Clinical trials: Pollution; Exposure
Healthy Participants
Wildfire Related Air Pollution Exposure and Cognitive Function Pilot Study
This study will examine how breathing wildfire-related air pollution (WRAP) for one hour affects healthy adults. The main question the study will answer if the effect of WRAP exposure on p-tau, a blood marker of cognitive…
- Trial name
- WRAP (NCT07151235)
- Testing
- Simulated wildfire smoke exposure, Clean Air exposure
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Healthy
Ozone Cardiovascular Effects in Genetically Susceptible People
Increases in air pollution are associated with increases in deaths from cardiovascular disease, but the investigators know little about how ozone air pollution affects the cardiovascular system.
- Trial name
- OZCARD (NCT01192477)
- Testing
- Ozone
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Exposure to Environmental Pollution
Impact of Exposure to Environmental Pollutants on Birth Outcomes in an Israeli Cohort
Objectives and hypothesis The scale and diversity of chemicals in worldwide use today is vast. Many of these chemicals are released into the environment where they are found in air, water, soil, house dust, and in the food…
- Trial name
- NCT03084445
- Where
- 3 sites in Israel
- Volunteers
- 2,394 people, healthy volunteers welcome
- Sponsor
- Assaf-Harofeh Medical Center
Cardiopulmonary Function, Environmental Exposures
Effects of LPG and Ventilation Interventions on Reducing HAP and Improving Cardiopulmonary Health
The goal of this clinical trial is to evaluate the independent and synergistic effects of liquefied petroleum gas (LPG) substitution and improved ventilation on household air pollution (HAP) reduction and cardiopulmonary health.
- Trial name
- NCT07005193
- Testing
- Cooking ventilation facilities, Using liquefied gas for cooking, Using solid fuels for cooking
- Where
- 3 sites in China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Huazhong University of Science and Technology
Nasal Obstruction, Exposure to Pollution
Rhinopharyngeal Retrograde Clearance is Effective to Adequate Upper Airways Function in Adults
Professionals working in polluted areas may present increased clinical airways symptoms and dysfunction. Rhinopharyngeal retrograde clearance (RRC) has been used to improve mucus clearance in infants with bronchitis and…
- Trial name
- NCT01976039
- Testing
- rhinopharyngeal retrograde clearance (RRC)
- Where
- 2 sites in Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Sleep, Pollution; Exposure
Investigating the Effect of Daily CARDIO® Capsules Supplementation on Improved Sleep in Healthy, Urban-Dwelling Adults
This study aims to explore the impact of supplementation with CARDIO® whole salmon oil capsules on healthy adult participants with sleep disruption related to particulate matter pollution.
- Conditions
- Sleep, Pollution; Exposure, Cough
- Trial name
- NCT06768970
- Testing
- CARDIO® salmon oil
- Where
- United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Hofseth Biocare ASA
Heart Rate, Heart Rate Variability
Air Pollution, Epigenetics and Cardiovascular Health: A Human Intervention Trial
In this study, the pills formulated are being used to try to ameliorate the effect of air pollution on epigenetic changes, specifically DNA methylation, potentially linked with particulate matter air pollution inhalation and…
- Conditions
- Heart Rate, Heart Rate Variability, Inflammation
- Trial name
- EPI-Air (NCT01864824)
- Testing
- methyl donor
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Pollution; Exposure, Respiratory Disease
Children's Health in London and Luton (CHILL)
Investigating the impact of London's Ultra Low Emission Zone on children's respiratory health
- Conditions
- Pollution; Exposure, Respiratory Disease, Child Development
- Trial name
- CHILL (NCT04695093)
- Testing
- Ultra Low Emission Zone (ULEZ)
- Where
- United Kingdom
- Volunteers
- 3,312 people, healthy volunteers welcome
- Sponsor
- Queen Mary University of London
Air Pollution
Health Effects of Repeated Exposure to Low Levels of Concentrated Ambient Particles in Healthy Young Volunteers
Purpose: To determine whether 3-day consecutive exposures to levels of fine particulate matter (PM2.5) that are close to the current 24-hr national standard will cause changes in inflammatory and cardiopulmonary endpoints in…
- Trial name
- NCT05323240
- Testing
- PM exposure, Filtered air exposure
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- U.S. EPA Human Studies Facility
Pollution; Exposure, Smoke Inhalation
Controlled Exposure of Healthy Nonsmokers to Secondhand and Thirdhand Cigarette Smoke
This study compares the health effects of dermal and inhalational exposure to thirdhand cigarette smoke to those of inhalational exposure to secondhand cigarette smoke in healthy, adult nonsmokers.
- Conditions
- Pollution; Exposure, Smoke Inhalation, Exposure to Pollution
- Trial name
- THS04 (NCT04013256)
- Testing
- Cigarette Smoke
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cardiovascular Function, Genotoxicity
Health Effects of Occupational Exposure to Combustion Particles - a Study on Volunteers Performing as Train Conductors
Ambient air pollution is a complex mixture of gaseous pollutants and particulate matter (PM). PM has a recognized important role in human health.
- Trial name
- BioTrack (NCT03104387)
- Testing
- Electric train, Diesel train
- Where
- Denmark
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Ozone Exposure During Rest and Exercise
Susceptibility of Cardiorespiratory Responses to Ozone During Cycling Exercise
Ground level ozone (O3) is a common airborne pollutant that is well recognized to cause negative respiratory symptoms and impair pulmonary function.
- Trial name
- NCT05473000
- Testing
- Exercise, Ozone, Room air
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Smoke Inhalation, Exposure, Inhalation
Lung Cancer Screening CT for Firefighters
Firefighters are at increased risk for cancer due to exposure to carcinogenic substances. Current lung cancer screening guidelines are predominantly based on smoking history and do not take into account high risk occupational…
- Conditions
- Smoke Inhalation, Exposure, Inhalation, Exposure to Pollution, Exposure Occupational
- Trial name
- NCT06836414
- Testing
- Low-dose Computerized tomography (CT) of Chest, Questionnaires, Medical History
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Exposure to Environmental Pollution, Adverse Effect of Unspecified General Anesthetic
Anesthetic Gas Leakage in Children During Tonsillectomy: a Comparison of Cuffed and Uncuffed Tracheal Tubes
Fires and operating room pollution may occur when anesthesia gases leak into the oropharynx during airway surgery. Investigators sought to measure the concentrations of anesthetic gases that leak into the mouth of children…
- Trial name
- NCT02725164
- Testing
- oxygen concentration, nitrous oxide concentration, carbon dioxide concentration
- Volunteers
- 31 people
- Sponsor
- State University of New York at Buffalo
Adverse Pregnancy Outcomes
The Mechanism of Adverse Pregnancy Outcomes Influenced by Maternal Air Pollution Exposure
This research evaluates the effects of maternal exposure to air pollution during pregnancy on adverse pregnancy outcomes, the general demographic information, the level of maternal exposure to air pollution, pregnancy-related…
- Trial name
- NCT04215406
- Testing
- The level of air pollution
- Where
- China
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Premature Birth, Respiratory Disease
Towards Life-Long Healthy Lungs: A Multidisciplinary Follow-up Framework for Preterm Infants
Approximately 8% of all births occur between 30-36 weeks of gestation ('moderate-late' prematurity). Respiratory tract infections (RTI) and wheezing illnesses disproportionally affect preterm infants resulting in a 1.5-2 fold…
- Conditions
- Premature Birth, Respiratory Disease, Respiratory Tract Infections, Preterm Birth
- Trial name
- LONG LOVE (NCT05618769)
- Testing
- LONG LOVE Framework
- Where
- Netherlands
- Volunteers
- 330 people
- Sponsor
- Franciscus Gasthuis
Environmental Tobacco Smoke Exposure, Depression
Healthy Outcomes of Pregnancy Education
The purpose of this study is to determine if an integrated intervention addressing active smoking, environmental tobacco smoke exposure, depression and intimate partner violence, would improve pregnancy outcome among African…
- Conditions
- Environmental Tobacco Smoke Exposure, Depression, Partner Abuse, Tobacco Smoking
- Trial name
- NCT00381823
- Testing
- Cognitive Behavioral Therapy
- Where
- United States
- Volunteers
- 1,750 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Pesticide, Breast Milk
Impact of Exposure to Persistent Organic Pollutants During Pregnancy on the Composition of Breast Milk and Consequences on the Newborn
Epidemiological studies link early exposure to persistent organic pollutants (POPs) with health consequences in the newborn. Experimental studies have shown the impact of POPs on the gut microbiota.
- Conditions
- Pesticide, Breast Milk, Pollution; Exposure, Meconium
- Trial name
- PESTIMICOBLAIT (NCT03969459)
- Testing
- breast milk collection, meconium collection, newborn feces collection
- Where
- France
- Volunteers
- 88 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Mild Hypertension, Air Pollution Exposure
Reducing Air Pollution to Lower Blood Pressure
Fine particulate matter <2.5 μm (PM2.5) air pollution is the fifth leading risk factor for global mortality. Mitigating the clinically significant blood pressure (BP) elevation from air pollution by reducing PM2.5 exposure will…
- Trial name
- AIR PRESSURE (NCT04908917)
- Testing
- Portable Air Cleaner with a HEPA Filter, Portable Air Cleaner without a HEPA Filter
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wayne State University
Idiopathic Pulmonary Fibrosis, Pulmonary Disease
Influence of Socioeconomic and Environmental Factors on the Natural History of Idiopathic Pulmonary Fibrosis
Idiopathic Pulmonary Fibrosis(IPF) is the most common idiopathic interstitial lung disease whose cause is unknown. With age and gender, socio-economic factors are the most influential indicators of health.
- Conditions
- Idiopathic Pulmonary Fibrosis, Pulmonary Disease, Pulmonary Medicine
- Trial name
- EXPOSOMFPI (NCT04619199)
- Testing
- Blood sample
- Where
- 16 sites in France
- Volunteers
- 200 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris