Clinical trials: Physiological Responses
Work of Breathing, Lung Transplant; Complications
Physiological Response in Lung Transplant Recipients Undergoing Neurally Adjusted Ventilatory Assist
Primary Graft Dysfunction (PGD) respresents the leading cause of mortality in early post-operative period of Lung Tranplantation (LTx). Protective ventilatory strategy could potentially reduce the risk of PGD in these patients.
- Conditions
- Work of Breathing, Lung Transplant; Complications, Neurally Adjusted Ventilatory Assist, Ventilator-Induced Lung Injury
- Trial name
- TRANS-NAVA (NCT03367221)
- Testing
- NAVA ventilation
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 20 people
- Sponsor
- Policlinico Hospital
Erectile Dysfunction, Arterial Hypertension
Correlation Study of Vascular Parameters in Hypertensive Men With Erectile Dysfunction
The purpose of the study is to assess the correlation of FMD of brachial artery and carotid intima media thickness with ED severity and clinical response to vardenafil in hypertensive men.
- Conditions
- Erectile Dysfunction, Arterial Hypertension, Endothelial Dysfunction
- Trial name
- NCT01084187
- Testing
- Vardenafil
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- Hospital Universitario Pedro Ernesto
Hydration, Dehydration
The Effect of Proprietary Water on Physiological and Perceptual Responses
The purpose of this study is to determine if drinking proprietary water (PW) during a standardized daily plan as compared to distilled water (control) and carbohydrate-electrolyte (CE) drink can improve hydration status over…
- Trial name
- NCT05451446
- Testing
- proprietary water, Active comparator
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Lower Extremity Lymphoedema, Leg Lymphoedema
Treatment Response to Different Lymphoedema Compression Programs Using a Pneumatic Compression Device
Proof of principle study in order to determine if there is a difference in treatment effect across the 3 study groups when treating lower extremity lymphoedema using a pneumatic compression device.
- Trial name
- NCT02031627
- Testing
- pneumatic compression - 1 hour per day, pneumatic compression - 2 hours per day, pneumatic compression - 4 hours per day
- Where
- United Kingdom
- Volunteers
- 21 people
- Sponsor
- Tactile Medical
Premature Ejaculation, Sexual Dysfunction
Brain Networks Implicated in Lifelong Premature Ejaculation Patients
Using Brain Mapping and Cognitive ERPs, the investigatos have searched for a Brain Networks involved during Inhibitory Control in Lifelong Premature Ejaculation (LPE) participants.
- Trial name
- LPE (NCT04850703)
- Testing
- Transcranial Radom Noise Stimulation, Take Dapoxetine, Compare LPE EEG endophenotype between participants and healthy controls
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Moises Domingo
Anesthesia, Stress, Physiological
Adductor Canal Block Versus Patient Controlled Analgesia, in the Surgical Stress Response for Anterior Cruciate Ligament Repair
To evaluate the surgical stress response in anterior cruciate ligament repair with an adductor canal block versus patient controlled endovenous analgesia.
- Conditions
- Anesthesia, Stress, Physiological, Surgery
- Trial name
- NCT04797546
- Testing
- Adductor Canal Block, Morphine Patient Controlled Analgesia
- Where
- Chile
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
Pain Response, Stress, Trauma
Characterizing Subjective and Physiological Responses to Stress and Pain and Cognitive Learning and Executive Function
The study design is to assess the between groups factor (controls, chronic pain, addicted individuals) and repeated measures factor of pain/stress (pain vs no pain) along with a longitudinal component to assess stress, pain and…
- Trial name
- NCT04419831
- Testing
- Yale Stress Pain Test (YSPT)
- Where
- United States
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yale University
Intubation Complication, Cardiovascular Morbidity
The Effects of Lidocaine and Magnesium Sulphate on the Attenuation of the Hemodynamic Response to Tracheal Intubation
Justification and Objectives: The hemodynamic response to stimuli of the airways is a common phenomenon and its control is important to decrease systemic repercussions.
- Trial name
- NCT02359370
- Testing
- Lidocaine, Magnesium Sulphate
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Hospital de Base
Obesity
GLP-1 Response and Effect in Individuals With Obesity Causing Genetic Mutations
The obesity epidemic is attributable to dietary and behavioral trends acting on a person's genetic makeup to determine body mass and susceptibility to obesity-related diseases.
- Trial name
- NCT02082496
- Testing
- Liraglutide
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Covid19
Use of Lung Ultrasound in Evaluating Physiological Response to Awake Self Proning
The primary objective of this study is to explore the physiological mechanism of awake, self proning among patients with acute hypoxemic respiratory failure induced by COVID-19, using LUS in the first three days and explore the…
- Trial name
- NCT04855162
- Where
- 2 sites in United States, Mexico
- Volunteers
- 74 people
- Sponsor
- Rush University Medical Center
Stress, Physiological, Stress, Psychological
A Comparison of Acute Psychobiological Responses to Laboratory Stress Tests
The Mannheim Multicomponent Stress Test (MMST) is a validated laboratory stress test that combines cognitive, emotional, acoustic and motivational stress components.
- Trial name
- NCT06066320
- Testing
- MMST, TSST
- Where
- United Kingdom
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Healthy
Effect of Prolonged Military Exercises With High Load Carriage, on Neuromuscular Fatigue and Physiological/Biomechanical Responses
Land military missions generally combine prolonged walking/moderate-pace-running and other physical actions such as creeping, jumping, shooting,… which are associated with the direct carrying of high to severe loads of equipment…
- Trial name
- NCT01127191
- Testing
- military equipment
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Transmission, Patient-Professional
The Effects of Filter During CPET on WOB and Aerosol Particle Concentrations
Due to the concerns of virus transmission during COVID-19 pandemic, multiple respiratory societies postpone or limit pulmonary function test, especially cardiopulmonary exercise test (CPET), as patients may generate large amount…
- Trial name
- NCT04526925
- Testing
- Respiratory filter in-line placed with the standard mouthpiece, Standard mouthpiece
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Physiological Responses, Behavior
Behavioural and Physiological Responses to Dog Visits in Nursing Homes
In brief the study aims to investigate how nursing home residents receiving dog visits respond to contact with the dog, by comparing visits with and without a dog present.
- Conditions
- Physiological Responses, Behavior, Mood
- Trial name
- NCT05516264
- Testing
- Dog visits/control visits, Control visits/dog visits
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Anxiety Wounds and Injuries
Healing Through Play
Wound dressing is a common procedure for children with injuries or wounds. The procedure can cause pain, fear, and anxiety. Children may also experience changes in heart rate and breathing when they feel distressed.
- Trial name
- Healing (NCT07909798)
- Testing
- Usual Care
- Where
- Jordan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Al-Zaytoonah University of Jordan
Overweight, Obesity
Sprint to Fitness: Effect of Outcome Expectations on Responses to Interval Exercise Training
The purpose of this study is to research the effects of exercising at high intensities for short periods of time on exercise tolerance and motivation.
- Trial name
- NCT03162978
- Testing
- HIIT + POE, HIIT only
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- USDA Grand Forks Human Nutrition Research Center
Stress (Psychology), Stress
Impact of OnabotulinumtoxinA (BOTOX®) on Stress
The purpose of this prospective single-center, blinded*, randomized, proof-of-concept study is to determine whether OnabotulinumtoxinA (BOTOX®) injections will change the level of stress perceived by generally healthy adult…
- Conditions
- Stress (Psychology), Stress, Healthy Adult Female Participants, Stress, Psychologic
- Trial name
- NCT06778421
- Testing
- Intramuscular injection, OnabotulinumtoxinA (Botox®) Injections, Sodium Chloride
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Center for Advanced Facial Plastic Surgery
Anorexia Nervosa
Meal-Based Exposure and Response Prevention in Anorexia Nervosa
Patients with anorexia nervosa (AN), a serious psychiatric disorder, exhibit restricted dietary intake and endorse fear of consuming calorie-dense foods, which in turn drives weight loss.
- Trial name
- NCT03747835
- Testing
- Exposure and Response Prevention, Motivational Interviewing
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Johns Hopkins University
Neuroendocrine Tumors, Pancreatic Neoplasms
Predictive Biomarkers of Response to Sunitinib in the Treatment of Poorly-differentiated NEURO-Endocrine Tumors
The purpose of this study is to identify predictive molecular markers of response to continuous daily sunitinib at dose of 37.5 mg used in patients with poorly-differentiated Advanced/Inoperable NEURO-Endocrine Tumors.
- Conditions
- Neuroendocrine Tumors, Pancreatic Neoplasms, Advanced Disease, Sunitinib
- Trial name
- NET (NCT01215578)
- Testing
- Sutent
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Protocol for Alpha MSH Infusion Study in Patients With Type 2 Diabetes
Alpha-melanocyte stimulatory hormone (α-MSH) is a melanocyte-stimulating hormone produced by the hypothalamus and released from the pituitary gland.
- Trial name
- α-MSH & T2DM (NCT06293664)
- Testing
- α-MSH infusion
- Where
- Kuwait
- Volunteers
- 13 people
- Sponsor
- Dasman Diabetes Institute