Clinical trials: Phrenic Nerve Injury
Acute Hypoxemic Respiratory Failure, Diaphragm Injury
Feasibility of Transvenous Phrenic Nerve Stimulation for Diaphragm Protection in Acute Respiratory Failure
This is a single-center proof-of-concept clinical trial designed to establish the feasibility of transvenous phrenic-nerve stimulation (PNS) to maintain diaphragm activation over the first 24 hours and for up to seven days of…
- Conditions
- Acute Hypoxemic Respiratory Failure, Diaphragm Injury, Lung Injury
- Trial name
- STIMULUS (NCT05465083)
- Testing
- Lungpacer AeroPace Protect System
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University Health Network, Toronto
ARDS, Human, Ventilator-Induced Lung Injury
Non-invasive Phrenic Nerve Stimulation in ARDS Patient
Reduced diaphragmatic activity during mechanical ventilation can lead to diaphragmatic disuse atrophy, atelectasis, increased lung stress and strain, and hemodynamic impairment.
- Conditions
- ARDS, Human, Ventilator-Induced Lung Injury, Diaphragm Injury
- Trial name
- NCT06572280
- Testing
- PNS group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Southeast University, China
Anesthesia, Local, Phrenic Nerve Paralysis
Interscalene Brachial Plexus Block Washout to Reverse Inadvertent Phrenic Nerve Blockade
One of the most frequently performed peripheral nerve blocks (the injection of local anesthetic near nerves to block sensation/ movement to a specific part of the body) is the interscalene brachial plexus block for upper…
- Conditions
- Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Phrenic Nerve Palsy on the Left
- Trial name
- NCT03677778
- Testing
- Normal saline injected via interscalene nerve catheter
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- Stanford University
Diaphragm Injury, Phrenic Nerve Paralysis
Measurement of Diaphragmatic Dysfunction After Thoracic Surgery
This study aims to measure diaphragmatic dysfunction with ultrasonography and nerve stimulation of the phrenicus nerve, in patients undergoing thoracic surgery for lung and esophageal cancer, and correlate measures of…
- Conditions
- Diaphragm Injury, Phrenic Nerve Paralysis, Thoracic Cancer, Postoperative Complications
- Trial name
- NCT04507594
- Testing
- Lung lobectomy OR esophagus cancer resection
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Aarhus University Hospital
We Evaluated CT-guided Localization of the Right Phrenic Nerve to Enhance Safety in Transcatheter Ablation
Right Phrenic Nerve Localization on CT for Ablation
The anatomical location of the right phrenic nerve (RPN) in close proximity to the right pulmonary veins has become a critical consideration for electrophysiologists performing pulmonary vein isolation, the cornerstone treatment…
- Trial name
- NCT07330791
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Centro Medico Teknon
Tetraplegia
Diaphragmatic Reinnervation of Tetraplegic Patients With Respiratory Insufficiency
This study evaluates the diaphragmatic reinnervation by inferior laryngeal nerve in tetraplegic patients with ventilatory insufficiency.
- Trial name
- TETRADIA-UNI (NCT01350297)
- Testing
- reinnervation
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Rouen
Ventilator Induced Lung Injury
Percutaneous Temporary Placement of a Phrenic Nerve Stimulator for Diaphragm Pacing, a First in Human Trial
Study conducted to confirm phrenic nerve stimulation using the Lungpacer LIVE Catheter, confirm capture of the diaphragm and confirm that the diaphragm can be paced in synchrony with mechanical ventilator breaths.
- Trial name
- NCT02670460
- Testing
- LIVE Catheter
- Where
- Paraguay
- Volunteers
- 24 people
- Sponsor
- Lungpacer Medical Inc.
Phrenic Nerve Injury
Modified Diaphragmatic Plication Rectifies Dyspnea
Traditional diaphragmatic plication (DP) surgery is employed to ameliorate respiratory function in patients with diaphragmatic paralysis, which is rather complicated. This study introduces a modified method of DP.
- Trial name
- NCT06775873
- Testing
- Modified diaphragmatic plication
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji University
Respiratory Failure, Mechanical Ventilation
Phrenic Nerve Block to Mitigate Self-inflicted Lung Injury
The purpose of this single-centered, proof of concept study is to determine whether it is feasible to perform a phrenic nerve block to reduce diaphragm electrical activity and, therefore, inspiratory effort and if such block…
- Trial name
- NCT03978845
- Testing
- Lidocaine
- Where
- Brazil
- Volunteers
- 10 people
- Sponsor
- University of Sao Paulo General Hospital
Ventilator Lung, Ventilator-Induced Lung Injury
Phrenic Identification in the ICU
This will be a prospective observational study where the investigator will scan patients' necks with an ultrasound and look for anatomical landmarks that may help identify the phrenic nerve.
- Conditions
- Ventilator Lung, Ventilator-Induced Lung Injury, Diaphragm Disease, Phrenic Nerve
- Trial name
- NCT05875883
- Testing
- Neck ultrasound
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- Unity Health Toronto
Anesthesia, Local, Phrenic Nerve Paralysis
Erector Spinae Plane Versus Interscalene Blocks for Shoulder Surgery
The goal of this study is the evaluation of erector spinae plane (ESP) blocks as an alternative to interscalene brachial plexus nerve blocks for rotator cuff repair and total shoulder arthroplasty procedures.
- Conditions
- Anesthesia, Local, Phrenic Nerve Paralysis, Upper Extremity Injury, Shoulder Injury
- Trial name
- NCT03807505
- Testing
- Interscalene brachial plexus nerve block, Erector spinae plane block
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Phrenic Nerve Palsy
Phrenic Nerve Injury During Pulmonary Vein Isolation With the Second-generation Cryoballoon.
To determine the most frequent complication associated with cryoballoon PVI. The main hypothesis is to explore the incidence of phrenic nerve palsy.
- Trial name
- YETI-Registry (NCT03645577)
- Where
- Germany
- Volunteers
- 731 people
- Sponsor
- University of Luebeck
Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB)
Comparing CPAP and BiPAP for Sleep-Disordered Breathing in People with Cervical Spinal Cord Injuries
Sleep-disordered breathing (SDB) is common in individuals with cervical spinal cord injuries, with studies suggesting prevalence rates ranging from 27% to 62%.
- Conditions
- Spinal Cord Injuries (SCI), Sleep Disordered Breathing (SDB), Sleep Apnea, Cervical Spinal Cord Injruy
- Trial name
- NCT06818604
- Testing
- CPAP, BiPAP
- Where
- Canada
- Volunteers
- 32 people
- Sponsor
- University of British Columbia
Ventilator-Induced Lung Injury
Percutaneous Temporary Placement of a Transvenous Phrenic Nerve Stimulator for Diaphragm Pacing Using Jugular Access
Study conducted to confirm phrenic nerve stimulation using the a transvenous Phrenic Nerve Stimulator in the left jugular vein.
- Trial name
- NCT03659552
- Testing
- LIVE Catheter
- Where
- Paraguay
- Volunteers
- 13 people
- Sponsor
- Lungpacer Medical Inc.
Weaning Failure, Central Respiratory Depression
Exploration of Mechanisms for Weaning Failure
This study is a prospective physiologic study. The primary study population will be adult invasive tracheal intubated patients with COPD, and investigators will collect relevant demographic data, vital signs, and baseline…
- Conditions
- Weaning Failure, Central Respiratory Depression, Diaphragm Injury, Phrenic Nerve Disorder
- Trial name
- NCT06424314
- Testing
- Monitoring of respiratory mechanics parameters
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital of Guangzhou Medical University