Clinical trials: Platelets Dysfunction
Ticagrelor, Aspirin
Reversal of the Antiplatelet Effects of Ticagrelor in Combination With Aspirin, Using Normal Platelets
The specific objective of this study is to investigate the potential for normal platelets to reverse the inhibition of platelet aggregation in patients treated with ticagrelor in combination with aspirin.
- Conditions
- Ticagrelor, Aspirin, Platelet Dysfunction Due to Drugs, Transfusion
- Trial name
- REVSTARTS (NCT03005704)
- Testing
- Antiplatelet treatment
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Platelet Dysfunction Due to Aspirin
Platelet Enzymatically Oxidized Phospholipids (eoxPL) Characterisation in a Healthy Cohort on and Off Aspirin
Healthy volunteers (n = 28) were recruited from the workplace (14 male, 14 female; age range 20-50 years). Ethical approval, which included informed consent, was from Cardiff University, Schools of Medicine and Dentistry Research…
- Trial name
- NCT05604118
- Testing
- Aspirin
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cardiff University
Neurosensory Disorder
Effect of Platelet Rich Fibrin Membrane on the Neurosensory Dysfunction After IAN Lateralization for Implant Placement.
In many cases the bone of the edentulous posterior mandibular regions is atrophied such that sufficiently long fixtures cannot be placed without encroaching on the inferior alveolar nerve so rehabilitation of these regions with…
- Trial name
- NCT03952663
- Testing
- inferior alveolar nerve lateralization and dental implant placement., platelet rich fibrin membrane around the nerve
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Cairo University
Platelet Dysfunction, Hemodilution
Effect of Aspirin, Hemodilution and Desmopressin on Platelet Dysfunction
Study hypothesis: Desmopressin (DDAVP) can improve platelet function under influence of aspirin, hemodilution and mild hypothermia Mild hypothermia (34-35oC) is known to cause platelet dysfunction.
- Conditions
- Platelet Dysfunction, Hemodilution, Mild Hypothermia, NSAID
- Trial name
- NCT01382134
- Testing
- Aspirin, desmopressin
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Heart Diseases, Coronary Disease
CES1 Carriers in the PAPI Study
This study builds, in part, upon preliminary results generated as part of the Pharmacogenomics Anti-Platelet Intervention (PAPI) Study (NCT00799396).
- Conditions
- Heart Diseases, Coronary Disease, Coronary Artery Disease, Cardiovascular Diseases
- Trial name
- NCT03188705
- Testing
- Clopidogrel, Aspirin
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Erectile Dysfunction, Erectile Dysfunction With Diabetes Mellitus
Serum YKL-40 Level and Platelets Indices Among Patients With Diabetic Erectile Dysfunction
The aim of this current study is to estimate serum level of YKL-40, serum total testosterone and platelets indices in diabetic patients with erectile dysfunction treated by daily tadalafil 5mg for 3 months.
- Trial name
- NCT05446493
- Testing
- Tadalafil 5mg
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aswan University
Erectile Dysfunction
Evaluating the Efficacy of Platelet-Rich-Plasma (PRP) for Erectile Dysfunction
There is great interest in restorative therapies (platelet-rich plasma (PRP) injections, shockwave therapy and stem cell therapy) for ED given their non-invasive nature.
- Trial name
- NCT06264635
- Testing
- Platelet-Rich-Plasma, Saline
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Erectile Dysfunction
The Role of Platelet Rich Plasma for Erectile Dysfunction
Purpose of Study: This randomized controlled trial investigates the role that platelet rich plasma injections into the penis may play to improve erectile function in men with erectile dysfunction.
- Trial name
- NCT04357353
- Testing
- Platelet rich plasma
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Platelet Dysfunction
Influence of Anesthesia Drugs on Impedance Aggregometry
Impedance aggregometry (IA) (Multiplate®)is a new whole blood platelet function test with potential use in anesthesia and intensive care. Most anesthetic drugs have been shown to have in vitro antiplatelet activity.
- Trial name
- NCT01454427
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Platelets Dysfunction, Hematological Diseases
Daily Ginger Drinking and Platelet Function
This study aims to examine the effect of ginger beverage consumption on platelets activity in apparently healthy Saudi adult volunteers.
- Trial name
- NCT02882776
- Testing
- Ginger drink
- Where
- Saudi Arabia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- King Abdullah International Medical Research Center
Bleeding, Platelet Dysfunction
Platelet Glycoproteins in Inherited Thrombocytopathy: Association With Aggregation Studies and Bleeding Severity
Disorders of platelet function are characterized by variable mucocutaneous bleeding manifestations and excessive hemorrhage following surgical procedures or trauma.
- Trial name
- NCT03648190
- Testing
- Flowcytometry analysis of platelets surface receptors
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Platelet Dysfunction Due to Aspirin Ingestion
AggreGuide 325 mg. Aspirin Study for Aspirin Induced Platelet Dysfunction
To test the AggreGuide A-100 AA Assay's effectiveness for detecting aspirin induced platelet dysfunction.
- Trial name
- NCT01915407
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Aggredyne, Inc.
Platelet Dysfunction, Traumatic Brain Injury
Correcting Platelet Dysfunction After Traumatic Brain Injury
This study evaluates the impact of platelet transfusion on geriatric patients with platelet dysfunction from Traumatic Brain Injury.
- Trial name
- NCT03182946
- Testing
- Platelet mapping Thromboelastography
- Where
- United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Hypercholesterolemia, Endothelial Dysfunction
Effects of Nutraceutical Therapies on Endothelial Function, Platelet Aggregation, and Coronary Flow Reserve
Hypercholesterolemia is considered one of the most important cardiovascular risk factors. Cardiovascular prevention include a class I indication to statins in addition to non-pharmacologic intervention and prevention strategies…
- Trial name
- NUTRENDO (NCT02969070)
- Testing
- LopiGLIK™ therapy, Armolipid Plus® therapy
- Where
- Italy
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Federico II University
Acute Renal Failure, Chronic Kidney Failure
The Role of Endothelium Dysfunction in Progression of CKD (Chronic Kidney Disease) After AKI (Acute Kidney Injury)
To understand how AKI (Acute Kidney Injury) leads to chronic kidney disease so therapies can be found to alter the progression of events thereby significantly impacting the long-term outcomes of children who develop AKI.
- Conditions
- Acute Renal Failure, Chronic Kidney Failure, Endothelial Dysfunction, Hemolytic-uremic Syndrome (HUS)
- Trial name
- NCT00358306
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Thyroid Dysfunction, Immune Thrombocytopenic Purpura
Study of Thyroid Dysfunction in Immune Thrombocytopenic Purpura Patients
Study of relation between thyroid dysfunction and immune thrombocytopenic purpura patients and if there is relation between them
- Trial name
- NCT07900334
- Testing
- Laboratory tests TSH, FT3, FT4 ,anti thyroglobulin antibodies, Anti -TPO antibodies
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sohag University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Hypothermia Induced Impairment of Primary Haemostasis
Desmopressin for Bleeding Related to Low Body Temperature
To study, with a prospective randomised controlled design, whether the subcutaneous administration of the haemostatic drug desmopressin, may improve the impairment of primary haemostasis due to mildly decreased temperature.
- Trial name
- NCT00902057
- Testing
- desmopressin
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong