Clinical trials: Peripheral Arterial Vascular Occlusion
Dyslipidemia, Atherosclerosis
Effects of Nicotinic Acid Plus Simvastatin Versus Simvastatin Alone on Carotid and Femoral Intima-Media Thickness in Patients With Peripheral Artery Disease (NASCIT)
Dyslipidaemia is characterized by low plasma levels of high-density lipoprotein cholesterol (HDL-c), elevated triglycerides and an increase in low density lipoprotein (LDL-c) particles, and has been unequivocally established as a…
- Trial name
- NASCIT (NCT00712049)
- Testing
- simvastatin, Nicotinic Acid
- Where
- Austria
- Volunteers
- 200 people
- Sponsor
- Medical University of Vienna
Chronic Limb Threatening Ischemia
Referrals for CLTI: Qualitative Study
The goal of this qualitative study is to explore the experiences of patients who have been diagnosed with chronic limb-threatening ischaemia (CLTI).
- Trial name
- NCT05659004
- Testing
- Qualitative interview
- Where
- 2 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- University of Hull
Peripheral Arterial Disease, Angina
Ranolazine Versus Placebo Effects on Exercise Tolerance in Patients With Heart Disease and Peripheral Arterial Disease
After 6 weeks of maximal Ranolazine therapy, tissue hemoglobin desaturation kinetics will change compared to placebo in patients with chronic angina and peripheral arterial disease.
- Trial name
- NCT00657514
- Testing
- Ranolazine
- Where
- 3 sites in United States
- Sponsor
- Colorado Prevention Center
Critical Limb Ischemia
Registry of First-line Treatments in Patients With Critical Limb Ischemia
The principal research question is which treatment modality between open surgical, endovascular and conservative therapy is the most effective in terms of limb salvage, survival and reinterventions in patients with critical limb…
- Trial name
- CRITISCH (NCT01877252)
- Testing
- Surgical revascularization, Endovascular revascularization, No vascular intervention
- Where
- Germany
- Volunteers
- 1,200 people
- Sponsor
- St. Franziskus Hospital
Peripheral Arterial Disease
Smartstep Smartphone PAD
The study aim is to evaluate the effectiveness of a coached, smartphone-enabled exercise program versus physician directed exercise therapy (usual care).
- Trial name
- SMARTSTEP (NCT03479255)
- Testing
- Smartphone-enabled structured exercise therapy (SE-SET), Standard exercise therapy
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Emory University
Peripheral Arterial Disease, Peripheral Artery Disease
Preliminary Tissue Monitoring During Endovascular Intervention Study
Tissue perfusion assessment is key to more accurate measurement of foot ischemia, which is in turn an important factor in appropriate treatment decisions.
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Arterial Occlusive Diseases
- Trial name
- mini-TIME (NCT04956523)
- Volunteers
- 20 people
- Sponsor
- Pedra Technology, PTE LTD
Peripheral Artery Disease
Radial accEss for nAvigation to Your CHosen Lesion for Peripheral Vascular Intervention: REACH PVI
The objective of this study is to evaluate acute clinical results of orbital atherectomy (OA) via radial artery access, including complication rates and cost effectiveness.
- Trial name
- REACH PVI (NCT03943160)
- Testing
- Diamondback 360 Extended Length Orbital Atherectomy System
- Where
- 6 sites in United States
- Volunteers
- 50 people
- Sponsor
- Abbott Medical Devices
Critical Limb Ischemia
Validation of OxyVu for Assessing Level of Amputation With Comparison to Other Modalities
Correlation of(OxyVu) values to to ABI, TBP, and TCOM in patients scheduled for foot level amputation because of critical limb ischemia, infection, or tissue necrosis.
- Trial name
- LOA (NCT00767923)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HyperMed
Peripheral Arterial Disease
Evaluation of the FreedomFlow™ Orbital Atherectomy System to Treat Peripheral Artery Disease
To evaluate the safety and effectiveness of the Cardio Flow FreedomFlow™ Orbital Circumferential Atherectomy System for atherosclerotic plaque removal and vessel compliance modification in de novo native target lesions in the…
- Trial name
- FASTII (NCT03635190)
- Testing
- Orbital Circumferential Atherectomy
- Where
- 13 sites in United States
- Volunteers
- 112 people
- Sponsor
- Cardio Flow, Inc.
Arterial Occlusive Disease, Intermittent Claudication
ATHERO: Advanced Technology Halting Early Re-Stenosis and Occlusion
The rise of minimal access surgery has heralded the approval of a number of endovascular devices with similar indications. This is particularly true for the treatment of lower extremity ischemia.
- Trial name
- NCT00407940
- Testing
- Lower extremity Atherectomy and Cryoplasty
- Where
- United States
- Sponsor
- University of California, San Diego
Critical Limb Ischemia
Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cells Implantation in Patients With Critical Limb Ischemia
The purpose of this study is to investigate the efficacy and safety of autologous transplantation of Adipose Tissue derived Mesenchymal stem cells (MSCs) in patient with critical limb ischemia
- Trial name
- NCT01663376
- Testing
- Autologous Adipose Tissue derived MSCs Transplantation
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- R-Bio
Critical Limb Ischemia
Revascularization in Nonagenarian Patients With Critical Lower Limb Ischaemia
The rise in life expectancy implies an increased number of nonagenarian patients who need evaluation for critical lower limb ischaemia (CLI).
- Trial name
- NONA-CLI (NCT02517840)
- Volunteers
- 53 people
- Sponsor
- Hospital Universitario Getafe
Peripheral Arterial Disease
Efficacity Study With the Protégé EverFlex Stent in Popliteal Lesions
This study will assess the results up to 12 months with the Protégé EverFlex stent (ev3) in patients presenting with a narrowing or blocking at the level of the knee artery, which leads to a limited walking distance, rest pain or…
- Trial name
- DUR-POP (NCT01412450)
- Testing
- nitinol stent
- Where
- 4 sites in Belgium
- Volunteers
- 60 people
- Sponsor
- Flanders Medical Research Program
Peripheral Arterial Disease
REFLOW Study, Investigating the Efficacy of the LEGFLOW DCB in TASC C&D Fempop Lesions
A physician initiated trial investigating the LEGFLOW Paclitaxel-Eluting Peripheral Balloon dilatation catheter for the treatment of femoropopliteal lesions longer than 15cm.
- Trial name
- NCT02580955
- Testing
- LEGFLOW DCB
- Where
- 4 sites in Belgium
- Volunteers
- 120 people
- Sponsor
- Flanders Medical Research Program
Critical Limb Ischemia (CLI)
Expanded Access Treatment of Subjects With Critical Limb Ischemia (CLI) With Minor Tissue Loss Who Are Unsuitable for Revascularization
A Phase III study of PLX-PAD for CLI patients with minor tissue loss who are unsuitable for revascularization has been initiated (PLX-CLI-03, PACE study).
- Trial name
- NCT03886506
- Testing
- PLX-PAD
- Where
- 2 sites in United States
- Sponsor
- Pluristem Ltd.
Peripheral Arterial Disease
Comparison of Lower Limb Endovascular Interventions With and Without the EndoNaut Workstation
To demonstrate that the use of EndoNaut for endovascular procedures on the femoropopliteal axis has a clinical impact for the patient (decrease in irradiation and the volume of contrast product) as well as for nursing staff…
- Trial name
- COMPAR-MI (NCT04709991)
- Testing
- Endovascular procedure
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Therenva
Wound Heal, Peripheral Artery Disease
Safety and Efficacy of the Noxsano Wound Care Bandage
This study is a prospective, interventional, non-randomized study designed to assess the safety and efficacy of the Noxsano Bandage (study device) in healthy subjects and wound care subjects with a diabetic lower extremity…
- Conditions
- Wound Heal, Peripheral Artery Disease, Ulcer, Leg, Ulcer Foot
- Trial name
- NCT04123093
- Testing
- Noxsano Bandage (Healthy Volunteers), Noxsano Bandage (Wound Care)
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- OhioHealth
Critical Limb Ischemia, Peripheral Artery Disease
Elutax-SV Drug-eluting Balloons for Below-the-knee Treatment
The aim of this observational study is to evaluate the outcomes and safety of the Paclitaxel-eluted balloon catheter ELUTAX SV for treatment of peripheral arterial disease (PAD) in below-the-knee vessels
- Trial name
- Apollo (NCT02539940)
- Testing
- Angioplasty Paclitaxel-eluted balloon catheter ELUTAX SV
- Where
- 10 sites in Germany
- Volunteers
- 166 people
- Sponsor
- Jena University Hospital
Cardiovascular Disease
Evaluation of Patients With Heart Disease Not Eligible for Research Protocols
An important mission of the National Institutes of Health (NIH) is to develop and carry out research studies designed to improve understanding of disease processes and treatments.
- Trial name
- NCT00001458
- Where
- United States
- Volunteers
- 7,829 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Peripheral Arterial Disease
Effects of Plant-Based Diet on Peripheral Arterial Disease
Cardiovascular disease (CVD), a condition predominantly caused by atherosclerosis, is the leading cause of morbidity and mortality in the investigator's society.
- Trial name
- NCT03798938
- Testing
- plant-based diet
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vascular Institute of Texas
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