Clinical trials: Peripheral Circulation
Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder
Gastrointestinal Motility Among Diabetes Patients
Gastrointestinal (GI) symptoms including vomiting, nausea, abdominal pain, constipation or chronic diarrhea affect a large number of patients with diabetes mellitus (DM).
- Conditions
- Diabetic Autonomic Neuropathy, Gastrointestinal Motility Disorder, Diabetes Mellitus, Change of Transit or Circulation
- Trial name
- NCT02573519
- Testing
- 11C Donepezil PET/CT scan, 3D-Transit, 3D-Transit during treatment with Pyridostigmine
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Cognitive Decline, Cognitive Dysfunction
Brain Vascular and Neurocognitive Health
The overall research objective of this proposal is to determine the acute and chronic impact of transcranial photobiomodulation on indices of cerebral vascular health and neurocognitive function.
- Conditions
- Cognitive Decline, Cognitive Dysfunction, Alzheimer Disease, Vascular Disease, Peripheral
- Trial name
- NCT06497413
- Testing
- Transcranial Photobiomodulation, Transcranial Photobiomodulation helmet (Neuradiant 1070 Plus) with no light administered
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Texas at Arlington
Peripheral Arterial Disease, Intermittent Claudication
Intermittent Negative Pressure to Improve Blood Flow in Patients With Peripheral Artery Disease: Effects After Long-term Treatment
Studies have shown that intermittent negative pressure (INP) can induce short-term increase in blood flow in the extremity in patients with peripheral artery disease (PAD).
- Trial name
- NCT03640676
- Testing
- FlowOx
- Where
- 3 sites in Norway
- Volunteers
- 72 people
- Sponsor
- Oslo University Hospital
Peripheral Artery Disease, Intermittent Claudication
Intermittent Negative Pressure to Improve Blood Flow in Patients With Peripheral Artery Disease: Optimal Pulse Pressure Regime
Recent studies have shown that applying intermittent negative pressure (INP) with short negative pressure (-40 mmHg) pulses to the lower extremities increase arterial blood flow velocity and skin blood flow.
- Conditions
- Peripheral Artery Disease, Intermittent Claudication, Lower Extremity Claudication
- Trial name
- NCT03547817
- Testing
- Intermittent negative pressure device
- Where
- Norway
- Volunteers
- 16 people
- Sponsor
- Oslo University Hospital
Diabetic Peripheral Neuropathy (DPN)
Ultrasound Assessment of Sciatic Nerve and Inferior Gluteal Artery in Diabetic Peripheral Neuropathy(DPN): Association With a Target Gene
Diabetic peripheral neuropathy (DPN) is a common and serious complication of diabetes that causes numbness, pain, and weakness, often starting in the feet.
- Trial name
- NCT07595887
- Testing
- No intervention (observational study)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Second Hospital of Shanxi Medical University
Traumatic Brain Injury
Application of Circulating Extracellular Vesicles in Early Disease Assessment and Prognosis After Traumatic Brain Injury
The purpose of this study was to observe the relationship between the changes of circulating extracellular vesicles and disease development and outcome in patients with traumatic brain injury, and to find early serum markers and…
- Trial name
- NCT05279599
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital
ANOCA - Angina With Non-obstructive Coronary Arteries, HFpEF - Heart Failure With Preserved Ejection Fraction
Peripheral Microvascular Blood Flow in ANOCA
An observational cross-sectional cohort study investigating whether peripheral endothelial function assessed using Laser speckle contrast analysis and coronary endothelial function measured with invasive coronary function testing…
- Trial name
- NCT05610410
- Testing
- Laser speckle contrast analysis
- Where
- Netherlands
- Volunteers
- 43 people
- Sponsor
- Amsterdam UMC, location VUmc
Congestive Heart Failure, Cardiomyopathy
Comparison of Different Locations for Pulse Oximetry Probes in Cardiovascular (CV) Patients With Poor Peripheral Perfusion
The purpose of this study is to determine if the forehand location for sensor placement has less episodes of signal dropout than the finger sensor location.
- Trial name
- NCT01128036
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Saint Luke's Health System
Volunteer, Adult
Effect of Transcutaneous Electrical Stimulation on Peripheral Blood Flow
The goal of this clinical trial is to learn if transcutaneous electrical nerve stimulation can affect blood flow in healthy volunteers.
- Trial name
- VASC-STIM (NCT07354607)
- Testing
- transcutaneous electrical nerve stimulation
- Where
- France
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Metropole Savoie
Cardiac Arrest
Evaluation of Perfusion Index as a Prognostication Tool for High Quality Cardiopulmonary Resuscitation
In order to monitor and improve cardiopulmonary resuscitation(CPR) quality, there is need for tools that provide real time feedback to responders.
- Trial name
- NCT06067464
- Where
- Egypt
- Volunteers
- 47 people
- Sponsor
- National Hepatology & Tropical Medicine Research Institute
Pacemaker Dependence
The Ability of Peripheral Perfusion Index To Detect Changes of Hemodynamics in Patients With Pacemaker
Pacemakers are widely used in postcardiotomy patients to avoid severe arrhythmia. The peripheral perfusion index (PI) has been considered as an effective parameter evaluating the circulation.
- Trial name
- NCT04952649
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shanghai Zhongshan Hospital
Diabetes
Effect of Flavanol-rich Cocoa on Peripheral and Cerebral Blood Flow in Type 2 Diabetes
Cocoa flavanols form part of the family of chemicals (also found in red wine and tea) which have aroused interest due to population studies suggesting that diets high in these substances might reduce risks of heart disease.
- Trial name
- NCT01654172
- Testing
- High Flavanol Cocoa, Low Flavanol Cocoa
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- University of Nottingham
Cold Exposure
The Influence of Race and MitoQ Supplementation on Skin Blood Flow in the Cold
Individuals who operate in cold weather are at risk of developing cold injuries, for example, frostbite. They also often experience a loss of hand function and joint mobility due to a decrease in skin temperature and blood flow.
- Trial name
- NCT06784531
- Testing
- Mitoquinone mesylate (MitoQ), Cold Water Hand Immersion, Cold Air Exposure
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Sepsis, Shock, Septic
Comparison of Peripheral Perfusion Indicators and Lactate Levels
In patients with septic shock undergoing intensive care unit monitoring, routine assessment of arterial and/or venous blood gas is conducted.
- Conditions
- Sepsis, Shock, Septic, Hypotensive, Lactate
- Trial name
- NCT06727318
- Where
- Turkey (Türkiye)
- Volunteers
- 192 people
- Sponsor
- Gulhane Training and Research Hospital
VA-ECMO
Optimizing Breathing and Blood Flow in Patients Treated With VA ECMO
The aim of this study is to characterize ventilation/perfusion (V/Q) matching in adult patients receiving peripheral VA ECMO support while on mechanical ventilation, and to evaluate the impact of PEEP titration guided by…
- Trial name
- ECMO-VP (NCT07141524)
- Testing
- Physiology measurements
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Beth Israel Deaconess Medical Center
Resistant Hypertension, Hemodynamic Instability
Effect of Electrical Stimulation and Exercise on Blood Flow in Patients With Resistant High Blood Pressure
The goal of this clinical trial is to learn if the combination between transcutaneous electrical nerve stimulation (TENS) and isometric exercise (IE) can improve blood pressure in men and women between 50 to 60 years old suffered…
- Conditions
- Resistant Hypertension, Hemodynamic Instability, Essential (Primary) Hypertension, Abdominal Obesity
- Trial name
- NCT07383220
- Testing
- Transcutaneous Electrical Nerve Stimulation, Isometric Exercise, Aerobic, Dynamic Resistance, stretch and Breathing Exercises and Lifestyle Modification Advices
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Mohamed Mohamed Ali Morgan
Peripheral Arterial Disease
To Investigate the Effect of Far-infrared Radiation on Lower Extremity Acupoints on the Blood Circulation of Lower Extremities in Patients With Hemodialysis
This study intends to irradiate the acupoints of both lower extremities of hemodialysis patients with far-infrared therapeutic apparatus to explore its effect on foot blood circulation, peripheral artery occlusion disease (PAOD)…
- Trial name
- NCT05822960
- Testing
- far-infrared radiation
- Where
- 2 sites in Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital