Clinical trials: Persons With Psychiatric Disorders, open to volunteers
Psychotic Disorders
Improving Heart and Metabolic Health in People With Severe Mental Illness Through a Long-term Clinical Trial
Background Cardiometabolic conditions-including cardiovascular disease, type 2 diabetes, and obesity-are highly prevalent among individuals with psychotic disorders.
- Trial name
- LAGOM (NCT06781801)
- Testing
- Intervention
- Where
- 6 sites in Sweden
- Volunteers
- 650 people
- Sponsor
- Vastra Gotaland Region
Primary Progressive Aphasia(PPA), Semantic Dementia
Intervention for Communication Quality of Life in Primary Progressive Aphasia
The goal of this clinical trial is to learn whether a personalized, multi-component, virtual speech language treatment program can improve communication and quality of life for adults with primary progressive aphasia (PPA) and…
- Conditions
- Primary Progressive Aphasia(PPA), Semantic Dementia, Logopenic Progressive Aphasia (LPA), Nonfluent Aphasia, Progressive
- Trial name
- Multi-PA (NCT07219680)
- Testing
- Multicomponent Lexical Retrieval Cascade Training, Multicomponent Video Implemented Script Training in Aphasia
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Maya Henry
Refractive Errors
Cognitive Level Enhancement Through Vision Exams and Refraction
The investigators aim to conduct a mixed-method study in which a randomised controlled trial (RCT) and a descriptive qualitative study will be conducted.
- Trial name
- CLEVER (NCT05458323)
- Testing
- Free near and Distance Vision glasses
- Where
- India
- Volunteers
- 820 people
- Sponsor
- Queen's University, Belfast
Alzheimer Disease
Feasibility and Interest of the 3D Ephemeris for Temporal Orientation in Alzheimer's: Pilot Study
In geriatric care, occupational therapists use validated tools to assess abilities and performance, identifying deficiencies and proposing rehabilitation programs.
- Trial name
- E3D (NCT06824142)
- Testing
- Evaluate in real-life conditions the effectiveness of an adapted external aid as a tool to support temporal orientation rehabilitation for individuals with Alzheimer's disease or related dementias in
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild Cognitive Impairment (MCI)
Instant Message-delivered Personalised Acceptance and Commitment Therapy (ACT) for Neuropsychiatric Symptoms in Persons With Mild Cognitive Impairment
This pilot study aims to develop an automated instant message-delivered intervention (i.e., EMI) for people with mild cognitive impairment, and to investigate the feasibility and effectiveness of the intervention.
- Trial name
- iact (NCT07332624)
- Testing
- Automated instant message-guided neuropsychiatric symptoms management
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Apathy, Apathy in Dementia
SENS'REM - SENSoriality and Multi-Sensory Emotional Reminiscences: a Pilot Study
SENS'REM is a pilot feasibility study evaluating a new non-drug therapeutic program based on multisensory reminiscence using immersive virtual reality in older adults living in nursing homes or long-term care units who present…
- Trial name
- SENS'REM (NCT07468305)
- Testing
- Multisensory Virtual Reality Reminiscence Intervention
- Where
- 2 sites in France
- Volunteers
- 10 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Intellectual Disability, Mild
Evaluation of CO-OP for Adolescents With Mild Intellectual Disability
Intellectual disability (ID) affects a person throughout life and includes difficulties to manage what is expected in everyday life based on age.
- Trial name
- CO-OPIF (NCT06691698)
- Testing
- The Cognitive Orientation to Daily Occupational Performance Approach
- Where
- 2 sites in Sweden
- Volunteers
- 60 people
- Sponsor
- Örebro University, Sweden
Alzheimer Disease
Memory for Music: Individual Intensive Musical Training in Alzheimer's Disease
This project, called Memory for Music, focuses on the increasing number of people worldwide living with dementia, especially Alzheimer's disease (AD).
- Trial name
- M4M (NCT06611878)
- Testing
- Music training - intensive, Music training - minimal, Treatment as Usual (TAU)
- Where
- 6 sites in Argentina, Austria and 1 more
- Volunteers
- 113 people
- Sponsor
- NORCE Norwegian Research Centre AS
Alcohol Use Disorder (AUD)
LSD Treatment for Persons With Alcohol Use Disorder
Lysergic acid diethylamide (LSD) was investigated in numerous clinical trials during the 1950s and 1960s. Specifically, the use of LSD in the treatment of AUD was investigated extensively.
- Trial name
- LYTA (NCT05474989)
- Testing
- LSD
- Where
- 2 sites in Switzerland
- Volunteers
- 128 people
- Sponsor
- Felix Mueller
Panic Disorder, Panic Disorder (With or Without Agoraphobia)
Qigong and Multicomponent Exercise in Panic Disorder
Panic disorder is a psychiatric disease characterized by recurrent panic attacks that occur in expected or unexpected situations and create feelings of intense fear, restlessness and discomfort.
- Conditions
- Panic Disorder, Panic Disorder (With or Without Agoraphobia), Panic Attacks and Disorders, Qigong
- Trial name
- NCT07439224
- Testing
- Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dokuz Eylul University
Dementia
Resilient Together for Dementia (RT-D)
This study will evaluate the feasibility and preliminary efficacy of the novel Resilient Together for Dementia (RT-D) intervention for couples following dementia diagnoses.
- Trial name
- RT-D (NCT06619327)
- Testing
- Resilient Together for Dementia, MEUC
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Methamphetamine Abuse, Methamphetamine-dependence
Feasibility of Long-term, High-dose Stimulant for Methamphetamine Use Disorder
Methamphetamine use disorder (MUD) is becoming an increasing public health concern in Canada. While the evidence on the efficacy and safety of prescription psychostimulants for the treatment of MUD is promising, the knowledge on…
- Conditions
- Methamphetamine Abuse, Methamphetamine-dependence, Addiction, Substance Abuse
- Trial name
- NCT06788587
- Testing
- LDX-01 plus TAU
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
People Who Use Opioids/People With Opioid Use Disorder (OUD)
Prescribe to Prevent HIV: A Hybrid Trial Helping Addiction Clinics Prevent HIV & Infections Through Safer Drug Use Support
In the U.S., an estimated 3.6 million people who inject drugs (PWID) face a growing yet preventable health crisis, with rising cases of serious injection-related infections (SIRI), including HIV, due to limited access to two…
- Trial name
- P2PH (NCT07073924)
- Testing
- Implementation strategy bundle
- Where
- 4 sites in United States
- Volunteers
- 536 people
- Sponsor
- University of Pittsburgh
Dementia Disorders, Mild Cognitive Impairment (MCI)
Multimodal Biomarkers in Individual With Cognitive Impairment and Dementia
Memory problems can range from normal aging to mild cognitive impairment (MCI) to dementia. This study looks at three ways of measuring what is happening in the brain at each of these stages: a blood test (GFAP), a brain MRI…
- Trial name
- NCT07812480
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cigarette Smoking
E-cigarettes for Harm Reduction Among Smokers With Serious Mental Illness
In this open-label, randomized controlled trial study, participants who smoke combustible cigarettes (CC) and are diagnosed with Serious Mental Illness (SMI) will be randomized in two arms to receive harm-reduction counseling and…
- Trial name
- NCT05815199
- Testing
- E-cigarette (EC), Nicotine Replacement Therapy (NRT), Harm-Reduction Counseling
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Unipolar Depression
Cognitive Enhancement in Unipolar Depression With Yoga
It is evident from recent studies that cognitive deficits persist even after remission of depressive episode. Hence, in this study, the investigators would like to see whether specific Yoga practice will help in enhancing…
- Trial name
- NCT06472492
- Testing
- Adjuvant yoga intervention
- Where
- India
- Volunteers
- 32 people
- Sponsor
- University of Pittsburgh
Dementia
Individualized Music Playlist Based on ISO Principle for De-escalation of Agitation in Dementia
The goal of this clinical trial is to evaluate the efficacy of an Individualized Music Playlist (InMP) composed of preferred music genres sequenced according to the ISO-Principle, for the immediate de-escalation of agitation in…
- Trial name
- NCT06104436
- Testing
- Individualized music playlist, Preferred music, Usual care
- Where
- Hong Kong
- Volunteers
- 81 people
- Sponsor
- The Hong Kong Polytechnic University
Choroid Disease, Caregiver
Dyadic Management Intervention in Older People With Co-occurring Cognitive Impairment and Diabetes as a Supplementary Approach to Chronic Diseases Self-Management Program
The goal of this study is to evaluate the effectiveness and implementation of a dyadic management of the Chronic Disease Self-Management Program (CDSMP) for older adults with co-occurring cognitive impairment and diabetes with…
- Conditions
- Choroid Disease, Caregiver, Self-management, Diabetes
- Trial name
- NCT07496359
- Testing
- CDSMP + caregiver support, Usual Care
- Where
- Hong Kong
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Depression, Anxiety
Identity-Based Transdiagnostic Therapy for Young People With Anxiety and Depression
Depression and anxiety are the most prevalent mental disorders among both the general population and young adults, and transdiagnostic treatments for these patients are mostly based on cognitive-behavioral therapy (CBT).
- Trial name
- IBTTYOUNG (NCT06384196)
- Testing
- Identity-Based Transdiagnostic Therapy (IBTT), Unified Protocol
- Where
- 2 sites in Spain
- Volunteers
- 138 people
- Sponsor
- University of Barcelona
Psychosis
Strategic Timing of Resistance Training to Guard Against Antipsychotic-Induced Metabolic Syndrome
This study is evaluating whether a supervised resistance training (strength training) programme is feasible to perform in a first-episode psychosis service.
- Trial name
- START GAAIMS (NCT07386483)
- Testing
- Resistance training programme
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- University College Dublin