Clinical trials: Placenta
Preeclampsia, Hypertension
Hypertension and Urine Protease Activity in Preeclampsia
Preeclampsia (PE) is a common disorder of pregnancy that complicates 4-7% of all pregnancies. It is a serious condition with acute proteinuria and hypertension and varying degrees of edema after 20 weeks of gestation.
- Conditions
- Preeclampsia, Hypertension, Proteinuria, Pregnancy
- Trial name
- HUPP (NCT01828138)
- Testing
- Sodium
- Where
- Denmark
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Hypoxia, Autophagy
Hypoxia-induced Autophagy in the Pathogenesis of MAP
To investigate the role of HIF 1α and LC3B in the pathogenesis of MAP, to evaluate the role of MMP-9 in the antenatal prediction of MAP, and to compare the expression of HIF1α, LC3B, and level MMP-9 between patients of placenta…
- Conditions
- Hypoxia, Autophagy, Placenta, Morbidly Adherent Placenta
- Trial name
- NCT05817448
- Testing
- HIF 1α and LC3B expression and MMP-9 level
- Volunteers
- 80 people
- Sponsor
- Assiut University
Pregnancy
Serum Concentrations of Pregnancy-associated Proteins for Assessment of Gestational Age Before Abortion
This will be a case-series multicenter study enrolling 800 pregnant people. Serum will be collected from people seeking abortion and assayed at a qualified laboratory.
- Trial name
- NCT04232189
- Testing
- no intervention
- Where
- 3 sites in United States
- Volunteers
- 275 people
- Sponsor
- Gynuity Health Projects
Placenta Accrete Spectrum
Quality of Life in Postpartum Women With Placenta Accrete Spectrum.
1. The objective of this study is to provide an overview of the core domains (physical,psychological,social) of quality of life and health state in postpartum women after the placenta accrete spectrum. 2.
- Trial name
- NCT04583540
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Assiut University
Caesarean Delivery
Regenerative Effects of Birth Material Derived Extracellular Vesicles
Stem cells offer great hope for a wide range of disorders, including age-related brain disease such as dementia. Mesenchymal stem cells (MSCs) are special types of adult stem cells found in various tissues like the umbilical…
- Trial name
- ReGAIN (NCT06866184)
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Anemia
The Study on Umbilical Cord Milking to Prevent and Decrease the Severity of Anemia in Preterms
The overall objective of the present study is to examine the effects of umbilical cord milking at birth in preterm infants to prevent and decrease anemia using a multi-center prospective randomized controlled trial comparing…
- Trial name
- NCT03023917
- Testing
- umbilical cord milking, umbilical cord clamping immediately
- Where
- China
- Volunteers
- 284 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Placenta Accreta
Comparison Between the Role of Transabdominal Ultrasound Versus Transvaginal Ultrasound in Evaluation of Placental Invasion in Cases of Placenta Previa Anterior Wall With Previous Uterine Scar
Objective: To compare between the role of Transabdominal ultrasound versus Transvaginal ultrasound in evaluation of placental invasion in cases of placenta previa anterior wall with previous uterine scar applying the unified…
- Trial name
- NCT03437291
- Testing
- Cesarean section, Transabdominal ultrasound, Transvaginal ultrasound
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Pregnancy, Malaria
L-ArGinine to pRevent advErse prEgnancy Outcomes (AGREE)
There are few safe, effective, and affordable interventions to improve pregnancy outcomes in low resource settings where the highest rates of poor birth outcomes occur.
- Conditions
- Pregnancy, Malaria, Nutrition, Placental Development
- Trial name
- AGREE (NCT05934318)
- Testing
- L-citrulline
- Where
- Kenya
- Volunteers
- 2,960 people, healthy volunteers welcome
- Sponsor
- Liverpool School of Tropical Medicine
Preeclampsia, Severe Preeclampsia
First-trimester Prediction of Preeclampsia
Preeclampsia is a complication of pregnancy related to adverse maternal and neonatal outcomes, including fetal growth restriction and perinatal death.
- Conditions
- Preeclampsia, Severe Preeclampsia, Fetal Growth Restriction, Preterm Birth
- Trial name
- PREDICTION (NCT02189148)
- Where
- 4 sites in Canada
- Volunteers
- 7,554 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Fetal Growth Restriction, Placental Insufficiency
Patterns of Aortic Isthmus Doppler in Early Fetal Growth Restriction , and the Changes in Aortic Isthmus Doppler Parameters With Every Changes of Other Early Iugr Parameters Like EFW, Uterine Artery Doppler, Cerebroplacental Ratio and Ductus Venosus Doppler in Comparison With Normal Group .
This study aims to evaluate the patterns of aortic isthmus Doppler in fetuses diagnosed with early fetal growth restriction (FGR) and to correlate these findings with the severity of FGR and other Doppler parameters.
- Conditions
- Fetal Growth Restriction, Placental Insufficiency, Aortic Isthmus Doppler, Cerebroplacental Ratio
- Trial name
- NCT07676708
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Twin to Twin Transfusion as Antepartum Condition, Monochorionic Diamniotic Placenta
Laser Photocoagulation of Communicating Vessels in Twin-to-Twin Transfusion Syndrome
The purpose of this study is to evaluate the use of diode laser photocoagulation of the communicating vessels in twin-to- twin transfusion syndrome (TTTS) with respect to maternal, fetal and neonatal outcomes.
- Trial name
- NCT05008744
- Testing
- Fetoscopic laser ablation
- Where
- 2 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Seattle Children's Hospital
Cesarean Delivery With Placental Previa
Venous Air Embolism in Cesarean Delivery, Especially Placental Previa
Effects of placenta previa on incidence and severity of venous air embolism in patients during cesarean delivery
- Trial name
- NCT00985764
- Testing
- cesarean delivery
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yonsei University
Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta
Austrian Registry on the Outcome of Monochorionic Pregnancies
About one third of twin pregnancies are resulting from a single fertilized oocyte. Two third of these monozygotic twins share a common placenta and are therefore called monochorionic.
- Conditions
- Twin Dichorionic Diamniotic Placenta, Twin Monochorionic Monoamniotic Placenta, Twin-To-Twin Transfusion Syndrome, Twin Pregnancy With Antenatal Problem
- Trial name
- MonoReg (NCT03171909)
- Where
- 13 sites in Austria
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Obesity, Pregnancy
Gestational Obesity and Interventions With Probiotics or Fish Oil Trial
Obesity is one of the most concerning health issues in the modern world, especially due to its association with greater risk of developing a wide range of chronic diseases.
- Conditions
- Obesity, Pregnancy, Inflammation
- Trial name
- GOPROFIT (NCT03215784)
- Testing
- Fish Oil, Probiotic
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do Rio de Janeiro
Dietary Habits
A Supervised Nutritional Program in Pregnancies and NF-κB Expression in Placenta
Nuclear factor kappa B (NF-κB) pathway and oxidative stress participate in endothelial dysfunction, which is one of the causes of preeclampsia.
- Trial name
- NCT01667939
- Testing
- Healthy Eating Index (HEI) in supervised pregnancies
- Where
- Mexico
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Materno-Perinatal Hospital of the State of Mexico
Knee Osteoarthritis
A Study to Evaluate the Efficacy and Safey of PTP-001 (MOTYS™) in Knee Osteoarthritis Patients (MOTION-P)
This is a multicenter, prospective, randomized, double-blind, placebo-controlled, parallel-arm, Phase 3 study of intra-articular administration of PTP-001 (MOTYS) for the treatment of knee osteoarthritis.
- Trial name
- MOTION-P (NCT07219771)
- Testing
- PTP-01
- Where
- 18 sites in United States, Australia
- Volunteers
- 300 people
- Sponsor
- Doron Therapeutics Inc.
COVID-19, COVID-19 Pneumonia
Effect of Covid 19 Infection on Fetomaternal Outcome
The novel coronavirus called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was discovered for the first time in December 2019 in Wuhan (China) and the disease it causes is called coronavirus disease 2019…
- Conditions
- COVID-19, COVID-19 Pneumonia, Fetal Growth Retardation
- Trial name
- NCT05160649
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Fayoum University
Preterm Premature Rupture of Membrane
Predictive Value of Maternal Serum Pentraxin 3 (PTX 3) and Heparin-binding Protein (HBP) for Chorioamnionitis in Preterm Premature Rupture of Membranes
Objective: The aim of this study was to investigate the predictive value of maternal serum pentraxin 3 (PTX3) and heparin-binding protein (HBP) for chorioamnionitis in preterm premature rupture of membranes (PPROM).
- Trial name
- NCT05207800
- Testing
- The concentrations of PTX3 and HBP were monitored in maternal blood, placental tissue and amniotic fluid.
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Hemorrhage, Placenta Accreta Spectrum
Prophylactic Occlusion Balloons of Both Internal Iliac Arteries in Caesarean Hysterectomy for PASD
The placenta accreta spectrum is a heterogeneous disorder due to abnormal placental invasion into the uterine wall putting at risk the lives of the patients by causing a massive hemorrhage.
- Conditions
- Hemorrhage, Placenta Accreta Spectrum, Cesarean Section Complications
- Trial name
- NCT06356493
- Testing
- caesarean hysterectomy with prior placement of prophylactic occlusion balloons of both internal iliac arteries, caesarean hysterectomy without prior placement of prophylactic occlusion balloons of both internal iliac arteries
- Where
- 2 sites in Tunisia
- Volunteers
- 38 people
- Sponsor
- Tunis University
Crohn's Disease
PDA001 for the Treatment of Adults With Moderate-to-Severe Crohn's Disease
This Phase 2a study evaluated the efficacy, safety, and tolerability of intravenous human placenta-derived cells (PDA001) compared with placebo in adults with moderate-to-severe Crohn's disease.
- Trial name
- NCT01155362
- Testing
- Human Placenta-Derived Cells PDA001 Intravenous Infusion, Vehicle Control
- Where
- 13 sites in United States
- Volunteers
- 50 people
- Sponsor
- Celularity Incorporated