Clinical trials: Placenta
Myelomeningocele
Cellular Therapy for In Utero Repair of Myelomeningocele - The CuRe Trial
Spina bifida, or myelomeningocele (MMC), is a birth defect that results in paralysis, excess fluid on the brain (hydrocephalus), and impaired ability to urinate and have bowel movements normally.
- Trial name
- CuRe (NCT04652908)
- Testing
- Placental Mesenchymal Stem Cells seeded on a commercially available dural graft extracellular matrix, Untreated contemporaneous cohort
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- University of California, Davis
Placenta Accreta
Paracervical Pouch in Placenta Accreta Spectrum
The study objective is the significance of the ultrasound detection of the paracervical pouch in placenta accreta spectrum. It aimed to evaluate its relation to the degree of placenta accreta spectrum, amount of the blood loss…
- Trial name
- pouch (NCT06100640)
- Where
- Egypt
- Volunteers
- 190 people
- Sponsor
- Alexandria University
Diabetic Foot Ulcer
Evaluating the Efficacy NeoThelium FT in the Treatment of Diabetic Foot Ulcers
This is a randomized controlled crossover trial evaluating the efficacy of NeoThelium FT in conjunction with standard of care vs. standard of care alone in treating diabetic foot ulcers.
- Trial name
- NCT06938685
- Testing
- Standard of Care, NeoThelium FT
- Where
- 8 sites in United States
- Volunteers
- 132 people
- Sponsor
- NuScience Medical Biologics, LLC
Peripheral Neuropathy, Trigeminal Neuralgia
Safety of Cultured Allogeneic Adult Umbilical Cordor Placental Derived Stem Cells Exosomes for Trigeminal Neuralgia
This trial will study the safety and efficacy of instillation of cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes for the treatment of Trigeminal Neuralgia.
- Trial name
- NCT05152368
- Testing
- cultured allogeneic adult umbilical cord or placental derived mesenchymal stem cell exosomes
- Where
- 2 sites in United States, Greece
- Volunteers
- 20 people
- Sponsor
- The Foundation for Orthopaedics and Regenerative Medicine
Chronic Hepatitis B
Vaccine+HBIG Versus Vaccine+Placebo for Newborns of HBsAg+ Mothers
Prevention of perinatal transmission is essential to decrease the global burden of chronic HBV. Recombinant HBV vaccine and hepatitis B immunoglobulin (HBIG) given after delivery to the newborns of HBsAg positive mothers is the…
- Trial name
- NCT01412567
- Testing
- Vaccine+HBIG
- Where
- India
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Govind Ballabh Pant Hospital
Scar; Previous Cesarean Section, Complications; Cesarean Section, Wound, Dehiscence
Optimization of the Healing Process of the Uterine Scar Tissue After Re-cesarean Section
This prospective, controlled, clinical, intervention study measures the number of uterine Cesarean section scars and median myometrial thickness of women who underwent two Cesarean sections six to nine months after their last…
- Trial name
- OPSTAR (NCT02703519)
- Testing
- resection of uterine scar tissue
- Where
- 2 sites in Germany
- Volunteers
- 116 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Placenta Accreta
Role of Placental Invasion Index in Decision Making of Placenta Accreta
This study will be conducted on women who have a diagnosis of placenta previ and using ultrasound to make the placenta invasion index and compare the accuracy of the diagnosis during the caesarean section whether it is accreta or…
- Trial name
- NCT05806528
- Testing
- Ultrasound
- Volunteers
- 100 people
- Sponsor
- Sohag University
Pre-Eclampsia, Induction of Labor
Labor Induction in Preeclampsia High-risk Women
Preeclampsia (PE) is one of the leading causes of maternal and perinatal morbidity and mortality. This pregnancy-specific disorder poses to both pregnant women and their offspring an increased risk of immediate and long-term…
- Trial name
- FORECAST-IOL (NCT05056467)
- Testing
- Induction of Labor
- Where
- 8 sites in China, Hong Kong and 5 more
- Volunteers
- 825 people
- Sponsor
- Chinese University of Hong Kong
Retained Product of Pregnancy
The Correlation Between Clinical Diagnosis of Retained Placenta And Histology
The main purpose is to evaluate the correlation in qualitative and quantitative manner between clinical diagnosis of retained placenta and histology.
- Trial name
- WHI (NCT02927730)
- Testing
- no interventions
- Volunteers
- 240 people
- Sponsor
- Bait Balev Hospital
Pregnancy Complications, Preeclampsia
Severe Pregnancy Complications Are Associated With Elevated Factor VIII Plasma Activity
Congenital and acquired thrombophilia were identified as risk factors for thrombosis in systemic vessels.Thrombophilias have also been recently found to be associated with preeclampsia, intrauterine fetal growth restriction…
- Conditions
- Pregnancy Complications, Preeclampsia, Placental Abruption, Intrauterine Fetal Growth Restriction
- Trial name
- NCT00573118
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Fetal Infection, Chorioamnionitis
Management of Prelabor Rupture of the Membranes at Term
Prolonged rupture of membranes has been associated with increased risk of chorioamnionitis and endometritis. In this study the investigators will investigate whether an early intervention to augment labor with oxytocin is…
- Conditions
- Fetal Infection, Chorioamnionitis, Endometritis, Cesarean Section Complications
- Trial name
- NCT04307069
- Testing
- Oxytocin
- Where
- Israel
- Volunteers
- 524 people
- Sponsor
- Rambam Health Care Campus
Ulcer Venous, Wound Heal
Observational Study to Investigate the Use of Sterilized Porcine Placental Tissue in the Treatment of Chronic VLU
The study is a multi-center, prospective, clinical trial designed to evaluate the use of InnovaMatrix AC sterilized porcine placental ECM to treat chronic VLUs .
- Trial name
- NCT06400875
- Testing
- InnovaMatrix® AC Sterilized, Porcine Placental Extracellular Matrix (ECM)
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- ConvaTec Inc.
Hysteroscopy, Minimally Invasive Surgical Procedures
Implementation of Hysteroscopy in Flanders and the Netherlands
By means of a questionnaire the investigators will study the implementation of hysteroscopy in Flanders and the Netherlands
- Conditions
- Hysteroscopy, Minimally Invasive Surgical Procedures, Polyp, Myoma
- Trial name
- NCT02853695
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- University Ghent
Preeclampsia, Intra-uterine Growth Restriction
Utero-placental Vascularisation in Normal and Preeclamptic and Intra-uterine Growth Restriction Pregnancies
Introduction Preeclampsia (PE) and intra-uterine growth restriction (IUGR) are two major pregnancy complications related to chronic utero-placental hypoperfusion.
- Trial name
- EVUPA (NCT02825277)
- Testing
- Doppler
- Where
- France
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Woman Suffering From a Pathology Frequently Associated With the Presence of These Anti-autoantibodies Type-I Interferons
Study of the Transmission of Anti-interferon Type 1 Alpha Autoantibodies From Mother to Child Via the Placental Barrier
The main objective of the study is to evaluate the frequency of placental transfer of self-Ab directed against the mother's IFN alpha in the newborn, in all women suffering from a pathology frequently associated with the presence…
- Trial name
- Pregiferon (NCT06371235)
- Testing
- Pregiferon
- Volunteers
- 250 people
- Sponsor
- CerbaXpert
Primary Mitochondrial Diseases
A First in Human Study to Evaluate the Safety of Infusion of MNV-BM-PLC (Autologous CD34+ Cells Enriched With Placenta Derived Allogeneic Mitochondria) in Patients With Primary Mitochondrial Diseases Associated With Mitochondrial DNA Mutation or Deletion
The study objectives are to evaluate the safety of a single intravenous (IV) infusion of autologous CD34+ cells enriched with placenta-derived allogeneic mitochondria in participant with primary mitochondrial disease associated…
- Trial name
- NCT04548843
- Testing
- Bone Marrow mobilization, Apheresis, MNV-BM-PLC infusion
- Where
- Israel
- Sponsor
- Minovia Therapeutics Ltd.
Periodontal Diseases, Periodontal Pocket
Assessment Of Healing After Periodontal Flap Surgery With And Without The Use Of Placental Extracts
All 16 chronic periodontitis (CP) subjects were clinically examined regarding the following clinical periodontal parameters: plaque index (PI), gingival index (GI), bleeding index (BI), Pocket Probing Depth (PPD) and Relative…
- Conditions
- Periodontal Diseases, Periodontal Pocket, Periodontitis
- Trial name
- NCT05936450
- Testing
- delivery of placentrex gel after open flap debridement, Open Flap Debridement
- Where
- India
- Volunteers
- 16 people
- Sponsor
- Dr Prabhuji MLV
Alterations of ECM in Umbilical Cord ECM in Preeclampisa, Alterations of ECM in Placenta in Preeclampisa
Extracellular Matrix Remodeling of the Umbilical Cord and Placenta in Preeclampsia
Preeclampsia affects 2% to 8% of all pregnancies and is a major cause of maternal morbidity an mortality worldwide.Althought the primary pathology leading to preeclampsia is remain not known, complex pathophysiologic pathways and…
- Trial name
- NCT01931891
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Zekai Tahir Burak Women's Health Research and Education Hospital
Pregnancy, Placenta Accrete Spectrum
Impact Tourniquet Conservative Placenta Accreta Neonatal APGAR
Placenta accreta spectrum disorder (PAS) refers to a condition where the placenta fails to separate naturally after childbirth, which can cause significant maternal and neonatal complications, including severe bleeding, leading…
- Conditions
- Pregnancy, Placenta Accrete Spectrum, Tourniquets, Apgar Score
- Trial name
- NCT07412925
- Testing
- Application Of A Tourniquet Around the lower segment of the uterus, Placenta Accreta spectrum conservative management
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kasr El Aini Hospital
Placenta Accreta
3D Placental Volume in Placenta Accreta
Placenta Accreta spectrum is a major obstetric disease nowadays. Different methods are used for antenatal diagnosis. In our study, investigators are aiming to compare 2 common ways for diagnosis, i.e; 3D Ultrasound and 2D with…
- Trial name
- NCT06755047
- Testing
- 3D Ultrasound, 2D ultrasound
- Where
- Egypt
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Assiut University