Clinical trials: Pharmaceutical Care
Hiv, Substance Use Disorders
Intervention to Improve HIV Self-care Among People Who Inject Drugs
This study will implement a pilot randomized controlled trial (RCT, N=50) to refine and assess the feasibility and acceptability of an emotion regulation and communication skills intervention designed to improve engagement in…
- Trial name
- iSTRIVE (NCT05819411)
- Testing
- Project iSTRIVE, incentivized Directly Observed Therapy (iDOT)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Massachusetts General Hospital
Health Knowledge, Attitudes, Practice
The Impact of a "Serious Game" on Improving Patient's Medication Knowledge
The purpose of this study is to assess the effects of an interactive educational program delivered through a patient portal on patients' medication knowledge and medication adherence.
- Trial name
- NCT01786044
- Testing
- MasterMed, Usual Care
- Where
- United States
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Crohn Disease, Ulcerative Colitis
Ultra-proactive Therapeutic Drug Monitoring in Inflammatory Bowel Disease
This is a comparative pragmatic trial in patients with UC and CD on maintenance treatment with IFX. All IBD patients from cohort A with maintenance IFX treatment at a referral IBD clinic are prospectively included between June…
- Trial name
- NCT04775732
- Testing
- infliximab therapeutic drug monitoring
- Where
- 2 sites in Belgium
- Volunteers
- 187 people
- Sponsor
- Imelda GI Clinical Research Center
HIV, Medication Adherence
SteadyRx: Smartphone ART Adherence Intervention for Drug Users
Antiretroviral therapy (ART) increases life expectancy and quality of life for individuals infected with HIV, and can reduce the chance of HIV transmission, but a high degree of adherence to ART is required to achieve these…
- Trial name
- NCT02317614
- Testing
- SteadyRx
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Johns Hopkins University
Immune Thrombocytopenia
Post IVIG Medication in Children With Immune Thrombocytopenia
This study is a single hospital system, single-arm year-long pilot to evaluate the feasibility of enrolling children with ITP who are receiving IVIG for treatment of disease to a scheduled post-infusion medication for 72 hours…
- Trial name
- NCT04741139
- Testing
- Acetaminophen and Diphenhydramine Only Product
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Baylor College of Medicine
Opioid Use Disorder, HIV Infections
Medication-assisted Treatment for Injecting Drug Users in Vietnam
HIV continues to spread around the world and new infections in Asia are one of the most important areas for prevention among drug using populations.
- Trial name
- OIT-HCMC (NCT05368675)
- Testing
- medication for opioid use disorder
- Volunteers
- 448 people
- Sponsor
- University of Pennsylvania
Medication Adherence, Cognitive Impairment
Medication Dispenser to Improve Care at Home for the Elderly
The purpose of this study is to investigate the efficacy of the Karie Automated Medication delivery device in enhancing medication adherence among a group of elderly patients with mild to moderate cognitive decline.
- Trial name
- NCT03511027
- Testing
- SME + Karie Device, SME only
- Sponsor
- Lee Verweel
Dementia, Alzheimer's Disease
Comparative Research of Alzheimer's Disease Drugs
Conduct a comparative effectiveness clinical trial of medication treatment for behavioral symptoms of Alzheimer's disease in a group of real-world memory care clinics with enhanced access to the Indiana Network for Patient Care.
- Trial name
- COMET-AD (NCT01362686)
- Testing
- Donepezil, Galantamine, Rivastigmine
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- Indiana University
Hepatitis C
Registry-based HCV Care Cascade Navigation at Atlanta's Grady Memorial Hospital
This study seeks to implement and evaluate a data-driven case navigation system for hepatitis C virus (HCV) treatment among persons who are either actively injecting drugs or who are receiving opioid substitution therapy (OST).
- Trial name
- EZ-C (NCT03441542)
- Testing
- Data-assisted Case Navigation, Standard of Care
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- National Opinion Research Center
Inappropriate Dose of Drug Administered, Health Behavior
A Trial to De-prescribe Inappropriate Medications in the Community Dwelling Elderly
The objective of this trial is to test the beneficial effect of a pharmacist-initiated knowledge transfer intervention to both patients and prescribers on the discontinuation of inappropriate prescriptions, compared to usual…
- Trial name
- D-PRESCRIBE (NCT02053194)
- Testing
- Pharmacist-led educational intervention
- Volunteers
- 600 people
- Sponsor
- Centre de Recherche de l'Institut Universitaire de Geriatrie de Montreal
Infectious Diseases
Safety and Efficacy Study of High Dose Colistin
Colistin is a rapidly acting bactericidal antimicrobial agent that possesses a post antibiotic effect against MDRO Gram-negative bacteria, such as as Pseudomonas aeruginosa, Acinetobacterbaumannii, and Klebsiella pneumonia.
- Trial name
- NCT02162966
- Testing
- High Dose Colistin, Standard Dose Colistin
- Where
- Saudi Arabia
- Volunteers
- 330 people
- Sponsor
- King Saud Medical City
Prevention Harmful Effects
Computerized Alcohol Screening for Children and Adolescents (cASCA) in Primary Care
The purpose of this study is to assess the psychometric properties of a brief screening questionnaire for alcohol problems among 9- to 18-year-old patients in pediatricians' offices, and to pilot test a personalized…
- Trial name
- cASCA (NCT02233946)
- Testing
- computer-facilitated brief intervention
- Where
- 5 sites in United States
- Volunteers
- 871 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Metastatic Prostate Cancer
The Present Study Aims to Compare Patients Who Receive the Investigational Product (177Lu-DOTA-rosopatamab) Plus Standard of Care, in Comparison to Standard of Care Only
This multinational, multicenter, prospective, randomized, controlled, open label Phase 3 study is designed to investigate and confirm the benefits and risks associated with the PSMA-targeted antibody, 177Lu DOTA rosopatamab…
- Trial name
- NCT04876651
- Testing
- 177Lu-DOTA-rosopatamb, Standard of Care
- Where
- 6 sites in Australia, New Zealand
- Volunteers
- 16 people
- Sponsor
- Telix Pharmaceuticals (Innovations) Pty Ltd
Cardiac Rehabilitation
Study on the Efficacy of HE and Therapeutic Group Factors on CR and QoL
This randomised study evaluates the efficacy of health education and therapeutic group factors on cardiac rehabilitation and quality of life in coronary patients attending cardiac rehabilitation programmes in Extremadura.
- Trial name
- NCT06127537
- Testing
- Therapeutic Intervention Group
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- Universidad de Extremadura
Major Depressive Disorder
The Antidepressant Advisor Study
The Antidepressant Advisor Study is a feasibility study to develop and probe the feasibility of a computerised decision support tool for GPs to prescribe antidepressant treatments.
- Trial name
- ADeSS (NCT03628027)
- Testing
- Computerised decision support algorithm
- Where
- United Kingdom
- Volunteers
- 86 people
- Sponsor
- King's College London
Diabetic Neuropathy With Neurologic Complication
Observational Study of the the Use of a Trigeminal Vagal Nerve Stimulator in the Routine Care of Native Americans With Diabetic Neuropathy Pain. Pain Scores, Drug Use and Glucose Measurements Will be Assessed
This is an observational study that will follow patients in the course of routine care and measure pain levels, glucose assessments and drug utilization for native American patients with diabetic neuropathy
- Trial name
- NCT07025356
- Testing
- Implantation of a trigeminal Vagus cervical nerve stimulator system, Implantation of a neurostimulator system for trigeminal vagal cervical nerve stimulation
- Where
- United States
- Volunteers
- 83 people
- Sponsor
- Vagus Nerve Society
Acute Mountain Sickness
EleVation carE: a Randomized Controlled Trial on the Prevention of Acute Mountain Sickness With Suxiao Jiuxin Pill
The aim of this randomized, controlled trial is to evaluate the safety and efficacy of Suxiao Jiuxin Pills for prevention of acute mountain sickness (AMS) after high altitude exposure in healthy volunteers, and its influences on…
- Trial name
- EVEREST (NCT06531161)
- Testing
- Suxiao Jiuxin Pill
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Peking University First Hospital
HIV Infection
Use of Incentives to Retain Drug Users in HIV Therapy
In many urban centres including Vancouver's Downtown Eastside, there is a high rate of HIV infection among users of illicit drugs.
- Trial name
- Incentives-2 (NCT01488942)
- Testing
- monetary reinforcer
- Where
- Canada
- Volunteers
- 139 people
- Sponsor
- University of British Columbia
Renal Failure, Medication Adherence
Adherence Enhancement for Renal Transplant Patients
Despite significant advances in the care of kidney transplant recipients, long term graft survival after renal transplantation remains suboptimal. Medication nonadherence and clinical inertia are key contributors to graft loss.
- Conditions
- Renal Failure, Medication Adherence, Hypertension
- Trial name
- NCT01859273
- Testing
- mHealth
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Medical University of South Carolina
Lung Cancer, Gastro-intestinal Cancer
The SOAR Study: a Study of Geriatric Assessment and Exercise for Older Adults and Their Support Person
Phase 2 randomized controlled study using a waitlist control group. The study also has a single arm pre-post test 12-week chair-based exercise arm for those who have received the geriatric assessment in the older adults with…
- Conditions
- Lung Cancer, Gastro-intestinal Cancer, Genito-Urinary Cancer, Breast Cancer
- Trial name
- SOAR (NCT05509751)
- Testing
- GAM, exercise, health education, online chair-based exercise combined with health education
- Where
- 2 sites in Canada
- Volunteers
- 60 people
- Sponsor
- Martine Puts
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