Clinical trials: Plasmapheresis
Multiple Sclerosis, Clinically Isolated Syndrome
Immunoadsorption vs. Plasmapheresis in the Escalation Therapy of Relapse in Multiple Sclerosis
This observational study investigates the efficacy and safety of immunoadsorption versus plasmapheresis in 60 patients with relapse in Multiple Sclerosis and Clinically isolated syndrome who do not fully recover after a high…
- Trial name
- NCT02671682
- Testing
- Immunoadsorption, Plasmapheresis
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Albert Christian Ludolph, Prof.
Focal Segmental Glomerulosclerosis
Permeability Factor in Focal Segmental Glomerulosclerosis
Focal segmental glomerulosclerosis (FSGS) is a renal syndrome characterized by proteinuria (usually nephrotic range), limited response to conventional therapy, and a poor renal prognosis, with progression to end stage renal…
- Trial name
- NCT00007475
- Testing
- Plasma exchange, Cyclophosphamide
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Respiratory Failure, Renal Failure, Acute
Plasma Exchange (PLEX) and Convalescent Plasma (CCP) in COVID-19 Patients With Multiorgan Failure
This Randomized Control Trial (RCT) proposes combination of extracorporeal cytokine removal by plasma exchange (PLEX) and additional infusion of convalescent plasma (CCP) collected from COVID-19 recovered individuals at the end…
- Trial name
- COVID-PLEX (NCT04634422)
- Testing
- Plasma exchange and convalescent plasma
- Where
- Denmark
- Volunteers
- 220 people
- Sponsor
- Wladimir Szpirt
Acute Disseminated Encephalomyelitis, Devic's Syndrome
Phase III Randomized, Double-Blind, Sham-Controlled Study of Plasma Exchange for Acute Severe Attacks of Inflammatory Demyelinating Disease Refractory to Intravenous Methylprednisolone
OBJECTIVES: I. Evaluate the effectiveness of plasma exchange in the treatment of acute severe attacks of inflammatory demyelinating disease in patients who have failed intravenous steroid therapy.
- Conditions
- Acute Disseminated Encephalomyelitis, Devic's Syndrome, Marburg's Variant of Multiple Sclerosis, Balo's Concentric Sclerosis
- Trial name
- NCT00004645
- Testing
- Plasma exchange
- Volunteers
- 22 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Septic Shock
Therapeutic Plasma Exchange in Adult Patients With Severe Sepsis
The incidence of sepsis (severe infection) has increased over the last four decades. Severe sepsis and septic shock are among the leading causes of death for patients admitted to critical care units with mortality ranging from…
- Trial name
- NCT04057872
- Testing
- Therapeutic plasma exchange
- Where
- 2 sites in Canada
- Volunteers
- 17 people
- Sponsor
- Alberta Health Services, Calgary
Kidney Transplantation, Antibody Mediated Rejection
Treatment of Chronic Active Antibody Mediated Rejection After Kidney Transplantation by Double-Filtration PlasmaPheresis or Plasma Exchange
In France around 90,000 cases of end-stage chronic kidney disease patients treated either by dialysis (60%) or renal transplantation (just over 40%).
- Trial name
- DFPP (NCT03436134)
- Testing
- Sessions of conventional apheresis, Sessions of news apheresis with double filtration
- Where
- France
- Volunteers
- 16 people
- Sponsor
- University Hospital, Grenoble
Sub-healthy, Hyperlipidemia
The Exploratory Study About the Effect of Using Double Filtration Plasmapheresis (DFPP) Removing Inflammatory Cytokines, Lipids and Toxic Metal Ions in Peripheral Blood in Adults
This study investigates whether using Double Filtration Plasmapheresis (DFPP) could improve the overall health of adults through removing inflammatory cytokines, lipids and toxic metal ions from peripheral blood.
- Conditions
- Sub-healthy, Hyperlipidemia, Toxic Metal Ions Accumulation
- Trial name
- NCT06224296
- Testing
- DFPP
- Where
- China
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Shanghai Cell Therapy Group Co.,Ltd
Hepatitis C
Double Filtration Plasmapheresis for Hepatitis C Virus (HCV) Genotype 1 Patients With High Viral Load
Hepatitis C virus (HCV) infection, a leading cause of cirrhosis, hepatocellular carcinoma (HCC) and liver transplantation, affects approximately 170 million individuals worldwide.
- Trial name
- NCT00977054
- Testing
- DFPP + Peg-IFN + RBV, Peg-IFN + RBV
- Where
- 6 sites in Taiwan
- Volunteers
- 59 people
- Sponsor
- National Taiwan University Hospital
Amyotrophic Lateral Sclerosis
Efficacy and Safety of Plasma Exchange With Albutein® 5% in Participants With Amyotrophic Lateral Sclerosis
This is a pilot, phase 2, prospective, open-label, single-arm study to evaluate disease progression, forced vital capacity, and the safety and tolerability of plasma exchange (PE) using Albutein® 5% in participants with…
- Trial name
- NCT02872142
- Testing
- Albutein 5%, Plasma Exchange
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Grifols Therapeutics LLC
Cirrhosis, Liver, Acute-On-Chronic Liver Failure
Plasma Exchange in Acute on Chronic Liver Failure
Acute on chronic liver failure (ACLF) is a distinct syndrome in patients with chronic liver disease with rapid clinical deterioration and has high short term mortality within one month.Despite aggressive clinical care, only half…
- Trial name
- PLEXAR (NCT04051437)
- Testing
- Plasma exchange, Standard medical treatment
- Volunteers
- 130 people
- Sponsor
- Asian Institute of Gastroenterology, India
Autoimmune Diseases
PK of Meropenem in Patients on Plasma Exchange
Therapeutic plasma exchange (TPE) has been shown to be an important procedure for treatment of a variety of refractory immune complex disorders, such as Guillain-Barré syndrome and neuromyelitis optica.
- Trial name
- NCT05042271
- Testing
- meropenem
- Where
- Thailand
- Volunteers
- 15 people
- Sponsor
- Prince of Songkla University
Plasmapheresis, Haematology
Plasmapheresis: a Multi-modal Approach
Only very few studies have prospectively looked at the effect of repeated intensive plasma donation. In collaboration with the Rode Kruis Vlaanderen, we have recently found that repeated whole blood donation with a 3-month…
- Conditions
- Plasmapheresis, Haematology, Sport Performance, Body Composition
- Trial name
- NCT05815615
- Testing
- Plasmapheresis
- Where
- Belgium
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Université Catholique de Louvain
Acute Liver Failure
A Study of the Effect of Plasmaexchange in Patients With Acute Liver Failure
The aim of this study is to examine if high-volume plasma exchange has a positive effect on mortality in patients with acute liver failure.
- Trial name
- NCT00950508
- Testing
- High volume plasma exchange, Standard medical treatment
- Where
- 3 sites in Denmark, Finland and 1 more
- Volunteers
- 183 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Lung Transplantation, Donor-specific Anti-human Leukocyte Antigen(HLA) Antibodies
Monitoring of Donor-specific Antibodies After Treatment With Immunoglobulins, Plasmapheresis and Rituximab in Lung Transplantation
Single-arm, prospective observational study
- Trial name
- NCT03798860
- Testing
- blood samples
- Where
- Germany
- Volunteers
- 340 people
- Sponsor
- Hannover Medical School
Kidney Failure
Evaluation of the Efficacy and Tolerance of Plasmapheresis by Double Cascade Filtration in a University Centre
A study is being carried out to evaluate the biological, technical and clinical/biological efficacy of this technique, the practice of which is standardized in the department, in order to evaluate our practices and to improve…
- Trial name
- DFPPSURV (NCT04261205)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Acute-On-Chronic Liver Failure
Efficacy and Safety of Hemoperfusion or Plasma Exchange Compared to Standard Medical Therapy in Patients With Acute on Chronic Liver Failure
The study is done with the aim of finding the association between the bilirubin and bile acids / DAMPS molecule with organ failures and sepsis in the patients with acute on chronic liver failure .
- Trial name
- NCT04013113
- Testing
- Haemoperfusion, Standard Medical Treatment, Plasma Exchange
- Where
- India
- Volunteers
- 250 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Clotting Disorder Due to Plasma Exchange Therapy, Humoral Rejection After Kidney Transplantation
Fibrinogen as a Surrogate for Global Haemostasis in Plasma Exchange
Plasma exchange is a frequently used therapy in many antibody-mediated disorders, such as humoral rejection after kidney transplantation.
- Trial name
- NCT02095821
- Where
- Germany
- Volunteers
- 2 people
- Sponsor
- Hannover Medical School
DFPP and Platelet Function
Double Filtration Plasmapheresis (DFPP) and Lipid Metabolism
Little clinic trials showed that Double Filtration Plasmapheresis (DFPP) could improve lipid metabolism, however, whether DFPP can improve platelet function and recover Endothelial function is unknown.
- Trial name
- NCT03491956
- Testing
- DFPP
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shanghai Pudong Hospital
Relapsing Forms of Multiple Sclerosis
A Multicenter Study to Assess the Effect of Plasma Exchange in Accelerating the Clearance of Natalizumab in Subjects With Multiple Sclerosis (MS)
Natalizumab (TYSABRI) is a protein-based drug that is manufactured by Biogen Idec in partnership with Elan Pharmaceuticals. Natalizumab is approved in the US and Europe for the treatment of Multiple Sclerosis (MS).
- Trial name
- NCT00424788
- Testing
- Plasma exchange, natalizumab treatment
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Biogen
COVID-19 Pneumonia, COVID-19 Respiratory Infection
Therapeutic Plasma Exchange Followed by Convalescent Plasma Transfusion in Severe and Critically Ill COVID-19 Patients
Therapeutic plasma exchange (TPE) has been proposed as a rescue therapy in critically ill COVID-19 patients. The aim of this study is to determine whether combining TPE with convalescent plasma (CVP) transfusion early during the…
- Conditions
- COVID-19 Pneumonia, COVID-19 Respiratory Infection, Acute Respiratory Failure, Acute Respiratory Distress Syndrome
- Trial name
- NCT04973488
- Testing
- Therapeutic plasma exchange
- Where
- Romania
- Volunteers
- 38 people
- Sponsor
- Novacescu Alexandru