Clinical trials: Platelet-rich Fibrin
Apical Periodontitis
Endodontic Microsurgery
Current literature on platelet rich fibrin (PRF) use in apicoectomies, also known as endodontic microsurgery, is sparse. PRF use in oral surgery or periodontal surgery has been more thoroughly researched.
- Trial name
- EMS (NCT06776289)
- Testing
- Platelet rich fibrin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Mark Schachman
Platelet-rich Fibrin, Simvastatin
Effect of Local Application of Platelet-rich Fibrin Scaffold Loaded With Simvastatin on Peri-implant Bone Changes
ACKGROUND: Simvastatin (SIM), a pharmacological drug used for hypercholesterolemia, has been found to have pleotropic effects on bones. Simvastatin together with the appropriate carrier may decrease bone loss around implants.
- Trial name
- NCT05008068
- Testing
- Simvastatin
- Where
- Egypt
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Gingival Recession
Advanced Platelet-Rich Fibrin and Coronally Advanced Flap for Gingival Recession Treatment
The goal of this clinical trial is to learn if adding a natural healing material works better to treat receding gums in adults. Receding gums is a condition where the gum tissue pulls back and exposes the tooth root.
- Trial name
- NCT07624591
- Testing
- Coronally Advanced Flap (CAF) combined with Advanced Platelet-Rich Fibrin (A-PRF), Coronally Advanced Flap (CAF) alone
- Where
- Vietnam
- Volunteers
- 11 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Bone Loss, Alveolar
Evaluation of Vertical Bone Gain After Ridge Augmentation With APRF & Xenograft Vs Collagen Membrane & Xenograft. RCT
Comparative study for evaluation of vertical bone gain after one stage ridge augmentation with advanced platelet rich fibrin (A-PRF) and xenograft versus guided bone regeneration using collagen membrane and xenograft.
- Trial name
- NCT03855852
- Testing
- Xenograft and Collagen membrane, Xenograft and APRF
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Cairo University
Platelet-rich Fibrin
Effect of Platelet-rich Fibrin on Soft Tissue, Periodontal Pocket Healing and Alveolar Bone Height After Third Molar Surgery
A Randomized, controlled clinical trial and split-mouth design was performed to assess and compare the effect of platelet-rich fibrin (PRF) on soft tissue healing, periodontal pocket depth and alveolar bone height distal to…
- Trial name
- NCT05866965
- Testing
- PRF, standard third molar surgical removal
- Where
- Vietnam
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Lam Cu Phong
Gingival Recession
CGF and PRF in the Gingival Recessions Treatment
This study hypothesized that CGFs' placement together with CAF may enhance the healing of soft tissues better than use of PRF together with CAF.
- Trial name
- NCT04261634
- Testing
- Concentrated Growth Factor Membrane, Platelet Rich Fibrin
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Bulent Ecevit University
Gingival Pigmentation
Effect of Injectable Platelet Rich Fibrin on Healing and Patient Satisfaction Following Laser Gingival Depigmentation
The objectives of the present study are to: 1. Evaluate the effect of I-PRF injection following laser gingival depigmentation technique on the healing period as a primary objective. 2.
- Trial name
- NCT05283668
- Testing
- i-PRF, Diode Laser
- Where
- Egypt
- Volunteers
- 8 people
- Sponsor
- Ain Shams University
Bone Regeneration
Alveolar Ridge Augmentation Following Tooth Extraction Using Bovine Xenograft With Platelet Rich Fibrin Membrane
fourteen patients requiring extraction of one posterior tooth with lost buccal bone (>50%) confirmed preoperatively by Cone-beam computed tomography (CBCT) scans.
- Trial name
- NCT05791123
- Testing
- a bone graft mixed with PRF & covered by PRF membrane in fresh extraction socket
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Future University in Egypt
TEETH EXTRACTION
Titanium-Prepared Platelet-Rich Fibrin for Extraction Socket Healing
Alveolar ridge preservation after tooth extraction is important for maintaining bone volume and facilitating future implant placement.
- Trial name
- TPRF-SOCKET (NCT07712497)
- Testing
- Titanium-Prepared Platelet-Rich Fibrin (T-PRF)
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Eskisehir Osmangazi University
Regenerative Inflammation
Evaluation of Platelet Rich Fibrin Matrix as Regenerative Material in Intraosseous Defects
Technological advancement has led to the development of concentrated platelets, by means of centrifugation, popularly known as Platelet concentrates which seem to be a convenient approach to obtain autologous growth factors.
- Trial name
- NCT03616925
- Testing
- Platelet Rich Fibrin Matrix kit, surgical open flap debridement
- Where
- India
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- KLE Society's Institute of Dental Sciences
Pulp Necrosis, Immature Permanent Teeth
PRF and CGF Scaffolds With EDTA in Regeneration
This study evaluated the regenerative outcomes of immature permanent teeth with necrotic pulps treated using three scaffold types-blood clot, platelet-rich fibrin (PRF), and concentrated growth factor (CGF)-combined with either…
- Conditions
- Pulp Necrosis, Immature Permanent Teeth, Open Apex, Periapical Periodontitis
- Trial name
- RET-EDTA-CGF (NCT07265804)
- Testing
- Blood Clot + 5% EDTA, Blood Clot + 17% EDTA, PRF + 5% EDTA
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Intrabony Defect, Intrabony Defects in Chronic Periodontitis
Treatment of Intrabony Defect in Patient With Periodontitis Stage III by Using I-PRF and Xenograft
Evaluate of the injectable platelet rich fibrin (I-PRF) with xenograft in Intrabony defects of Periodontitis patient stage III versus Xenograft alone.
- Trial name
- NCT07261878
- Testing
- injectable platelet rich fibrin and xenograft, Xenograft alone
- Where
- 2 sites in Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
Female Pattern Hair Loss, Platelet-Rich Plasma
The Efficacy and Safety of Platelet-rich Fibrin and Platelet Rich Plasma in Female Pattern Hair Loss Patients
The goal of this clinical trial is to compare between platelet-rich fibrin and platelet-rich plasma in female pattern hair loss .
- Conditions
- Female Pattern Hair Loss, Platelet-Rich Plasma, Platelet-rich Fibrin
- Trial name
- PRF (NCT06440655)
- Testing
- Platelet rich plasma, Platelet rich fibrin
- Where
- 2 sites in Thailand
- Volunteers
- 10 people
- Sponsor
- Siriraj Hospital
Furcation Defects
Comparison of Platelet Rich Fibrin as Graft & Membrane Vs Hyaluronic Acid & Amniotic Membrane in the Treatment of Interradicular Defects
This study is intended to compare the efficacy of platelet-rich fibrin as a graft and a membrane versus hyaluronic acid(Gengigel) and amniotic membrane in the treatment of mandibular grade II furcation defects.
- Trial name
- CPRFGMHATID (NCT03578744)
- Testing
- Conventional Flap surgery
- Where
- India
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Gingival Recession, Localized
Extended Platelet- Rich Fibrin Membrane Combined With Vestibular Incision Subperiosteal Tunnel Access Technique to Treat Localized Gingival Recession
This study will be performed to clinically evaluate and compare the effectiveness of extended platelet-rich fibrin (e-PRF) membrane versus de-epithelized free gingival graft (DFGG) in combination with vestibular incision…
- Trial name
- alb prf REC (NCT07079293)
- Testing
- Preparation of Extended PRF, Harvesting of Free Gingival Graft and preparation of CTG, VISTA technique
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Lateral Sinus Lifting
Lateral Sinus Augmentation Utilizing Bovine Bone Mixed with Platelet-rich Fibrin
Background: In sinus augmentation procedure, graft resorption remains a major dilemma of various graft materials. Objective: To estimate the graft volume changes following lateral sinus augmentation utilizing cone beam computed…
- Trial name
- NCT06810921
- Testing
- lateral sinus lift
- Where
- Iraq
- Volunteers
- 34 people
- Sponsor
- University of Baghdad
Periodontal Diseases, Periodontal Attachment Loss
Clinical Effectiveness of Biologic Agents as an Adjunct to Non-surgical Periodontal Therapy of Intrabony Defects
The aim of the present study is to clinically and radiographically compare the efficacy of recombinant human platelet-derived growth factor (rhPDGF), Leukocyte-Platelet Rich Fibrin (L-PRF) and Enamel Matrix Derivatives (EMD) in…
- Conditions
- Periodontal Diseases, Periodontal Attachment Loss, Pocket, Periodontal, Intrabony Periodontal Defect
- Trial name
- NCT05858411
- Testing
- SRP+rhPDGF, SRP+L-PRF, MINST alone
- Where
- Albania
- Volunteers
- 88 people
- Sponsor
- G. d'Annunzio University
Bisphosphonate-Associated Osteonecrosis of the Jaw
Prospective Randomized Study: Assessment of PRF Efficacy in Prevention of Jaw Osteonecrosis After Tooth Extraction
This prospective study will include patients taking or having taken bisphosphonates and needing dental extractions. The aim of this study is to validate the contribution of PRF (Platelet Rich Fibrin) in tooth extraction sites.
- Trial name
- PRF (NCT02198001)
- Testing
- tooth extraction with antibiotics (amoxicillin- clavulanate, clindamycine), atraumatic extraction
- Where
- 3 sites in Belgium
- Volunteers
- 100 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Alveolar Osteitis
Alvogyl Versus Platelet-Rich Fibrin for Healing of Alveolar Osteitis
Alveolar osteitis, commonly known as dry socket, is a painful complication that can occur after tooth extraction, particularly following removal of a mandibular third molar.
- Trial name
- NCT07790653
- Testing
- Alvogyl Dressing, Platelet-Rich Fibrin (PRF)
- Where
- Pakistan
- Volunteers
- 102 people
- Sponsor
- CMH Lahore Medical College and Institute of Dentistry