Clinical trials: Poisoning
Organophosphate Poisoning
The Use of Self-reported Symptoms as a Proxy for Acute Organophosphate Poisoning Among Nepali Farmers
The purpose of this study is to evaluate self-reported symptoms as a proxy for acute organophosphate poisoning by examining self-reported acute organophosphate poisoning symptoms and PchE activity in response to occupational…
- Trial name
- NCT02838303
- Testing
- Organophosphate
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Anesthesia, Local, Block
Suprainguinal Fascia Iliaca Compartment Block in Direct Anterior Approach to Total Hip Arthroplasty
The goal of this study is to determine whether or not a suprainguinal fascia iliaca compartment nerve block is effective at improving postoperative pain control in patients receiving an anterior approach hip replacement surgery.
- Trial name
- NCT05237479
- Testing
- Suprainguinal fascia ilica block
- Volunteers
- healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Leishmaniasis, Cutaneous Leishmaniases
A Clinical Study to Develop a Controlled Human Infection Model Using Leishmania Major-infected Sand Flies
The disease leishmaniasis mainly occurs in hot and tropical countries, affects millions of people and causes around 20,000 deaths across the world every year.
- Conditions
- Leishmaniasis, Cutaneous Leishmaniases, Insect Bites
- Trial name
- LEISHChallenge (NCT04512742)
- Testing
- biting by Phlebotomus duboscqi infected with Leishmania major
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of York
Aflatoxicosis
Evaluation of ACCS100 to Reduce Aflatoxin Exposure in Kenya
The purpose of this study is to pilot test the effectiveness, acceptability, and palatability of ACCS100 in a high-risk Kenyan population.
- Trial name
- ACCS100 (NCT02188953)
- Testing
- ACCS100
- Where
- Kenya
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kenya Medical Research Institute
Malnutrition, Manihot Species Poisoning
Caregiver Training to Prevent Konzo Disease in Children in Democratic Republic of Congo (DRC)
The proposed research adapted the caregiver training and child neurodevelopmental assessment capacity that the PI previously built in Uganda beginning in 2008, to a community-based intervention model for the prevention of konzo…
- Trial name
- NCT04036708
- Testing
- Wetting method (WTM), Mediational Intervention for Sensitizing Caregivers (MISC)
- Where
- Democratic Republic of the Congo
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Ricin Poisoning
IM Recombinant Ricin Toxin Vaccine (RVEc) - 3-Dose Primary Series With Boost
This study seeks to determine the safety and immunogenicity of a series of 3 primary vaccinations and a booster vaccination of Recombinant ricin toxin A-chain 1-33/44-198 (rRTA 1-33/44-198) vaccine (RVEc) at 10, 50, or 75 μg IM.
- Trial name
- NCT02385825
- Testing
- RVEc
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Postoperative Pain
The Effect of Different Obturation Techniques on Postobturation Pain in Single-Visit Root Canal Treatment
The goal of this prospective clinical randomized study is to evaluate the effect of different obturation techniques on postobturation pain in single-visit root canal treatment in 18-60 years old patient who present no systemic…
- Trial name
- NCT06146894
- Testing
- Single obturation technique (Bioceramic Sealer), lateral condensation technique (Bioceramic Sealer), Warm Vertical condensation technique (Bioceramic Sealer)
- Where
- Egypt
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University
Fluorosis, Dental, Fluorosis
Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine
Introduction Systemic exposure to fluoride is a significant challenge for global public health; this is because although fluoride prevents dental caries, prolonged exposure to high concentrations can cause adverse effects on…
- Trial name
- NCT07232888
- Testing
- multicomponent intervention, Conventional intervention
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio Nariño
Organophosphate Poisoning
Farming, Personal Protective Equipment, Nepal
According to the World Health Organization pesticide poisoning is a major health problem due to the millions of cases annually occurring worldwide.
- Trial name
- NCT02137317
- Testing
- LAPPE (locally adapted personal protective equipment)
- Where
- Nepal
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Neutrophil, Phyllanthus Abnormis Poisoning
To Exam the Effects of Phyllanthus Niruri Extracts on Human Neutrophils
To exam the effects of Phyllanthus niruri extracts(corilagin, phyllanthin and brevifolin) on human neutrophils
- Trial name
- NCT05206058
- Testing
- venipuncture
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency
Pharmacokinetics of Nebulized Amikacin in Non Invasive Ventilated Healthy Volunteers.
The purpose of the study is to compare the pharmacokinetics of nebulized amikacin administered with three vibrating mesh nebulizers coupled with a single limb circuit bilevel ventilator in healthy volunteers.
- Conditions
- Acute Respiratory Insufficiency, Chronic Respiratory Insufficiency, Bronchospasm and Obstruction
- Trial name
- NIV-NEBU (NCT01901497)
- Testing
- Nebulizer
- Where
- Belgium
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University Hospital St Luc, Brussels
Organophosphorus Poisoning
A Study of Inhaled Atropine Sulfate in Healthy Adults
MicroDose Defense Products, LLC is developing an atropine dry powder inhaler (ADPI). This pilot study compares the pharmacokinetics (PK) of inhaled dry powder atropine as delivered by the ADPI to atropine delivery from the…
- Trial name
- NCT00947596
- Testing
- atropine sulfate
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- MicroDose Defense Products L.L.C.
Atelectasis, Block
Effect Posterior QLB on Atelectasis
We aimed to investigate the effect of posterior quadratus lumborum block on postoperative atelectasis in inguinal hernia surgery in pediatric patients.
- Conditions
- Atelectasis, Block, Pediatrics, Quadratus Lumborum Block
- Trial name
- NCT04830280
- Testing
- posterior quadratus lumborum block
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Diquat Poisoning
The Correlation Between the Metabolism and the Functional Status of Multiple Organs in the Early Stage of Diquat Poisoning
Diquat (DQ), as a conductive biocidal herbicide, is classified as medium according to Chinese pesticide toxicity classification standards.
- Trial name
- NCT05168111
- Testing
- Detect the serum sample
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Lead Poisoning
Exposure, Dose, Body Burden and Health Effects of Lead
This is a study of the effects that lead has on the health of the central nervous system (for example, memory), peripheral nervous system (for example, sensation and strength in the hands and fingers), kidneys, blood pressure…
- Trial name
- NCT00013819
- Volunteers
- 944 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Tick Bites, Tick Resistance
Acquired Tick Resistance in Naturally Exposed Participants
Tick-borne diseases are increasing worldwide, and there are currently few effective ways to prevent them. One promising new strategy is to develop a vaccine that targets the tick itself ("anti-tick vaccine") to block the…
- Trial name
- TICK REACT (NCT07479537)
- Testing
- Tick challenge
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Nitrogen Narcosis, Inner Ear Decompression Illness
The Effect of Nitrogen Narcosis on Motor Performance in Divers Who Have Sustained an Inner Ear Decompression Illness
Nitrogen starts to have narcotic properties depths below 30m and can cause symptoms such as euphoria, impaired judgement and impaired neuromuscular coordination.
- Trial name
- NCT07446348
- Testing
- Nitrogen-oxygen breathing mixture
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Plymouth
Jaw Tracking, Occlusion
Evaluation of the Impact of Integrating Dynamic Patient-Specific Motion and Implementing a Jaw Tracking System in the Attribution of the Occlusion in Full-Arch Restorations Through a Digital Workflow: A Clinical Study
The maxillomandibular relationship of diagnostic and definitive casts is a fundamental procedure in prosthodontics. Depending on the prosthodontic treatment involvement, different maxillomandibular relationship records can be…
- Trial name
- NCT06773728
- Testing
- Record occlusal contacts, Tracking of jaw movement
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Mercury Poisoning, Lead Poisoning
Environmental Contaminants and Infant Development
This study is designed to examine the effects of prenatal exposure to environmental contaminants on cognitive and behavioral development and physical growth in two groups of Inuit infants-one in Northern Quebec; the other in…
- Trial name
- NCT00013858
- Where
- Canada
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Postoperative Cognitive Dysfunction, Delirium
Peri-Anesthetic Imaging of Cognitive Dysfunction
Recent data suggests that anesthetics can have prolonged effects on gene expression, protein synthesis and processing as well as cellular function in ways that the investigators are only beginning to understand, especially in the…
- Conditions
- Postoperative Cognitive Dysfunction, Delirium, Dementia, Neurotoxicity
- Trial name
- PAICOD (NCT01322672)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University