Clinical trials: Peripheral Blood Flow
Hepatic Flow Changes
Hepatic Blood Flow Changes During Fluid Challenge Assessed by MRI in Volunteers Subjects.
Hepatic artery and portal flows are both regulated to assume the whole hepatic blood flow. Each counts for respectively 25% and 75%.
- Trial name
- PORTEAU (NCT03589261)
- Testing
- MRI (magnetic resonance imaging)
- Where
- France
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Diabetes Mellitus, Type 1, Hypertension
Correlation of Flicker Induced and Flow Mediated Vasodilatation in Patients With Endothelial Dysfunction and Healthy Volunteers.
A couple of studies have shown that illuminating the eye with diffuse flickering light is accompanied by an increase of retinal vessel diameters, optic nerve head blood flow and retinal blood flow.
- Conditions
- Diabetes Mellitus, Type 1, Hypertension, Hypercholesterolemia, Regional Blood Flow
- Trial name
- NCT00432029
- Testing
- Forearm blood flow measurement, Flow mediated dilation (FMD), Zeiss Retinal Vessel Analyzer (RVA), Stimulation with Flicker-light
- Where
- Austria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Choroid, Retina
Effect of Different Intensities of Repeated Low-Level Red-Light Therapy on Choroidal and Retinal Blood Flow Among Adults
The purpose of this clinical trial is to evaluate the effect of different intensities of repeated low-level red-light (RLRL) therapy on the choroidal and retinal blood flow among adults.
- Trial name
- NCT05747742
- Testing
- RLRL device
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The Second People's Hospital of Foshan
Healthy
Role of Nitric Oxide in Optic Nerve Head Blood Flow Regulation During Experimental Increase of Intraocular Pressure in Healthy Humans
Autoregulation is defined as the ability of a vascular bed to adapt its vascular resistance to changes in perfusion pressure. In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of…
- Trial name
- NCT00914394
- Testing
- NG-monomethyl-L-arginine (L-NMMA), Phenylephrine, Laser Doppler Flowmetry
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Amblyopia, Regional Blood Flow
Amblyopia and Neurovascular Coupling in the Retina of Humans
The visual disorder of amblyopia affects 2% to 3% of the population. Amblyopia is a developmental condition that is characterized by reduced vision of the eye due to the presence of a sensory impediment during visual development…
- Trial name
- NCT00312390
- Testing
- Flicker, Retinal Vessel Diameter, Retinal Blood Flow
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Women, Sympathetic Nervous System
Early Neurovascular Adaptations in Aging Women
Our goal is to enhance our understanding of early vascular adaptations in aging women with an emphasis on the sympathetic nervous system.
- Conditions
- Women, Sympathetic Nervous System, Aging, Blood Flow
- Trial name
- NCT06520982
- Testing
- Norepinephrine, Isoproterenol, Acetylcholine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Endothelial Function, Cognition
Cognitive and Cerebral Blood Flow Effects of Vitamin C
This investigation is interested in the effects of high dose vitamin C on endothelial function in healthy humans. A high fat meal will be utilized to induce endothelial dysfunction.
- Trial name
- NCT01055418
- Testing
- Vitamin C
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Sports Physical Therapy
Upper Limb Blood Flow Restriction in Handball Players
Introduction. Blood flow restriction therapy involves the use of an occlusion cuff placed over an extremity resulting in a partial reduction of arterial blood flow and total restriction of venous return. Objectives.
- Trial name
- NCT06423196
- Testing
- Experimental group
- Where
- Spain
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Coronary Artery Disease
Myocardial Perfusion Imaging Galmydar Rest/Stress
A single center, phase 0/1 clinical imaging study designed to assess the role of [68Ga]Galmydar PET/CT imaging in human subjects.
- Trial name
- NCT05625490
- Testing
- Ga-68 Galmydar, 13N-ammonia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Vascular Disease, Heart Disease
Effects of Urocortins on Forearm Arterial Blood Flow in Healthy Volunteers (Protocol 3)
Impairment of the heart's pumping capacity (heart failure) remains a major clinical problem with a poor prognosis and the search for novel treatments remains an important area of research.
- Trial name
- NCT01096706
- Testing
- NO clamp, Saline, Fluconazole
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Postprandial Hypotension, Healthy
GastroFlow: Investigation of the Gastrointestinal Blood Flow in Patients With Postprandial Hypotension
This project will describe the mechanisms of action and the relative contributions of GIP to changes in gastrointestinal blood flow induced by oral glucose and endogenous GIP with the use of a receptor antagonists GIP(3-30)NH2 in…
- Conditions
- Postprandial Hypotension, Healthy, Blood Flow
- Trial name
- Gastroflow (NCT07381816)
- Testing
- MRI + GIPR antagonist (Tool), MRI + hangrip, Saline and oral glucose
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Stroke, Problem of Aging
Modulation of Cerebral Blood Flow Using Iron Chelators
The purpose of this study is determine if the iron chelator, desferrioxamine can increase blood levels of hypoxia-inducible transcription factor 1 (HIF-1 protein) and to see if there is a corresponding increase in blood flow to…
- Trial name
- DFO (NCT01365104)
- Testing
- desferrioxamine
- Where
- United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Brain Concussion, Post-Concussion Syndrome
Cerebral Blood Flow Regulation and Concussions
The purpose of this study is to understand how biochemical markers in blood, balance disturbances, and cognitive performance are related to brain blood flow changes after a concussion.
- Trial name
- NCT02754206
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Southern Methodist University
Alzheimer Disease, Dementia
Apolipoprotein E (APOE) Genotype Effects on Triglycerides and Blood Flow in the Human Brain
High fat feeding (HFF) increases the risk of Alzheimer's disease (AD) but individuals who carry the AD risk gene E4 paradoxically improve after acute HFF.
- Trial name
- NCT04692441
- Testing
- Heavy Cream
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Washington
Pregnancy
Vascular Responses to UV Exposure in Pregnancy
Season of birth influences pregnancy for reasons that remain unclear however the answer may lie in the amount of sunshine pregnant women are exposed to.
- Trial name
- NCT02482363
- Testing
- UVA radiation
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Preterm Labor, Cerebral Palsy
Calcium Channel Blockers Compared to Magnesium Sulfate in Fetal Cerebral Blood Flow
The aim of this study is to investigate the possible use of calcium channel as a neuroprotectant in cases with PTL. This will be done by comparing the effect they have on cerebral blood vessels with the already established MgSo4.
- Trial name
- NCT02591004
- Testing
- Magesium sulphate, Nifedipine, Doppler on fetal middle cerebral artery
- Where
- Egypt
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Kasr El Aini Hospital
Obstructive Sleep Apnea, Hypertension
Effect of Selective and Nonselective Cyclooxygenase Enzyme Inhibition on Arterial Blood Pressure and Cerebral Blood Flow With Exposure to Intermittent Hypoxia in Humans
The study has been designed to assess the effect of cyclooxygenase inhibition on blood pressure, cerebral blood flow, ventilation and renal hemodynamics following chronic intermittent hypoxia exposure.
- Conditions
- Obstructive Sleep Apnea, Hypertension, Cardiovascular Diseases, Stroke
- Trial name
- NCT01280006
- Testing
- Intermittent hypoxia, Indomethacin, Celecoxib
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Healthy Males, Neuromuscular Function
Cerebral Blood Flow and PETCO2 on Neuromuscular Function During Environmental Stress
Environmental stress, such as low oxygen availability (hypoxia), has been associated with impaired neuromuscular performance; however, the mechanisms associated with these performance decrements remain unclear.
- Trial name
- NCT01830335
- Testing
- Indomethacin
- Where
- Canada
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Brock University
Blood Flow Restriction and Low-Intensity Resistance Training
Resistance Training and Blood Flow Restriction
The primary purposes of the proposed study is 1) To examine the changes of muscle fiber cross-sectional areas in the leg extensor muscles (vastus lateralis) pre- to post- 6 weeks of high-intensity resistance training and…
- Trial name
- NCT04938947
- Testing
- Blood Flow Restriction Cuffs, Low-Intensity Resistance Training, High-Intensity Resistance Training
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Shoulder and Upper Arm Injury
Contralateral Blood Flow Resistance Improves Scapular Muscle Activation During Pickleball Forehand Swings
Participants will perform table tennis, pickleball, and tennis swings while arm and leg muscles are analyzed with surface electromyography. Then blood flow resistance will be added to the non-swinging arm.
- Trial name
- NCT07728838
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Texas Woman's University