Clinical trials: Physiologic Changes
Healthy Adult Participants
Physiological Responses to Upper Limb NMES
The primary objective of this study is to explore the application of the Firefly® device for delivering NMES to anatomically defined regions of the upper limb and to observe associated physiological changes.
- Trial name
- NCT07635979
- Testing
- Firefly NMES device
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- Kieron.Day
Obesity, Overweight
A Study of Orforglipron for the Maintenance of Body Weight Reduction in Participants Who Have Obesity or Overweight With Weight-Related Comorbidities (ATTAIN-MAINTAIN)
The main purpose of this study is to evaluate the efficacy and safety of orforglipron on maintenance of body weight reduction in participants who previously completed treatment with injectable tirzepatide (Zepbound) or injectable…
- Trial name
- NCT06584916
- Testing
- Orforglipron
- Where
- 29 sites in United States, Puerto Rico
- Volunteers
- 376 people
- Sponsor
- Eli Lilly and Company
Bradycardia
Effectiveness of Pacemaker With Closed Loop Stimulation Compared to Pacemakers With and Without Standard Rate Response
This is a randomized, prospective, single-blinded, multi-center study involving approximately 1500 patients at 100 centers. The purpose of this study is to demonstrate the effectiveness of Closed Loop Stimulation (CLS) rate…
- Trial name
- CLEAR (NCT00355797)
- Testing
- Closed Loop Stimulation (CLS), Standard Rate Adaptive (R) Technology, Non-rate adaptive (DDD) pacing
- Where
- 99 sites in United States
- Volunteers
- 1,491 people
- Sponsor
- Biotronik, Inc.
Vaccine Reaction
(VIII): The Eight Study and Immunologic Response Sub-study
The study's objective is to test the hypothesis that immune system activation and subsequent systemic inflammation can be detected through continuously tracking multiple bio signals including physiologic variables (ECG, skin…
- Trial name
- NCT05237024
- Where
- 2 sites in United States, Canada
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- physIQ, Inc.
Physiological Stress, Cognitive Performance
Dietary Intervention With Brain-friendly Diet
To evaluate the effect of dietary intervention on metabolic risk profile, and on potential simultaneous changes in physiological and cognitive functions and to collect a unique database using state-of-the-art technologies on…
- Conditions
- Physiological Stress, Cognitive Performance, LDL Cholesterol
- Trial name
- BRAVE (NCT03346486)
- Testing
- Control diet, Intervention diet
- Where
- Finland
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Fazer Group
Impotence
Assessment of Onset, Safety & Toleration of UK-369,003 in Male Erectile Dysfunction
To determine the onset of action, safety and toleration of different formulations and doses of UK-369,003 in patients with erectile dysfunction.
- Trial name
- NCT00141349
- Testing
- UK-369,003
- Where
- 39 sites in United States
- Volunteers
- 300 people
- Sponsor
- Pfizer
Avenanthramides
Avenanthramides and Exercise
The aim of the proposed study is to examine whether long-term dietary supplementation (8 weeks) of an oat flour cookie rich in avenanthramides (AVA) could enhance blood antioxidant capacity and reduce blood inflammatory markers…
- Trial name
- NCT02584946
- Testing
- Avenanthramides
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Obstetric Labour, Premature, Premature Ejaculation
A Study To Assess The Pharmacokinetics Of Different Modified Release Formulations Of GSK221149 In Healthy Adult Subjects
PreTerm Labor (prior to 37 weeks gestation) is the largest single cause of infant morbidity and mortality and is frequently associated with long-term disability. Oxytocin is a hormone produced by the body during labor.
- Trial name
- NCT00449709
- Testing
- GSK221149
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Stress
Acute Stress Recovery
The proposed study aims to evaluate whether different features of a relaxation room affect how individuals recover from acute stress.
- Trial name
- ASR (NCT05298189)
- Testing
- MindBreaks - Audio-visual, MindBreaks - Auditory-only, MindBreaks - Visual-only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Well Living Lab, Inc.
Impotence
Assessment Of Duration Of Action, Safety & Toleration Of UK369,003 and Cialis In Patients With Erectile Dysfunction
Assessment of duration of action, safety \& toleration of different formulations and doses of UK-369,003 and Cialis in patients with male erectile dysfunction.
- Trial name
- NCT00174486
- Testing
- UK0369,003, Cialis (Tadalafil)
- Volunteers
- 300 people
- Sponsor
- Pfizer
Erectile Dysfunction, Sexual Dysfunction
Real-world Longitudinal Follow-up Study of a Digital Health Application in Erectile Dysfunction
The goal of this observational study is to assess the long-term effectiveness of a digital health application for treating erectile dysfunction in men aged 18 and older.
- Trial name
- RELOED (NCT06501144)
- Where
- Germany
- Volunteers
- 317 people
- Sponsor
- Kranus Health GmbH
Obesity, Overweight
A Study of LY3437943 in Participants Who Have Obesity or Are Overweight
This is a study of LY3437943 in participants who have obesity or are overweight. The main purpose is to learn more about how LY3437943 affects body weight loss. The study will last about 18 months and may include up to 18 visits.
- Trial name
- NCT04881760
- Testing
- LY3437943
- Where
- 28 sites in United States, Puerto Rico
- Volunteers
- 338 people
- Sponsor
- Eli Lilly and Company
Breast Cancer
Randomized Study of Combination Chemotherapy With or Without Focused Microwave Thermotherapy Before Surgery in Treating Women With Large Breast Cancer Tumors
The purpose of this randomized Phase III study is to determine whether preoperative focused microwave heat treatment and chemotherapy combined are more effective than preoperative chemotherapy alone in the treatment of large…
- Trial name
- Medifocus301 (NCT01204801)
- Testing
- Focused Microwave Thermotherapy, Chemotherapy (control)
- Where
- 2 sites in United States, Canada
- Volunteers
- 238 people
- Sponsor
- Medifocus, Inc.
Erectile Dysfunction
Bioequivalence Study Comparing Two Test Products With One Reference Product, All Containing 5 mg Yohimbine
Type: Bioequivalence study in male healthy volunteers, therapeutical indication (erectile disfunction) not studied Products, dosage, and route of administration: Test 1: Yohimbin "Spiegel"® (Desma GmbH, Germany), tablet…
- Trial name
- NCT00975325
- Testing
- Yohimbine
- Where
- Germany
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Walter Ritter GmbH & Co
PHYSIOLOGICAL PHENOMENA, Homeostasis
Truway Whole-Body Digital Twin and Physiologic Resilience Study (TRU-OMNIBODY)
TRU-OMNIBODY is a prospective observational study designed to develop and independently validate a research-only whole-body digital twin.
- Conditions
- PHYSIOLOGICAL PHENOMENA, Homeostasis, Physical Functional Performance, Cardiorespiratory Fitness
- Trial name
- TRU-OMNIBODY (NCT07805044)
- Testing
- Standardized Physiologic Resilience Challenge, Multimodal Whole-Body Physiologic Monitoring, Research-Only Whole-Body Digital Twin Analysis
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Truway Health, Inc.
Stroke, Hand Function
Hand Training & Brain Changes
10 participants with upper-limb impairment will be recruited from community sources. They will be invited to participate in a 15-day trial involving the IRegained device.
- Trial name
- NCT05811819
- Testing
- Treatment using the MyHand System
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- IRegained Inc.
Skin Barrier Function, Wound Healing
Clinical Observational Study on Changes in Skin Physiological Parameters Following Ablative and Non-Ablative Fractional Laser Treatment at Different Doses
This clinical observational study investigates the dose-response relationship between laser energy intensity and skin damage/repair by applying different parameter sets of fractional ablative (CO2) and non-ablative (M22) lasers…
- Trial name
- NCT07561242
- Testing
- Ablative Fractional Carbon Dioxide Laser, Non-ablative Fractional Laser (1565 nm)
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- ChinaNorm
Vulvar Atrophy, Vulvovaginal Signs and Symptoms
Changes in the Impact of Genitourinary Syndrome of Menopause With a Novel Nonhormonal Vulvovaginal Gel Assessed by PROMs.
The goal of this clinical trial is to improve the management of Genitourinary syndrome of menopause (GSM) to preliminary assess safety and effectivity of a novel hormone-free mucosa composition (XCMIM20m) applied topically to the…
- Conditions
- Vulvar Atrophy, Vulvovaginal Signs and Symptoms, Genitourinary Syndrome of Menopause, Quality of Life
- Trial name
- STOPGSMP (NCT06962345)
- Testing
- Hormone-free vulvovaginal gel with the tested composition XCMIM20m
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Mucosa Innovations, S.L.
Stroke
Physiological Changes From Hand Movement Training
11 participants with upper-limb impairment will be recruited from community sources. They will be invited to participate in a 15-day trial involving the IRegained device.
- Trial name
- NCT05811806
- Testing
- Treatment using the MyHand System
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- IRegained Inc.
Cognitive Change, Sleep Deprivation
Sleep Deprivation Study
The purpose of this study is to evaluate the measures of brain function, both neurophysiological (event-related potentials (ERPs) and functional (cognitive assessments), in response to sleep deprivation.
- Conditions
- Cognitive Change, Sleep Deprivation, Caffeine
- Trial name
- NCT05560620
- Testing
- Sleep Deprivation, Caffeine, No Caffeine
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- NeuroCatch Inc.