Clinical trials: Pleural Effusion
COPD, ILD
Validation and Clinical Utility of the Lung Sliding Index (LSI) for Differentiating Pulmonary Diseases
This upcoming case-control study aims to confirm the Lung Sliding Index (LSI), a new ultrasound score that measures how well the pleura moves, in various lung diseases.
- Conditions
- COPD, ILD, Bronchiectasis, Pneumothorax
- Trial name
- NCT06983366
- Testing
- Lung Ultrasound
- Where
- Egypt
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pleural Infection, Pleural Adhesions
Chemical vs Mechanical Pleural Adhesiolysis for Liberation of Captive Pleura in Stacked Effusion
The purpose of this study is to compare the clinical and radiological efficacy of chemical pleural adhesiolysis (using either intrapleural 3% hydrogen peroxide or intrapleural corticosteroids) versus mechanical pleural…
- Conditions
- Pleural Infection, Pleural Adhesions, Pleural Effusion, Pleural Empyema
- Trial name
- NCT07713329
- Testing
- Intrapleural Hydrogen Peroxide (H_2O_2), Intrapleural Corticosteroids, Thoracoscopic Mechanical Pleurolysis
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Delta University for Science and Technology
Cirrhosis of the Liver, Ascites
Ultrasound Assessment of Diaphragmatic Structure and Function in Patients With Liver Cirrhosis: A Point-of-Care Tool for Predicting Complications and Sarcopenia in Limited Resource Settings
The goal of this observational study is to learn how liver cirrhosis affects the diaphragm, the main muscle used for breathing, in adults.
- Conditions
- Cirrhosis of the Liver, Ascites, Pleural Effusion Disorder, Hepatocellular Carcinoma (HCC)
- Trial name
- NCT07667608
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pleural Effusion, Tuberculosis, Pleural
TBP Survey Among Respiratory Physicians
Tuberculosis is a major infectious disease with a high mortality burden in the Asia-Pacific region and worldwide. Among various types of extrapulmonary tuberculosis, tuberculous pleuritis (TBP) is amongst the most common…
- Trial name
- NCT06390969
- Testing
- Survey
- Where
- Hong Kong
- Volunteers
- 418 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications
Driving Pressure During Surgeries With High Risk for Postoperative Pulmonary Complications
The goal of this clinical trial is to compare two different types of perioperative mechanical ventilation (MV), specifically Protective Mechanical Ventilation (PMV) and MV with the lowest possible Driving Pressure (ΔP), in…
- Conditions
- Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complications, Postoperative Respiratory Failure, Postoperative Bronchospasm
- Trial name
- NCT07186933
- Testing
- PEEP titration for Minimum Driving Pressure, Lung Protective Ventilation
- Where
- Greece
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University General Hospital of Patras
Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple
AI Assisted Detection of Chest X-Rays
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Pulmonary Nodules, Solitary, Pulmonary Nodules, Multiple, Pulmonary Consolidation, Pneumothorax
- Trial name
- AID-CXR (NCT06075836)
- Testing
- Cases reading, Ground truthing
- Where
- United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Pleural Effusion, Malignant, Lung Cancer Stage IV
Comparing Different Sizes of Small-bore Chest Drains in Malignant Pleural Effusion
Malignant pleural effusion (MPE) is a very common medical condition, especially among patients with disseminated cancers. Chest drain insertion aims to drain the pleural fluid collection and relieve dyspnea.
- Conditions
- Pleural Effusion, Malignant, Lung Cancer Stage IV, Chest Tubes
- Trial name
- NCT04669223
- Testing
- Seldinger chest drain insertion
- Where
- Hong Kong
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Auscultation, Breathing Sound
Enhancing Respiratory Auscultation Skills Among Medical Students: Digital Stethoscopes in Medical Education
Objectives: This study aims to assess the effectiveness of a novel digital stethoscope curriculum integrated into respiratory auscultation training for medical students.
- Conditions
- Auscultation, Breathing Sound, Asthma, Pneumonia
- Trial name
- NCT06359158
- Testing
- Digital stethoscope use
- Where
- Taiwan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chung Shan Medical University
Atrial Fibrillation, Pericardial Effusion
Active Clearance of Chest Tubes After Cardiac Surgery: A Prospective Randomized Controlled Study
The purpose of this study is to assess the effectiveness of the PleuraFlow® Active Tube Clearance (ATC) technology in reducing the rate of postoperative atrial fibrillation (POAF) among post cardiac surgery patients and to…
- Conditions
- Atrial Fibrillation, Pericardial Effusion, Pleural Effusion, Hemothorax
- Trial name
- NCT02808897
- Testing
- Standard drainage, Active Tube Clearance drainage
- Where
- 2 sites in Canada
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- Montreal Heart Institute
Pneumothorax, Pleural Effusion
Diagnosis and Classification of Pleural Diseases Using Ultrasound Channel Data
Background: The Pleura is a double-layered membrane that surrounds the lungs. Pathological processes that involve the Pleura are called "Pleural diseases".
- Trial name
- NCT04418804
- Testing
- Chest ultrasound
- Where
- Israel
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Israel Aharoni
Pleural Diseases, Pleural Mesothelioma
Prospective Data Collection on Clinical, Radiological and Patient Reported Outcomes After Pleural Intervention
The PROSPECT study aims to look at the number of problems or side effects which occur after patients have had a procedure completed to remove fluid or air from the space between the lung and the chest wall.
- Conditions
- Pleural Diseases, Pleural Mesothelioma, Pneumothorax, Pleural Effusion
- Trial name
- PROSPECT (NCT05910112)
- Testing
- Pleural interventions
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pleural Effusion
Pigtail Catheter for Drainage of (Pneumothorax/Simple Effusion) is a Effective Procedure
Assessment and evaluation of Pigtail application in drainage of pneumothorax and haemothorax.
- Trial name
- pigtail (NCT05641779)
- Testing
- pigtail
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Assiut University
Empyema, Pleural, Parapneumonic Effusion
Management of Pleural Space Infections
Currently, there is no high-quality evidence comparing the clinical outcomes and cost effectiveness of surgical drainage combined with antibiotics versus dual-agent intrapleural fibrinolytic therapy (IPFT) catheter drainage of…
- Trial name
- NCT03873766
- Testing
- Intrapleural Medications, Surgery, Pleural Sampling
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Swedish Medical Center
Solid Tumor, Pleural Effusion
Collection of Pleural Effusion Fluid
At the Laboratory for Molecular and Cellular Therapy (LMCT) of the Vrije Universiteit Brussel, Belgium, we study resistance mechanisms that hamper effective immunotherapy for solid cancer patients.
- Conditions
- Solid Tumor, Pleural Effusion, Metastasis
- Trial name
- NCT05539183
- Testing
- Blood withdrawal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Thoracocentesis of Pleural Effusion
Pleural Manometry in Thoracocentesis
The study aiming to measure the pleural pressure during thoracocentesis in patients with pleural effusion and the value of their measurement in both diagnostic and therapeutic decisions.
- Trial name
- NCT04420663
- Testing
- Pleural Manometry
- Where
- Egypt
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Aly Sherif Hassaballa
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Other Acute Illnesses Presenting to the Hospital, Heart Failure
Evaluation of Implementation of a National Point-of-Care Ultrasound Training Program
This VA QUERI Partnered Evaluation Initiative will evaluate the impact of an immersive Point-of-care Ultrasound (POCUS) Training Course on provider skill acquisition and retention; the frequency of POCUS use by trained providers…
- Conditions
- Other Acute Illnesses Presenting to the Hospital, Heart Failure, Pneumonia, Deep Venous Thrombosis
- Trial name
- NCT03296280
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Pleural Effusion, Cancer, Lung
The Safety and Efficacy of Fibrinolysis in Patients With an Indwelling Pleural Catheter for Multi-loculated Malignant Pleural Effusion.
The safety and efficacy of fibrinolysis in patients with an indwelling pleural catheter for multi-loculated malignant pleural effusion.
- Trial name
- NCT03678090
- Testing
- tPA standard dosage, tPA low dosage
- Volunteers
- healthy volunteers welcome
- Sponsor
- Yale University
Pleural Effusion
Physical Therapy Intervention in Pleural Effusion
To know the effects of a physical therapy intervention in patients hospitalized with pleural effusion. The investigators will study the effects of the intervention in hospital stay, health status, psychologica distress and…
- Trial name
- NCT04294485
- Testing
- Physical therapy
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad de Granada
Pleural Effusion, Pleural Diseases
Talc Outpatient Pleurodesis With Indwelling Catheter
This study will be a prospective, randomized trial comparing a new protocol to the standard of care. The investigators protocol and the standard of care involves a previously established procedure that will be completed in the…
- Conditions
- Pleural Effusion, Pleural Diseases, Malignant Pleural Effusion
- Trial name
- TOPIC (NCT03973957)
- Testing
- Indwelling pleural catheter placement, Fentanyl Citrate, Talc Slurry
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- The Cooper Health System