Clinical trials: Placenta
Placenta Accreta, Third Trimester
Ultrasound Scoring System for Diagnosis and Prediction of Severity and Surgical Outcomes of Placenta Accreta Spectrum
Primary Objective: To determine the optimal cutoff values of the ultrasound score for different PAS subtypes (no PAS, placenta accreta, placenta increta, and placenta percreta).
- Trial name
- NCT07755709
- Volunteers
- 50 people
- Sponsor
- Sohag University
Placental Transfusion
Placental Transfusion and Cord Clamping
To compare the evolution of the infant's weight before delayed cord clamping (2 minutes after birth) as an indirect measure of the volume of placental transfusion in a group of healthy and fullterm newborns, placed at the level…
- Trial name
- NCT01497353
- Testing
- Position at introitus level, position at Maternal Abdomen
- Where
- 3 sites in Argentina
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fundacion para la Salud Materno Infantil
Pulmonary Edema
Thoracic Fluid Content During Hypervolemic Hemodilution
Thoracic fluid content (TFC) is one of the many variables measured by the ICON electrical cardiometry (EC) device (Osypka Medical).
- Trial name
- NCT04689516
- Testing
- Thoracic fluid content estimation
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Cairo University
Placenta Previa
Tocolytic Therapy in Conservative Management of Symptomatic Placenta Previa
The objective of our study is to determine the clinical utility related to the maintenance oral nifedipine therapy in patients with symptomatic placenta previa.
- Trial name
- NCT00620724
- Testing
- Nifedipine
- Where
- France
- Volunteers
- 109 people
- Sponsor
- University Hospital, Rouen
Preeclampsia, Placenta Diseases
Investigating CD 71 in Preeclamptic Pregnancies
Objective: Upon reviewing studies aimed at understanding and investigating the pathogenesis of preeclampsia, it has been observed that CD71 has not been previously examined.
- Trial name
- NCT06668545
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Manisa Celal Bayar University
Placenta Previa, Placenta Accreta
Management of Placenta Accreta Spectrum
placenta accreta spectrum is group of disorders which have a depate about the best way of management. this is a descriptive study about the best techniques to reduce morbidity and mortalities related to it.
- Trial name
- NCT04609527
- Testing
- Management of placenta accreta spectrum
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Assiut University
Twin Monochorionic Diamniotic Placenta
Safety and Efficacy of Fetoscopes Used in Fetoscopic Selective Laser Photocoagulation
The purpose of this study is to evaluate the safety and efficacy of the investigational fetoscopes used in patients undergoing fetoscopic selective laser photocoagulation for complicated monochorionic-diamniotic pregnancies.
- Trial name
- NCT06022510
- Testing
- Fetoscopy Sets for Anterior and Posterior Placentas
- Where
- United States
- Sponsor
- Michael A Belfort
Placenta Accreta, Placenta Previa
Topical Adrenaline Versus Warm Saline Solution for Minimizing Intraperitoneal Bleeding During Caesarian Delivery for Placenta Previa / Accreta Spectrum ( PAS)
Placenta accreta spectrum (PAS), encompassing the terms placenta accreta, increta, and percreta; abnormally invasive placenta; morbidly adherent placenta; and invasive placentation, is a leading cause of life-threatening…
- Trial name
- NCT06030479
- Testing
- Topical adrenaline, Warm saline
- Where
- Egypt
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fetal Growth Retardation
Non-invasive Placental Chromosome Exploration of Intrauterine Growth Restriction
The objective of this project is the non-invasive prenatal detection of placenta-limited aneuploidies, in patients whose fetuses have a intrauterine growth restriction below 3rd percentile, in parallel with an amniocentesis.
- Trial name
- DPNI-RCIU (NCT05023161)
- Testing
- Blood samples
- Where
- 3 sites in France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Bordeaux
Placental Vascular Pathologies, Venous Thromboembolism Diseases
Prediction of the Risk of Placental Vascular Pathology and Venous Thromboembolic Disease
Venous thromboembolic (VTE) disease is the first cause of maternal mortality in the world. Some other pregnancy pathologies called Placental Vascular Pathologies (PVP) are linked to VTE by biological thrombophilia and are the…
- Trial name
- AngioPred (NCT00695942)
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Placenta Accreta Spectrum
Risk Factors, Prognosis and Prediction Models for Placenta Accreta Without Prior Cesarean Section
1. Identify the risk factors for Placenta accreta spectrum (PAS) disorders in women without prior caesarean section (CS). 2. Clarify the prognostic factors of the disease and explore individualized treatment options to improve…
- Trial name
- NCT06383923
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Pathologic Processes, Diabetes Mellitus
Clinical Trial Assessing Human Placental Membrane Products and Standard of Care Versus Standard of Care in Nonhealing DFUs and VLUs
The purpose of the study is to evaluate the efficacy of multiple human placental membrane products and Standard of Care (SOC) versus SOC alone in the management of nonhealing diabetic foot ulcers (DFUs) and venous leg ulcers…
- Conditions
- Pathologic Processes, Diabetes Mellitus, Glucose Metabolism Disorders, Metabolic Diseases
- Trial name
- C5CAMP (NCT06674980)
- Testing
- Standard of Care - DFU, AM/Single - DFU, AM/Double - DFU
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- C5 Biomedical
Multiple Sclerosis, Secondary-Progressive Multiple Sclerosis
Evaluate the Safety and Feasibility of Allogeneic Mesenchymal Stem Cells in Patients With Multiple Sclerosis
To assess the safety and of a single dose of IV infusion of placenta derived Mesenchymal Stem Cells (PLMSCs) in patients with secondary progressive Multiple Sclerosis (SPMS) disease.
- Conditions
- Multiple Sclerosis, Secondary-Progressive Multiple Sclerosis, Mesenchymal Stem Cells
- Trial name
- MS (NCT06360861)
- Testing
- Allogenic placenta derived mesenchymal stem cells
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Tehran University of Medical Sciences
Pregnancy, Thrombophilia
TIPPS: Thrombophilia in Pregnancy Prophylaxis Study
The TIPPS trial seeks to determine the safety and effectiveness of low-molecular-weight heparin (LMWH), an anticoagulant, in preventing placenta mediated pregnancy complications and venous thromboembolism (VTE) in women with…
- Conditions
- Pregnancy, Thrombophilia, Pregnancy Complications
- Trial name
- TIPPS (NCT00967382)
- Testing
- dalteparin sodium
- Where
- 12 sites in United States, Canada
- Volunteers
- 292 people
- Sponsor
- Ottawa Hospital Research Institute
Intrauterine Growth Restriction
MRI Assessment of Placental Health
The ultimate goal of this project is to develop methods that allow informed decision-making on the delivery time of fetuses that are at increased risk of stillbirth due to IUGR.
- Trial name
- NCT02297724
- Testing
- Oxygen
- Where
- 2 sites in United States, Spain
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
High Risk Pregnancy, Congenital Heart Disease
Fetal Electrophysiologic Abnormalities in High-Risk Pregnancies Associated With Fetal Demise
Each year world-wide, 2.5 million fetuses die unexpectedly in the last half of pregnancy, 25,000 in the United States, making fetal demise ten-times more common than Sudden Infant Death Syndrome.
- Conditions
- High Risk Pregnancy, Congenital Heart Disease, Fetal Hydrops, Twin Monochorionic Monoamniotic Placenta
- Trial name
- NCT03775954
- Testing
- Fetal Magnetocardiogram and Neonatal Electrocardiogram, Substudy only: Maternal/Infant Pharmacogenomic assessment postnatally
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Medical College of Wisconsin
Intrauterine Contraceptive Device Complication
Intra-cesarean Post Placental Introducer Withdrawal IUD Insertion Technique
This is a prospective randomized controlled study that was conducted to compare between the conventional (manual) technique of post placental IUD insertion and a new technique (intra-cesarean post placental introducer withdrawal…
- Trial name
- IUD (NCT05788354)
- Testing
- IUD insertion during cesarean section
- Where
- 2 sites in Egypt
- Volunteers
- 788 people, healthy volunteers welcome
- Sponsor
- Cairo University
Gestational Trophoblastic Neoplasia, Choriocarcinoma
Study of TRC105 and Bevacizumab in Patients With Refractory Gestational Trophoblastic Neoplasia (GTN)
The purpose of the study is to determine the overall response rate of single agent TRC105 and the combination of TRC105 and bevacizumab in patients with refractory GTN (including choriocarcinoma, placental site trophoblastic…
- Conditions
- Gestational Trophoblastic Neoplasia, Choriocarcinoma, Placental Site Trophoblastic Tumor, Epithelioid Trophoblastic Tumor
- Trial name
- NCT02664961
- Testing
- TRC105, Bevacizumab
- Where
- 3 sites in United States
- Volunteers
- 3 people
- Sponsor
- Tracon Pharmaceuticals Inc.
HIV Infections
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery
A new approach to HIV prevention currently being studied includes the use of topical microbicides, substances that kill microbes.
- Trial name
- NCT00540605
- Testing
- Tenofovir 1% vaginal gel
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Infertility, Female, Infertility of Uterine Origin
Progesterone Levels and Endometrial Compaction in Frozen-Thawed Embryo Transfer Cycles
This study is intended to determine whether there is a correlation between endometrial compaction and serum progesterone levels on the day of frozen embryo transfers by using transvaginal sonography for the endometrial assessment.
- Conditions
- Infertility, Female, Infertility of Uterine Origin, Implantation; Placenta
- Trial name
- NCT04554654
- Testing
- transvaginal ultrasound,
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Cem Demirel