery Occlusive Disease
The purpose of this study is to investigate the effect of subcutaneous injection of botulinum toxin A on wound healing caused by lower extremity ischemia.
- Conditions
- Chronic Ulcer of Lower Extremity, Wound, Botulinum Toxins, Type A, Blood Circulation
- Trial name
- NCT06878482
- Testing
- Botulinum toxin A
- Where
- South Korea
- Volunteers
- 15 people
- Sponsor
- Yonsei University
Peripheral Artery Disease
LEVANT 2 Continuation Registry of the Lutonix® Drug Coated Balloon (DCB)
The purpose of the study is to collect additional safety and efficacy information on the Lutonix (formerly Moxy) Drug Coated Balloon for treatment of stenosis or occlusion of the femoral and popliteal arteries.
- Trial name
- NCT01628159
- Testing
- Lutonix Drug Coated Balloon
- Where
- 64 sites in United States, Austria and 3 more
- Volunteers
- 657 people
- Sponsor
- C. R. Bard
Cardiac Event, Coronary Artery Disease
Comparison of Clopidogrel-based Antiplatelet Agent Treatment and Aspirin Plus Low Dose Rivaroxaban Therapy
The study aims to conduct a randomized controlled trial among adults aged 19 years or older who have experienced acute myocardial infarction at least one year prior, or who have other comorbidities such as peripheral arterial…
- Conditions
- Cardiac Event, Coronary Artery Disease, Peripheral Artery Disease, Bleeding
- Trial name
- OACART (NCT07796217)
- Testing
- Aspirin and low-dose rivaroxaban, Clopidogrel with or without aspirin
- Where
- South Korea
- Volunteers
- 2,758 people
- Sponsor
- Seoul National University Bundang Hospital
Peripheral Arterial Disease
A Clinical Study on Efficacy & Safety Profile of Propionyl-L-carnitine Tablets for Peripheral Arterial Diseases
The main objective of this study is to evaluate the effectiveness and safety of the propionyl-L-carnitine hydrochloride tablets among Chinese population in comparison with the placebo, for treatment of the peripheral arterial…
- Trial name
- PLC (NCT00809497)
- Testing
- Propionyl-L-carnitine Tablets
- Where
- China
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Peripheral Arterial Disease, Diabetic Foot
Efficacy and Safety of Intramuscular PDA-002 in Subjects With Diabetic Foot Ulcer With and Without PAD.
This is a Phase 2, multicenter, randomized, double-blind, placebo-controlled, dose-ranging study evaluating the efficacy and safety of intramuscular administration of human placenta-derived cells (PDA-002) in subjects with…
- Trial name
- DFU-002 (NCT02264288)
- Testing
- PDA-002
- Where
- 45 sites in United States
- Volunteers
- 159 people
- Sponsor
- Celularity Incorporated
Intermittent Claudication, Critical Limb Ischemia
Choice of Material for Above-Knee Femoro-Popliteal Bypass Prosthetic Graft (PopUp)
This trial was designed to challenge the wide held view that polytetrafluoroethylene (PTFE) performs better than Dacron for above knee femoropopliteal bypass.
- Trial name
- NCT00300690
- Testing
- 6 mm Uni-graft® (B-Braun), 6 mm Gore-Tex® (WL Gore)
- Volunteers
- 400 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Intermittent Claudication
An E-health Intervention for Patients With Peripheral Artery Disease
The specific study aim is to determine whether a 12-week digitally delivered behavior change intervention for patients with peripheral artery disease increases walking ability, reduces smoking, improves quality of life and…
- Trial name
- I-PAD (NCT05029739)
- Testing
- A PAD-specific smartphone application (e-intervention) developed for patients with Peripheral Artery Disease
- Where
- 5 sites in Sweden
- Volunteers
- 155 people
- Sponsor
- Sahlgrenska University Hospital
Acute Pain
Effect of Remote Local Peripheral Nerve Cooling on Pain of Arterial Puncture
In this project, volunteers will be recruited to cool the superficial skin of the axillary brachial plexus away from the puncture point, resulting in local peripheral nerve cooling, and observe its impact on the pain of arterial…
- Trial name
- NCT06838572
- Testing
- Skin cooling to 20°C, Skin cooling to 15°C, Skin cooling to 8°C
- Where
- China
- Volunteers
- 100 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University
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