Clinical trials: Pneumonia; Pulmonary Infection
COVID-19, Vaccination Hesitancy
An Online Game to Help Canadian Adults Identify COVID-19 Vaccine Misinformation With One-Month Follow-Up
COVID-19 vaccine misinformation contributed to vaccine hesitancy and preventable illness. This study tested whether a brief online game helps Canadian adults identify COVID-19 vaccine misinformation, and whether effects last one…
- Conditions
- COVID-19, Vaccination Hesitancy, Health Misinformation, Communication
- Trial name
- NCT07758296
- Testing
- Gamified misinformation refutation quiz, Refutational text blog post (active control)
- Where
- United States
- Volunteers
- 4,071 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Covid-19
CPI-006 Plus Standard of Care Versus Placebo Plus Standard of Care in Mild to Moderately Symptomatic Hospitalized Covid-19 Patients
This is a phase 3, randomized, placebo controlled, double-blind, multicenter, stratified study of CPI-006 plus standard of care (SOC) versus placebo plus SOC in mild to moderately symptomatic hospitalized Covid-19 patients with…
- Trial name
- NCT04734873
- Testing
- CPI-006 2 mg/kg + SOC, CPI-006 1 mg/kg + SOC
- Where
- 91 sites in United States, Argentina and 10 more
- Volunteers
- 46 people
- Sponsor
- Corvus Pharmaceuticals, Inc.
COVID - 19, Long COVID Syndrome
Dapagliflozin for Long COVID Syndrome
This is a randomized, placebo-controlled study. Patients with long COVID will be randomized to receive dapagliflozin or placebo for 12 months.
- Conditions
- COVID - 19, Long COVID Syndrome, SARS CoV-2
- Trial name
- DALCO (NCT06907251)
- Testing
- Dapagliflozin (DAPA)
- Where
- Canada
- Volunteers
- 192 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Post Acute COVID-19 Syndrome
Digital Health Intervention Based on Artificial Intelligence to Support the Personalized Recovery of Long COVID Patients Affected by Fatigue (AIDA)
The AIDA feasibility study builds upon mental health and technology acceptance theoretical frameworks. It examines the feasibility of a mobile-based digital program to support patients with long covid affected by fatigue.
- Trial name
- AIDA (NCT05483829)
- Testing
- Adhera® Fatigue for Long COVID program
- Where
- Spain
- Volunteers
- 15 people
- Sponsor
- Adhera Health, Inc.
COVID-19
Vitamin D Supplementation and Clinical Improvement in COVID-19
Background and objective Vitamin D is important as the interaction between vitamin D and its receptors at the immune cells stimulates innate and adaptive immunity.
- Trial name
- NCT05126602
- Testing
- Vitamin D3 10000 IU, Vitamin D3 1000 IU
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Bumi Herman
Parkinson Disease, COVID-19
Effect of Remote Cognitive Intervention in Patients With Parkinson's Disease During the COVID-19 Pandemic
Retrospective study to evaluate the effect of a remote cognitive-rehabilitative intervention during the Covid outbreak in subjects with Parkinson's disease.
- Conditions
- Parkinson Disease, COVID-19, Mild Cognitive Impairment
- Trial name
- TELEPARK (NCT05476302)
- Testing
- Cognitive digital treatment
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- Istituto Nazionale di Ricovero e Cura per Anziani
Volume Outcome Relationship Among COVID-19 Inpatients in US Hospitals
Hospital COVID-19 Surge and Associated Mortality Risk
A retrospective cohort study will be conducted using a large administrative database of U.S. hospitals to understand the volume-outcome relationship among patients hospitalized with COVID-19.
- Trial name
- NCT04688372
- Testing
- Surge Index
- Where
- United States
- Volunteers
- 144,116 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Respiratory Symptoms, Autonomic Nervous System Dysfunction
CoVID-19 Evaluation of Neurological and Autonomic Nervous System Troubles in Intensive Care Unit Patients
Since the spread of the COVID-19 disease, several studies have reported the presence of neurological symptoms in patients infected with SARS-CoV-2 such as dysgeusia, hypo or anosmia, hypopsia, the presence of headaches or…
- Trial name
- COVENANT-ICU (NCT06060795)
- Testing
- Electro-conductance measurement
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier St Anne
COVID-19
VA CoronavirUs Research and Efficacy Studies-1
The purpose of this study is to determine if treatment with convalescent plasma improves the clinical outcomes of Veterans who are hospitalized and require supplemental oxygen due to COVID-19.
- Trial name
- VACURES-1 (NCT04539275)
- Testing
- Convalescent Plasma
- Where
- 24 sites in United States, Puerto Rico
- Volunteers
- 75 people
- Sponsor
- VA Office of Research and Development
Pneumonia
Innovative Treatments in Pneumonia (ITIP) 3
This is a prospective observational study assessing the clinical outcomes of children 2 to 59 months of age with both pneumonia and other co-morbidities presenting to a tertiary hospital outpatient setting in Malawi, Africa who…
- Trial name
- NCT02960919
- Testing
- oral amoxicillin or parenteral ampicillin/ penicillin and gentamicin, parenteral ampicillin/ penicillin, gentamicin
- Where
- 2 sites in Malawi
- Volunteers
- 1,001 people
- Sponsor
- Save the Children
Covid19
Intravenous Immunoglobulins for the Treatment of Covid-19 Patients: a Clinical Trial
The current project is based on the immunological studies covering the potential of disease induced immunoglobulins as treatment regime.
- Trial name
- NCT04548557
- Testing
- intravenous immunoglobulin therapy
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Health Sciences Lahore
COVID-19 Pandemic, Quality of Life
Comparison of Quality of Life After Discharge of the Mild and Moderate COVID-19 Patients With or Without Herbal Medicine
The purpose of this study is to see how the acute stage COVID-19 treatments by use of herbal medicine (Shen Cao Gan Jiang Tang) affect quality of life and symptoms at 3 months after hospital discharge.
- Trial name
- NCT05228873
- Testing
- Shen Cao Gan Jiang Tang (Gan Cao Gan Jiang Tang with Ginseng)
- Where
- Vietnam
- Volunteers
- 300 people
- Sponsor
- University of Medicine and Pharmacy at Ho Chi Minh City
Ventilator Associated Pneumonia
Diagnostic Stewardship for Ventilator Associated Pneumonia
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for patients who have respiratory…
- Trial name
- NCT05989269
- Testing
- Modified lab reporting
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- University of Maryland, Baltimore
COVID-19, Dysglycemia
Can Intensive Insulin Therapy Improve Outcomes of COVID-19 Patients
Evaluation of the reciprocal relation between hyperglycemia/diabetes mellitus (HG/DM) and COVID-19 disease and the effect of mode of insulin therapy; intensive (IIT) or conventional (CIT) on patients' outcomes All patients…
- Trial name
- NCT05441631
- Testing
- Insulin, Subcutaneous Insulin
- Where
- Egypt
- Volunteers
- 436 people
- Sponsor
- Benha University
Field Hospitals, COVID-19 Pandemic
Health System Dynamic & Resource Requirement in a South African COVID-19 Field Hospital
The aim of this study is to describe the patient clinical profile, resource requirements, and health system dynamics in a field hospital during the second wave of the Coronavirus (COVID-19) pandemic, leading to the outbreak of…
- Conditions
- Field Hospitals, COVID-19 Pandemic, Health Systems, Global Health
- Trial name
- NCT05113875
- Where
- South Africa
- Volunteers
- 596 people
- Sponsor
- University of Cape Town
Extreme Prematurity, Covid19
Extremely Premature Births During the Peak of the COVID-19 Pandemic: an International Study of the Active SafeBoosC III Departments
This is a retrospective, observational study based on the consortium of the SafeBoosC-III randomised clinical trial. This study will evaluate if the number of admitted extremely preterm infants has decreased in the SafeBoosC-III…
- Trial name
- NCT04527601
- Where
- Denmark
- Volunteers
- 885 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Community-acquired Pneumonia
Duration of Antibiotic Treatment in Community-acquired Pneumonia
International and national clinical guidelines recommend short antibiotic regimens in patients with non-severe community-acquired pneumonia (CAP) who have reached clinical stability.
- Trial name
- ADAPT (NCT05762328)
- Testing
- Reminders to the assistant clinicians of the need to adhere to clinical guidelines regarding the duration of antibiotic treatment community-acquired pneumonia
- Where
- Spain
- Volunteers
- 2,000 people
- Sponsor
- Instituto de Investigacion Sanitaria La Fe
Respiration, Artificial, COVID-19
Healthcare-associated Infections in Severe COVID-19 During 2020
In patients who develop ARDS due to SARS-CoV-2 (CARDS), a longer duration of invasive mechanical ventilation (IMV) and ICU stay has been reported compared to ARDS not associated with SARS-CoV-2.
- Conditions
- Respiration, Artificial, COVID-19, Health Care Associated Infection
- Trial name
- COVIACS (NCT04819165)
- Testing
- COVID-19
- Where
- Argentina
- Volunteers
- 252 people
- Sponsor
- Sanatorio Anchorena San Martin
Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients
Pulmonary Microbiota Changes and Clinical Outcomes in Neurosurgical ICU Patients With Artificial Airways
After neurosurgery, many patients need to stay in the intensive care unit (ICU) and use a breathing machine (mechanical ventilation) because of issues like decreased consciousness, weak breathing, or poor airway protection.
- Conditions
- Ventilator-Associated Pneumonia (VAP), Intensive Care Unit (ICU) Patients, Microbiome Dysbiosis
- Trial name
- NCT07129174
- Where
- 3 sites in China
- Volunteers
- 220 people
- Sponsor
- Jian-Xin Zhou
COVID-19, COVID-19 Pneumonia
Self-proning and Repositioning in COVID-19 Outpatients at Risk of Complicated Illness
The rapid development of safe and effective COVID-19 treatment is a global health priority. Numerous studies evaluating therapies for this disease are currently underway, but the majority of these are in hospitalized patients…
- Conditions
- COVID-19, COVID-19 Pneumonia, Proning, Hospitalization
- Trial name
- NCT05518474
- Testing
- Self-proning
- Where
- Canada
- Volunteers
- 11 people
- Sponsor
- Unity Health Toronto
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