Clinical trials: Physical Frailty
Colon Cancer, Colon Neoplasm
Geriatric Assessment and Intervention in Older Patients Undergoing Surgery for Colorectal Cancer
The GEPOC study investigates the effect of comprehensive geriatric assessment and intervention for frail older patients (65 years or older) undergoing elective surgery for colorectal cancer.
- Conditions
- Colon Cancer, Colon Neoplasm, Frail Elderly Syndrome, Colorectal Cancer
- Trial name
- GEPOC (NCT03719573)
- Testing
- Geriatric intervention
- Where
- Denmark
- Volunteers
- 67 people
- Sponsor
- Herlev and Gentofte Hospital
Frail Elderly Syndrome, Fall
Relationship Between the Risk of Falls and Frailty, and the Effect of a Physical Exercise Program on These Conditions in the Elderly: a Randomized Crossover Clinical Trial.
The goal of this randomized crossover clinical trial is to examine the effectiveness of a new therapeutic exercise program in elderly patients with risk of falls and physical fragility.
- Trial name
- NCT05940779
- Testing
- Therapeutic exercise program
- Where
- Spain
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Valencia
Frail Elderly Syndrome, Acute Coronary Syndrome
Frailty Assessment in Elderly Patients With Acute Coronary Syndrome
Frailty is known as an independent risk factor for morbidity and mortality in older cardiac patients . It is an important factor on the cardiologist decision between conservative and invasive treatment in older patient with acute…
- Trial name
- NCT03365505
- Volunteers
- 200 people
- Sponsor
- Meir Medical Center
Frail Elderly, Clostridioides Difficile
Clostridioides Difficile and Frailty
CDI is a major cause of antibiotics-associated diarrhoea. More than half of the patients affected are 70 years or older and frail. Mortality among older patients with CDI is high.
- Conditions
- Frail Elderly, Clostridioides Difficile, Geriatric Assessment, Faecal Microbiota Transplantation
- Trial name
- CLODIFRAIL (NCT05447533)
- Testing
- Comprehensive geriatric assessment (CGA), Continued geriatric care, Faecal microbiota transplantation (FMT)
- Where
- Denmark
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Health Services for the Aged, Frailty
e-GAB: Electronic Geriatric Assessment Bundle: Development of an Arabic Self-administered Android CGA Application
The aim of this study is to design and assess the accuracy of administering the electronic Geriatric Assessment Bundle (e-GAB) compared to geriatrician performed comprehensive geriatric assessment (CGA) in a group of Egyptian…
- Conditions
- Health Services for the Aged, Frailty, Cognitive Impairment, Depression
- Trial name
- NCT04211285
- Testing
- e-GAB, standard physician performed CGA
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Physical Inactivity, Frailty
The 'Outdoor Rehab-Fit' App-based Physical Activity Education Intervention for Frail Older Adults in Hong Kong
In recent years, research teams around the world have developed interventions to educate older adults to use outdoor exercise facilities (OEFs) to improve health outcomes like strength, balance, mobility, PA level, and weight.
- Trial name
- NCT06326710
- Testing
- mHealth, Health Talk
- Where
- Hong Kong
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Frailty, Sarcopenia
The SHAPE Project (Hospital System for Physical Activity and Active Participation) After Hospitalized Decompensation of Respiratory Chronic Diseases
It is widely established that a lack of adapted physical activity (APA) and sedentary behaviors increase the prevalence of frailty, which exacerbates chronic diseases.
- Conditions
- Frailty, Sarcopenia, Hospital Discharge, Physical Activity
- Trial name
- SHAPE (NCT07663955)
- Testing
- Hospital System for Physical Activity and Active Participation
- Where
- Spain
- Volunteers
- 90 people
- Sponsor
- Hospital Universitari de Bellvitge
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Sarcopenia, Aging
Effects of Polyphenol Supplementation and Exercise on Physical Performance in Older Adults
After approximately age 40 years, individuals experience a natural loss of muscle mass, strength, and physical function that is linked to higher risks of falls, disability, loss of independence, and mortality.
- Conditions
- Sarcopenia, Aging, Frailty
- Trial name
- NCT07441343
- Testing
- Polyphenol Rich-Extract, Resistance Band-Based & Aerobic Stationary Cycling Exercise
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Dr. Chris McGlory, PhD
Frailty, Length of Stay
Evaluation of Prioritized Assessment for Older Patients Living With Frailty Presenting to the Emergency Department
The older population is getting older and growing in size worldwide. This requires healthcare to adapt to meet the complex medical and nursing needs of the older patient group.
- Conditions
- Frailty, Length of Stay, Emergency Department Visit, Older Patients
- Trial name
- NCT06869148
- Testing
- Prioritized assessment for older patients living with frailty
- Where
- Sweden
- Volunteers
- 1,217 people, healthy volunteers welcome
- Sponsor
- University Hospital, Linkoeping
Sarcopenia, Intrinsic Capacity
Multi-Component Nutrition, Intrinsic Capacity, and Physical Function in Older Adults
To evaluate the effects of a 12-week multi-component nutritional formula on World Health Organization (WHO) Integrated Care for Older People (ICOPE) intrinsic capacity domains, physical function, and metabolic biomarkers in…
- Trial name
- NCT07815158
- Testing
- Multi-Component Nutritional Formula
- Where
- Taiwan
- Volunteers
- 70 people
- Sponsor
- National Yang Ming Chiao Tung University
Age-related Muscle Decline
CALM-AF-AI: Counteracting Age-related Loss of Muscle With AAV-Follistatin Combined With Angiogenesis-Inducing VEGF Plasmid Gene Therapy
This Phase 1/2a, open-label, non-randomized study is designed to evaluate the safety and tolerability of intramuscular AAV9-Follistatin gene therapy administered either as monotherapy or in combination with a VEGF-encoding…
- Trial name
- CALM-AF-AI (NCT07443826)
- Testing
- AAV9-Follistatin gene therapy, VEGF Plasmid
- Where
- Honduras
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Unlimited Biotechnology LLC
Chronic Kidney Diseases
Description of Treatment Patterns and Population Characteristics of Pre-dialysis CKD Patients in the Czech Republic
The decision making in the Czech nephrology offices depends on the local common practice which is likely to be heterogenous. In other words, the same patient would be indicated to different therapy and regimen at different sites.
- Trial name
- NCT05380843
- Where
- 5 sites in Czechia
- Volunteers
- 1,200 people
- Sponsor
- Value Outcomes Ltd.
Chronic Diseases in Older Adults, Malnutrition
Elderly Health Profile in a Rural Village of Assiut
This study aims to assess the health, nutrition, functional status, and quality of life of older adults living in Al-Boura village in Assiut, Egypt.
- Conditions
- Chronic Diseases in Older Adults, Malnutrition, Frailty, Functional Decline Geriatric Health
- Trial name
- RURAL-AGE (NCT07263087)
- Where
- Egypt
- Volunteers
- 330 people
- Sponsor
- Assiut University
Music Therapy, Frailty
Effect of Music Therapy in Improving the Physical Fitness and Depression in the Frailty of the Community Elderly
Research Design This study adopted randomized clinical trials design, with two groups of pre-tests and post-tests, a single-blind test, a single-blind test, and intentional sampling.
- Conditions
- Music Therapy, Frailty, Physical Fitness, Depression
- Trial name
- NCT04799574
- Testing
- music therapy activities
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
HIV Infection, Aging
My Smart Age With HIV: Smartphone Self-assessment of Frailty
Understanding the complexity of aging and frailty in chronic HIV infection motivated Italian team members to begin to build a frailty index (FI) including 37 health variables at the Modena HIV Metabolic Clinic (MHMC).
- Trial name
- MySAwH (NCT02663856)
- Testing
- observational
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- University of Modena and Reggio Emilia
Mild Cognitive Impairment, Old Age; Debility
Dual Task Perturbation Training for OAwMCI
Studies have determined that compared to cognitively intact older adults (CIOA), older adults with mild cognitive impairment (OAwMCI) exhibit more pronounced balance and gait impairments which lead to an increased risk of falls…
- Trial name
- NCT04938349
- Testing
- Dual task perturbation training
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Frailty, Muscle Weakness
Effectiveness of Protein Supplementation on Frailty Improvement, Muscle Strength and Physical Performance Among Pre-Frail Elderly People
The goal of this randomized clinical trial is to study the effectiveness of protein supplements in frailty improvement, muscle strength, physical performance, energy intake and body composition of pre-frail elderly people.
- Conditions
- Frailty, Muscle Weakness, Physical Dependence, Weight Loss
- Trial name
- NCT05648617
- Testing
- SUSTINEX Hydrolyzed Whey Protein
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Colo-rectal Cancer
NURSE-led Geriatric Assessment in Older Colorectal Cancer Patients
Older colorectal cancer patients frequently present with frailty, comorbidity, and other age-related vulnerabilities that may affect treatment tolerance and outcomes.
- Trial name
- NURSE-GA (NCT07872787)
- Testing
- Nurse-led Geriatric Assessment
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Helse Stavanger HF
Physical Trauma
Trauma Specific Frailty Index
Increasing age is a known predictor of morbidity and mortality after a traumatic injury with worst outcomes seen in patients with age greater than 65 years.
- Trial name
- TSFI (NCT04216381)
- Testing
- Trauma Specific Frailty Index Questionnaire
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- Methodist Health System