Clinical trials: Placenta
Stage 2 Pulmonary Sarcoidosis, Stage 3 Pulmonary Sarcoidosis
Safety of Intravenous Infusion of Human Placenta-Derived Cells (PDA001) for the Treatment of Adults With Stage II or III Pulmonary Sarcoidosis
The primary objective of the study is to assess the safety and tolerability of a single dose of PDA001 (given twice) in subjects with Stage II or III Pulmonary Sarcoidosis (PS) who are refractory to one or more of the following…
- Trial name
- NCT01440192
- Testing
- PDA001 (cenplacel-L)
- Where
- 4 sites in United States
- Volunteers
- 4 people
- Sponsor
- Celularity Incorporated
Pre-Eclampsia, Intrauterine Growth Restriction
PEPPI Study: Identification of Women at Risk for Placental Dysfunction
The main purpose of this study is to evaluate Fetal Medicine Foundation's pre-eclampsia risk calculator using maternal characteristics, first trimester serum placental growth factor (PlGF) and mean arterial pressure (MAP) in a…
- Conditions
- Pre-Eclampsia, Intrauterine Growth Restriction, Polycystic Ovary Syndrome, Iron-deficiency
- Trial name
- NCT06115122
- Testing
- Pre-eclampsia screening program
- Where
- Finland
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Oulu University Hospital
Preeclampsia (PE), Intrauterine Growth Restriction (IUGR)
Statin Intervention for Severe Early-Onset Placental Insufficiency. (STATIN-PRE Trial)
In pregnancies with placental insufficiency, the only available treatment is close monitoring to determine the point at which the risks of preterm birth for the baby are lower than the risks of continuing the pregnancy.
- Conditions
- Preeclampsia (PE), Intrauterine Growth Restriction (IUGR), Placental Insufficiency
- Trial name
- STATIN-PRE (NCT07098975)
- Testing
- Pravastatin 40 mg
- Where
- 2 sites in Spain
- Volunteers
- 154 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Folate, Folate Bioavailability
PREconception Folic Acid Clinical Efficacy (PREFACE) Trial
A study to help understand what forms of folic acid are most effective to increase folate status during pregnancy for the best protection against neural tube defects
- Conditions
- Folate, Folate Bioavailability, Clinical Trials, Pregnancy
- Trial name
- PREFACE (NCT06641245)
- Testing
- Folic Acid, 5-MTHF (5-methyltetrahydrofolate)
- Volunteers
- 272 people
- Sponsor
- University of British Columbia
Solid Tumors
Anti-ALPP CAR-T Cells Immunotherapy for Advanced Solid Tumors
The goal of this clinical trial is to evaluate the safety and efficacy of anti-ALPP chimeric antigen receptor (CAR)-modified T (CAR-T) cells in treating patients with ALPP-positive Advanced Solid Tumors.
- Trial name
- NCT04627740
- Testing
- Retroviral vector-transduced autologous T cells to express anti-ALPP CARs
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Xinqiao Hospital of Chongqing
Pregnancy Related, Umbilical Cord Issue
Association Between Blood Volume, the Interval From Delivery to Cord Clamping, and Number of Umbilical Cord Milking
Delayed umbilical cord clamping (DCC), usually 1-3 minutes, is reported to be beneficial for term and preterm infants. Nevertheless, there are reasons that urge us to reevaluate the effect of DCC.
- Conditions
- Pregnancy Related, Umbilical Cord Issue, Placental Transfusion
- Trial name
- NCT04898868
- Testing
- cord blood spontaneous drainage, Umbilical cord miking
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Syncytiotrophoblast
From Cytotrophoblast to Syncytiotrophoblast
A deeper understanding of the syncytiotrophoblast development processes and its properties may allow a better understanding of the placenta pathological process for the development of treatment models for the relevant pregnancy…
- Trial name
- NCT02368821
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Meir Medical Center
Cesarean Section Complications
Topical Tranexamic Acid Plus Bilateral Uterine Artery Ligation During Cesarean Delivery
Placenta previa (PP) is an obstetric condition that is closely linked with massive obstetric hemorrhage with a varied incidence about once in every 200 live births.
- Trial name
- NCT03741075
- Testing
- BUA, topical tranexamic acid
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aswan University Hospital
Fetal Growth Retardation
Antenatal Allopurinol in Intrauterine Growth Restriction
Growth retardation in utero may be caused by uteroplacental vascular insufficiency. When Doppler ultrasound studies of the umbilical artery are abnormal pathological intrauterine growth restriction (IUGR) can be diagnosed.
- Trial name
- NCT00346463
- Testing
- Allopurinol
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- UMC Utrecht
Uterine Cavity, Conservative Management
Endometrial Cavity After Conservative Management of PAS Patients by Hysteroscopy
This study aimed to evaluate the endometrial cavity by hysteroscopy after different conservative management of placenta accrete spectrum (PAS), that has impact on the future fertility outcome and menstrual pattern of patients.
- Conditions
- Uterine Cavity, Conservative Management, Placenta Accreta
- Trial name
- NCT07662187
- Testing
- Resection and reconstruction, Cervical eversion and pouch closure, Anterior and posterior sutures
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Sohag University
Cholestasis of Pregnancy
Association of Intrahepatic Cholestasis of Pregnancy and Chronic Placental Inflammation
This observational prospective study will help to determine if an immune process similar to allograft rejection is responsible for the occurrence of an intrahepatic cholestasis of pregnancy (ICP).
- Trial name
- INTREPIDE (NCT05197387)
- Where
- 11 sites in France
- Volunteers
- 322 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Preemptive Therapy of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
Phase 1B/2 Clinical Trial Assessing the Safety, Tolerability and Preliminary Efficacy of the Intravenous Administration of Allogeneic Placental Mesenchymal Cells for the Preemptive Treatment of Patients At Risk for Acute Kidney Injury Following Cardiac Surgery
This clinical trial is designed to evaluate KELI-101 versus placebo for the prevention of acute kidney disease leading to chronic kidney disease in subjects at high risk for acute kidney injury following cardiac surgery.
- Trial name
- MesAKI (NCT06678399)
- Testing
- KELI-101
- Volunteers
- 91 people
- Sponsor
- Kelifarma
Pregnancy Related, Fever
Assessment of Labour Progress by Intrapartum Ultrasound
Assessment of labor progress via digital exams is considered the standard of care in most delivery rooms. However, this method can be stressful, painful and imprecise and multiple exams increase the risk for chorioamnionitis.
- Conditions
- Pregnancy Related, Fever, Chorioamnionitis, Labor Complication
- Trial name
- NCT04651309
- Testing
- Transperineal Ultrasound
- Where
- Israel
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Kaplan Medical Center
Placental Oxygenation
Could the Cerebral Oximetry be a Good Technology to Measure Placental Oxygenation?
To assess the potential of the cerebral oximeter to measure placental oxygenation
- Trial name
- NCT01834599
- Testing
- cerebral oximetry
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Placenta Accreta
Pulmonary Artery Doppler and Neonatal Outcome in Placenta Accreta Spectrum Patients
To correlate ultrasonographic markers of fetal lung maturity including Pulmonary artery Doppler indices in the late preterm and early term in placenta accreta spectrum patients with neonatal outcome.
- Trial name
- NCT04911322
- Testing
- ultrasonography
- Where
- Egypt
- Volunteers
- 71 people
- Sponsor
- Cairo University
Stillbirth
Revealed Versus Concealed Cerebroplacental Ratio
The purpose of this study is to evaluate the role of an integrated strategy at selecting fetuses for delivery at term based on a combination of fetal biometry and cerebroplacental ratio (CPR) to reduce stillbirth rate and adverse…
- Trial name
- NCT02907242
- Testing
- Revealment
- Where
- 9 sites in Chile, Czechia and 4 more
- Volunteers
- 11,582 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Preterm Birth, Twin Dichorionic Diamniotic Placenta
Vaginal Progesterone in Twin With Short Cervix
Aim of the work The aim of this study is to assess the efficacy of the use of vaginal progesterone as a method of prevention of preterm labour in twin gestations with short cervix .
- Trial name
- NCT02697331
- Testing
- Progesterone
- Where
- Egypt
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Placenta Accreta, Cesarean Hysterectomy
Conservative Treatment of PAS With or Without IIL
In the current study, the investigators aimed to compare the benefits of internal iliac ligation in placenta accreta spectrum
- Conditions
- Placenta Accreta, Cesarean Hysterectomy, Pelvic Devascularization
- Trial name
- PASIIL (NCT05232981)
- Testing
- Ligation of the bilateral internal iliac arteries, Shehat's technique
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Pregnancy, Obese
Validation of Ultrasound in Predicting a Low Lying Placenta Throughout Pregnancy
This is a prospective observational study comparing venous Doppler flow in the lower extremities of pregnant women. Pregnant women with a BMI >/= 30 will be compared to those with a BMI < 30.
- Trial name
- NCT02689739
- Testing
- venous duplex ultrasound
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Anxiety Depression, Placenta Previa
Anxiety and Depressive Symptoms in Placenta Previa / Accreta
placenta previa is an obstetric complication which is associated with depression and anxiety. As little is known about the emotional reaction to the diagnosis of placenta previa/accrete, a study is badly needed to estimate the…
- Trial name
- NCT05529381
- Where
- Egypt
- Volunteers
- 73 people
- Sponsor
- Assiut University