Clinical trials: Peripheral Sensitization
Diabetes Mellitus (DM)
Central Sensitization in Painful and Painless Diabetic Peripheral Neuropathy
This research is structured as a cross-sectional observational study. The primary objective is to compare central sensitization across painful and painless phenotypes of diabetic peripheral neuropathy.
- Trial name
- NCT07316322
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Inonu University
Neuropathic Pain
Exploring the Role of the GABAergic Modulation in Pain Transmission in Human
Neuropathic pain affects about 7% of the general population in European countries. Meta-analyses indicate that only a minority of neuropathic pain patients has adequate response to drug therapy and management of neuropathic pain…
- Trial name
- NDMC-101 (NCT03375034)
- Testing
- NDMC 20mg, NDMC60mg, Clonazepam 1.5mg
- Where
- Switzerland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jules Desmeules
Pelvic Pain, Vulvodynia
Psychosocial Factors and Central Sensitization in Chronic Pelvic Pain
The purpose of this study is to determine if the psychosocial factors in women with chronic pelvic pain are predisposing, precipitant or maintenance factors, and relate these factors with central sensitization and dysfunctional…
- Conditions
- Pelvic Pain, Vulvodynia, Pudendal Neuropathy
- Trial name
- NCT02856334
- Where
- 2 sites in Spain
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Lumbar Radiculopathy, Central Sensitisation
Identifying Pain Generators and Potentiators of Residual Complaints Following Lumbar Discectomy
Lumbar discectomy (i.e. surgically removing a hernia) is frequently performed in Belgium to treat lumbar radiculopathy. Every year >12,000 interventions are performed with variable long-term results.
- Trial name
- DISC-PAIN (NCT05022251)
- Testing
- Lumbar discectomy
- Where
- Belgium
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University Ghent
Central Nervous System Sensitization, Peripheral Nervous System Disorders
Effects of Soft Tissue Treatment vs Mechanisms Explanation to Treat Delayed Onset Muscles Soreness Among Sport Climbers
The aim of the present research is to define the effects of short manual treatment of soft tissues compared to mechanisms explaining in Delayed Onset Muscle Soreness (DOMS) among sport climbers and to address the mechanisms of…
- Conditions
- Central Nervous System Sensitization, Peripheral Nervous System Disorders, Muscle Soreness, Muscle Strength
- Trial name
- NCT04255212
- Testing
- Soft tissue treatment, Mechaninsms explanation, Control Group
- Where
- 2 sites in Italy
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Achilles Tendon Pain
Achilles Pain Block
The purpose of this study is to better understand how the peripheral and central nervous system interact to produce the sensation of pain and motor patterns in patients with achilles tendinopathy (AT).
- Trial name
- APB (NCT03316378)
- Testing
- Ropivacaine injection
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ruth Chimenti
Chronic Plantar Fasciitis, Control Group
Frequency of Neuropathic Pain in Patients With Plantar Fasciitis
Study Design This prospective cross-sectional study was undertaken between November 2023 and March 2024. Written and verbal informed consent was obtained from all patients.
- Trial name
- NCT06348017
- Where
- Turkey (Türkiye)
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Yozgat City Hospital
Osteoarthritis, Knee
Effects of Central Sensitization on Response to Conventional Physical Therapy in Patients With Knee Osteoarthritis
The aim of this study was to investigate the relationship between central sensitization (CS) and poor response to conventional physical therapy in patients with knee osteoarthritis (OA) by evaluating clinical parameters of pain…
- Trial name
- NCT05518097
- Testing
- Conventional physical therapy program
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Ankara University
Work-related Illness
Central and Peripheral Sensitization, Pain Mediators in Thumb Pain Among Physiotherapists
The work-related thumb pain is a common problem among physiotherapists which deal with this experience at least once in their life.
- Trial name
- NCT05345496
- Where
- Italy
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- University of Turin, Italy
Chronic Pain, Central Sensitisation
Effect of Boswellia Serrata on Pain Intensity, Central and Peripheral Sensitization, and Pain Modulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Boswellic acids, the triterpenes found in the gum resins of Boswellia serrata (family: Burseraceae), are traditionally used in the Indian…
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- BSPP (NCT07109843)
- Testing
- Boswellia serrata extract
- Where
- Austria
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Carpal Tunnel Syndrome
Mechanisms of Neural Mobilization in the Treatment of Chronic Pain
The purpose of this study was to determine the effect of a manual therapy technique (neural mobilization) on measures of clinical pain and function, experimental pain sensitivity, and on the function of the median nerve in…
- Trial name
- NCT00929123
- Testing
- neural mobilization, healthy controls
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Chronic Pain, Central Sensitisation
The Effect of Griffonia Simplicifolia on Pain Intensity, Central and Peripheral Sensitization, Painmodulation in Healthy Volunteers
This planned study is based on a randomized, placebo-controlled cross-over design. Griffonia simplicifolia contains the serotonin-precursor 5-hydroxytryptophan (5-HTP), an endogenous amino acid.
- Conditions
- Chronic Pain, Central Sensitisation, Peripheral Sensitization, Neuroinflammatory Response
- Trial name
- NCT06893822
- Testing
- Griffonia simplicifolia
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Fibromyalgia
Generalized Hypersensitivity in Patients With Fibromyalgia Syndrome
Fibromyalgia (FM) is a chronic musculoskeletal pain disorder with unknown causes. Our previous studies showed abnormal sensations of second pain (wind-up), indicating central hypersensitivity as an important mechanism of FM.
- Trial name
- NCT04415866
- Testing
- Paced Auditory Serial Addition task (PASAT)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Florida
Complex Regional Pain Syndrome Type I
Pain in Complex Regional Pain Syndrome
CRPS is a complex pain condition that usually develops in response to trauma and immobilization which is very painful and debilitating.
- Trial name
- NCT04667364
- Testing
- Transcutaneous electrical nerve stimulation (TENS)
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Esbjerg Hospital - University Hospital of Southern Denmark
Chronic Pain Syndrome, Chronic Daily Headache
Offset Analgesia as a Measure of Central Sensitization in Children
Pediatric chronic pain disorders are common and consequential in Western societies, occurring in 25-80% of population-based samples with a median prevalence of 11-38% and significant pain-related disability in 3-5% of these…
- Conditions
- Chronic Pain Syndrome, Chronic Daily Headache, Functional Abdominal Pain Syndrome, Musculoskeletal Pain Disorder
- Trial name
- NCT03445403
- Testing
- Offset analgesia
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cervicogenic Headache, Central Sensitization
Central Sensitization and Neuropathic Pain in Cervicogenic Headache
Cervicogenic headache is a type of secondary headache that originates from the structures of the neck and can spread toward the head and facial regions.
- Conditions
- Cervicogenic Headache, Central Sensitization, Neuropathic Pain
- Trial name
- NCT07292181
- Testing
- Clinical assessment with standardized questionnaires
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Gulseren Demir Karakilic
Pain
Remote Ischemic Preconditioning Mechanism Study
This research is being done because pain is a significant problem for patients with a variety of medical problems and following surgery or traumatic injury.
- Trial name
- NCT01541436
- Testing
- Remote Ischemic Preconditioning, Capsaicin, UV-B
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Rotator Cuff Tears, Central Sensitisation
Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair.
- Conditions
- Rotator Cuff Tears, Central Sensitisation, Neuropathic Pain
- Trial name
- NCT06367998
- Testing
- Pregabalin
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- The Catholic University of Korea
Pain, Chronic, Pain, Acute
The Effect of Palmitylethanolamide on Central and Peripheral Sensitization After Heat-induced Hyperalgesia
This planned study is based on a randomized, placebo-controlled cross-over design. Palmityhlethanolamide (PEA) is an endogenous fatty acid amide from the group of N-Acetylethanolamides, which analgesic, anti-inflammatory and…
- Conditions
- Pain, Chronic, Pain, Acute, Central Sensitisation, Neuroinflammatory Response
- Trial name
- NCT04662827
- Testing
- Palmithylethanolamid
- Where
- Austria
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Neuropathic Pain
GABAergic Modulation in Pain Transmission in Human: Effect of the GABAA Agonist Clobazam on Peripheral and Central Sensitisation
In animal, the GABAergic system modulates central sensitisation, which is a key phenomenon in pain processing. The development of GABAA agonists targeting the subunits of the GABAA receptor implicated in nociception, but not the…
- Trial name
- NCT01291316
- Testing
- Clonazepam, Tolterodine, clobazam
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva