Clinical trials: Peripheral Blood Flow
Cerebrovascular Disorder, Epilepsy
Brain Blood Flow Studies of Language and Memory
Positron Emission Tomography (PET) is a technique used to investigate the functional activity of the brain. The PET technique allows doctors to study the normal processes of the brain (central nervous system) of normal…
- Trial name
- NCT00001288
- Testing
- 15 O Water, FDG
- Where
- United States
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Postural Tachycardia Syndrome (POTS)
Effect of Dietary Sodium Intake on Vascular Endothelium
The investigators will test the hypothesis that markers of vascular endothelial dysfunction will be exaggerated acutely with an extreme high sodium diet compared to an extreme low-sodium diet.
- Trial name
- NCT01550315
- Testing
- Pulsitile Arterial Tonometry (PAT) Protocol, Calf Blood Flow in Reactive Hyperemia (CBF-RH), Evaluation of Forearm-Mediated Dilation
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Myocardial Ischemia
Multi-modality Imaging of Ischemia With 18F-FDG PET and CTA
Coronary artery disease results in narrowing of the blood vessels supplying oxygenated blood to the heart muscle. Diagnosis in patients with symptoms of chest pain is now quickly done with CT coronary angiography.
- Trial name
- NCT01520025
- Testing
- PET MPI imaging with 18F-Fluorodeoxyglucose
- Where
- Canada
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Normal Subjects
A Feasibility Study to Determine PET/CT Imaging of Blood Flow to the Bone
To evaluate if a commonly used medical bone scan, called positron emission tomography/computed tomography (PET/CT) with sodium fluoride can measure bone blood flow to the hip.
- Trial name
- PETCT (NCT03557450)
- Testing
- PET/CT Scan
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Changes in Blood Flow to the Brain, Changes Depending on the Form of Walking
Influence of Direction of Movement While Walking
The aim of the study is evaluation of cerebral blood flow (based on testing the rate of flow in middle cerebral arteries by transcranial Doppler ultrasound) during different forms of walking training - walk forwards and…
- Trial name
- NCT01254968
- Where
- Poland
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Silesia
Cognitive Change
Cognitive and Cerebral Blood Flow Effects of Zanthozylum Armatum Fruit Extract in Healthy Adults Aged 30 - 55
Zanthozylum armatum (Z. armatum)-otherwise known as Nepalese pepper, or timut-is an perennial shrub found in India and across Southeast Asia. Preparations of the bark, fruit and seeds of Z.
- Trial name
- NCT03673930
- Testing
- Zanthozylum armatum
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Atherosclerosis, Heart Failure, Congestive
The Role of Angiotensin Type I Receptor in the Regulation of Human Peripheral Vascular Function
The renin angiotensin system (RAS) plays an important physiological and pathophysiological role in the control of blood pressure and plasma volume.
- Conditions
- Atherosclerosis, Heart Failure, Congestive, Hypertension, Myocardial Infarction
- Trial name
- NCT00001628
- Testing
- Angiotensin II type 1 receptor antagonists
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Hemorrhage
Pulsatile Perfusion Therapy Phase II
Individuals who suffer from a stroke, cardiac arrest, or traumatic bleeding (hemorrhage) injuries often have compromised blood flow and oxygen to the brain which can lead to the death of brain cells, and if the patient survives…
- Trial name
- PPT2 (NCT05983744)
- Testing
- 0 Hz Control, 0.1 Hz PPT, 0.05 Hz PPT
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Caroline Rickards
Pregnancy, Physical Activity
The Effect of Physical Activity During Pregnancy on Uterine and Fetal Parameters
This study investigates the relationship between physical activity levels and fetal health in the third trimester of pregnancy. Using the PPAQ and daily step counts, researchers will measure physical activity and examine its…
- Trial name
- TEOPADPUFP (NCT07147777)
- Where
- Turkey (Türkiye)
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Antalya Training and Research Hospital
Perfusion, Perioperative/Postoperative Complications
The Effect of Trendelenburg Position on CCA Blood Flow
The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.
- Trial name
- NCT04233177
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Healthy Volunteer, Artery Disease
Normal Reference Values in Han Adults of Extremity Arterial Structure and Hemodynamics by High-frequency Ultrasound
In recent years, high-frequency ultrasound, due to its higher resolution, can clearly display the superficial vascular structure and blood flow, and can detect vascular lesions early, providing a new non-invasive tool for…
- Trial name
- NOVAEA-HFUS (NCT05970926)
- Testing
- high-frequency ultrasound
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- First Hospital of China Medical University
Obstructive Sleep Apnea of Adult, Hypoxia, Brain
Cerebral Blood Flow and Ventilatory Responses During Sleep in Normoxia and Intermittent Hypoxia
A prospective double blind, placebo-controlled, randomized cross-over trial to evaluate the effect of lowering cerebral blood flow on the ventilatory chemoreflexes (acute hypoxic and hypercapnic ventilatory responses).
- Conditions
- Obstructive Sleep Apnea of Adult, Hypoxia, Brain, Sleep Apnea, Sleep Disorder
- Trial name
- NCT03255408
- Testing
- Drug Lowering Cerebral Blood Flow (CBF) and Normoxia Sleep, Drug Lowering CBF and Intermittent Hypoxia Sleep
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Myocardial Blood Flow Reserve, Mechanical Dyssynchrony
Mechanical Dyssynchrony and Microvascular Dysfunction by SPECT
The project is aimed at studying the feasibility of mechanical dyssynchrony of the left ventricle of the heart, determined by SPECT (gated MPI), as well as its stress-induced dynamics, in the evaluation of patients with coronary…
- Conditions
- Myocardial Blood Flow Reserve, Mechanical Dyssynchrony, Coronary Arterial Disease (CAD)
- Trial name
- MD&MD (NCT06969547)
- Testing
- dynamic SPECT (two-day rest/stress protocol), gated myocardial perfusion imaging, blood sampling
- Where
- Russia
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Microcirculation
Use of Laser Speckle to Study Cutaneous Blood Flow at Exercise in Healthy Subjects
We aim to test the hypothesis that Laser speckle contrast imaging allows for the measurement of cutaneous blood flow during exercise.
- Trial name
- Speckle-move (NCT01152008)
- Testing
- tourniquet ischemia
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Healthy
Can Erythropoietin Protect the Cerebral Blood Flow and Oxygenation During Simulated Dive?
During facial cooling and especially during breath hold, can mammals - and also humans - elicit a so called dive reflex, causing bradycardia, peripheral vasoconstriction and centralization of blood flow to brain, lungs and heart…
- Trial name
- NCT00265486
- Testing
- Recombinant human Erythropoietin
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Retinopathy
Coupling of Neural Activity and Retinal Blood Flow in Diabetes
The prevalence of diabetes is increasing and the management of the disease is nowadays considered a major challenge. Affected patients have increased mortality and morbidity as well as a significant drop in the quality of life.
- Trial name
- NCT01375166
- Where
- Austria
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 2 Diabetes Mellitus
Enhancement of Cerebral Vasoreactivity and Cognition by Intranasal Insulin in Type 2 Diabetes
Our goal is to determine the acute effects of intranasal insulin on regional perfusion and cognition of older adults. We propose a pilot study to examine the effect of a single dose of intranasal insulin on regional…
- Trial name
- NCT01206322
- Testing
- Intranasal insulin
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Obstructive Sleep Apnea Syndrome
Cerebral Blood Flow and Childhood Obstructive Sleep Apnea
Obstructive sleep apnea syndrome (OSAS) causes hypoxemia and hypercapnia, which may impair cerebral blood flow and cause deficits in behavior.
- Trial name
- NCT02995837
- Testing
- Sleep Study, Neurocognitive Testing, CBF During Wakefulness
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Children's Hospital of Philadelphia
Healthy, Hypercapnia
Study of Brain Blood Flow During Induced Hypercapnia (Excess Blood Carbon Dioxide)
This study will evaluate magnetic resonance imaging (MRI ) methods for measuring changes in the brain's blood flow during hypercapnia (a condition of excess carbon dioxide in the blood).
- Trial name
- NCT00001845
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Skeletal Muscle Atrophy
Post-operative Electrical Muscle Stimulation to Stimulate Muscle Protein Synthesis in Humans
Skeletal muscle accounts for approximately 45-55% of total body mass in healthy adults and plays a pivotal role in whole-body metabolic health, locomotion and physical independence.
- Trial name
- PoEMS (NCT05997095)
- Testing
- Neuromuscular electrical stimulation (NMES/0
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Nottingham