Clinical trials: Polypharmacy
Psychiatric Disorder
Using Pharmacogenetics to Identify Patients With Polypharmacy at Risk of Medication Adverse Effects
The Researchers are trying to learn more about how individuals break down and process medications based on their genes. The Researchers want to find out whether subjects will have fewer side effects if they take different…
- Trial name
- NCT03748355
- Testing
- Pharmacogentic Analysis
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nonadherence, Patient, Polypharmacy
Pharmacist Intervention to Reduce Post-Hospitalization Utilization
This is a randomized trial testing a peri- and post-discharge pharmacist-led medication management intervention on post-discharge utilization, including both readmissions and emergency department visits within 30 days of…
- Conditions
- Nonadherence, Patient, Polypharmacy, Readmission
- Trial name
- NCT04071951
- Testing
- Pharmacist-led Hospital Discharge Care Intervention
- Where
- 2 sites in United States
- Volunteers
- 6,478 people
- Sponsor
- Cedars-Sinai Medical Center
ACUTE MYELOGENOUS LEUKEMIA
Investigating the Prevalence and Prognostic Importance of Polypharmacy in Adults Treated for Newly Diagnosed Acute Myelogenous Leukemia (AML)
Prevalence and prognostic significance of polypharmacy has not been evaluated in adults undergoing treatment for AML. Investigating the significance of polypharmacy in this population may help improve patient assessment and…
- Trial name
- NCT02662920
- Testing
- No Intervention
- Volunteers
- 209 people
- Sponsor
- Wake Forest University Health Sciences
Polypharmacy, Multimorbidity
A Multidisciplinary Intervention Including a Clinical Decision Support System and an App for Drug Therapy Management in Older Patients
"La Casa nel Parco" (CANP) Project is a European Union and Regione Piemonte funded multidisciplinary project aimed to explore innovative technology application in older subject care.
- Conditions
- Polypharmacy, Multimorbidity, Aged
- Trial name
- FARMA-CANP (NCT04391218)
- Testing
- Multidisciplinary Approach Group
- Volunteers
- 89 people
- Sponsor
- A.O.U. Città della Salute e della Scienza
Schizophrenia, Schizoaffective Disorder
Conversion to Antipsychotic Monotherapy
This is a 12-week, with a 32-week follow-up, rater-blind, randomized controlled trial to determine whether patients with chronic schizophrenia or schizoaffective disorder receiving two different antipsychotics simultaneously will…
- Trial name
- MOPE (NCT01368458)
- Testing
- Conversion to Antipsychotic Monotherapy
- Volunteers
- 24 people
- Sponsor
- Nathan Kline Institute for Psychiatric Research
Polypharmacy, Gabapentin
Deprescription of Gabapentinoids in Medical Inpatients
In this trial, investigators will distribute educational brochures with information about the deprescription of gabapentinoids (gabapentin and pregabalin) to inpatients in five medical wards spread across two tertiary-care…
- Conditions
- Polypharmacy, Gabapentin, Pregabalin
- Trial name
- GABA-WHY (NCT04855578)
- Testing
- In-Hopsital Patient Educational Brochure, Physician Education about Gabapentinoid Prescription
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Polypharmacy
Pharmacological Optimization by a Specialized Outpatient Consultation Team
Background Polypharmacy is a common condition among older adults and is a major issue of concern for its association with adverse drug reactions and adverse health outcomes, including falls, functional and cognitive impairment…
- Trial name
- NCT05408598
- Where
- Spain
- Volunteers
- 104 people
- Sponsor
- Fundacion Miguel Servet
Neurologic Disorder, Chronic Disease
Parent-Reported Symptom Assessments in Children Taking Multiple Medications
This study plans to learn about how to measure symptoms (like tiredness or rash) in children with special healthcare needs who take 5 or more medications. Sometimes symptoms change in severity over time or new symptoms develop.
- Conditions
- Neurologic Disorder, Chronic Disease, Pediatric Disorder
- Trial name
- PRSA (NCT03849066)
- Testing
- Parent-Reported Symptom Assessment
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Colorado, Denver
HIV, Alcohol Use
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 1
This pilot intervention will consist of a brief intervention for patients with HIV who take 5 or more medications and currently (within the past month) consume alcohol.
- Trial name
- NCT05560932
- Testing
- IMB-motivational interviewing (MI) techniques (IMB-MI)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Xerostomia
The Efficacy of Thyme Honey Mouth Rinse on Polypharmacy-induced Xerostomia
The study is designed to evaluate the clinical efficacy of thyme honey as a mouth rinse in the management of polypharmacy-induced xerostomia concerning the unstimulated whole salivary flow rate and quality of life of patients…
- Trial name
- NCT06201923
- Testing
- Honey Mouthwash, Normal saline
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Medication Therapy Management
A Collaborative Approach to Medication Reviews for Older Patients With Polypharmacy
In patients aged 65 years and older, polypathology is frequent and often associated with polypharmacy. This polypharmacy may be a source of iatrogeny due to pharmacokinetic interactions, enhanced sensitivity of older people to…
- Trial name
- BIMEDOC (NCT03909035)
- Testing
- Medication therapy management
- Where
- France
- Volunteers
- 697 people
- Sponsor
- University Hospital, Toulouse
Iatrogenic Disease
Rationalisation of Polypharmacy by the Geriatric Consultation Team
Polypharmacy is a common problem in elderly, leading among others to increased adverse drug events. The aim of this pilot study was to evaluate whether a systematic medication evaluation by a geriatric consultation team using the…
- Trial name
- RASP-GCT (NCT02165618)
- Testing
- Medication review, based on but not limited to the RASP list
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Delirium, Age-Related Cognitive Decline
Acute Care for Elders (ACE) Program at OHSU Hospital
The purpose of this investigation is to assess the effectiveness of a multi-disciplinary Acute Care for Elders (ACE) program dedicated to the care of patients age 70 and older admitted to Oregon Health \& Science University's…
- Conditions
- Delirium, Age-Related Cognitive Decline, Frail Elderly, Hospital Acquired Pressure Ulcer
- Trial name
- NCT02119078
- Testing
- Acute Care of Elders focused geriatric care
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Oregon Health and Science University
Polypharmacy, Deprescribing
MedSafer E-care: an Automated Deprescribing Solution (E-CARE Study)
The investigators will link MedSafer (a Canadian-made electronic tool) with a large multi-national electronic medical record (EMR), MED e-care, through an existing application programming interface (API) that provides clinicians…
- Conditions
- Polypharmacy, Deprescribing, Adverse Drug Event
- Trial name
- E-CARE (NCT04087109)
- Testing
- Electronic decision support for deprescribing (MedSafer tool)
- Where
- Canada
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Hiv, Alcohol Drinking
HIV and Alcohol Research Center Focused on Polypharmacy (HARP) Pilot 2 (2nd HARP Pilot Intervention)
The focus of this pilot will be on falls and neurocognitive symptoms, and the impact of alcohol, cannabis use, and medications on these outcomes.
- Conditions
- Hiv, Alcohol Drinking, Fall, Cannabis Use
- Trial name
- HARP (NCT06513819)
- Testing
- Information Motivation Behavioral and Motivational Interviewing (IMB-MI) technique
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
HIV (Human Immunodeficiency Virus)
Multimorbidity and Polypharmacy in People With HIV vs. the General Population in the Basque Country
People living with HIV now have a life expectancy similar to that of the general population, thanks to major advances in antiretroviral treatment.
- Trial name
- NCT07621224
- Testing
- No intervention
- Volunteers
- 12,546 people, healthy volunteers welcome
- Sponsor
- Biogipuzkoa Health Research Institute
Deprescriptions, Polypharmacy
Optimising Medication With Focus on Deprescribing in Frail Older People With Multidose Drug Dispensing Systems
Overuse is common in frail older people with polypharmacy, especially in frail older users of multidose drug dispensing (MDD) systems.
- Conditions
- Deprescriptions, Polypharmacy, Primary Health Care, Community Pharmacy Services
- Trial name
- NCT05609981
- Testing
- Clinical medication review focused on deprescribing
- Where
- Netherlands
- Volunteers
- 318 people
- Sponsor
- SIR Institute for Pharmacy Practice and Policy
Potentially Inappropriate Medications
PIM Incidence in Older Cardiovascular Patients During COVID-19 Pandemics
The aim of the study is to assess the incidence of potentially inappropriate medication (PIM) administration, polypharmacy, and potential drug-drug-interactions (PDDIs) in cardiovascular patients enrolled in the reimbursement…
- Trial name
- PIM-BARS (NCT05336565)
- Testing
- Electronic medical record analysis
- Where
- Russia
- Volunteers
- 1,000 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Age 65 and Older, Polypharmacy
Effect of Longitudinal Care in Primary Health Care: An Analysis From the Patient's Perspective
Objective To explore and describe the opinions of Primary Health Care chronically ill users regarding being cared for over time by the same reference professional.
- Conditions
- Age 65 and Older, Polypharmacy, Cronic Lung Disease, Mental Disorder
- Trial name
- CUALIPRIM (NCT07320053)
- Where
- 2 sites in Spain
- Volunteers
- 26 people
- Sponsor
- IBS Granada
Major Neurocognitive Disorder
GPS Project Evaluation of the Impact of the Reorganization of Work Into a Family Medicine Group on Pharmacotherapy and Support for the Autonomy of Seniors With Major Neurocognitive Disorders
The model of care tested in the GPS project aims to optimize pharmacotherapy for seniors undergoing cognitive assessment or suffering from major neurocognitive disorder (MCND) at home.
- Trial name
- NCT04889794
- Testing
- GPS clinical intervention
- Where
- 2 sites in Canada
- Volunteers
- 400 people
- Sponsor
- CHU de Quebec-Universite Laval