Clinical trials: Photorefractive Keratectomy
Moderate Hyperopia
Single-step Transepithelial PRK for Hyperopia
Hyperopia is one of the commonest refractive errors encountered in ophthalmology practice. Laser in situ keratomileusis (LASIK) has been widely used to correct hyperopia especially with the advent of femtosecond laser technology…
- Trial name
- NCT05261685
- Testing
- Single-step transepithelial PRK
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Postoperative Pain
Oral Gabapentin Versus Placebo for Treatment of Postoperative Pain Following Photorefractive Keratectomy
The purpose of this study is to determine the effectiveness of an oral medication called gabapentin in reducing pain after Photorefractive Keratectomy (PRK) eye surgery and to assess the frequency of use of rescue medication…
- Trial name
- NCT00793910
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Epithelium, Corneal
Comparison of the Effect of 4th Generation Fluoroquinolones, Gatifloxacin and Moxifloxacin, on Epithelial Healing Following Photorefractive Keratectomy (PRK), A Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel (WU # 2335-99)
The purpose of this study is a prospective,double-blinded, randomized trial to compare the rate of healing following PRK after the use of two commercially available 4th generation fluoroquinolones, moxifloxacin and gatifloxacin.
- Trial name
- NCT00414011
- Testing
- Moxifloxacin, Gatifloxacin
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Refractive Surgery
CONTOURA vs WFO Ablation PRK & LASIK
This is a prospective randomized contralateral double-masked study. Each patient will be randomized as to which eye undergoes wave-front optimized (WFO) vs.
- Trial name
- NCT05037370
- Testing
- Wave-Front Optimized (WFO) ablation vs Topography-guided (TG) ablation
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Keratoconus
Topography Versus Non-Topography-Guided PRK With CXL in Keratoconus
To our knowledge, this study is one of the first to compare the visual results of non-topography-guided and topography-guided photorefractive keratectomy (PRK) applying sequential and simultaneous corneal cross-linking (CXL)…
- Trial name
- keratoconus (NCT03890718)
- Testing
- Photorefractive keratectomy in mile keratoconus
- Where
- Iran
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Shahid Beheshti University
Myopia
Evaluation of Conventional Photorefractive Keratectomy (PRK) in U.S. Army Personnel, Substudy of: Initial Evaluation of Excimer Laser Keratorefractive Surgery in U.S. Army Personnel
The purpose of this study is to: 1. evaluate the safety and efficacy of conventional PRK in U.S. Army personnel who have naturally occurring myopia with or without astigmatism. 2.
- Trial name
- NCT00412568
- Testing
- Photorefractive Keratectomy (PRK)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Dry Eye
Investigator Initiated Study to Assess the Efficacy of OC-01 (Varenicline) Nasal Spray on Signs and Symptoms of Dry Eye Disease Following Photorefractive Keratectomy (PRK)
Evaluate the safety and effectiveness of OC-01 (varenicline) nasal spray among subjects suffering from dry eye following photorefractive keratectomy (PRK)
- Trial name
- NCT05045508
- Testing
- OC-01 (varenicline 0.6mg/ml) nasal spray
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brandon Baartman
Steroid Ophthalmic Insert
Comparison of the Postoperative Use of Dextenza vs a Standard Regimen After PRK
Naval Refractive Surgery Center proposes a prospective, single-site, randomized, non-FDA regulated clinical trial with bilateral commercial treatment for for PRK.
- Trial name
- NCT05587231
- Testing
- Dextenza 0.4Mg Ophthalmic Insert, Topical Fluorometholone
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Navy Medical Center San Diego
Must be PRK Candidate
Safety and Efficacy of Lotemax Versus FML in Subjects Undergoing PRK for the Correction of Mild to Moderate Myopia, 3- Month Follow-up Study
STUDY OBJECTIVE: To evaluate and compare the safety and efficacy of (corneal Wound Healing and Intraocular Pressure) Fluorometholone and Loteprednol after photorefractive keratectomy (PRK) surgery.
- Trial name
- NCT02974387
- Testing
- Fluorometholone(FML), Loteprednol (Lotemax)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr Salouti Eye Research Center
Myopia, Hypermetropia
Anesthetic Impregnated Bandage Soft Contact Lens (BSCL) in Pain Management After Photorefractive Keratectomy (PRK)
Compared to laser-assisted in situ keratomileusis (LASIK), Photorefractive Keratectomy (PRK) is associated with more discomfort and requires more downtime.
- Conditions
- Myopia, Hypermetropia, Refractive Errors, Astigmatism
- Trial name
- NCT04283331
- Testing
- Proparacaine Ophthalmic
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Beeran Meghpara, MD
Myopia
Corneal WFG Versus AF Trans PRK in Myopic Patients With High Corneal HOA
compare the efficacy, safety and predictability of corneal wavefront guided (WFG) and aberration free ablation in single-step transepithelial photorefractive keratectomy (TransPRK) in myopic patients with high pre-existing…
- Trial name
- NCT03786861
- Testing
- corneal WFG group, aberration free group
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Ophthalmology, Photorefractive Keratectomy ("PRK")
Ocular Bandage Gel (OBG) Pivotal Trial in Patients Undergoing Photorefractive Keratectomy ("PRK")
Prospective, randomized, masked (reading center), controlled pivotal study of Ocular Bandage Gel (OBG) vs. a bandage contact lens (BCL) in subjects who have undergone bilateral photorefractive keratectomy (PRK).
- Conditions
- Ophthalmology, Photorefractive Keratectomy ("PRK"), Laser Assisted Surgery, Refractive Surgery
- Trial name
- NCT03938883
- Testing
- Ocular Bandage Gel (OBG), Bandage Contact Lens (BCL)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Eyegate Pharmaceuticals, Inc.
Pain, Vision Nearsighted
Post Photorefractive Keratectomy (PRK) Use of an Eye Shield for Maintaining Vision and Mitigating Pain
The purpose of this research is to determine if an investigational thin shield over the cornea can safely and effectively reduce or eliminate pain following Post Photorefractive Keratectomy (PRK).
- Trial name
- Nexis-CS0032 (NCT01592643)
- Testing
- Eye Shield
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Stanford University
Corneal Epithelial Wound Healing
Effect of Topical Fluoroquinolones on Epithelial Wound Healing After PRK
The prescribed antibiotic for prophylaxis of infection following PRK should be effective at eradicating a potential infection. In addition, the antibiotic should have a rapid onset of action, effectively penetrate the target…
- Trial name
- NCT00569881
- Testing
- gatifloxacin and moxifloxacin
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Donnenfeld, Eric, M.D.
Photorefractive Keratectomy, Myopia
Cannabinoid vs Opioid for Photorefractive Keratectomy Pain Control
Photorefractive Keratectomy (PRK) is a commonly performed corneal refractive surgery but has significant post-operative pain. Pain medications after PRK are typically opioid-acetaminophen combinations.
- Conditions
- Photorefractive Keratectomy, Myopia, Hyperopia
- Trial name
- NCT05477875
- Testing
- oral cannabinoid, oral codeine/acetaminophen
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Florida
Keratoconjunctivitis Sicca
Goblet Cell Response and Dry Eye Symptoms After PRK and LASIK
Purpose: To develop a screening metric by examining both the characteristics of the preoperative tear film and the intracellular signaling pathways of conjunctival goblet cells in order to determine if there are certain…
- Trial name
- NCT00411827
- Testing
- PRK with conjunctival impression cytology before and after surgery, LASIK with conjunctival impression cytology before and after surgery
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Post-operative Pain Control
Post-operative Pain Control After Photorefractive Keratectomy Comparing Acetaminophen/Codeine vs Acetaminophen/Oxycodone
Photorefractive keratectomy (PRK) is a refractive error correction procedure that helps eliminate or reduce the dependence on corrective lenses. An important aspect of PRK is post-operative pain management.
- Trial name
- NCT04399122
- Testing
- acetaminophen/codeine vs acetaminophen/oxycodone
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- 59th Medical Wing
Astigmatism
Comparison of Cross-cylinder and Conventional Photorefractive Keratectomy(PRK) in Correcting Medium-high Astigmatism
The purpose of this study is to determine whether cross-cylinder approach is more effective than routine method in laser correction of astigmatism.
- Trial name
- PRK (NCT00663923)
- Testing
- photorefractive keratectomy (PRK)
- Where
- Iran
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tabriz University
Corneal Opacity
The Use of MMC During PRK and Its Effect on Postoperative Topical Steroid Requirements
1. Purpose To evaluate the use of mitomycin-C (MMC) as an intraoperative adjunct during photorefractive keratectomy (PRK), its effect on postoperative healing and its ability to reduce the postoperative topical steroid course…
- Trial name
- NCT02030990
- Testing
- Mitomycin-C, Fluorometholone 1% topical ocular steroid
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Postoperative Pain
Comparison of Oral Gabapentin and Pregabalin in Postoperative Pain Control After Photorefractive Keratectomy
Purpose: To compare the efficacy of oral gabapentin and its newer analogue pregabalin in postoperative pain control after photorefractive keratectomy (PRK).
- Trial name
- NCT00954187
- Testing
- Gabapentin, pregabalin
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- Loma Linda University