Clinical trials: Platelet Reactivity
Diabetes
Pharmacokinetics of Antiplatelet Drugs in Diabetic pAtients
Clopidogrel efficacy appears diminished in patients with type 2 diabetes (T2D) who continue to show an increased risk of adverse cardiovascular events and mortality compared to those without T2D.The aim of the first project is to…
- Trial name
- PANDDA (NCT02302508)
- Testing
- Clopidogrel, Prasugrel, Ticagrelor
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
CORONARY ARTERY DISEASE
"Potential Effect of Acute and Chronic Caffeine Administration on Platelet Reactivity in Patient With Coronary Artery Disease on Dual Antiplatelet Therapy"
Prasugrel is a potent thienopyridine antiplatelet agent that selectively and irreversibly inhibits ADP-induced platelet aggregation mediated by the P2Y12 receptor.
- Trial name
- CyCLOPS (NCT02054988)
- Testing
- caffeine, not caffeine
- Where
- Italy
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza
Platelet Aggregation
Low Dose Aspirin Studied With the AggreGuide
This study is to determine whether the AggreGuide platelet aggregometer can discern the effect of low dose aspirin on subjects platelet aggregation using arachidonic acid as the agonist.
- Trial name
- NCT01603966
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Edward R. Teitel, M.D.
Platelet Reactivity
Low-dose of Ticagrelor and Standard-dose Clopidogrel on Platelet Effects in Chinese Patients With Stable CAD.
Ticagrelor has been demonstrated to provide a more rapid and more powerful inhibition of platelet aggregation compared with clopidogrel in coronary artery disease (CAD) patients.
- Trial name
- NCT03679091
- Testing
- low-dose ticagrelor, Clopidogrel
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Harbin Medical University
Aspirin, Circadian Rhythm
Aspirin AM or PM: Effect on Circadian Rhythm of Platelet Reactivity
Low-dose aspirin is a cornerstone in the secondary prevention of cardiovascular disease (CVD) and is usually taken on awakening, although evidence regarding optimal time of intake is lacking.
- Conditions
- Aspirin, Circadian Rhythm, Platelet Activation, Cardiovascular Diseases
- Trial name
- NCT01900639
- Testing
- change time of intake of aspirin
- Where
- Netherlands
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Critical Limb Ischemia
Aspirin and Clopidogrel Reactivity in Patients With Critical Limb Ischemia (CLI)
Critical Limb Ischemia (CLI) is defined as limb pain that occurs at rest, or impending limb loss that is caused by severe compromise of blood flow to the affected extremity.
- Trial name
- NCT02094755
- Testing
- Blood draw only
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Healthy Volunteers
A Study of the Effect of Epinephrine on Platelet Reactivity in Subjects Treated With Ticagrelor
The study is an experimental observational study in ten healthy volunteers. Based on an in vitro study, it is hypothesize that a low dose epinephrine infusion will improve platelet function in healthy volunteers who have received…
- Trial name
- NCT03441412
- Testing
- Ticagrelor 90mg, Epinephrine, Metoprolol
- Where
- Sweden
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Fentanyl, Platelet Reactivity
Platelet Reactivity With Fentanyl, Morphine, or no Narcotic
The goal is to determine whether fentanyl and morphine have similar effects in reducing aspirin's effect upon platelets in emergency department patients with chest discomfort.
- Trial name
- NCT05367336
- Testing
- Morphine, Fentanyl
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Corewell Health South
HIV-infected Patients
Effect of Aspirin on Abacavir-induced Platelet Reactivity in HIV-infected Patients
The specific research questions addressed in the present study are: to investigate the impact of treatment with low-dose aspirin in HIV-1-infected patients treated with ABC and test it would result in decreased in vivo platelet…
- Trial name
- ABC-ASA (NCT03316534)
- Testing
- Aspirin
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera di Perugia
Hypertension
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms.
- Trial name
- NCT01785511
- Testing
- UVA Radiation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Platelet Aggregation, Spontaneous, Vascular Thrombosis
The Effects of Dietary Erythritol on Platelet Reactivity and Vascular Inflammation
The purpose is to conduct a dietary intervention study in which human participants will consume beverages sweetened with erythritol or aspartame, each for 2 weeks, in a randomized crossover design
- Trial name
- EASI (NCT05967741)
- Testing
- Erythritol, Aspartame
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Healthy Volunteers, Erythritol
SUVY VerSus SAccharose (SUVISA)
Sugar substitutes are increasingly used to reduce sugar intake. SÜVY is a food ingredient combining erythritol and polydextrose.
- Trial name
- SUVISA (NCT07901491)
- Testing
- SÜVY, Sucrose
- Where
- France
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Minerais SAS
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiovascular Prevention
A Pilot Study to Investigate Platelet Reactivity in Patients With Elevated Lipoprotein(a) and Its Response to Antiplatelet Therapy
The Lp(a)-PLAT Study is designed to close a critical evidence gap in cardiovascular prevention for the roughly 20% of the population who carry genetically determined elevations in lipoprotein(a) - a recognised pro-thrombotic and…
- Trial name
- Lp(a)-PLAT (NCT07720934)
- Testing
- Aspirin, Clopidogrel
- Where
- Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- François MACH
Immune Thrombocytopenia
The Association Between Platelet Reactivity and Bleeding Risk in Adult ITP
It seems reasonable to assume that patients who present significant bleeding symptoms may have different quality of platelets than those without bleeding.
- Trial name
- NCT03377439
- Testing
- Platelet function tests
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Shandong University
Platelet Aggregation, Nutritional and Metabolic Disease
Acute Assessment of Platelet Reactivity After the Intake of Oleocanthal
The investigators have previously observed a reduced level of platelet aggregation 2 hours after healthy male individuals were asked to drink extra virgin olive oil (EVOO) that provided a higher level of one specific phenolic…
- Conditions
- Platelet Aggregation, Nutritional and Metabolic Disease, Cardiovascular Diseases
- Trial name
- NCT03528603
- Testing
- Oleocanthal-Rich Extra Virgin Olive Oil, Oleocanthal-low Extra Virgin Olive Oil
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Postprandial Glucose, Platelet Activation
Cimarrón Bean Extrudate Solution on Platelet Function and Biochemical Parameters
This non-randomized acute clinical trial evaluates the effect of consuming a water-based solution of Cimarrón bean extrudate on platelet function and postprandial glycemia in adults.
- Trial name
- CBE-SP (NCT07043829)
- Testing
- SPVCE (Solution Phaseolus vulgaris L. var. Cimarrón Extrudate in Water)
- Where
- Chile
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Talca
Stable Angina
Downstream Molecular Signals of P2Y12 Receptors in Hyporeactive Patients Under Clopidogrel Treatment A Possible Mechanism of HOTPR(High On-Treatment Platelet Reactivity)
The investigators designed the following experiment to observe the pattern of administration in vitro, which can be completely excluded liver enzyme cytochrome P450 metabolism under the influence and observe the relevant P2Y12…
- Trial name
- NCT03190005
- Testing
- clopidogrel
- Where
- Taiwan
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Taipei City Hospital
Diabetes Mellitus Type 2 Platelets Reactivity Statin
Effect of Allopurinol on Mono and Co-administration With Statins on Platelets Reactivity on Diabetic Patiets Treated With Aspirin and Insulin
Diabetes mellitus is associated with an increased risk of cardiovascular disease. Substantial clinical and experimental evidence suggest that both diabetes and insulin resistance cause a combination of endothelial dysfunctions…
- Trial name
- NCT03195153
- Testing
- Atorvastatin 80mg, ALLOPURINOL 300 MG, Atorvastatin 80mg AND allopurinol 300 mg
- Where
- Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Roma La Sapienza