Clinical trials: Platelet Rich Fibrin
PRF Growth Factor Release
Comparison of Growth Factor Releases and Degradation Rates of Membranes Obtained From A-PRF+, L-PRF, and Alb-PRF
Platelet-rich fibrin (PRF) is widely used in regenerative dentistry because of its autologous growth factor release and fibrin scaffold properties.
- Trial name
- PRF (NCT07778160)
- Testing
- Albumin-Platelet Rich Fibrin (Alb-PRF), Advanced Platelet-Rich Fibrin (A-PRF), Leukocyte-Platelet Rich Fibrin (L-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Congenital Diaphragmatic Hernias
Contribution of PRF in CDH in Children With Prothetic Patch Closure
Improved management of giant congenital diaphragmatic hernias (CDH) in neonates : decreased risk of morbidity and mortality due to prosthesis release.
- Trial name
- HECODIAP (NCT03861182)
- Testing
- Biological functionalization of the prosthetic materials by PRF
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Bisphosphonate-Associated Osteonecrosis of the Jaw
Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
This prospective study will include patients taking or having taken bisphosphonates and needing dental extractions. The aim of this study is to validate the contribution of PRF (Platelet Rich Fibrin) in tooth extraction sites.
- Trial name
- PRF (NCT02198001)
- Testing
- tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine), atraumatic extraction
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Chronic Leg Ulcer
Efficacy of Platelet-rich-Fibrin Gel in Patients With Chronic Leg Ulcers
Platelet rich Fibrin (PRF) gel is an emerging as a novel treatment option for chronic leg ulcers and has the potential to become the 1st line option in these conditions.
- Trial name
- NCT07294521
- Testing
- Platelet rich Fibrin (PRF)
- Where
- Pakistan
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Periodontitis
Effect of Periodontitis on the Quality and Quantity of Leukocyte- and Platelet-Rich Fibrin (L-PRF)
Periodontitis is a chronic inflammatory disease that destroys the supporting tissues of the teeth and may also increase systemic inflammatory burden.
- Trial name
- NCT07693725
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Suleyman Demirel University
Mastication Disorder
Evaluation of Platelet Rich Fibrin on Reduction of Periodontal Problems After Surgical Removal of Mandibular Third Molar
The purpose of this study is to determine the influence of platelet rich fibrin to reduction of periodontal problems after surgical removal of third molar.
- Trial name
- NCT01583491
- Testing
- autologous platlet rich fibrin, one side in control group
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Majid Eshghpour
L-PRF, Dental Implants
Evaluation of the Effect of Leucocyte Platelet-Rich Fibrin (L-PRF) Technique Applied in Post-extraction Sockets Before Placement of Dental Implants
Aim of study: The application of L-PRF membrane in post-extraction sockets outmatches the use of a) allograft covered with a collagen fleece b) allograft combined with L-PRF membrane c) natural healing, with reference to bone…
- Conditions
- L-PRF, Dental Implants, Osseointegration, Alveolar Bone Grafting
- Trial name
- NCT07387913
- Testing
- Allograft and collagen membrane, Allograft and L-PRF membrane, L-PRF
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Tear Trough Hollowing, Under Eye Bags
Platelet Rich Fibrin for Tear Trough Rejuvenation
The purpose of this study is to investigate the efficacy and longevity of Platelet Rich Fibrin (PRF) in combination with hyaluronic acid filler for cosmetic volume restoration of the tear troughs.
- Trial name
- NCT03313934
- Testing
- Hyaluronic Acid Filler and Platelet Rich Fibrin (PRF), Hyaluronic Acid Filler and Saline
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Rejuva Medical Aesthetics
Dental Caries, Pulp Caping
Clinical and Radiographic Evaluation of Indirect Pulp Capping Using Platelet Rich Fibrin Versus Mineral Trioxide Aggregate in Deep Carious Molars: a Randomized Controlled Trial
The aim of this study is the clinical and radiographic evaluation of (Platelet-Rich Fibrin (PRF) versus Mineral Trioxide Aggregate (MTA) in indirect pulp capping when used with deep carious molars over 1 year follow up.
- Conditions
- Dental Caries, Pulp Caping, Indirect Pulp Treatment, Indirect Pulp Cap
- Trial name
- NCT06889363
- Testing
- MTA, PRF
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Cairo University
Gingival Recession
Effect of Dose-dependent Platelet Rich Fibrin(PRF)
Miller Class I Gingival Recessions (GR) have been treated by using Coronally Advanced Flap (CAF) with Platelet Rich Fibrin membrane (PRF membrane) or Connective Tissue Graft (CTG).
- Trial name
- PRF (NCT02882464)
- Testing
- PC-02 Centrifuge device,2PRF+CAF, PC-02 Centrifuge device, 4 PRF+CAF, CTG+CAF
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gazi University
Impact Molar, Mandible Cyst
Bone Defects Reconstruction After Dentigerous Cyst Enucleation With Autogenous Demineralized Dentin Matrix- ADDM and Advanced Platelet-Rich Fibrin- A-PRF.
This prospective clinical study evaluates bone healing following dentigerous cyst enucleation associated with impacted mandibular third molar extraction.
- Conditions
- Impact Molar, Mandible Cyst, Bone Regeneration, Platelet Rich Fibrin
- Trial name
- Cystregen (NCT07652216)
- Testing
- Impacted third molar extraction, Advanced Platelet-Rich Fibrin (A-PRF), Mandibular dentigerous cyst enucleation
- Where
- Poland
- Volunteers
- 35 people
- Sponsor
- Jagiellonian University
Periodontitis, Periodontal Inflammation
Hyaluronic Acid and Albumin-PRF in Non-Surgical Periodontal Therapy
Periodontitis is a chronic inflammatory disease that leads to the destruction of the supporting tissues of the teeth. Non-surgical periodontal treatment is the first-line approach for the management of periodontitis; however, the…
- Trial name
- NCT07415148
- Testing
- Non-Surgical Periodontal Treatment, Albumin Platelet-Rich Fibrin (Alb-PRF), Hyaluronic Acid Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 51 people
- Sponsor
- Inonu University
Vocal Cord Paralysis
Administration of Platelet-rich Fibrin to Autologous Fat Tissue in Injection Laryngoplasty for Vocal Cord Paralysis
The study tries to see the effect of using a combination of platelet-rich fibrin (PRF) and autologous fat as a filler for injection laryngoplasty procedures to treat unilateral adductor vocal cord paralysis.
- Trial name
- NCT04839276
- Testing
- Injection Laryngoplasty with Platelet-rich Fibrin and Autologous Fat, Injection Laryngoplasty with Autologous Fat
- Where
- Indonesia
- Volunteers
- 19 people
- Sponsor
- Fakultas Kedokteran Universitas Indonesia
Peridontal Disease
Efficacy of Injectable Platelet-rich Fibrin Versus Platelet-Rich Plasma As Adjunctive to Scaling and Root Planning in Non-surgical Periodontal Therapy of Periodontitis Patients
The study aims to evaluate the Efficacy of Injectable Platelet-rich Fibrin versus Platelet-Rich Plasma as adjunctive to scaling and root planning in non-surgical periodontal therapy of Periodontitis patients (Randomized…
- Trial name
- PRP-IPRF (NCT06685393)
- Testing
- Platelet rich plasma (PRP), INJECTABLE PLATELET RICH FIBRIN(I-PRF)
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- ELsabbahy Ahmed Mohamed Youssef
Osseointegration Failure of Dental Implant
A Randomised Control Clinical Trial Investigating the Effect of H-PRF on Implant Stability and Marginal Bone Levels
This research will be a randomised controlled trial (RCT) investigating whether the use of Horizontal Platelet Rich Fibrin (H-PRF) increases implant stability compared to those implants placed without H-PRF, and therefore…
- Trial name
- NCT06453330
- Testing
- Horizontal platelet-rich fibrin (H-PRF)
- Where
- Ireland
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Dublin, Trinity College
Alveolar Cleft
Evaluation of Secondary Alveolar Cleft Reconstruction
The rehabilitation of the disorganized maxilla is the primary objective of secondary alveolar bone grafting (SABG) for alveolar clefts, as the bony reconstruction of the discontinued maxillary arch would permit proper anterior…
- Trial name
- NCT06621719
- Testing
- Alveolar Cleft Reconstruction
- Where
- Egypt
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Injectable Plasma-rich Fibrin Versus Low-Level Laser Therapy on Othodontic Movement
Assessment of Different Orthodontic Tooth Movements Assisted With Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
The present prospective clinical study will be undertaken for assessment of the effect of application of Injectable plasma-rich fibrin versus Low-Level Laser Therapy onthe rate of different orthodontic tooth movements,
- Trial name
- NCT05966987
- Testing
- Low-level Laser Therapy vs. Injectable Platelets-rich Fibrin
- Where
- Egypt
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Temporomandibular Joint Disc Displacement
Evaluation of the Efficacy of Injectable Platelet-Rich Fibrin Mixed With Hyaluronic Acid in Treatment of Temporomandibular Joint Internal Derangement
we inject I-PRF and Hyaluronic Acid inside the human TMJ with internal derangement after arthrocentesis, and follow-up is made to evaluate the effect of this treatment.
- Trial name
- NCT07373730
- Testing
- Hyalgan 20 mg in 2 ML Prefilled Syringe, I-PRF
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Gingival Recession
Coronally Advanced Flap and PRF With or Without Demineralized Freeze-dried Bone Allograft in Gingival Recession
Gingival recession is defined as the apical migration of gingival margin beyond cemento-enamel junction with the exposure of root surface.
- Trial name
- NCT02835430
- Testing
- Coronally advanced flap and PRF with DFDBA, Coronally advanced flap and PRF without DFDBA
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Treatment of Periodontal Intra-bony Defects
The Present Study Was Performed to Evaluate the Efficacy of Lyophilized-PRF in Treatment of Periodontal Intra-bony Defects
The present study will be performed to evaluate the efficacy of lyophilized platelet-rich fibrin alone and combined with nanocrystalline hydroxyapatite in treatment of periodontal intra-bony defects through: 1.
- Trial name
- NCT06625528
- Testing
- open flap debridement
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University