Clinical trials: Pollution; Exposure
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Pollution Related Respiratory Disorder, Pollution; Exposure
Lung and Heart Function Across Decades of Life in Health
The main objective of this study is to develop baseline "normal" reference values of both lung and heart function for healthy adults within the age range relevant to the United States Veteran population who served in the…
- Conditions
- Pollution Related Respiratory Disorder, Pollution; Exposure, Dyspnea, Cardiopulmonary
- Trial name
- NCT07641413
- Testing
- Healthy control
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Allergies
Air Pollution and Allergens - Attenuation of Health Effects Particle Reduction
The study probes the effects of combined exposures to diesel exhaust and allergens on lung function and on the immune system, specifically focusing on the ability of a particle depletion technique to attenuate effects we and…
- Trial name
- DE3 (NCT02017431)
- Testing
- Allergen, Saline, Particle depleted diesel exhaust
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Lung Function, Heart Rate Variability
Effects of Exposure to Biomass-burning Air Pollution on Lung Function, Heart Rate Variability and Inflammatory Markers in Sugarcane Workers
Introduction: Non-mechanized sugar cane harvesting preceded by burning, an important and prevalent professional activity of agribusiness segment of the Brazilian economy, exposes workers and people of neighboring towns to high…
- Conditions
- Lung Function, Heart Rate Variability, Oxidative Stress, Systemic Inflammatory Response
- Trial name
- NCT01371188
- Where
- Brazil
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- InCor Heart Institute
Exposure to Environmental Pollution, Non-occupational
Epigenetic Effect Modifications With Ozone Exposure on Healthy Volunteers
The purpose of this protocol is to assess whether epigenetic factors in healthy individuals make a person more or less responsive to lung inflammation following ozone exposures.
- Trial name
- Geminoz (NCT02469428)
- Testing
- Clean air, Ozone
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Environmental Protection Agency (EPA)
Lung Diseases
Assessment of Exposures of the Mother-infant Pair to the Air Pollution of São Paulo
A single group of pregnant women who was analyzed in the first and in the third trimesters of pregnancy
- Trial name
- NCT02807038
- Testing
- Lung function test
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Pneumonia, Pollution; Exposure
The Effect of Household Air Pollution on Lung Function Growth in Infants With Pneumonia in Sub-Saharan Africa
This study will evaluate the feasibility and acceptability of a household-based clean air intervention
- Conditions
- Pneumonia, Pollution; Exposure, Lung Function Decreased, Chronic Respiratory Disease
- Trial name
- PLUS2 (NCT05724082)
- Testing
- Clean Air Intervention
- Where
- Uganda
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Asthma in Children, Pollution; Exposure
Evidence Driven Indoor Air Quality Improvement
The aim is to identify the underlying disease mechanisms driving specific asthma phenotypes as well as certain disease outcomes and their relation to impaired indoor air quality.
- Trial name
- NCT05992389
- Where
- Croatia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Srebrnjak
Cardiovascular System, Health
Acute Effects of Meteorological Factors and Air Pollution on Cardiovascular Health
The goal of this observational study is to analyze the acute effects of meteorological factors and air pollution on cardiovascular system. The main question it aims to answer is: 1.
- Trial name
- NCT06663267
- Testing
- NOT
- Where
- China
- Volunteers
- 350,000 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Hangzhou Normal University
Healthy Individuals, Allergic Rhinitis
Health Effects of Wood Smoke and Traffic-Related Air Pollution Exposures: a Necessary Comparison
Accumulating evidence demonstrates that breathing air pollutants leads to devastating increases in sickness and death worldwide over time.
- Trial name
- WADE (NCT06749093)
- Testing
- Filtered Air (FA), Wood Smoke (WS), Diesel Exhaust (DE)
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Pollution; Exposure
Milwaukee Day Cares Indoor Air Quality Assessment and Educational Response Study
This CTSI pilot study will assess for benefit of a community health worker or nursing student taught green cleaning curriculum (developed by the local asthma coalition) provided to Milwaukee County day care staff.
- Trial name
- NCT03675009
- Testing
- Educational Programming
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Pollution; Exposure
Optimizing Ventilation to Improve Health
Our overall goal is to optimize preferred, ventilating windows/apertures/vents in low-income neighborhoods of Dhaka, Bangladesh. We will: I. Collect baseline data on housing types and finalize windows/vents protoypes. II.
- Trial name
- NCT03894995
- Testing
- Installation of ventilation
- Where
- Bangladesh
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Stanford University
Inflammation
Effects of Dietary Supplements on Response to Air Pollution
This study will determine if a comprehensive antioxidant/anti-inflammatory dietary supplement pack can offer protection against a decline in lung function and increase in inflammation and oxidative stress following acute exposure…
- Trial name
- NCT01488656
- Testing
- Antioxidant, anti-inflammatory dietary supplement
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Utah State University
Occupational Exposure
Air Quality Monitoring and Health Surveillance of Workers in the Photocopier Units
To monitor air quality in selected photocopier units and to assess the health status of workers who are exposed to emissions from photocopiers.
- Trial name
- NCT01289184
- Where
- India
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Avinashilingam Deemed University
Pulmonary Disease, Chronic Obstructive, Airway Disease
Innate Immunity in Ozone-induced Airway Inflammation in COPD
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death in the United States. Patients with COPD are routinely exposed to indoor and outdoor air pollution, which appears to cause escalation of their…
- Conditions
- Pulmonary Disease, Chronic Obstructive, Airway Disease, COPD Exacerbation, Pollution; Exposure
- Trial name
- CO3PD (NCT04669743)
- Testing
- Ozone exposure
- Where
- 3 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Psychological Stress, Psychological Well-Being
DivAirCity Social Health Survey
To reduce stress among urban residents, the consortium members of the European Council Horizon 2020 research program DivAirCity install different stress reducing, noise reducing and air quality improving means in the five cities…
- Conditions
- Psychological Stress, Psychological Well-Being, Pollution; Exposure
- Trial name
- DivAirCitySH (NCT06274229)
- Testing
- Air pollution and noise reducing installations
- Where
- Germany
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Environmental Exposure, Ozone
Lung Mucus Hypersecretion and NQO1
The research plan proposes translational studies in relevant animal models and human subjects in order to identify host (genetic) susceptibility factors that confer vulnerability to the prototypal air pollutant, ozone.
- Conditions
- Environmental Exposure, Ozone, Air Pollution, Genetic Susceptibility
- Trial name
- NCT00729352
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Health Effects of Ambient Air Pollution
Effects of Omega-3 Fatty Acids in Ambient Air Pollution Exposure in Healthy Adults
This observational study recruits healthy individuals who have been routinely taking high amount (at least 3 g/wk) of dietary eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and those who don't, and examines the…
- Trial name
- PISCES (NCT02921048)
- Testing
- omega-3 fatty acids
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- U.S. EPA Human Studies Facility
Non-smoking, Healthy Adults
Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
The purpose of this research project is to examine whether short-term use of portable air pollution filtration can result in changes in indoor airborne pollutants and impact on cardiovascular and respiratory health outcomes of…
- Trial name
- NCT02736487
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Endothelial Dysfunction
The Cardiovascular Effects of Nitrogen Dioxide Exposure
Exposure to air pollution has been linked to increased cardiorespiratory morbidity and mortality. The exact component of air pollution that mediates this effect is unknown, but the link is strongest for fine combustion derived…
- Trial name
- NCT00774514
- Testing
- Forearm Vascular Study
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh