Clinical trials: Phase 1
HIV Infections
Safety of and Immune Response to a Modified Vaccinia Ankara (MVA) HIV Vaccine in HIV Uninfected Adults
The purpose of this study is to determine the safety and the immune responses to the HIV vaccine candidate, MVA-CMDR. This vaccine was designed to induce immune responses to three HIV "passenger" genes encoded with the viral…
- Trial name
- NCT00376090
- Testing
- MVA-CMDR
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Safety, Peripheral Neuropathy
Xanamem™ in Healthy Elderly Subjects
Xanamem™ is being developed as a potential drug for Alzheimer's disease. This study drug has been designed to change the cortisol levels in the brain. Cortisol is a naturally occurring hormone in the body.
- Conditions
- Safety, Peripheral Neuropathy, Cortisol, Central Nervous System
- Trial name
- XanaHES (NCT03830762)
- Testing
- Xanamem
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Actinogen Medical
Autosomal-dominant Hyper-IgE Syndrome
Safety, Tolerability, and Immunogenicity of One Dose of NDV 3A Vaccine in People With STAT3-Mutated Hyper-IgE Syndrome
Background: AD-HIES is a disease that weakens the immune system. It puts people at risk for infections, particularly Staph and Candida infections.
- Trial name
- NCT02996448
- Testing
- NDV-3A
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Safety, Tolerability
Safety, Tolerability and Pharmacokinetics of AM1476 in Healthy Subjects
This is a First in Human (FIH), double-blind, randomised, placebo-controlled study designed to evaluate safety, tolerability and pharmacokinetics (PK) of single and multiple ascending oral doses of AM1476 in healthy subjects.
- Trial name
- NCT04691115
- Testing
- AM1476
- Where
- United Kingdom
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- AnaMar AB
Osteoarthritis Pain, Chronic Low Back Pain
Study To Assess Changes In The Number Of Nerves In The Skin At The Site Where Where Tanezumab Is Injected
Subcutaneous administration of tanezumab can result in changes in the number of nerves around the injection site in the thigh.
- Conditions
- Osteoarthritis Pain, Chronic Low Back Pain, Pain Due to Interstitial Cystitis
- Trial name
- NCT01030640
- Testing
- tanezumab
- Where
- 2 sites in United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Pfizer
Dyslipidemias
A Clinical Trial to Compare and Evaluate the Safety and Pharmacokinetics of CKD-391(2)
A clinical trial to compare and evaluate the safety and pharmacokinetics of CKD-391(2)
- Trial name
- NCT06088017
- Testing
- CKD-391(2), CKD-331, D337
- Where
- South Korea
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Chong Kun Dang Pharmaceutical
Osteoarthritis, Rheumatoid Arthritis
A Phase 1 Clinical Trial to Evaluate the Safety and Pharmacokinetic Characteristics of DW1809-T2
Randomized, Open-label, Oral, Single-dose, two-Sequence, four-Period, crossover study
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Back Pain, Acute Upper Respiratory Tract Infection
- Trial name
- NCT05214690
- Testing
- DW1809-T2, DW1809-1
- Where
- South Korea
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Healthy Subjects
A Single Dose Crossover Study In Healthy Subjects To Evaluate Different Formulations Of PF-06882961
This open label study will evaluate the pharmacokinetics (PK) following single oral doses of different formulations of PF-06882961, including controlled release (CR) tablets at 2 release rates (long and short duration), an…
- Trial name
- NCT03492697
- Testing
- PF-06882961 Immediate Release Tablet, PF-06882961 Controlled Release Tablet (long), PF-06882961 Controlled Release Tablet (short)
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Pfizer
Botulism
Phase 1 PK Study of XOMA 3AB
This is a phase I, single-center, placebo-controlled, double-blinded, dose escalation study of anti-botulinum toxin monoclonal antibodies in healthy adult volunteers.
- Trial name
- NCT01357213
- Testing
- XOMA 3AB
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Healthy
Clinical Trial of GX-I7 in Healthy Volunteers
This is a Phase 1, randomized, double-blind, placebo-controlled, single ascending dose study designed to assess the safety, tolerability, pharmacokinetics and pharmacodynamics of GX-I7 in healthy volunteers.
- Trial name
- NCT02860715
- Testing
- GX-I7
- Where
- South Korea
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Genexine, Inc.
Healthy
A Study of SSS68 Following a Single Subcutaneous Administration in Healthy Adult Participants
This is a randomized, double-blind, placebo-controlled, single ascending dose phase I clinical study to evaluate the safety, tolerability, PK, PD and immunogenicity of SSS68 in healthy adult participants following a single…
- Trial name
- NCT07606976
- Testing
- SSS68
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Shenyang Sunshine Pharmaceutical Co., LTD.
Coronavirus Infection, COVID
Monovalent Recombinant COVID19 Vaccine
This is a study to test a new vaccine (Covax-19) against COVID-19. COVID-19 is a potentially deadly disease that is caused by a new strain of coronavirus called SARS-CoV-2.
- Trial name
- COVAX19 (NCT04453852)
- Testing
- COVID19 vaccine, Saline
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Vaxine Pty Ltd
Healthy Volunteer
A Study to Assess the Safety, Tolerability and How Single Ascending Doses of ABBV-859 Moves Through the Body of Healthy Adult Participants
The objective of this study is to assess the pharmacokinetic (PK), immunogenicity, safety, and tolerability of ABBV-859 after single ascending doses in healthy adult volunteers.
- Trial name
- NCT07736638
- Testing
- ABBV-859
- Where
- 2 sites in United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- AbbVie
Healthy, Pharmacokinetics of ASP0456
A Safety and Pharmacokinetics Study of ASP0456 in Healthy Subjects
A study to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single ascending dose of ASP0456 in non-elderly healthy subjects.
- Trial name
- NCT01279915
- Testing
- ASP0456
- Where
- Japan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Astellas Pharma Inc
Healthy Volunteers, Overweight or Obesity
A Study of Multiple Doses of Orally Administered RO7795081 in Otherwise Healthy Chinese Adult Participants With Obesity or Overweight
This is an investigator- and participant-blind, randomized, placebo-controlled, parallel-group, Phase I study evaluating the safety, tolerability, pharmacokinetics, and pharmacodynamics of multiple doses of orally administered…
- Trial name
- NCT07499050
- Testing
- RO7795081
- Where
- 2 sites in China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hoffmann-La Roche
Safety, Tolerability
Phase 1 Clinical Trial of RHN-001 in Healthy Adult Volunteers
The goal of this clinical Trial is to assess the safety, tolerability and Pharmacokinetic profile of 750 mg single oral dose of RHN-001 and 1500 mg of RHN-001 administered orally in fasted and fed conditions in healthy adult…
- Conditions
- Safety, Tolerability, Pharmacokinetics
- Trial name
- NCT05847218
- Testing
- RHN-001 (one tablet 750mg), RHN-001 (750mg * 2 Tablets)
- Where
- Pakistan
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- RH Nanopharmaceuticals
Healthy Volunteers
Safety and Pharmacokinetics Study of CPL500036 Compound in Healthy Volunteers
The planned study is to determine the safety and pharmacokinetic properties of CPL500036 compound after single and multiple (two weeks) administration in healthy volunteers.
- Trial name
- NCT03873324
- Testing
- CPL500036 compound
- Where
- Poland
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Celon Pharma SA
Healthy Subjects, Infection, Human Immunodeficiency Virus
GSK1349572 Drug Interaction Study With Protease Inhibitors
A study in healthy volunteers to determine whether there is a drug interaction between GSK1349572 and the HIV protease inhibitors lopinavir/ritonavir and darunavir/ritonavir
- Trial name
- NCT00774735
- Testing
- GSK1349572
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
A Study to Evaluate Effect of IN-A001 on Pharmacokinetics of Tacrolimus in Healthy Volunteers
This study aims to investigate the effect of IN-A001 50mg on the pharmacokinetics of Tacrolimus 5mg in healthy volunteers
- Trial name
- NCT05353010
- Testing
- Tacrolimus, IN-A001(Tegoprazan), IN-A001(Tegoprazan) + Tacrolimus
- Where
- South Korea
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- HK inno.N Corporation
Healthy Volunteers
Effect of Food on PC14586 in Healthy Volunteers and the PK of PC14586 in Healthy Japanese Volunteers
This is a 2-part Phase 1 cross-over study to assess the effects of food on the pharmacokinetics of PC14586 in healthy volunteers.
- Trial name
- NCT05249348
- Testing
- PC14586
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- PMV Pharmaceuticals, Inc
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