Clinical trials: Polymers
Advanced HER2-positive Breast Cancer
Study of Paclitaxel Polymeric Micelles Combined With HP and Adebelimab Versus Taxane Combined With HP as First-Line Treatment for Advanced HER2-Positive Breast Cancer
This study is a randomized, open-label, controlled, multicenter Phase II trial conducted in patients with advanced HER2-positive breast cancer, aimed at evaluating the efficacy and safety of paclitaxel polymer micelles for…
- Trial name
- SPECTACLE (NCT07581795)
- Testing
- Paclitaxel polymer micelles combined with trastuzumab, pertuzumab, and adrelumab, Taxanes combined with trastuzumab and pertuzumab.
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fudan University
Coronary Heart Disease
Rapamycin-Eluting Stents With Different Polymer Coating to Reduce Restenosis (ISAR-TEST-3)
The purpose of this study is to evaluate the efficacy of 3 different rapamycin-eluting-stent platforms to reduce coronary artery reblockage after stent implantation
- Trial name
- NCT00350454
- Testing
- rapamycin-eluting Stent with permanent polymer, rapamycin-eluting stent with biodegradable polymer, polymer-free, rapamycin-eluting stent
- Where
- 2 sites in Germany
- Volunteers
- 605 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Triple-Negative Breast Cancer (TNBC), Neoadjuvant Therapy
Paclitaxel Polymeric Micelles and Carboplatin in Combination With Iparomilimab and Tuvonralimab Neoadjuvant Therapy for Triple-negative Breast Cancer（UPGRADE-TNBC）
This is a prospective, single-arm, multicenter study to observe and evaluate the efficacy and safety of paclitaxel polymeric micelles and carboplatin in combination with iparomilimab and tuvonralimab in neoadjuvant therapy for…
- Trial name
- UPGRADE-TNBC (NCT06910072)
- Testing
- paclitaxel polymeric micelles + carboplatin + iparomilimab and tuvonralimab
- Where
- China
- Volunteers
- 32 people
- Sponsor
- Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Peri-implant Soft Tissue Healing
Comparison of BioHPP (High Performance Polymer) - vs Titanium- vs Zirconia Abutments
The project is a prospective, randomized, controlled study. The material BioHPP (High Performance Polymer) is compared with the gold-standard abutment materials titanium and zirconia in terms of peri-implant soft tissue healing.
- Trial name
- NCT06737263
- Testing
- BioHPP abutment, Titanium abutment, Zirconia abutment
- Where
- Austria
- Volunteers
- 60 people
- Sponsor
- Medical University of Graz
Coronary Artery Disease
Safety and Efficacy Registry of Yinyi Stent
Drug-eluting stents effectively reduce restenosis but may increase late thrombosis and delayed restenosis. Persistent polymer could be responsible.
- Trial name
- SERY-I (NCT01373645)
- Testing
- Yinyi stent
- Where
- China
- Volunteers
- 1,045 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Coronary Restenosis
Per-cutaneous Intervention Based Paclitaxel and Sirolimus-Eluting Versus Bare Stents for the Treatment of de Novo Coronary Lesions (PAINT)
Objectives: PRIMARY OBJECTIVE: To compare the in-stent late loss at 9 months of paclitaxel- and sirolimus- eluting stents with the late loss of bare metal control stents.
- Trial name
- NCT00752362
- Testing
- Milennium Matrix® (Control), Infinnium®, Supralimus®
- Where
- 11 sites in Brazil
- Volunteers
- 280 people
- Sponsor
- Sahajanand Medical Technologies Limited
Coronary (Artery); Disease
Trial of MiStent Compared to Xience in Japan
To compare the MT005 (MiStent) with the XIENCE with respect to target lesion failure (TLF) at 12 months in a non-inferiority trial in a "real world" patient population and to confirm that the domestic extrapolation of the…
- Trial name
- DESSOLVEJ (NCT02972671)
- Testing
- MiStent (MT005) Coronary Artery Stent, Xience Coronary Artery Stent
- Where
- 10 sites in Japan
- Volunteers
- 120 people
- Sponsor
- Micell Technologies
Atherosclerosis
Optical Coherence TomOgraphy Assessment of the Drug-Eluting Stent
BACKGROUND Treatment of coronary atherosclerotic disease has been significantly advanced by interventional cardiology, and the advent of coronary arterial stents.
- Trial name
- OCTOBER (NCT01012583)
- Volunteers
- 1 people
- Sponsor
- Chinese PLA General Hospital
Sarcoma
MAGNATE-S: Paclitaxel Polymer Micelles Combo in Advanced Sarcoma
What is this study about? This is a medical research study testing a new drug combination ("Paclitaxel Polymer Micelles" + "Gemcitabine" + "Targeted Therapy") for patients with locally advanced unresectable or metastatic bone and…
- Trial name
- MAGNATE-S (NCT07359053)
- Testing
- Paclitaxel Polymer Micelles + Gemcitabine + Lenvatinib, Paclitaxel Polymer Micelles + Gemcitabine + Anlotinib
- Where
- China
- Volunteers
- 46 people
- Sponsor
- Shanghai 6th People's Hospital
Palmar Hyperhidrosis
A Polymer Film Device to Treat Excessive Palmar Sweating
Perspiration or sweating is a normal physiological response to increased body temperature, environmental heat and humidity, emotions, nervousness, or physical exertion.
- Trial name
- NCT06881394
- Testing
- Polymer Skin Barrier
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Miller Biosciences LLC
Coronary Disease
Nonpolymer- and Polymer-Based Drug-Eluting Stents for Restenosis (ISAR-TEST-1)
The purpose of this study is to assess the efficacy of nonpolymer-based rapamycin-eluting stent compared to standard polymer-based paclitaxel-eluting stent to reduce reblockage of coronary arteries.
- Trial name
- NCT00140530
- Testing
- Paclitaxel-eluting stent (Taxus), Rapamycin-eluting stent
- Where
- 2 sites in Germany
- Volunteers
- 450 people
- Sponsor
- Deutsches Herzzentrum Muenchen
Hypertrophic
Investigation of a Novel Silicone Dressing to Maximize the Outcomes of Scar Revision Procedures (IMPROVE)
Neodyne has developed an investigational dressing for post-operative incision care. Neodyne is conducting this research to study whether the investigational dressing, called the Neodyne Dressing, can minimize scar formation in a…
- Trial name
- IMPROVE (NCT01430130)
- Testing
- embrace device
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Neodyne Biosciences, Inc.
Coronary Artery Disease
Biofreedom Stent in All Comer Population
AIM OF THE STUDY: The aim of the present registry is to investigate the procedural as well as the long-term clinical results in terms of safety and efficacy of the polymer-free DES technology in all comers patients with an…
- Trial name
- NCT02858739
- Testing
- BIOFREEDOM STENT
- Where
- Italy
- Volunteers
- 1,000 people
- Sponsor
- University of Roma La Sapienza
High Bleeding Risk Patients, DAPT(Dual Antiplatelet Therapy)
OCT-based DAPT Cessation in HBR Patients
This study investigates whether patients with diabetes mellitus (DM) and a high risk of bleeding can safely stop dual antiplatelet therapy (DAPT) earlier than usual after receiving a special type of stent called a polymer-free…
- Conditions
- High Bleeding Risk Patients, DAPT(Dual Antiplatelet Therapy), Coronary Artery Disease, Diabetes Mellitus
- Trial name
- NCT07238764
- Testing
- Optical Coherence Tomography-based early DAPT discontinuation
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Federal State Budgetary Institution, V. A. Almazov Federal North-West Medical Research Centre, of the Ministry of Health
Coronary Artery Disease
Plan to Evaluate Early Endothelialization of a Polymer Free Sirolimus-eluting Coronary Stent System (VIVO ISARTM) Compared With Everolimus-eluting Durable Polymer Stent (XIENCE SkypointTM) in Patients Undergoing Percutaneous Coronary Intervention.
To evaluate the stent endothelialization (> 20 microns) of VIVO ISARTM versus XIENCE SkypointTM stents at 1-month (very early strut covered) at follow-up by Optical Coherence Tomography (OCT) implanted IN THE SAME PATIENT during…
- Trial name
- NCT06214819
- Testing
- VIVO ISAR DES implanted in the First lesion, XIENCE Skypoint DES implanted in the Second lesion, XIENCE Skypoint DES implanted in the First lesion, VIVO ISAR DES implanted in the Second lesion
- Where
- 4 sites in Spain
- Volunteers
- 40 people
- Sponsor
- Fundación EPIC
Coronary Artery Disease
Single Long vs Two Short Overlapping Bioabsorbable Polymer DES
Multiple overlapping drug-eluting coronary stents (DES) are usually needed to treat long coronary stenoses but this strategy is expensive and the response to overlapping DES has not been extensively studied.
- Trial name
- ROCCO (NCT01718106)
- Testing
- implantation of a bioabsorbable polymer DES
- Where
- Italy
- Volunteers
- 300 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Catheter-Associated Urinary Tract Infections, Urinary Catheterization
Anti-fouling Silicone Urinary Catheter for Adults Needing Long-term Catheterisation: a Pilot and Feasibility Study
This single-centre randomised pilot and feasibility study assessed whether an anti-fouling zwitterionic silicone urinary catheter can be deployed and evaluated in frail, elderly adults who require long-term indwelling…
- Conditions
- Catheter-Associated Urinary Tract Infections, Urinary Catheterization, Biofilms
- Trial name
- NCT07759986
- Testing
- Anti-fouling zwitterionic silicone urinary catheter, Conventional silicone urinary catheter
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Cheng-Kung University Hospital
Mucositis Oral, Head and Neck Cancer
MucoLox Formulation to Mitigate Mucositis Symptoms in Head/Neck Cancer
This study will examine if the administration of prophylactic MucoLox formulation versus sodium bicarbonate mouthwash in subjects with head/neck cancer receiving radiation ± chemotherapy will result in significantly fewer…
- Trial name
- NCT03461354
- Testing
- MucoLox, Sodium Bicarbonate
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Wake Forest University Health Sciences
Acute Coronary Syndrome
Direct Complete Versus Staged Complete Revascularization in Patients Presenting With Acute Coronary Syndromes and Multivessel Disease
To test whether immediate complete revascularization is non-inferior to staged (but within six weeks after index procedure) complete revascularization in Patients presenting with ACS, including Non-ST-elevation ACS (NSTEACS) and…
- Trial name
- BioVasc (NCT03621501)
- Testing
- Percutaneous coronary intervention
- Where
- Netherlands
- Volunteers
- 1,525 people
- Sponsor
- Erasmus Medical Center
Ischemia, Coronary Artery Disease
A Pilot First In Man Study of EXCEL-Ⅱto Treat the Patients With de Novo Coronary Artery Lesions
One of the purpose of this study is to assess the preliminary safety and feasibility,and to provide related information and evidence for the design of the further pivotal randomized control trial.the other purpose is to assess…
- Trial name
- CREDIT (NCT01909869)
- Testing
- EXCEL-Ⅱ
- Where
- China
- Volunteers
- 45 people
- Sponsor
- JW Medical Systems Ltd