Clinical trials: Photon Radiotherapy
NPC Patients, Nasopharyngeal Cancinoma (NPC)
Prospective Immuno-Radiomic Profiling in Nasopharyngeal Carcinoma Treated With Proton or Photon Chemoradiotherapy
To prospectively investigate and integrate radiomic and immunologic signatures in patients with nasopharyngeal carcinoma (NPC) treated with either proton or photon radiotherapy, with the aim of identifying biomarkers associated…
- Trial name
- IMPRINT (NCT07232680)
- Testing
- Proton chemoradiotherapy, Photon chemoradiotherapy
- Where
- Taiwan
- Volunteers
- 500 people
- Sponsor
- Cheng-En Hsieh
Early Breast Cancer, Radiation Associated Cardiac Failure
The DBCG Proton Trial: Photon Versus Proton Radiation Therapy for Early Breast Cancer
The majority of early breast cancer patients are treated with adjuvant radiation therapy (RT) as part of their multimodal therapy.
- Trial name
- NCT04291378
- Testing
- Proton versus photon radiation therapy
- Where
- 8 sites in Denmark
- Volunteers
- 1,502 people
- Sponsor
- Danish Breast Cancer Cooperative Group
Liver Cancer, Adult
Liver Function Investigation With SPECT
This is a Phase 1 pilot study to assess feasibility and utility of 99mTc-mebrofenin hepatobiliary scintigraphy for measurement of functional liver change due to radiotherapy.
- Trial name
- LiverINSPECT (NCT02967848)
- Testing
- 99mTc-mebrofenin hepatobiliary scintigraphy (HBS), Indocyanine Green, Liver Elasticity
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Royal North Shore Hospital
Head and Neck Cancers - Nasopharyngeal
Photon Therapy Face Mask on Dermatitis Post Head and Neck Radiotherapy
A randomized controlled trial (RCT), 60 HNC patients who underwent radiotherapy (RT) with or without chemotherapy represented the sample of the study.
- Trial name
- dermatitis (NCT05855265)
- Testing
- photon therapy face mask
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Khadra Mohamed Ali
Breast Cancer
A Prospective Cohort Study of Proton and Photon Therapy for Left-sided Breast Cancer.
The goal of this study is to investigate the differences in toxicity and efficacy between proton and photon hypofractionated radiotherapy following lumpectomy or mastectomy for breast cancer.
- Trial name
- NCT06677879
- Testing
- Proton radiotherapy, Photon radiotherapy
- Where
- China
- Volunteers
- 780 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Glioblastoma
Dose-Escalated Photon IMRT or Proton Beam Radiation Therapy Versus Standard-Dose Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma
This randomized phase II trial studies how well dose-escalated photon intensity-modulated radiation therapy (IMRT) or proton beam radiation therapy works compared with standard-dose radiation therapy when given with temozolomide…
- Trial name
- NCT02179086
- Testing
- Photon Beam Radiation Therapy, Proton Beam Radiation Therapy, Temozolomide
- Where
- 237 sites in United States, Canada
- Volunteers
- 624 people
- Sponsor
- NRG Oncology
Lung Neoplasms
Concurrent Chemoradiotherapy Using Intensity Modulated Radiotherapy (IMRT) & Docetaxel-cisplatin (or Carboplatin) Followed by Adjuvant Chemotherapy for Inoperable Stage III Non-small-cell Lung Cancer
Primary Objective: Response rate (by contrast CT scan) Secondary Objectives: Progression-free survival (PFS) Overall survival (OS)
- Trial name
- C-CRISP (NCT01266512)
- Testing
- DOCETAXEL, Intensity Modulated Radiotherapy (IMRT), CISPLATIN
- Where
- Hong Kong
- Volunteers
- 34 people
- Sponsor
- Sanofi
Cancer, Solid Tumor
MNPR-101-PCTA-177Lu Expanded Access Program (EAP) for Patients With Solid Tumor Cancer
The purpose of this Expanded Access Program (EAP) is to allow use of the investigational therapeutic agent, MNPR-101-PCTA-177Lu, for treatment of urokinase plasminogen activator receptor (uPAR)-positive solid tumors identified…
- Conditions
- Cancer, Solid Tumor, Solid Tumor Cancer, Oncology
- Trial name
- NCT06980519
- Testing
- MNPR-101-PCTA-177Lu
- Where
- United States
- Sponsor
- Monopar Therapeutics
Retroperitoneal Sarcoma
Proton or Photon RT for Retroperitoneal Sarcomas
This research study is a Phase I clinical trial. Phase I clinical trials test the safety of an investigational intervention. Phase I studies also try to define the appropriate dose of the investigational therapy to use for…
- Trial name
- NCT01659203
- Testing
- IG-IMPT, IG IMRT
- Where
- 10 sites in United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Mesenchymal Tumor
High-Dose Proton/Photon RT + Surgery of Sarcomas of the Thoracic, Lumbar Spine/Sacrum
The purpose of this study is to test the effectiveness of high dose radiation administered by both proton and photon therapy. Radiation is an effective treatment for many types of tumors and it is thought that radiation alone…
- Trial name
- NCT00592345
- Testing
- Proton Beam Radiation, Photon Beam Radiation, Interoperative radiation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Massachusetts General Hospital
Cancer of the Prostate
Proton Boost in Prostate Cancer
This study uses photon radiation with a proton boost to treat prostate cancer. The purpose of this study is to determine if proton therapy as a boost following photon intensity modulated radiation therapy (IMRT) produces…
- Trial name
- NCT03564275
- Testing
- Proton Boost
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Cincinnati
Esophageal Cancer
Dose Escalated Proton Beam Therapy or Photon Therapy for Esophageal Cancer
This study will evaluate if proton beam therapy as part of chemoradiation results in a decrease in diffusion lung capacity of carbon monoxide (DLCO) compared to photon radiation therapy for esophageal carcinoma.
- Trial name
- ES01 (NCT03234842)
- Testing
- Proton Beam Therapy, Photon Radiation Therapy, Chemotherapy
- Where
- United States
- Sponsor
- University of Florida
Low Grade Glioma
ROCOCO - Low Grade Glioma - Planning Study
The cost of particle therapy (PT) are considerably higher than conventional radiotherapy (RT) with photons. Considering potential dosimetric advantages of PT, it is necessary to determine if PT are more cost-effective than…
- Trial name
- ROCOCO LGG (NCT02607397)
- Where
- 4 sites in Germany, Netherlands
- Volunteers
- 25 people
- Sponsor
- Maastricht Radiation Oncology
Breast Cancer, Cardiotoxicity
Cardiotoxicity in Breast Cancer Patients Treated With Proton or Photon Radiotherapy: A RadComp Companion Study
This is a companion study to the "Pragmatic Randomized Trial of Proton vs Photon Therapy for Patients with non-Metastatic Breast Cancer Receiving Comprehensive Nodal Radiation: A Radiotherapy Comparative Effectiveness (RadComp)…
- Trial name
- NCT04361240
- Testing
- Proton vs Photon Radiation
- Where
- 6 sites in United States
- Volunteers
- 172 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Meningioma
Proton Dose Escalation for Patients With Atypical or Anaplastic Meningiomas
The trial evaluates the effect of a moderately increased radiation dose in patients with atypical (grade II) and anaplastic (grade III) meningioma after incomplete or no surgery. Endpoint is recurrence-free survival after 5 years.
- Trial name
- PANAMA (NCT02978677)
- Testing
- Radiotherapy 68 Gy(RBE), Radiotherapy 72 Gy(RBE), Radiotherapy 60 Gy(RBE)
- Volunteers
- 90 people
- Sponsor
- Technische Universität Dresden
Glioblastoma
Proton and Heavy Ion Beam Radiation vs. Photon Beam Radiation for Newly Diagnosed Glioblastoma.
This is a multi-center prospective phase 3 clinical trial to explore the efficacy and side effects of standard-dose photon radiation versus standard-dose proton radiation versus carbon ion boost plus standard proton radiation for…
- Trial name
- NCT04536649
- Testing
- Radiotherapy
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Shanghai Proton and Heavy Ion Center
Prostate Cancer
Quality of Life Study for Prostate Cancer Patients
The goal of this behavioral research study is to look at patients' quality of life after treatment or management for prostate cancer.
- Trial name
- NCT00561444
- Testing
- Questionnaire
- Where
- 3 sites in United States
- Volunteers
- 1,051 people
- Sponsor
- M.D. Anderson Cancer Center
Prostate Cancer
Radiation Therapy in Treating Patients With Stage I, Stage II, or Stage III Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays and other types of radiation to kill tumor cells. Giving radiation therapy in different ways may kill more tumor cells.
- Trial name
- NCT00258466
- Testing
- radiation therapy
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Prostate Cancer
A Prospective Comparative Study of Outcomes With Proton and Photon Radiation in Prostate Cancer
This study is a large, prospective, pragmatic, controlled comparison of patient-centric outcomes [quality of life (QOL), toxicity, and disease control] between parallel cohorts of men with prostate cancer treated simultaneously…
- Trial name
- COMPPARE (NCT03561220)
- Testing
- Standard of Care IMRT (Photon), Standard of Care Proton Therapy, Proton Arm 1: Standard Proton Therapy
- Where
- 53 sites in United States
- Volunteers
- 3,000 people
- Sponsor
- University of Florida
Diffuse Intrinsic Pontine Gliomas (DIPG)
IMPT Versus IMRT for Diffuse Intrinsic Pontine Glioma
This is a prospective, open-label, multicenter, phase III randomized controlled trial comparing intensity-modulated proton therapy (IMPT) with intensity-modulated radiation therapy (IMRT) in participants aged 3-18 years with…
- Trial name
- NCT07869524
- Testing
- Intensity-Modulated Proton Therapy (IMPT), Intensity-Modulated Radiation Therapy (IMRT)
- Where
- China
- Volunteers
- 142 people
- Sponsor
- Shandong Cancer Hospital and Institute