Clinical trials: Physiological Conditions
Cancer-related Problem/Condition, Sexuality
The Find Your PATHS (Pragmatic Assessment of a Tool to Help Survivors) to Sexual Health and Parenthood Study
Concerns with sexual health and fertility are common among cancer patients, survivors and their partners. Literature reviews suggest that over 60% of survivors have reproductive health problems yet fewer than 20% get professional…
- Conditions
- Cancer-related Problem/Condition, Sexuality, Fertility
- Trial name
- PATHS (NCT03345264)
- Testing
- Online, interactive self-help program
- Where
- United States
- Volunteers
- 361 people, healthy volunteers welcome
- Sponsor
- American Cancer Society, Inc.
Urinary Incontinence, Anal Incontinence
Tridimensional Pelvic Floor Ultrasound and Quality of Life Scores Questionnaires in Nulliparous or Parous Women
Evaluation of the impact of the delivery in the system of suspension and sustentation of pelvic floor, by 3D ultrasound and quality of life questionnaires.nt
- Conditions
- Urinary Incontinence, Anal Incontinence, Sexual Dysfunction, Self Esteem
- Trial name
- NCT03656601
- Testing
- 3D pelvic ultrasound
- Where
- Brazil
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Hypoxia
Ketone Esters for Optimization of Operator Performance in Hypoxia
The primary purpose of the study was to investigate effects of an orally administered ketone ester drink on endurance exercise performance during acute extreme hypoxia.
- Trial name
- HVMN7 (NCT07065864)
- Testing
- Ketone ester
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Florida Institute for Human and Machine Cognition
Mitochondrial Biogenesis, Inflammation
EFFECTS OF PYRROLOQUINOLINE QUINONE (PQQ) SUPPLEMENTATION ON NON-ENDURANCE TRAINED ATHLETES
The aim of this study was to investigate the effects of six weeks of PQQ supplementation in non-endurance-trained individuals on: 1. physiological and metabolic response during a FATmax-VO₂peak exercise test 2.
- Trial name
- NCT07148726
- Testing
- Pyrrole Quinoline Quinone (PQQ)
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Padova
Obesity, Sweeteners
Mapping the 'Sweet Brain' in Healthy Participants
The human brain has a central role in regulating appetite and food intake. It integrates many metabolic, hedonic and trait-related signals that affect eating behaviour and determine when and how much we eat.
- Trial name
- NCT04162457
- Testing
- Stevia, Glucose, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Hyperoxia / High FiO₂ Exposure, Interval Training
Oxygen as a Metabolic Modulator: Divergent Physiological Adaptations to Hypoxic and Hyperoxic Tabata Training.
The purpose of this study is to examine how breathing air with different oxygen concentrations (higher or lower than normal) during high-intensity interval training affects: Aerobic capacity (VO₂max) Ventilatory thresholds Blood…
- Conditions
- Hyperoxia / High FiO₂ Exposure, Interval Training, HIIT, High Intensity Interval Training
- Trial name
- NCT07551869
- Testing
- FIO2 modulation during HIIT protocol on assault bike
- Where
- Belgium
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Haute Ecole Bruxelles-Brabant
Sepsis, Maternal Sepsis
mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis
A prospective observational cohort study investigating physiological parameters vs biological markers of whole blood in septic and non-septic pregnant woman to predict systemic immune health
- Conditions
- Sepsis, Maternal Sepsis, Maternal Sepsis During Labor, SIRS
- Trial name
- NCT05023954
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Maternal; Malnutrition, Infant Malnutrition
Impact of Maternal Stress on Infant Stunting
This study takes place in rural Mam-Mayan communities of Guatemala characterized by high rates of childhood stunting. It aims to characterize women's exposure to nutrition, infection and psychosocial stressors vs.
- Conditions
- Maternal; Malnutrition, Infant Malnutrition, Physiological Stress, Emotional Stress
- Trial name
- NCT02755012
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- McGill University
Pain, Postoperative, Analgesics, Opioid
Evaluation of Abdominal Wall Block With Liposomal Bupivacaine for Post-Operative Analgesia in Donor Nephrectomy
A blinded randomized control trial in living kidney donors. The study group will receive a liposomal bupivacaine Trans Quadratus Lumborum (TQL) block after the induction of general anesthesia.
- Conditions
- Pain, Postoperative, Analgesics, Opioid, Analgesics, Non-Narcotic, Physiological Effects of Drugs
- Trial name
- NCT03294109
- Testing
- Abdominal wall block with liposomal bupivicaine
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Obesity
GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations
The obesity epidemic is attributable to dietary and behavioral trends acting on a person's genetic makeup to determine body mass and susceptibility to obesity-related diseases.
- Trial name
- NCT02082496
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Hypoxia, Hypercapnia
The Effect of Hypercapnia on Physiological Parameters During Short-term Breathing
The aim of the project is to evaluate the effect of hypercapnia on physiological parameters in a healthy person during short-term hypoxia and hypercapnia.
- Conditions
- Hypoxia, Hypercapnia, Cardiac Output, High
- Trial name
- HYPERCO (NCT05441007)
- Testing
- Hypoxic, Hypercapnic, Hypoxic and Hypercapnic
- Where
- Czechia
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Czech Technical University in Prague
COPD, Asthma
Study of Inflammatory and Physiological Profiles of Healthy and Diseased Lung
There are over 700,000 UK hospital admissions every year with lung disease symptoms. Two of the most common lung diseases contributing to these numbers are asthma and chronic obstructive pulmonary disease (COPD).
- Conditions
- COPD, Asthma, Airway Disease
- Trial name
- RETAIN (NCT06144476)
- Where
- United Kingdom
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Adiposity
The Role of Oxytocin-receptor Signalling in Physiological Regulation of Eating Behaviour in Individuals with Obesity
The present study evaluates appetite, glucose metabolism, gastrointestinal motility and energy expenditure in men and women with obesity (BMI 30-40 kg/m2) under oxytocin exposure compared to placebo.
- Trial name
- FOxy (NCT06189001)
- Testing
- Oxytocin
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Pregnancy Related, Weight Change, Body
POWERMOM, A Healthy Pregnancy Research Community
This study will take advantage of the open source framework of ResearchKit developed by Apple to bring research directly to participants.
- Conditions
- Pregnancy Related, Weight Change, Body, Health Problems in Pregnancy, Behavior
- Trial name
- NCT03085875
- Where
- United States
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Scripps Translational Science Institute
Stunting, Severe Acute Malnutrition
Changes in Nerve Electro Physiologic Properties in Children Before and After Correction of Malnutrition
The goal of this clinical trail study is to measure neurophysiologic parameters to assess the effect of malnutrition on the peripheral nervous system and their response to treatment in three categories (SAM, severe wasting, and…
- Conditions
- Stunting, Severe Acute Malnutrition, Wasting
- Trial name
- NCT05891457
- Testing
- Nutritional Intervention
- Where
- Bangladesh
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Athletic Performance Enhancement
Effects of Blood Flow Restriction Training on Physical Function, Muscle Adaptations, and Performance in Roller Skaters
This randomized controlled trial evaluates the effects of adding blood flow restriction training to regular roller skating training on neuromuscular function under non-fatigued and fatigued conditions, muscle morphology, body…
- Trial name
- NCT07736157
- Testing
- Blood Flow Restriction Roller Skating Training, Standardized Roller Skating Training
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Adenomyosis, Uterine Leiomyoma
The Association Between Adenomyosis/Uterine Myoma and Lower Urinary Tract Symptoms
The aim of this study is to assess the relationship between adenomyosis/myoma and lower urinary tract symptoms, sexual function and gastrointestinal symptoms.
- Trial name
- NCT02495311
- Testing
- myomectomy or adenomyomectomy
- Where
- Taiwan
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Far Eastern Memorial Hospital
Cervical Dystonia, Primary
Effects of Botulinum Toxin on Muscle and Brain Activity
This study will look into the effects of Botulinum Toxin in patients with primary cervical dystonia. The effects will be determined by neck muscle activity measurements and brain function activity measurements.
- Trial name
- NCT02837185
- Testing
- Botulinum Toxin injection, Physiological measures
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Cataract Surgery
The Effect of Hand Massage Applied Before Cataract Surgery on Anxiety, Surgical Fear, Pain and Physiological Parameters
ABSTRACT Objective: The research was conducted as a prospective randomized controlled experimental study to determine the effect of hand massage applied before cataract surgery on anxiety, surgical fear, pain and physiological…
- Trial name
- NCT05232513
- Testing
- Hand massage
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- TC Erciyes University
Metabolic Syndrome X, Cardiovascular Diseases
The Effects of Beta-glucan Enriched Oatcake Consumption on Metabolic Disease Risk Factors
The purpose of this study is to determine whether daily consumption of soluble fibre, oat beta glucan (4g), for six weeks will have any impact on overweight/obese individuals in terms of risk factors used to define metabolic…
- Trial name
- NCT02615444
- Testing
- Beta-glucan enriched oatcake, Isocaloric control
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University