Clinical trials: Pleural Effusion, Malignant
Malignant Pleural Effusion, Indwelling Pleural Catheter
Malignant Pleural Effusions: Evaluating the psYchosocial Impact of Indwelling Pleural Catheters on Patients
The purpose of this study is to better understand the impact that Indwelling Pleural Catheters have on patients with malignant pleural effusions from a psychosocial point of view.
- Trial name
- MY-IPC (NCT05372055)
- Testing
- Semi-structure interviews
- Where
- United Kingdom
- Volunteers
- 18 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Lung Cancer
Pleural Catheters Versus Thoracoscopic Pleurodesis
The goal of this clinical research study is to compare 2 different methods for treating a pleural effusion. Researchers also want to learn how the treatment you receive effects your quality of life (your ability to do the things…
- Trial name
- NCT01117740
- Testing
- MDASI Questionnaire
- Where
- United States
- Volunteers
- 445 people
- Sponsor
- M.D. Anderson Cancer Center
Pleural Effusion, Pleural Effusion, Malignant
Multiple Biomarkers in Undiagnosed Pleural Effusion
The purpose of this clinical trial is to evaluate the ability of various biomarkers measured in serum and/or pleural fluids to estimate the risk of finding cancer in patients with undiagnosed pleural effusions.
- Trial name
- NCT00316134
- Testing
- Procedure/Surgery
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Fujirebio Diagnostics, Inc.
Malignant Mesothelioma, Metastatic Cancer
Video-Assisted Surgery or Talc Pleurodesis in Treating Patients With Malignant Mesothelioma
RATIONALE: Video-assisted surgery to remove part of the tissue layer covering the inside of the chest cavity may be effective in treating pleural effusion and cause less damage to normal tissue.
- Trial name
- MesoVATS (NCT00821860)
- Testing
- talc, therapeutic thoracoscopy, therapeutic videothoracoscopy
- Where
- 5 sites in United Kingdom
- Volunteers
- 196 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
NSCLC
Safety and Efficacy of NK510 to Treat NSCLC
This study assesses the safety and efficacy of NK510 combined with PD-(L)1 inhibitors for relapsed/refractory advanced NSCLC, with two administration routes: intravenous infusion and intrapleural perfusion for malignant pleural…
- Trial name
- NCT06097962
- Testing
- NK510, Tislelizumab，atezolizumab or sugemalimab, systemic therapy as selected by the investigator
- Where
- China
- Volunteers
- 12 people
- Sponsor
- Base Therapeutics (Shanghai) Co., Ltd.
Advanced Solid Tumors, Malignant Pleural Effusions
WSK-IM02 in Advanced Solid Tumors With Malignant Effusions (Phase I)
This is a prospective, single-center, interventional, phase I, dose-escalation, single-arm study designed to evaluate the safety, tolerability, and preliminary efficacy of intrapleural/intraperitoneal infusion of WSK-IM02 in…
- Conditions
- Advanced Solid Tumors, Malignant Pleural Effusions, Malignant Ascites
- Trial name
- NCT07615894
- Testing
- WSK-IM02
- Where
- China
- Volunteers
- 9 people
- Sponsor
- WestVac Biopharma Co., Ltd.
Thoracocentesis of Pleural Effusion
Pleural Manometry in Thoracocentesis
The study aiming to measure the pleural pressure during thoracocentesis in patients with pleural effusion and the value of their measurement in both diagnostic and therapeutic decisions.
- Trial name
- NCT04420663
- Testing
- Pleural Manometry
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aly Sherif Hassaballa
Lung Cancer, Small Cell Lung Cancer
QUILT-2.013: First-Line Treatment for Extensive Stage Small Cell Lung Cancer
This trial is titled "A Phase 1b/2 trial of AMG 479 or AMG 102 with Platinum-Based Chemotherapy as First-Line Treatment for Extensive Stage Small-Cell Lung Cancer (SCLC)." Part 1, the phase 1b portion of this study, is a…
- Conditions
- Lung Cancer, Small Cell Lung Cancer, Solid Tumors, Extensive-stage Small Cell Lung Cancer
- Trial name
- SCLC (NCT00791154)
- Testing
- AMG 479, Etoposide, AMG 102
- Volunteers
- 213 people
- Sponsor
- NantCell, Inc.
Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer
Docetaxel With Either Cetuximab or Bortezomib as First-Line Therapy in Treating Patients With Stage III or Stage IV Non-Small Cell Lung Cancer
This randomized phase II trial is studying how well giving docetaxel together with either cetuximab or bortezomib works as first-line therapy in treating patients with stage III or stage IV non-small cell lung cancer.
- Conditions
- Adenocarcinoma of the Lung, Adenosquamous Cell Lung Cancer, Large Cell Lung Cancer, Malignant Pleural Effusion
- Trial name
- NCT00118183
- Testing
- docetaxel, cetuximab, bortezomib
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Cancer Institute (NCI)
Pleural Effusion, Pleural Diseases
Talc Outpatient Pleurodesis With Indwelling Catheter
This study will be a prospective, randomized trial comparing a new protocol to the standard of care. The investigators protocol and the standard of care involves a previously established procedure that will be completed in the…
- Conditions
- Pleural Effusion, Pleural Diseases, Malignant Pleural Effusion
- Trial name
- TOPIC (NCT03973957)
- Testing
- Indwelling pleural catheter placement, Fentanyl Citrate, Talc Slurry
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System
Malignant Pleural Effusion
A Phase I Study Evaluating SCB-313(Recombinant Human TRAIL-Trimer Fusion Protein) for the Treatment of Malignant Pleural Effusion
To evaluate the safety and tolerability of single dose of SCB-313 by intrapleural injection.To evaluate the safety and tolerability of repeated dose of SCB-313 by intrapleural injection once a day for 3 days, and to determine the…
- Trial name
- NCT04123886
- Testing
- SCB-313
- Where
- China
- Volunteers
- 14 people
- Sponsor
- Sichuan Clover Biopharmaceuticals, Inc.
Malignant Pleural Effusions
A Prospective, Randomized Controlled Trial for a Rapid Pleurodesis Protocol for the Management of Pleural Effusions
Background: Malignant pleural effusions form a significant proportion of respiratory and oncology work-load. The efficacy of thoracoscopic talc poudrage which is the current standard of care is limited by lung entrapment which…
- Trial name
- NCT00758316
- Testing
- Thoracoscopy and Pleurx, Thoracoscopy
- Where
- Singapore
- Volunteers
- 120 people
- Sponsor
- Singapore General Hospital
Fallopian Tube Cancer, Metastatic Cancer
Intraperitoneal vs Intravenous Chemotherapy Following Neoadjuvant Chemotherapy in Ovarian Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel, carboplatin, and cisplatin, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Conditions
- Fallopian Tube Cancer, Metastatic Cancer, Ovarian Cancer, Peritoneal Cavity Cancer
- Trial name
- NCT00993655
- Testing
- carboplatin, cisplatin, paclitaxel
- Where
- 50 sites in United States, Canada and 2 more
- Volunteers
- 275 people
- Sponsor
- Canadian Cancer Trials Group
Malignant Pleural Effusion
Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing.
- Trial name
- NCT06964321
- Testing
- intercostal tube drainage, big tail catheter drainage, ultrasound-guided aspiration
- Volunteers
- 66 people
- Sponsor
- Assiut University
Lung Cancer, Metastatic Cancer
Positron Emission Tomography and Computed Tomography in Planning Treatment for Patients Undergoing 3-Dimensional Conformal Radiation Therapy for Non-Small Cell Lung Cancer That Cannot Be Removed by Surgery. ICORG 06-35
RATIONALE: Diagnostic procedures, such as positron emission tomography and computed tomography, may help learn the extent of disease and allow doctors to plan 3-dimensional conformal radiation therapy.
- Trial name
- NCT00958321
- Testing
- computed tomography, 3-dimensional conformal radiation therapy, fludeoxyglucose F 18
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Cancer Trials Ireland
Pleural Effusion, Malignant
Cisplatin for Malignant Pleural Effusion in Patients With Non-small-cell Lung Cancer
To assess the effect and toxicity of intrapleural administration of hypertonic cisplatin for malignant pleural effusion in patients with non-small-cell lung cancer.
- Trial name
- NCT02407912
- Testing
- cisplatin
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Shantou University Medical College
Pleural Effusion, Malignant, Lung Neoplasms
Management of Malignant Pleural Effusion - Indwelling Pleural Catheter or Talc Pleurodesis
Prospective study of the effect of Talc Pleurodesis vs. Indwelling Pleural catheter in treatment of patients with malignant pleural effusion
- Trial name
- NCT02825095
- Testing
- Talc Pleurodesis, Indwelling Pleural Catheter, chest ultrasound
- Volunteers
- 120 people
- Sponsor
- Rambam Health Care Campus
Non-expandable Lung, Trapped Lung
ARMSTRONG - Air entRainMent vS sTandard tReatment in nOn-expandable luNG
This is a randomised controlled trial evaluating whether controlled air introduction into pleural space (air entrainment) during pleural effusion drainage reduces pain, improves patient satisfaction, and facilitates more…
- Conditions
- Non-expandable Lung, Trapped Lung, Pleural Effusion, Malignant Pleural Effusions (Mpe)
- Trial name
- ARMSTRONG (NCT06959719)
- Testing
- Air Entrainment - intentional introduction of the atmospheric air into the pleural space.
- Where
- United Kingdom
- Volunteers
- 41 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Malignant Pleural Effusions (Mpe), Medical Thoracoscopy
Safety and Feasibility of Medical Thoracoscopy Using Single-use Flexible Bronchoscope Versus SemiRigid Pleuroscope in Pleural Effusion
Pleural effusion is a common problem in hospital patients. It may arise from a wide range of diseases. There is a multitude of recognised causes of pleural effusion, and in addition, other pleural conditions such as pleural…
- Conditions
- Malignant Pleural Effusions (Mpe), Medical Thoracoscopy, Pleural Effusion
- Trial name
- FLEXPLEUR2 (NCT07726784)
- Testing
- Single-Use Flexible Bronchoscope, Semi-Rigid Pleuroscope
- Where
- 2 sites in Malaysia
- Volunteers
- 36 people
- Sponsor
- National University of Malaysia
Pleural Effusion, Pleural Effusion, Malignant
Use of Guidance Videos to Increase Engagement and Decrease Anxiety in Patients Undergoing Pleural Tap
Patients planned to undergo a pleural tap will get verbal explanation or watch a personalized guidance video in addition to verbal explanation.
- Conditions
- Pleural Effusion, Pleural Effusion, Malignant, Pleural Pleurisy Effusion
- Trial name
- NCT04254445
- Testing
- Personalized training video
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- GistMed Ltd.