Clinical trials: Pleural Effusions, open to volunteers
Malignant Pleural Effusions (Mpe)
A Phase II Study to Evaluate JMKX000197 Injection Versus Cisplatin in the Treatment of Malignant Pleural Effusion
This study aims to evaluate the efficacy and safety of intrapleural JMKX000197 compared with intrapleural cisplatin in patients with malignant pleural effusion.
- Trial name
- NCT07649369
- Testing
- JMKX000197, Cisplatin
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Shanghai Jeyou Pharmaceutical Co., Ltd.
Peritoneal Dialysis, Peritoneal Dialysis (PD)
Iodine Starch Test Use in Pleuroperitoneal Leak
This is a study to see how a simple test can be used to check if fluid in the chest cavity contains starch. Some people with kidney failure have dialysis treatment by putting fluid in the tummy cavity, and sometimes the fluid can…
- Conditions
- Peritoneal Dialysis, Peritoneal Dialysis (PD), Pleural Cavity Effusion, Hydrothorax
- Trial name
- PIT-PLPD (NCT07857564)
- Testing
- Iodine tincture
- Volunteers
- 30 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Lung Cancer (NSCLC), Malignant Pleural Effusions (Mpe)- Pleurodesis
Furmonertinib Plus Radiotherapy for EGFR+ NSCLC With Pleural Effusion
This study is designed as a prospective, multi-center investigation to explore the efficacy and safety of furmonertinib combined with upfront thoracic radiotherapy with or without metastatic lesion radiotherapy in subjects with…
- Trial name
- NCT07482605
- Testing
- Furmonertinib, Thoracic Radiotherapy (TRT)
- Volunteers
- 63 people
- Sponsor
- Jiangmen Central Hospital
Malignant Pleural Effusion
Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion
Pleural effusion is common in different diseases and especially malignant effusions can have fast onset symptoms such as chest pain, dyspnoea, and coughing.
- Trial name
- NCT06964321
- Testing
- intercostal tube drainage, big tail catheter drainage, ultrasound-guided aspiration
- Volunteers
- 66 people
- Sponsor
- Assiut University
Lung Cancer, Non-Small Cell
A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC
This is a phase II study. All patients are stage IV non-squamas non-small cell lung cancer(NSCLC) with malignant pleura effusion, Eastern Cooperative Oncology Group (ECOG) performance status 0-2.
- Trial name
- NCT06769295
- Testing
- AK112
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Sichuan University
Tuberculous Pleural Effusion
Efficacy and Safety of Intrapleural Fibrinolytic Therapy in Tuberculous Pleural Effusion Versus Non-Tuberculous Pleural Infection
This retrospective cohort study evaluates the efficacy and safety of intrapleural fibrinolytic therapy (tPA/DNase) in patients with tuberculous pleural effusion compared with non-tuberculous pleural infection at Hospital Canselor…
- Trial name
- FIB-TB (NCT07823075)
- Testing
- Intrapleural Fibrinolytic Therapy (IPFT)
- Where
- Malaysia
- Volunteers
- 160 people
- Sponsor
- National University of Malaysia
Pleural Infection
Pleural Space Saline Irrigation in Addition to Standard Intrapleural Thrombolytic Therapy in Empyema/Complicated Parapneumonic Effusion
The purpose of this study is to see if there is any benefit in adding saline irrigation through a chest tube to the standard course of treatment for people diagnosed or suspected of having a pleural space infection.
- Trial name
- NCT06434324
- Testing
- Saline Irrigation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Lung Adenocarcinoma, Malignant Pleural Effusions (Mpe)
Ex Vivo Drug Response Profiling and Outcome Prediction in Lung Adenocarcinoma
This observational study evaluates if ex-vivo lung cancer drug sensitivity testing results correlate with the driver mutations found by genetic sequencing and if it can predict treatment response.
- Trial name
- NCT07636252
- Testing
- Non-Interventional Study
- Where
- Israel
- Volunteers
- 400 people
- Sponsor
- Sheba Medical Center
Suspected Malignant Lung Neoplasm, Pleural Effusion
First Local Anaesthesia Thoracoscopy for Pleural Effusion Diagnosis.
Non randomized study with two groups. The study group includes patients with suspected malignant pleural effusion, in whom the investigation of pleural effusion begins directly with pleural biopsy by Local Anesthesia Thoracoscopy…
- Conditions
- Suspected Malignant Lung Neoplasm, Pleural Effusion, Pleural Effusion, Malignant, Mesothelioma, Malignant
- Trial name
- FLAT (NCT06946498)
- Testing
- Local Anesthesia Thoracoscopy, Pleuroscopy with Rigid Thoracoscope and Forceps biopsies
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- National and Kapodistrian University of Athens
Pneumonia, Pleural Effusion
Pneumonia and Pleuropneumonia in Hospitalized Children
Describe the epidemiology of hospitalized pediatric pneumonia and pleuropneumonia with pleural effusion: frequency, clinical and biological characteristics, responsible bacteria and pneumococcus place, antibiotic resistance…
- Trial name
- NCT05274607
- Where
- France
- Volunteers
- 20,000 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
Pleural Effusion, Frist Time Indication to Perform a Thoracentesis
Improvement to Perform Thoracocentesis After a Specific Training in Medical Students With the Supervised Use of an Augmented Reality Simulator
Monocentric study, aiming to assess the improvement of medical students to perform a first-time thoracentesis after training using a specific training using an augmented virtual reality simulator, versus standard training.
- Conditions
- Pleural Effusion, Frist Time Indication to Perform a Thoracentesis, Medical Student Training
- Trial name
- ARPEGES (NCT05960747)
- Testing
- Simulation group
- Where
- 2 sites in France
- Volunteers
- 340 people
- Sponsor
- University Hospital, Strasbourg, France
Malignant Pleural Effusion, Non-small Cell Lung Cancer
Oncodrivers in Malignant Pleural Effusions Associated With Non-small Cell Lung Cancer: A Prospective Study.
Oncological treatment of patients with disseminated non-small cell lung cancer (NSCLC) is depending on the status of programmed death-ligand 1 (PD-L1), anaplastic lymphoma kinase (ALK) and epidermal growth factor receptor (EGFR)…
- Trial name
- NCT04806412
- Testing
- meassurement of PD-L1, ALK, EGFR
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Naestved Hospital
Pleural Diseases, Pleural Effusion
Confocal Laser Endomicroscopy Guided Medical Thoracoscopy for the Diagnosis of Pleural Disease
A prospective multicenter randomized controlled trial was conducted to evaluate the efficacy and safety of thoracoscopic biopsy guided by confocal optical real-time microscopic imaging (nCLE) in the diagnosis of fibrinal pleurisy…
- Trial name
- NCT06741839
- Testing
- Confocal laser endomicroscopy guided pleural biopsy using medical thoracoscopy, Plerual biopsy using medical thoracoscopy
- Where
- China
- Volunteers
- 158 people
- Sponsor
- China-Japan Friendship Hospital
Complicated Pleural Effusion/ Empyema
Effectiveness and Safety of Sodium Bicarbonate Pleural Lavage in the Treatment of Complex Pleural Effusion
The goal of this clinical trial is to evaluate the safety and efficacy of sodium bicarbonate pleural lavage in treating complex pleural effusion in adult.
- Trial name
- SAPLIC (NCT06734481)
- Testing
- Sodium bicarbonate pleural lavage, Saline pleural lavage
- Where
- China
- Volunteers
- 260 people
- Sponsor
- First Affiliated Hospital of Ningbo University
Advanced Malignant Solid Tumor, Malignant Pleural Effusion
A Study of MT027 in Patients with Pleural Malignant Tumors
This is a phase I open label, single-arm, dose-escalation study to evaluate the feasibility, safety, tolerability, PK/PD, and to determine RP2D of MT027 via an locoregional delivery in subjects with pleural malignant tumors, who…
- Conditions
- Advanced Malignant Solid Tumor, Malignant Pleural Effusion, Pleura Carcinoma, Pleural Mesothelioma
- Trial name
- NCT06726564
- Testing
- MT027 cells suspension
- Where
- China
- Volunteers
- 18 people
- Sponsor
- Suzhou Maximum Bio-tech Co., Ltd.