Clinical trials: Physiological Responses
Sepsis, Maternal Sepsis
mSEP: Testing of Physiological and Immune-metabolic Blood Markers for Maternal Sepsis
A prospective observational cohort study investigating physiological parameters vs biological markers of whole blood in septic and non-septic pregnant woman to predict systemic immune health
- Conditions
- Sepsis, Maternal Sepsis, Maternal Sepsis During Labor, SIRS
- Trial name
- NCT05023954
- Testing
- Blood test
- Where
- United Kingdom
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Heart Failure
Selective Coronary Vein Sampling in Left Bundle Branch Block and CRT
Cardiac resynchronisation therapy (CRT) prolongs the life and improves the symptoms in patients with heart failure and electrical dyssynchrony.
- Trial name
- MicroCRT (NCT02396875)
- Testing
- Blood sampling and exercise protocol pre and post CRT implant, Peripheral blood sampling, Central blood sampling pre and post CRT implant
- Where
- United Kingdom
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Hepatitis C
Sofosbuvir (GS-7977) in Combination With PEG and Ribavirin for 12 Weeks in Treatment Experienced Subjects With Chronic HCV Infection Genotype 2 or 3
This study is to evaluate the safety, tolerability, and antiviral efficacy of sofosbuvir (SOF) in combination with peginterferon alfa 2a (PEG) and ribavirin (RBV) administered for 12 weeks in participants with chronic genotype 2…
- Trial name
- NCT01808248
- Testing
- SOF, PEG, RBV
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- Gilead Sciences
Chronotropic Incompetence
Comparison of Physiologic Response With Rate Adaptive Pacing Driven by Minute Ventilation and Accelerometer
Some patients' heart rates do not increase as needed during activities and exercise, which can make them feel tired and fatigued easily.
- Trial name
- RAP (NCT02003378)
- Testing
- Pacemaker sensor set to MV, Pacemaker sensor set to XL
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Albany Medical College
Motor Learning and Physiological Adaptation
Effects of Active Upper-Limb Exoskeleton Training in Simulated Hyper-Gravity on Fine Motor Performance, Brain-Muscle Connectivity, Cardiovascular System and Stress Responses in Real Hyper-Gravity
The aim of the study presented here is to assess the effects of exoskeleton training on performance in a real hypergravity situation.
- Trial name
- EGOS (NCT07278245)
- Testing
- Training with an exoskeleton
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Centre National d'Etudes Spatiales
Exhaustion - Physiological
Physiologic Adaptations to Interval and Continuous Running at Low Volume and Vigorous Intensity Over 14-Weeks.
The purpose of this study was to verify physiological responses to constant-load (continuous) vs. variable-intensity (interval) during 14 weeks of aerobic exercise on active men.
- Trial name
- NCT01816451
- Testing
- running training
- Where
- Brazil
- Volunteers
- 35 people
- Sponsor
- University of Trás-os-Montes and Alto Douro
COVID-19
Responses to CPET in Subjects With Persistent Exercise Intolerance After COVID-19: an Open-Source Exercise Network
This retrospective collaborative study on persistent exercise intolerance after COVID-19 offers to perform a large descriptive analysis of CPET performed in real-life by pulmonologists, cardiologists and physiologists.
- Trial name
- NCT05532995
- Where
- 29 sites in Canada, France and 2 more
- Volunteers
- 1,200 people
- Sponsor
- Association pour la Complementarite des Connaissances et des Pratiques de la Pneumologie
Body Temperature Changes, Heat Stress
Consecutive Occupational Heat Exposure With and Without Overnight Cooling
Extreme heat events are becoming more frequent, intense, and prolonged, increasing the risk of heat-related illness among workers exposed to hot environments.
- Conditions
- Body Temperature Changes, Heat Stress, Heat Exposure, Heat Fatigue
- Trial name
- NCT07656519
- Testing
- Simulated occupational heat exposure with recovery at recommended indoor temperature limit, Simulated occupational heat exposure with recovery in an overheated indoor environment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Healthy
Hormonal Balance in Stress, Fatigue, and Recovery: Dynamics of Pre-Competition Responses
This observational study investigates how elite athletes respond physiologically and psychologically to pre-competitive stress in the context of a high-stakes performance test.
- Trial name
- NCT06917677
- Testing
- 2000-meter maximal effort test on rowing ergometer
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Poznan University of Physical Education
Raynaud's Phenomenon Secondary to Connective Tissue Disease
Efficacy and Safety of Vascana® in Subjects With Secondary Raynaud's Phenomenon
The purpose of this study is to determine the ability of Vascana (0.9% nitroglycerin topical cream) to treat and prevent the symptoms experienced by subject's with Raynaud's Phenomenon.
- Trial name
- NCT02688270
- Testing
- Vascana (0.9% nitroglycerin cream)
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Covis Pharma S.à.r.l.
Cytokine Release Syndrome, Neoplasms
Continuous Temperature Monitoring (CTM) for Cytokine Release Syndrome (CRS), an Immune-Related Adverse Event
Background: Drugs or cell therapies to treat cancer can sometimes cause cytokine release syndrome (CRS). That is, the body makes too many cytokines after treatment. Cytokines are proteins that play a role in the immune system.
- Conditions
- Cytokine Release Syndrome, Neoplasms, Lymphoma, Precursor Cell Lymphoblastic Leukemia-Lymphoma
- Trial name
- NCT07499128
- Testing
- TempTraq, VitalTraq
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- National Cancer Institute (NCI)
Exercise-induced Oxidative Stress
Physiological Effect of Ataulfo Mango (Manguifera Indica) Beverage in Exercise
The aim of this study is to assess the antioxidant capacity of two mango base beverages (AM1, AM2), against exercise-induced oxidative stress.
- Trial name
- NCT03182543
- Testing
- Mango pulp beverage, Mango pulp and peel beverage, Control beverage
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Ciudad Juarez
Sport Participation
High-Intensity Interval Training Across Exercise Environments: Acute Effects on Physiological Stress, Cardiovascular Responses, Executive Function, and Psychological Experience
The goal of this clinical trial utilizing a randomized crossover design)is to explore the modulating effects of different exercise environments （green parks, outdoor athletic tracks, and indoor settings) on acute responses to…
- Trial name
- NCT07488715
- Testing
- HIIT in Indoor Environment, HIIT in Outdoor Athletic Track, HIIT in Green Park Environment
- Where
- China
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Sport
Sports Nutritional Physiological Phenomena
Blood, Muscle and Exercise Responses to Sodium Bicarbonate Supplementation
The aim of this study is to evaluate the changes in activity of transporters of H+ (monocarboxylate transporters; MCT1, MCT4, NHE) following sodium bicarbonate supplementation and subsequent exercise performance.
- Trial name
- NCT03505970
- Testing
- Sodium bicarbonate, Maltodextrin
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Hypoxia, Altitude, Cold Exposure
Effects of Physical Training in Altered Environmental Conditions on Exercise Performance
The main objective of the study is to evaluate the physiological-biochemical effects of physical training under artificially altered climatic conditions (using a hypoxic thermoclimatic chamber) in particular to determine the…
- Conditions
- Hypoxia, Altitude, Cold Exposure, Heat Exposure
- Trial name
- NCT06159374
- Testing
- exercise and environmental conditions
- Where
- Poland
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- University School of Physical Education, Krakow, Poland
Retinopathy of Prematurity
Infant-parent Skin-to-skin Contact During Screening for Retinopathy
Retinopathy of prematurity (ROP) is a feared complication of premature birth. If discovered in time, the disease can be treated, and impaired vision or blindness can be reduced.
- Trial name
- NCT02780544
- Testing
- skin-to-skin contact, incubator, Sucrose
- Where
- Norway
- Volunteers
- 34 people
- Sponsor
- St. Olavs Hospital
Cardiovascular Physiology
Effects of Tart Cherry and Aronia Extract Supplementation on Selected Physiological Parameters in Endurance-Trained Men
This study will evaluate the effects of four weeks of oral supplementation with a double-standardized tart cherry (Prunus cerasus) and aronia (Aronia melanocarpa) extract on cardiovascular regulation and exercise performance in…
- Trial name
- NCT07885098
- Testing
- Standardized Tart Cherry and Aronia Extract
- Where
- Poland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Critical Ill Patients
Looking at the Physiological Response of Ergometry in Critical Care Patients
Exploring the physiological and metabolic demands of passive ergometry in the critical ill patient.
- Trial name
- NCT04383171
- Testing
- Motomed cycle ergometer (MOTOmed letto2 - Reck, Reckstr 1-5, Betzenweiler 88422, Germany).
- Volunteers
- 12 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Muscle, Skeletal, High-Intensity Interval Training
Whey Protein Support to Metabolic and Performance Adaptations in Response HIIT
High intensity interval training (HIIT) has recently emerged as a time efficient alternative to conventional endurance exercise, conferring similar or superior benefits in terms of metabolic and performance adaptations in both…
- Conditions
- Muscle, Skeletal, High-Intensity Interval Training, Exercise
- Trial name
- NCT03570424
- Testing
- Nutrient support to HIIT
- Where
- Ireland
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Limerick
Spinal Muscular Atrophy
Exploring the Physiologic, Pharmacodynamic, and Clinical Responses of Skeletal Muscle in Patients With Spinal Muscular Atrophy Treated With SMN-Directed Therapies
In this observational study, researchers are looking at the effects of spinal muscular atrophy (SMA) drugs on the muscles and nerve cells in patients with SMA.
- Trial name
- NCT06532474
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- St. Jude Children's Research Hospital