Clinical trials: Phase 2
Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia
A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Patients Undergoing Haploidentical Hematopoietic Stem Cell Transplant
This phase Ib trial tests the safety, side effects, and how well cytomegalovirus (CMV)-modified vaccinia Ankara (MVA) Triplex vaccine works in enhancing CMV-specific immunity and preventing CMV viremia in patients undergoing…
- Conditions
- Accelerated Phase Chronic Myeloid Leukemia, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Chronic Lymphocytic Leukemia
- Trial name
- NCT07020533
- Testing
- Biospecimen Collection, Electronic Health Record Review, Haploidentical Hematopoietic Cell Transplantation
- Where
- 3 sites in United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase
Clinical Assessment of UV Photofunctionalization on Stability and Osseointegration of Early Loaded Implants
The goal of this clinical trial is to learn if UV light treatment (photo functionalization) works to help dental implants heal faster and become stable enough for early use in adults missing teeth in the lower back jaw.
- Conditions
- Evaluating the Clinical Efficacy of Applying Ultraviolet Photofunctionalization (UV phF) to Standard Titanium Implants Immediately Before Surgery, Monitoring Early Implant Stability and Osseointegration During the Critical Initial Healing Phase, Determining the Feasibility and Success Rate of an Accelerated "Early Loading" Protocol, Assessing the Survival Rate of the Implants, Along With the Peri-implant Soft Tissue Response and Marginal Bone Preservation
- Trial name
- UV (NCT07868744)
- Testing
- UV-photofunctionalized titanium dental implants
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Phase I
Pilot Study on the Effects of Psilocybin on Belief Updating and Insight Formation
The primary aim of this phase I mechanistic pilot study is to evaluate the effects of psilocybin on aspects of cognition in healthy adult volunteers.
- Trial name
- NCT07818564
- Testing
- Psilocybin (Usona Institute)
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Brown University
Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission
CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant
This phase II trial studies how well multi-peptide CMV-modified vaccinia Ankara (CMV-MVA Triplex) vaccination of stem cell donors works in preventing cytomegalovirus (CMV) viremia in participants with blood cancer undergoing…
- Conditions
- Accelerated Phase CML, BCR-ABL1 Positive, Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission, Chronic Lymphocytic Leukemia
- Trial name
- NCT03560752
- Testing
- Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Type I Chiari Malformation, Cerebral Hemodynamic
Analysis of Disturbances in Neurofluid Dynamics in Type I Chiari Malformations
A global analysis of craniospinal hemodynamics and hydrodynamics is necessary to better understand the pathophysiology of Chiari malformations.
- Conditions
- Type I Chiari Malformation, Cerebral Hemodynamic, Craniospinal Hydrodynamic, Phase Contrast MRI
- Trial name
- NEUROFLUX-C (NCT06502431)
- Testing
- phase contrast sequences
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Acute Myeloid Leukemia, Acute Lymphoid Leukemia
Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)
This is a first in children prospective study of allogeneic hematopoietic cell transplant using a centrally manufactured engineered donor graft (Orca-Q).
- Conditions
- Acute Myeloid Leukemia, Acute Lymphoid Leukemia, Mixed Phenotype Acute Leukemia, Acute Undifferentiated Leukemia
- Trial name
- NCT05322850
- Testing
- Orca-Q
- Where
- 4 sites in United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Florida
Major Depression Moderate, Major Depression Severe
EEG Microstate and Neuroinflammatory Biomarkers in Older Age Patients With Major Depressive Disorder Receiving ECT
This study aims to investigate the neurophysiological and inflammatory changes associated with electroconvulsive therapy (ECT) in older age patients diagnosed with Major Depressive Episode, Major Depression, and Bipolar Disorder…
- Conditions
- Major Depression Moderate, Major Depression Severe, Major Depression With Comorbid Anxiety Symptoms, Major Depression With Panic Attacks
- Trial name
- NCT07740694
- Testing
- Electroconvulsive Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Delayed Sleep Phase Syndrome
Experimental Manipulation of Sleep and Circadian Rhythms and the Role Played on Reward Function in Teens
Adolescence is a time of heightened reward sensitivity and greater impulsivity. On top of this, many teenagers experience chronic sleep deprivation and misalignment of their circadian rhythms due to biological shifts in their…
- Trial name
- CARRS-P2 (NCT04792697)
- Testing
- Increase morning bright light, Decrease evening blue light, Sleep Scheduling
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Luteal Phase Insufficiency
Early Luteal Phase Progesterone Kinetics After hCG-Induced Ovulation in Modified Natural Cycle
This pilot study evaluates how progesterone levels change after hCG-triggered ovulation in modified natural cycles. Forty women preparing for frozen embryo transfer will have blood tests over 6 days to monitor hormone levels.
- Trial name
- CineP4 (NCT07028710)
- Testing
- hCG
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Delayed Sleep Phase Syndrome, Delayed Sleep Phase
Pathophysiology of Circadian Rhythm Delayed Sleep Wake Phase Disorder
The goal of this study is to understand factors that contribute to delayed sleep wake phase disorder (DSWPD). The investigators will examine whether patients with DSWPD exhibit alterations in circadian rhythms and sensitivity to…
- Trial name
- NCT06471374
- Testing
- Circadian rhythm assessment, Light sensitivity assessment
- Where
- 2 sites in United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
This Study Will Develop Nurse Bridge and Test Its Six-month Effects on Nursing Students' Career Outcomes Using a Two-phase Randomized Controlled Trial
The Effectiveness of a Digital Career-Focused Mobile Application on Nursing Students' Career Planning and Career Trajectories .
Methods: This three-year experimental study is divided into two phases. In the first phase, a mixed-methods approach will be used.
- Trial name
- NurseBridge (NCT07628673)
- Testing
- Nurse Bridge App
- Where
- Taiwan
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Menstrual Cycle, Luteal Phase Progesterone Levels
Corpus Luteum Function and Cardiovascular Adaptation in a Natural MOCK Cycle.
In infertility treatment, embryos are created in vitro after eggs have been fertilised by sperm using in vitro fertilisation or intracytoplasmic sperm injection techniques.
- Conditions
- Menstrual Cycle, Luteal Phase Progesterone Levels, Luteal Phase Adaptation, MOCK Cycle
- Trial name
- CLEAR (NCT07648381)
- Testing
- Blood samples for the analysis of biomarkers., Transvaginal ultrasound for follicle and endometrium measurements., Mean Arterial Pressure measurement.
- Where
- Belgium
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
This is a Phase I Study Conducted in Healthy Volunteers
Single Ascending Dose Study of ATH-097 in Healthy Participants
This is a Phase I, A Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ATH-097 in Healthy Participants
- Trial name
- NCT07640269
- Testing
- ATH-097
- Where
- Australia
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Atheron Therapeutics, Ltd.
Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia
Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts From HLA-Matched Related and Unrelated Donors in Preventing GVHD
This phase II trial is for patients with acute lymphocytic leukemia, acute myeloid leukemia, myelodysplastic syndrome or chronic myeloid leukemia who have been referred for a peripheral blood stem cell transplantation to treat…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive, Acute Biphenotypic Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Undifferentiated Leukemia
- Trial name
- NCT02220985
- Testing
- Allogeneic Hematopoietic Stem Cell Transplantation, Cyclophosphamide, Fludarabine Phosphate
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Acute Phase Response
Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
The purpose of this study is to detail the precise temporal changes in the APR that occur in response to exercise in order to determine the types of exercise that confer maximal reparative fibrinolysis.
- Trial name
- NCT03398304
- Testing
- Graded Exercise, Marathon participation
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Sepsis, Intensive Care (ICU)
Investigation of the Relationship Between MD, MLR and NLR With APRs in Sepsis in the ICU
The aim of this study is to investigate, in patients admitted to the intensive care unit either for reasons other than sepsis who subsequently develop sepsis or with a primary diagnosis of sepsis, whether monocyte distribution…
- Conditions
- Sepsis, Intensive Care (ICU), Acute Phase Biomarkers
- Trial name
- NCT07537179
- Testing
- Monocyte Distribution
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Oguz Gundogdu
Acute Phase Response
Disorders of the Acute Phase Response Following Trauma and Invasive Surgery
The purpose of the proposed study is to test these hypotheses through the following aims: 1. To determine if early plasmin activation following severe injury correlates with SIRS, TIC and complications throughout convalescence in…
- Trial name
- NCT03741023
- Testing
- Blood draw (venipuncture or fingerstick)
- Where
- United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Phase 1 First-in-human Study Involving Healthy Subjects
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TNX-1500 in Healthy Subjects
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose Escalation Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of TNX-1500 in Healthy Subjects
- Trial name
- NCT07473752
- Testing
- TNX-1500, Keyhole Limpet Hemocyanin (KLH)
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Tonix Pharmaceuticals, Inc.
Pharmakokinetic, Open Label
A Phase 1, Open-Label, Parallel-Group, Single-Dose Study To Compare The Pharmakokinetics Of TNX-102 SL (Cyclobenzaprine Hydrochloride Sublingual Tablet) In Non-Elderly Versus Elderly Participants
TNX-102 SL has recently been approved by the United States (US) Food and Drug Administration (FDA) under the brand name TONMYA for the treatment of fibromyalgia.
- Conditions
- Pharmakokinetic, Open Label, Phase 1
- Trial name
- NCT07413367
- Testing
- TNX-102 SL Tablet
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tonix Pharmaceuticals, Inc.
Circadian Rhythm, Menstrual Cycle Phase
Investigating the Effects of Time-of-day and Menstrual Cycle Phase (Low and High Progesterone) on Female's Cognitive and Strength Performance
This study is designed to determine whether time-of-day and menstrual cycle phase influence athletic performance and is expected to contribute valuable insight into how both time-of-day, and hormonal factors can influence…
- Conditions
- Circadian Rhythm, Menstrual Cycle Phase, Female Athletes, Executive Function (Cognition)
- Trial name
- NCT07399847
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Lancaster University