Clinical trials: Placenta
Antiphospholipid Syndrome in Pregnancy
The Value of Placental Vascularization and Placental Volume in Pregnancy in APLS
Antiphospholipid antibodies are autoantibodies directed against phospholipid-binding proteins. Among these groups of antibodies, lupus anticoagulant (LA) and anticardiolipin antibodies (aCL)
- Trial name
- NCT03505840
- Testing
- Ultrasound with Doppler and 3D technology
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aljazeera Hospital
Chorioamnionitis
Ampicillin / Sulbactam vs. Ampicillin / Gentamicin for Treatment of Chorioamnionitis
Chorioamnionitis is an infection of the placenta and amniotic membranes (bag of waters) surrounding the baby inside of a pregnant woman prior to delivery.
- Trial name
- NCT00879190
- Testing
- Unasyn, Ampicillin/gentamicin
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Stanford University
Complications Associated With Artificial Fertilization, Placenta; Implantation
Effect of Assisted Hatching on Vitrified Embryo Transfer Clinical Outcome
The objective of study is to assess the possible impact of assisted hatching on the implantation, pregnancy rate and delivery rate after transfer of vitrified-warmed human embryos.
- Conditions
- Complications Associated With Artificial Fertilization, Placenta; Implantation, Pregnancy
- Trial name
- VitHatSZMC (NCT02124291)
- Testing
- Mechanical Assisted Hatching
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Shaare Zedek Medical Center
Placenta, Retained
GOT-IT Trial: Glyceryl Trinitrate for Retained Placenta
A retained placenta (RP) is a complication after a normal birth, which affects nearly 11,000 women in the UK per year. This is where the placenta is not delivered spontaneously after giving birth.
- Trial name
- GOT-IT (NCT02085213)
- Testing
- Glyceryl Trinitrate
- Where
- United Kingdom
- Volunteers
- 1,107 people
- Sponsor
- University of Edinburgh
Type 2 Diabetes
Safety and Efficacy Study of Umbilical Cord/Placenta-Derived Mesenchymal Stem Cells to Treat Type 2 Diabetes
The purpose of this study is to evaluate the safety and efficacy of mesenchymal stem cells (MSCs) derived from human umbilical cord/placenta at a dose of 1.0E+6 MSC/kg for type 2 diabetes.
- Trial name
- NCT01413035
- Testing
- MSC
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shandong University
CARBETOCIN FOR PREVENTION OF PLACENTAL RETAINED
Randomized Clinical Trial for Comparison Of Intravenous Carbeitocin Versus Oxytocin In Management Of Placental Delivery In Second Trimester Interruption
Intravenous Carbetocin is more efficient than intravenous infusion oxytocin in management of placental delivery in 2nd trimester interruption.
- Trial name
- NCT01827124
- Testing
- Carbetocin, oxytocin
- Where
- Egypt
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Wafaa Uthman Ahmed
Very Low Birth Weight Infant, Placental Transfusion
Extrauterine Placental Transfusion In Neonatal Resuscitation Of Very Low Birth Weight Infants
To investigate the effect of extrauterine placental transfusion (EPT) compared to delayed cord clamping (DCC) on the mean hematokrit on the first day of life in very low birth weight infants (VLBW) born by caesarian section.
- Conditions
- Very Low Birth Weight Infant, Placental Transfusion, Anemia
- Trial name
- EXPLAIN (NCT03916159)
- Testing
- Extrauterine placental transfusion (Intervention group), Delayed cord clamping (Control group)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Universitätsklinikum Köln
Pregnant Women Requiring Amniocentesis
Prenatal Screening for Imprinting Anomalies Implicated in Beckwith Wiedemann and Silver Russell Syndromes
Losses of imprinting are involved in various syndromes. Those occurring in the 11p15 region lead to Beckwith-Wiedemann and Silver-Russell Syndromes.
- Trial name
- DASIRUWIBE (NCT01842659)
- Testing
- Methylation Index
- Where
- France
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Spinal Cord Injuries
Safety of Cultured Allogeneic Adult Umbilical Cord or Placental Derived Mesenchymal Stem Cells for SCI
This trial will study the safety and efficacy of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells for the treatment of Spinal Cord Injury.
- Trial name
- NCT05152290
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cells
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Placenta Accreta / Percreta
Prediction of Placenta Accreta Outcome in Pregnant Woman With Placenta Previa Using (hcg_h ) as Abiomarkers
To check if maternal serum (hcg _h ) in second and third trimester in pregnant woman with placenta previa can predict placenta accreta at delivery or predict adverse maternal and neonatal outcome
- Trial name
- NCT06761885
- Volunteers
- 74 people
- Sponsor
- Assiut University
Preeclampsia, Chronic Periodontitis
microRNA 155 Levels and Periodontal Microflora (Bacteria and Virus) in Preeclampsia.
Preeclamptic women with and without chronic periodontitis were recruited for the study. Subgingival plaque samples and placental tissue samples(postpartum) were obtained from the participants for the microbial analysis(bacteria…
- Trial name
- NCT04277390
- Testing
- clinical intervention for microbial analysis and MIR155 as biomarker
- Where
- India
- Volunteers
- 445 people, healthy volunteers welcome
- Sponsor
- Meenakshi Ammal Dental College and Hospital
Cardiometabolic Health, Pregnancy Related
Cardiometabolic Health in First Time Pregnancy
Women who experience placental complications (syndromes) during pregnancy, such as pre-eclampsia (high blood pressure and kidney problems), gestational hypertension (high blood pressure during pregnancy) and fetal growth…
- Conditions
- Cardiometabolic Health, Pregnancy Related, Diabetes, Placental; Syndrome, Dysfunction
- Trial name
- POPPY (NCT05856318)
- Where
- 7 sites in United Kingdom
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Postpartum Hemorrhage
The Effect of Placental Cord Drainage on the Third Stage of Labor and the Amount of Postpartum Bleeding
The aim of the study was to evaluate the effect of controlled placental cord drainage by opening the clamp at the maternal end after the umbilical cord is cut during birth on the duration of the third stage of labor (departure of…
- Trial name
- NCT07279545
- Testing
- Placental cord drainage
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi Gulhane Tip Fakultesi
Placenta Accreta Spectrum
Conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique With or Without Hayman Sutures
This study evaluates whether adding Hayman sutures in the conservative Management of Placenta Accreta Spectrum Using Kasr Al-Ainy Technique reduces intraoperative blood loss and improves outcomes
- Trial name
- NCT07519993
- Testing
- Kasr Al-Ainy Technique Alone, Kasr Al-Ainy Technique + Hayman Sutures
- Volunteers
- 48 people
- Sponsor
- Cairo University
Obstetric Labor, Premature
Inflammation and Cell Maturation in Preterm Delivery Placentas - in Vitro and in Vivo Effect of Progesterone
The aim of this study is to investigate the In Vitro and In Vivo effect of progesterone on immature myeloid cells (IMC), inflammation characteristics and maturation into dendritic cells (DC).
- Trial name
- NCT03211338
- Testing
- Culture with progesterone, Culture without progesterone, Culture with growth factors
- Where
- Israel
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Pre-Eclampsia, Fetal Growth Retardation
Comparison of Doses of Acetylsalicylic Acid in Women With Previous History of Preeclampsia
Placental insufficiency is the source of preeclampsia (PE) and intrauterine growth retardation (IUGR). Current data demonstrate a significant beneficial effect of prophylactic use of aspirin on the recurrence of placental…
- Conditions
- Pre-Eclampsia, Fetal Growth Retardation, Premature Birth, Placental Insufficiency
- Trial name
- NCT01352234
- Testing
- Acetylsalicylic Acid 160 mg, Acetylsalicylic Acid 80 mg
- Where
- Canada
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Chronic Periodontitis, Preterm Labor
Gingival Crevicular Fluid and Placental Tissue Levels of Interleukin-17 as a Possible Marker for Preterm Labor in Patients With Chronic Periodontitis
This case control-study measures the levels of Interleukin-17 in gingival crevicular fluid and placental tissue samples of pregnant females as a possible marker in determining whether or not an association exists between chronic…
- Trial name
- NCT03171675
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Open Wound
Prospective Case Series Evaluating the Efficacy and Safety of NeoThelium FT for Open Wounds
This is a prospective case series evaluating the efficacy and safety of NeoThelium FT Amnion Skin Graft in the Mangement of Open Wounds
- Trial name
- NCT07041177
- Testing
- NeoThelium FT
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- NuScience Medical Biologics, LLC
Diabetic Nephropathies, Peripheral Nervous System Diseases
A Efficacy and Safety Study of Intramuscular Injection of Human Placenta-Derived Cells (PDA-002) in Subjects With Diabetic Peripheral Neuropathy
This is a Phase 2, randomized, double-blind, placebo-controlled, dose range finding study in subjects who have diabetic peripheral neuropathy (DPN). The study will enroll approximately 24 subjects.
- Trial name
- NCT02552277
- Testing
- PDA-002
- Where
- 7 sites in United States
- Volunteers
- 26 people
- Sponsor
- Celularity Incorporated
Placenta Accreta
Intraoperative Ureteric Dissection vs Preoperative Ureteric Stenting in Women With Abnormally Invasive Placenta
80 Egyptian pregnant female patients will be enrolled in our prospective study. All candidates will have the diagnosis of placenta percreta [confirmed by 2D and 3D ultrasound and Doppler by senior sonographer].
- Trial name
- NCT03763916
- Testing
- Ureteric dissection, Preoperative ureteric stenting, Cesarean hysterectomy
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University