Clinical trials: Pleural Diseases
Non-small Cell Lung Cancer, Spread Through Air Space
Deep Learning Signature for Predicting Aggressive Histological Pattern in Resected Non-small Cell Lung Cancer
The purpose of this study is to evaluate the performance of a PET/ CT-based deep learning signature for predicting aggressive histological pattern in resected non-small cell lung cancer based on a multicenter prospective cohort.
- Conditions
- Non-small Cell Lung Cancer, Spread Through Air Space, Visceral Pleural Invasion, Lymphovascular Invasion
- Trial name
- NCT05925738
- Testing
- PET/CT-based Deep Learning Signature
- Where
- 3 sites in China
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Shanghai Pulmonary Hospital, Shanghai, China
Splenomegaly, Pleural Effusion
Evaluation of a Pocket-Sized Ultrasound Device As an Aid to the Physical Examination
The 40 resident study subjects will be randomized to either receive a training session on use of a pocket-sized ultrasound or to receive training on physical exam skills.
- Trial name
- NCT01948076
- Testing
- resident with GE vscan
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Acute Respiratory Disease, COPD Exacerbation Acute
Study of Hospitalised Patients With Acute Respiratory Conditions
The goal of this observational study is to learn about the short- and long-term outcomes of people admitted to hospital with an acute respiratory condition, including exacerbations of chronic lung disease, and to understand…
- Conditions
- Acute Respiratory Disease, COPD Exacerbation Acute, Asthma, Pneumonia
- Trial name
- CHESTY (NCT05095090)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Leicester
Mesothelioma, Lung Neoplasms
Chest Wall Motion Analysis in Disease
Breathing movements, called chest wall motion, are very complex. The investigators are studying how movement of the abdomen, ribs and diaphragm contribute to breathing and how this differs with different diseases in the chest.
- Conditions
- Mesothelioma, Lung Neoplasms, Surgery, Cystic Fibrosis
- Trial name
- CWM (NCT02958683)
- Testing
- Chest wall motion analysis
- Where
- United Kingdom
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Heart of England NHS Trust
Solid Tumor, Pleural Effusion
Collection of Pleural Effusion Fluid
At the Laboratory for Molecular and Cellular Therapy (LMCT) of the Vrije Universiteit Brussel, Belgium, we study resistance mechanisms that hamper effective immunotherapy for solid cancer patients.
- Conditions
- Solid Tumor, Pleural Effusion, Metastasis
- Trial name
- NCT05539183
- Testing
- Blood withdrawal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Pneumothorax, Biopsy, Needle
CT-guided Lung Biopsy Risk Optimization Method
The purpose of this randomized controlled study is to evaluate the extent to which injection of a small amount of fluid in the pleural cavity at the biopsy site may reduce the risk of pneumothoraces, in addition to patient…
- Conditions
- Pneumothorax, Biopsy, Needle, Risk Factors, Radiology, Interventional
- Trial name
- BROM-I (NCT06340178)
- Testing
- Fluid application during ct-guided lung biopsy
- Where
- Switzerland
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
The Efficacy of Percutaneous Catheter vs. Open Chest Tube, Traumatic Hemothorax
Multi-center:The Small (14F) Percutaneous Catheter vs. Large (28-40F) Open Chest Tube for Traumatic Hemothorax (P-CAT)
After sustaining severe trauma to the chest, patients will often bleed into the chest cavity (pleural space) which is called hemothorax or they may also experience air leakage within the chest cavity in combination with the…
- Trial name
- P-CAT (NCT03546764)
- Testing
- Percutaneous catheter
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Pleural Effusion, Malignant, Lung Cancer Stage IV
Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion
Malignant pleural effusion (MPE) is a very common medical condition, especially among patients with disseminated cancers. Chest drain insertion aims to drain the pleural fluid collection and relieve dyspnea.
- Conditions
- Pleural Effusion, Malignant, Lung Cancer Stage IV, Chest Tubes
- Trial name
- NCT04669223
- Testing
- Seldinger chest drain insertion
- Where
- Hong Kong
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Pain; Catheter (Other)
The Application of Virtual Reality Goggles During Pleural Catheter Insertion
The aim of this study is to examine the effects of virtual reality glasses applied to individuals who will undergo pleural catheter placement on pain, anxiety, and vital parameters.
- Trial name
- NCT07027917
- Testing
- Virtual Reality Goggles
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pneumothorax
The Development and Experimental Application of a New Thoracostomy Trocar
Traditional closed thoracostomy exhibit certain shortcomings. Blind dissection is a lengthy process that is difficult for unskilled physicians, whereas the use of a traditional trocar is relatively likely to damage internal…
- Trial name
- TDEANTT (NCT02543138)
- Testing
- Trocar
- Where
- South Korea
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Hanyang University
Traumatic Pneumothorax
Pigtail Catheter Versus Chest Tube in the Management of Traumatic Pneumothorax
A small 14-French(F) pigtail catheter (PC) has been shown to work equally well with traditional 32-40F chest tube (CT), especially in traumatic pneumothorax. There are no clinical data on tube-site pain.
- Trial name
- NCT01537289
- Testing
- Pigtail catheter insertion (Cook), chest tube (28-French)
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Pleural Infection, Pleural Adhesions
Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion
The purpose of this study is to compare the clinical and radiological efficacy of chemical pleural adhesiolysis (using either intrapleural 3% hydrogen peroxide or intrapleural corticosteroids) versus mechanical pleural…
- Conditions
- Pleural Infection, Pleural Adhesions, Pleural Effusion, Pleural Empyema
- Trial name
- NCT07713329
- Testing
- Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Pneumothorax, Intestinal Obstruction
The Impact of Artificial Intelligence-Assisted X-ray Interpretation on Radiologists' Diagnostic Performance
This study tests whether an artificial intelligence (AI) tool helps radiologists read X-rays more accurately. Radiologists read X-rays to find diseases such as pneumonia, bone fractures, and abdominal problems.
- Conditions
- Pneumothorax, Intestinal Obstruction, Spondylolysis, Renal Calculus
- Trial name
- NCT07870928
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The Third Affiliated Hospital of Southern Medical University
Pleural Effusion
Not Invasive Monitoring of Pleural Drainage
This study investigates if data about monitoring the drainage of pleural effusion can be collected by non invasive sensors (feasibility).
- Trial name
- NCT01778270
- Testing
- Body Bioimpedance Sensor
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- RWTH Aachen University
Computed Tomography, Biopsy, Pneumothorax, Chest Tube, Plug
Computed Tomography (CT) Guided Lung Biopsy With Plug
Protocol Title: Computed Tomography (CT) Guided Lung Biopsy with BioSentry Plug, Evaluation of Safety and Efficacy.
- Trial name
- NCT03526640
- Testing
- The BioSentry Tract Sealant System
- Where
- Norway
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- University Hospital, Akershus
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Lung Cancer, Pneumothorax
Outpatient Chest Tube Management Following Thoracic Resection Improves Patient Length of Stay and Satisfaction Without Compromising Outcomes
Discharging patients home with air leak and chest tube to portable drainage device after thoracic resection is cost effective and safe without compromising patients outcome or satisfaction.
- Conditions
- Lung Cancer, Pneumothorax, Subcutaneous Emphysema
- Trial name
- NCT01551082
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Alliance of Cardiothoracic and Vascular Surgeons
Pleural Effusion, Tuberculosis, Pleural
TBP Survey Among Respiratory Physicians
Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common…
- Trial name
- NCT06390969
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong