Clinical trials: Platelet Rich Fibrin
Sinus Floor Augmentation, Graftless Sinus Elevation
Fibrin Glue Versus Titanium Platelet-rich Fibrin in Lateral Sinus Lifting
Graftless sinus lift with simultaneous implant placement is one of the new techniques, this new technique is presented based on the physiology of intrasinus bone repair.
- Trial name
- NCT05831267
- Testing
- Fibrin Glue, T-PRF, Negative control
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Hams Hamed Abdelrahman
Recession
Effect of Monolayer Versus Multilayer Leucocyte-Platelet Rich Fibrin (L-PRF) in Interdental Papillary Reconstruction
The interdental papilla is very small but it has a great implication from an aesthetic view, more specifically in the anterior region because it is always displayed during smiling.
- Trial name
- NCT04091802
- Testing
- interdental papilla reconstruction with L-PRF
- Volunteers
- 20 people
- Sponsor
- Ain Shams University
Gingival Recession, Generalized
Comparison of De-Epithelialized Gingival Graft With or Without Platelet Rich Fibrin in Multiple Gingival Recessions
The aim of this study is to compare the clinical efficacy and patient reported outcome measures of de-epithelialized gingival graft (DGG) with or without platelet rich fibrin on treatment of multiple adjacent gingival recessions…
- Trial name
- NCT06509867
- Testing
- DGG, Platelet rich fibrin
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kutahya Health Sciences University
Gingival Overgrowth
Comparison of I-PRF, T-PRF, and 0.8% Hyaluronic Acid Applications in Wound Healing After Gingivectomy.
Objectives: This study aimed to evaluate the effect of injectable platelet-rich fibrin (i-prf), titanium-prepared platelet-rich fibrin (t-prf), and 0.8% hyaluronic acid (HA) gel on clinical periodontal parameters, wound healing…
- Trial name
- NCT06865092
- Testing
- injectable platelet-rich fibrin, titanium-prepared platelet-rich fibrin, Hyaluronic Acid (HA)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Saglik Bilimleri Universitesi
Joint Disease
Extracellular Vesicles in Fibrin Gel for Cartilage Repair
This project aims to produce and study in vitro/ex vivo a platelet rich plasma (PRP)-derived fibrin gel loaded with mesenchymal stromal cells (MSC)-extracellular vesicles (EVs), to combine the positive results on cartilage growth…
- Trial name
- GelVex (NCT06713902)
- Where
- Italy
- Volunteers
- 51 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Pain, Postoperative, Trismus
Comparison of the Effect of A-PRF and L-PRF on Outcomes After Removal of Impacted Mandibular Third Molar
In this study, it was aimed to investigating and comparing the postoperative effects of leukocyte- and platelet-rich fibrin (L-PRF) and advanced platelet-rich fibrin (A-PRF) in terms of pain, swelling on the cheek, and trismus…
- Conditions
- Pain, Postoperative, Trismus, Swelling
- Trial name
- NCT03672669
- Testing
- Advanced Platelet Rich Fibrin (A-PRF), Leukocyte- and platelet-rich fibrin (L-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Near East University, Turkey
Chronic Suppurative Otitis Media
Platelet Rich Fibrin Augmented Tympanoplasty Versus Cartilage Tympanoplasty
This study was performed to compare healing and hearing outcomes of two tympanoplasty techniques, performed for patients with total or subtotal tympanic membrane perforations.
- Trial name
- NCT05967845
- Testing
- cartilage tympanoplasty, platelet rich fibrin augmented tympanoplasty
- Where
- Egypt
- Volunteers
- 156 people
- Sponsor
- Mansoura University
Impacted Third Molar Tooth, Postoperative Pain
Effects of Platelet-Rich Fibrin and Kinesio Taping on Postoperative Recovery in Oral Surgery
This study investigates the effectiveness of Platelet-Rich Fibrin (PRF) and Kinesio Taping in reducing postoperative pain, edema, and improving recovery following impacted third molar surgery.
- Conditions
- Impacted Third Molar Tooth, Postoperative Pain, Postoperative Edema
- Trial name
- PRFKTOralSur (NCT06900894)
- Testing
- Platelet-Rich Fibrin (PRF), Kinesio Taping, Standard Postoperative Care
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Mustafa Kemal University
Tooth Loss, Recession, Gingival
Use of Leucocyte- and Platelet-rich Fibrin Membranes in Single Implant
The objective of this randomized controlled clinical trial is to evaluate the increase of soft tissue thickness around single implants installed in maxillary esthetic area with the use of Leucocyte-Platelet rich Fibrin (L-PRF)…
- Trial name
- NCT03660566
- Testing
- Test - Implant with L-PRF, Control - Implant without L-PRF
- Where
- Brazil
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual Paulista Júlio de Mesquita Filho
Gingival Recession
Platelet-Rich Fibrin Prepared With Titanium in the Treatment of Multiple Gingival Recessions
The aim of this study was to treat the areas with Miller Class I bilateral multiple gingival recession in the maxillary teeth using the Titanium Platelet-Rich Fibrin (T-PRF), an autogenous biomaterial applied in combination with…
- Trial name
- NCT05270941
- Testing
- COMPARISON OF PLATELET-RICH FIBRIN PREPARED WITH TITANIUM AND SUBEPITHELIAL CONNECTIVE TISSUE GRAFT
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Necmettin Erbakan University
Patients Receiving Direct Oral Anticoagulants
Effect of Tranexamic Acid-Modified Leukocyte- and Platelet-Rich Fibrin on Hemostasis and Wound Healing After Tooth Extraction in Patients Receiving Direct Oral Anticoagulants
This randomized split-mouth clinical study evaluated the effects of tranexamic acid-modified leukocyte- and platelet-rich fibrin (L-PRF) on hemostasis, postoperative pain, and soft-tissue wound healing after tooth extraction in…
- Trial name
- NCT07830875
- Testing
- Tranexamic Acid-Modified L-PRF, Absorbable Gelatin Sponge
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people
- Sponsor
- Cumhuriyet University
PRF, Gingival Recession
Clinical Evaluation of Platelet Rich Fibrin Membrane With or Without Hyaluronic Acid Along With Coronally Advanced Flap in the Treatment of Rt1 Gingival Recession
Gingival recession is a common mucogingival deformity that may result in root hypersensitivity, esthetic concern, plaque accumulation, and difficulty in oral hygiene maintenance.
- Conditions
- PRF, Gingival Recession, Hyaluronic Acid
- Trial name
- NCT07662447
- Testing
- root coverage with multilayered PRF, root coverage with multilayered PRF and hyaluronic acid
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Gulf Medical University
Periodontal Disease, Periodontitis
Evaluation of the Influence of PRF (Platelet-rich Fibrin) on the Clinical Parameters and the Concentration of Selected Inflammation Mediators in GCF (Gingival Crevice Fluid) of Patients With Periodontitis
Assessment of the influence of injectable platelet-rich fibrin (i-PRF) on the clinical parameters and the inflammation mediators levels in the gingival crevicular fluid (GCF) in patients with periodontitis.
- Trial name
- PRFperio (NCT06920849)
- Testing
- SRP+iPRF, SRP
- Where
- Poland
- Volunteers
- 40 people
- Sponsor
- Medical University of Bialystok
Irreversible Pulpitis
Assessment of L-PRF, Nanohydroxyapatite Combined With L-PRF Using Pulpotomy in Mature Mandibular First Molars
Clinical and Radiographic Assessment of L-PRF, Nanohydroxyapatite material combined with L-PRF scaffold in Vital pulp Therapy. Treatments in Mandibular First Molars with Closed Apices, Randomized Controlled Trial.
- Trial name
- NCT06613932
- Testing
- pulpotomy
- Where
- Egypt
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Intrabony Periodontal Defect
Evaluation of Modified Minimally Invasive Surgical Technique and Platelet Rich Fibrin With or Without Vitamin Pool A and C for Management of Periodontal Intrabony Defects
This study aims to assess clinical and radiographic outcomes after the use of vitamins A and C with PRF versus PRF alone in the treatment of periodontal intrabony defect.
- Trial name
- NCT05499598
- Testing
- Experimental: Modified minimally invasive surgical technique with PRF and vitamins A and C, Modified minimally invasive surgical technique with PRF
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Platelet-rich Fibrin
Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery
A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to…
- Trial name
- NCT05866965
- Testing
- PRF, standard third molar surgical removal
- Where
- Vietnam
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Lam Cu Phong
Deficient Interdental Papilla
Comparative Evaluation of Alb PRF Versus Connective Tissue Graft in Reconstruction of Deficient Interdental Papilla
This study will evaluate the efficacy of Alb PRF membrane in comparison to a subepithelial connective tissue graft in the reconstruction of interdental papillae.
- Trial name
- NCT07597135
- Testing
- Albumin (5% serum-protein solution containing immunoglobulins), connective tissue graft
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- ahmed mostafa ahmed abo el soud
Third Molars Extraction
The Use of Advanced Platelet-rich Fibrin in Mandibular Third Molar Surgery
The purpose of the study is to quantify the levels of platelets and inflammatory markers in A-PRF from a standard venous whole blood sample, and to evaluate the effect of A-PRF on postoperative discomfort and complications…
- Trial name
- NCT07761338
- Testing
- Third molar
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Alveolar Ridge Preservation
Ridge Preservation With Platelet Rich Fibrin Augmented With Freeze Dried Bone Allograft
Improved predictability and quality of bone healing after a tooth is removed is clinically relevant, in that, it improves our ability to achieve successful implant placement at edentulous sites.
- Trial name
- NCT03043885
- Testing
- FDBA, PRF, Blood Clot
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Fibrin/Therapeutic Use, Blood Platelets
Effects of the Use of Platelet-rich Fibrin on Bone Regeneration After Impacted Third Molar Surgery
The purpose of this study is to evaluate the bone regeneration after impacted third molar surgery on split mouth design using platelet-rich fibrin.
- Conditions
- Fibrin/Therapeutic Use, Blood Platelets, Molar, Third, Bone Regeneration
- Trial name
- NCT02890680
- Testing
- Platelet-rich fibrin, Control group
- Where
- Brazil
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University