Clinical trials: Pleural Effusions
Pleural Effusion, Frist Time Indication to Perform a Thoracentesis
Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use of an Augmented Reality Simulator
Monocentric study, aiming to assess the improvement of medical students to perform a first-time thoracentesis after training using a specific training using an augmented virtual reality simulator, versus standard training.
- Conditions
- Pleural Effusion, Frist Time Indication to Perform a Thoracentesis, Medical Student Training
- Trial name
- ARPEGES (NCT05960747)
- Testing
- Simulation group
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Strasbourg, France
Renal Cell Cancer Metastatic, Non-small Cell Lung Cancer Metastatic
Intrapleural Instillation of the Nivolumab in Cancer Patients With Pleural Effusion.
Patients with advanced cancers who have pleural effusion, especially those requiring pleural evacuation, experienced poorer survival when treated with immunotherapy.
- Conditions
- Renal Cell Cancer Metastatic, Non-small Cell Lung Cancer Metastatic, Pleural Effusion, Malignant
- Trial name
- NCT04749602
- Testing
- Nivolumab
- Where
- 5 sites in Russia
- Volunteers
- 26 people
- Sponsor
- Kidney Cancer Research Bureau
Heart Disease, Pleural Effusion
Pleural and Pericardial Effusion Following Open Heart Surgery
One of the most common postoperative complications after open cardiac surgery is fluid accumulation between the pleural membranes or in the pericardial sac.
- Conditions
- Heart Disease, Pleural Effusion, Pericardial Effusion
- Trial name
- IMAGING (NCT02045641)
- Testing
- pleuracentesis
- Where
- Denmark
- Volunteers
- 76 people
- Sponsor
- Aarhus University Hospital Skejby
Pleural Infection
Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE)
Objectives: A pilot study to assess the feasibility of a randomization trial protocol comparing low (2.5mg) and standard (10mg) doses of intrapleural tissue plasminogen activator (tPA) with deoxyribonucleases (DNase) in…
- Trial name
- NCT05766124
- Testing
- Tissue Plasminogen Activator
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- Chinese University of Hong Kong
Pleural Effusion, Malignant
Relationship Between Pleural Elastance and Effectiveness of Pleurodesis on Recurrent Malignant Pleural Effusion
The objective of this study is to analyze the correlation between pleural elastance and the radiological effectiveness (measured by chest tomography) of pleurodesis performed via catheters in patients with RMPE.
- Trial name
- NCT01819363
- Testing
- Pleural elastance
- Where
- Brazil
- Volunteers
- 140 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Critical Illness, Cardiac Complication
The INSIGHT Feasibility Study Ultrasound in the Intensive Care Unit: A Randomised Controlled Feasibility Trial
Point-of-care ultrasound (PoCUS) is a rapidly evolving method of clinical assessment within the intensive care unit (ICU) with training predominantly aimed at physicians.
- Conditions
- Critical Illness, Cardiac Complication, Pleural Effusion, Consolidation
- Trial name
- INSIGHT (NCT05569798)
- Testing
- Whole body point of care ultrasound scan
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- King's College Hospital NHS Trust
Cancer
Intrapleural BG00001 in Treating Patients With Malignant Pleural Mesothelioma or Malignant Pleural Effusions
RATIONALE: Using BG00001 to insert the gene for interferon-beta into a person's pleural cavity may improve the body's ability to fight cancer.
- Trial name
- NCT00066404
- Testing
- recombinant adenovirus-hIFN-beta
- Where
- United States
- Sponsor
- Abramson Cancer Center at Penn Medicine
Effusion
Neutrophil-to Lymphocyte and Monocyte-to-Lymphocyte Ratios in Exudative Pleural Effusion
Exudative pleural effusion (EPE) presents a diagnostic challenge, requiring accurate biomarkers to predict outcomes and guide treatment.
- Trial name
- NCT07003204
- Testing
- medical thoracoscopy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Pleural Effusion, Malignant, Prognosis
Longitudinal Follow up of Patients With Pleural Effusion
This study aims to evaluate the clinical course of patients diagnosed with pleural effusion and determine various clinical factors and biomarkers associated that can predict the diagnosis and clinical outcome and prognosis of…
- Trial name
- NCT04670562
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Seoul National University Bundang Hospital
Pleural Effusion, Malignant
Safety Profile of Iodopovidone as an Agent for Pleurodesis in Malignant Pleural Effusion
Iodopovidone is safe when using as a pleurodesis sclerosing agent for malignant pleural effusion, with minimal adverse events, especially reducing dose.
- Trial name
- NCT01670786
- Testing
- pleurodesis
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Grupo de Pesquisa em Pleura e Oncologia Toracica
Pleural Effusion
Tenecteplase (TNK) for Loculated Pleural Effusions in Patients With Malignancy
The objective of the study is to determine the safety and efficacy of TNK infusion for the treatment of loculated pleural effusions in patients with known malignancy compared to normal saline infusion.
- Trial name
- NCT01580618
- Testing
- normal saline, TNK (Tenecteplase)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Kaiser Permanente
Pleural Diseases
Rigid Versus Semirigid Thoracoscopy in Diagnosing Pleural Diseases: a Randomized Study
The purpose of our study was to compare the size and the quality of biopsy samples together with the diagnostic adequacy of semirigid thoracoscopy with that of rigid instrument in prospective, randomized fashion.
- Trial name
- NCT01366261
- Testing
- semirigid thoracoscopy, rigid thoracoscopy
- Where
- Slovenia
- Volunteers
- 84 people
- Sponsor
- Aleš Rozman
Pleural Effusion, Malignant, Pleural Effusion
A Randomised Study Evaluating Diagnostics of Pleural Effusion Among Patients Suspect of Cancer.
Pleural fluid can be caused by cancer. Patients with repeated presentation of pleural fluid where initial diagnostic tests have been inconclusive are the focus of this trial.
- Conditions
- Pleural Effusion, Malignant, Pleural Effusion, Pleura; Exudate
- Trial name
- NCT04233359
- Testing
- Local anesthetic thoracoscopy, US-guided pleural biopsy
- Where
- 2 sites in Denmark
- Volunteers
- 4 people
- Sponsor
- Naestved Hospital
Pleural Effusion, Pneumothorax
Thoracic Drains in Intensive Care Units: Comparison of Seldinger and Surgical Methods
This prospective randomized multicenter study is intended to investigate tolerance and effectiveness of thoracic drainage conducted by Seldinger technique with small drains, or by a surgical-like technique with large armed…
- Conditions
- Pleural Effusion, Pneumothorax, Hemothorax
- Trial name
- DrainICU (NCT04438317)
- Testing
- Pleural drainage procedure with Seldinger procedure, Pleural drainage procedure with surgical-like technique
- Where
- France
- Volunteers
- 227 people
- Sponsor
- University Hospital, Clermont-Ferrand
Pleural Effusion
Use of the Triggering Receptor Expressed on Myeloid Cells-1 (TREM-1) in the Diagnosis of Pleural Effusion
The aim of this trial is to evaluate the level of TREM-1 in different kinds of pleural effusion.
- Trial name
- NCT00166894
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Pleural Effusion, Malignant, Pleural Mesothelioma
A Comparative Study Between Regional Anesthesia in Thoracoscopes and the Conventional General Anesthesia
Video-assisted thoracic surgery (VATS) is usually performed with general anesthesia and single lung ventilation. However, performing thoracic surgery under awake regional anesthesia has several potential advantages including…
- Conditions
- Pleural Effusion, Malignant, Pleural Mesothelioma, Pleural Empyema, Pulmonary Diseases or Conditions
- Trial name
- VATS (NCT05077111)
- Testing
- Thoracic Epidural Anesthesia, General Anesthesia with One Lung Ventilation
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mohamed Reda Ashour
Malignant Pleural Effusion, Respiratory Disease
AMPLE-3: IPC Plus Talc vs VATS in Management of Malignant Pleural Effusion
The purpose of this study is to determine if an indwelling catheter is more effective than surgical pleurodosis in treating malignant pleural effusion.
- Conditions
- Malignant Pleural Effusion, Respiratory Disease, Cancer
- Trial name
- AMPLE-3 (NCT04322136)
- Testing
- Pleurodesis via Video-assisted thoracoscopic surgery, Indwelling pleural catheter (with talc pleurodesis if suitable)
- Where
- Australia
- Volunteers
- 158 people
- Sponsor
- The University of Western Australia
Pleural Effusion
Using Pleural Effusions to Diagnose Cancer
Pleural effusions (PE) are common conditions that signal either infection or cancer. The investigators aim to develop, validate, and prospectively assess the MAPED score, a clinical score that predicts malignancy at admission.
- Trial name
- MAPED (NCT03319472)
- Where
- Greece
- Volunteers
- 439 people
- Sponsor
- University of Patras
Suspected Malignant Lung Neoplasm, Pleural Effusion
First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.
Non randomized study with two groups. The study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by Local Anesthesia Thoracoscopy…
- Conditions
- Suspected Malignant Lung Neoplasm, Pleural Effusion, Pleural Effusion, Malignant, Mesothelioma, Malignant
- Trial name
- FLAT (NCT06946498)
- Testing
- Local Anesthesia Thoracoscopy, Pleuroscopy with Rigid Thoracoscope and Forceps biopsies
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Malignant Pleural Effusion, Malignancy
Feasibility of Ambulatory Talc. Pleurodesis
Patients with malignant pleural disease often experience a significant symptom burden and a short life expectancy. The cornerstone of their treatment is relieving breathlessness by draining fluid from around the lungs and…
- Conditions
- Malignant Pleural Effusion, Malignancy, Palliative Care
- Trial name
- NCT06682936
- Testing
- ambulatory chest drain and talc pleurodesis
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- David Rollins