Clinical trials: Peripheral Neuropathic Pain
Individuality, Narrative Medicine
PopPK Profile of Qishe Pill: Study Protocol for a Phase I Clinical Trial
Qishe Pill (Shanghai Sundise Traditional Chinese Medicine Co., Ltd, China), composed of processed Radix Astragali, Muscone, Szechuan Lovage Rhizome, Radix Stephaniae Tetrandrae, Ovientvine, and Calculus Bovis Artifactus, has been…
- Trial name
- NCT02294448
- Testing
- Qishe Pill
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve
Two Measures of Tactile Acuity in CRPS Type I Patients
This study aims to investigate whether two different measures of tactile acuity lead to comparable results in patients diagnosed with CRPS Type I of the upper extremity.
- Conditions
- CRPS Type I of the Upper Extremity, Neuropathy of the Median Nerve, Healthy Controls
- Trial name
- NCT01888783
- Testing
- Tactile acuity measured by 2PD and the GOT
- Where
- Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Ruhr University of Bochum
Herpes Zoster (HZ)
Obesity and Obesity-Related Factors and Risk of Herpes Zoster (Shingles) and Postherpetic Neuralgia
The investigators' objectives are to examine the longitudinal association of obesity and obesity-related factors and risk of incident herpes zoster (HZ), also known as shingles, and the longitudinal association of obesity and…
- Trial name
- NCT06638177
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Neuropathic Pain, Pain
Optimized Programming in Spinal Cord Stimulation (SCS) System
The objective of this study is to evaluate extent, location, and perception of paresthesia as a function of anode/cathode configuration.
- Trial name
- OP (NCT00871819)
- Testing
- Precision Spinal Cord Stimulation (SCS)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation
Diabetes Mellitus, Diabetic Neuropathy
Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery.
- Conditions
- Diabetes Mellitus, Diabetic Neuropathy, Postoperative Pain Management
- Trial name
- ANKLE-DM (NCT07404124)
- Testing
- Ultrasound-Guided Ankle Block
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Hyperalgesia, Pain Insensitivity, Congenital
The Relationship Between Saliva β-endorphins Levels, Cold Pressor Test and Perception of Pain in Oral Surgery Procedures
The purpose of this study is to evaluate the correlation between β-endorphin levels in blood plasma and saliva in healthy participants with different pain sensitivity and in those with acute pain in oral and maxillofacial region.
- Trial name
- NCT03164161
- Testing
- Cold pressor test, β-endorphins evaluation in saliva, β-endorphins evaluation in blood plasma
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Lithuanian University of Health Sciences
Pain, Acute, Pain, Neuropathic
Exercise and Pain in Non-Hispanic Blacks and Whites
Non-Hispanic Blacks tend to report higher levels of pain, experience pain more frequently, and be under-treated for pain compared to non-Hispanic Whites.
- Conditions
- Pain, Acute, Pain, Neuropathic, Analgesia, Aerobic Exercise
- Trial name
- NCT03609957
- Testing
- Aerobic Exercise Training, Interval Training
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Georgia State University
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Neuropathic Pain
Cortical Plasticity After Motor Cortex Stimulation in Healthy Subject and Chronic Pain Patients
The primary aim of this study is to evaluate the induction of sensory-motor cortex plasticity after motor cortex stimulation in healthy subjects, using laser-evoked nociceptive cortical potentials, and in chronic neuropathic pain…
- Trial name
- NCT02849834
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- France
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Chronic Pain, Low Back Pain
High Frequency Stimulation Trials in Patients With Precision Spinal Cord Stimulator System
Study designed to compare the conventional stimulation programming versus the high frequency stimulation programming of the spinal cord stimulator for subjects who already have a spinal cord stimulator.
- Conditions
- Chronic Pain, Low Back Pain, Radiculopathy, Complex Regional Pain Syndrome (CRPS)
- Trial name
- HFSCS (NCT02265848)
- Testing
- High frequency stimulation, Low frequency stimulation
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- The Center for Clinical Research, Winston-Salem, NC
Facial Pain, Comorbidity
Somatosensory Investigation of Orofacial Pain Patients
Orofacial pain, specially neuropathic orofacial pain, is a challenge of diagnosis and treatment in orofacial pain. It is associated with sensory abnormalities.With increasing life expectancy of the population is more and more…
- Conditions
- Facial Pain, Comorbidity, Neuralgia
- Trial name
- QST (NCT02910336)
- Testing
- Quantitative Sensory Testing
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Peripheral Neuropathic Pain
Gabapentin and Pregabalin Effects on Inflammation and Cardiac Function in Peripheral Neuropathic Pain
This prospective, controlled, observational cohort study will evaluate short-term changes in inflammatory biomarkers and subclinical cardiac function in adults with peripheral neuropathic pain who are prescribed gabapentin or…
- Trial name
- NCT07755514
- Testing
- Gabapentin, Pregabalin
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Giresun University
Nerve Pain
Objective Assessment of Sensory Nerve Fiber Sensitivity
This pilot study utilizes a unique technology to determine nerve fiber sensitivity. This will allow us to determine whether this method and device can discern changes in pain intensity and type, which is predicated on differing…
- Trial name
- NCT03596489
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Julia Finkel
Pain, Pain, Acute
Assessing Opioid Care Practices Using CPV Patient Simulation Modules
This study will test the quality of opioid-related physician care decisions using a patient-simulation based measurement and feedback approach that combines multiple-choice care decisions with real-time, personalized scoring and…
- Conditions
- Pain, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04080037
- Testing
- Quality IQ Patient Simulations
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Qure Healthcare, LLC
Morton Neuroma
Comparative Effectiveness of Cryoablation Versus Steroid and Lidocaine Alone for Treatment of Morton's Neuroma
Morton's neuroma is a benign thickening involving the plantar interdigital nerve, most common in middle aged women. Morton's neuroma is one of the most frequent diagnoses seen in the investigators podiatry clinic and is difficult…
- Trial name
- NCT05501262
- Testing
- Cryoablation, Nerve block
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Diabetic Neuropathy, Neuropathic Pain
Pain In Neuropathy Study
In the context of peripheral neuropathy, we will aim to elucidate correlates between sensory symptoms and: Sensory nerve dysfunction. Cutaneous small nerve fibre innervation density. Psychological co-morbidity.
- Conditions
- Diabetic Neuropathy, Neuropathic Pain, Chronic Pain, Carpal Tunnel Syndrome
- Trial name
- PINS (NCT02672059)
- Testing
- Observation
- Where
- United Kingdom
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- King's College London
Spinal Cord Injuries, Neuropathic Pain
Identifying Body Awareness-related Brain Network Changes During Cognitive Multisensory Rehabilitation for Reduced Neuropathic Pain in People With Spinal Cord Injury
Many adults with spinal cord injury (SCI) suffer from long-term debilitating neuropathic pain. Available treatments, including opioids, are ineffective at eliminating this pain.
- Trial name
- NCT04706208
- Testing
- Cognitive Multisensory Therapy, Usual Care, Clinical Assessment
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Pain, Trigeminal Neuralgia
Transcranial Magnetic Stimulation (TMS) Effects on Pain Perception
The purpose of this study is to investigate the effects of transcranial magnetic stimulation on pain perception.
- Conditions
- Pain, Trigeminal Neuralgia, Neuropathic Pain
- Trial name
- NCT00349050
- Testing
- laboratory pain assessment, transcranial magnetic stimulation
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS)
Two Point Discrimination
SPECIFIC AIMS Pain in both youth and adults is a complex, subjective and personal experience, and remains poorly understood. One particularly perplexing dimension of some forms of pain is the tendency of pain to spread outside of…
- Conditions
- Ehlers-Danlos Syndrome (EDS), Complex Regional Pain Syndrome (CRPS), Amplified Musculoskeletal Pain Syndrome (AMPS), Low Back Pain
- Trial name
- TPD (NCT03686748)
- Testing
- Two-point discrimination training, One-point discrimination training
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati