Clinical trials: Polypharmacy Patients
Multiple Chronic Conditions, End Stage Disease
Optimising Drug Therapy in Polymedicated Patients According to the Person-centered Care Model
Introduction: In recent years, multi-aging has increased by 25%. This is related to plutipatology, frailty, polymedications, elevated sanitary cost, low quality of life, adverse events and mortality.
- Trial name
- NCT04188470
- Testing
- person-centered care model
- Where
- 2 sites in Spain
- Volunteers
- 208 people
- Sponsor
- Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
Chronic Disease
Prioritising and Optimising Multi-medication in Multimorbidity
Objective: To investigate whether the complex intervention will improve the appropriateness of prescriptions in elderly multi-morbid patients with multi-medication in general practices.
- Trial name
- PRIMUM (NCT01171339)
- Testing
- Optimization strategy (complex intervention)
- Where
- Germany
- Volunteers
- 505 people
- Sponsor
- Goethe University
Schizophrenia, Schizoaffective Disorder
Comparison of Antipsychotic Combination Treatment of Olanzapine and Amisulpride to Monotherapy
A study to examine whether an antipsychotic combination treatment of olanzapine and amisulpride is more effective than olanzapine and amisulpride alone.
- Trial name
- COMBINE (NCT01609153)
- Testing
- Olanzapine, Amisulpride, Olanzapine and Amisulpride
- Where
- 21 sites in Germany
- Volunteers
- 328 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Medication Review, Polypharmacy
Medication Review in Chronic Complex or Polymedicated Patients After Hospital Discharge.
The goal of this prospective multicentre clustered randomized controlled trial is to evaluate the effect on new hospitalization episodes of a multidisciplinary medication review in primary care patients with polypharmacy or…
- Conditions
- Medication Review, Polypharmacy, Disease, Chronic
- Trial name
- NCT05799430
- Testing
- Multidisciplinary medication review, Control group
- Where
- Spain
- Volunteers
- 372 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Metabolic Syndrome
Pomegranate Consumption by Poly-medicated Metabolic Syndrome Patients
The objective is to evaluate whether the medication in polymedicated metabolic syndrome patients could determine the effects of a pomegranate extract on i) metabolic markers, ii) inflammatory markers, and iii) the modulation of…
- Trial name
- NCT04075032
- Testing
- Pomegranate extract
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- National Research Council, Spain
Comorbidity, Medication Therapy Management
Team Approach to Polypharmacy Evaluation and Reduction
In an aging population, most seniors suffer from multiple chronic conditions. When the number of medications taken is ≥5 (polypharmacy), the burden of taking so many together can do more harm than good.
- Trial name
- TAPER (NCT02562352)
- Testing
- TAPER program
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- McMaster University
Polypharmacy
Development & Pilot of the Technology-Enabled Alliance for Medication Therapy Management
The investigators will link community pharmacy and primary care practices via a shared electronic health record to improve medication therapy management for older patients taking complex prescription (Rx) regimens.
- Trial name
- TEAM (NCT04575155)
- Testing
- TEAM Strategy
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- Northwestern University
Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction (HFrEF and HFmrEF)
Polypharmacy, Safety, and Medication Adherence in Patients With Chronic Heart Failure With Reduced and Mildly Reduced Ejection Fraction
This prospective registry study (FARAON) aims to assess the prevalence, structure, safety profile, and dynamics of polypharmacy, as well as its association with medication adherence, quality of life, and clinical outcomes in…
- Trial name
- FARAON (NCT07640854)
- Where
- Russia
- Volunteers
- 130 people
- Sponsor
- National Medical Research Center for Therapy and Preventive Medicine
Patient Discharge, Drug-Related Side Effects and Adverse Reactions
Improving Medication Prescribing-Related Outcomes for Vulnerable Elderly in Transitions
Medication safety is a crucial health issue for every older Canadian since many of the medications causing serious harm are those which also have life-saving or important symptom-relieving benefits.
- Conditions
- Patient Discharge, Drug-Related Side Effects and Adverse Reactions, Aged, Health Care Costs
- Trial name
- IMPROVE-IT (NCT04077281)
- Testing
- Medication Coordinated care
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Deprescriptions, Antidepressive Agents
Patient-centred Deprescribing of Psychotropic, Sedative and Anticholinergic Medication in Elderly Patients With Polypharmacy
The PARTNER study is a multicentre, two-arm, pragmatic cluster-randomised trial evaluating the impact of a focused and patient-centred cooperation between general practitioners (GPs) and community pharmacists (PARTNER…
- Conditions
- Deprescriptions, Antidepressive Agents, Antipsychotic Agents, Analgesics, Opioid
- Trial name
- PARTNER (NCT05842928)
- Testing
- PARTNER intervention, Control intervention
- Where
- 3 sites in Germany
- Volunteers
- 352 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Child, Only, Disabilities Multiple
Pediatric Medication Therapy Management Trial
The purpose of this study is to evaluate whether an intervention called Pediatric Medication Therapy Management (pMTM) improves the identification and management of medication-related problems among children with medical…
- Conditions
- Child, Only, Disabilities Multiple, Medication Interaction, Medication Compliance
- Trial name
- pMTM (NCT05761847)
- Testing
- Pediatric Medication Therapy Management (pMTM)
- Where
- United States
- Volunteers
- 371 people
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus, Type 2/Prevention & Control, Diabete Type 2
Therapeutic Adherence in Type 2 Diabetes
A quasi-experimental, non-randomized, prospective, longitudinal study comparing the use of WhatsApp messaging versus the SMART technique in patients with type 2 diabetes to improve treatment adherence
- Conditions
- Diabetes Mellitus, Type 2/Prevention & Control, Diabete Type 2, Treatment Adherence
- Trial name
- NCT07837856
- Testing
- Group I (WhatsApp) motivational and educational messages delivered periodically, Group II: To implement the SMART method
- Where
- Mexico
- Volunteers
- 250 people
- Sponsor
- Instituto Mexicano del Seguro Social
HIV Infections
Switch to TAF+FTC+BIC in HIV-1-infected Patients Over 65 Years Old at Risk of Polymedication
Patients infected and living with HIV are getting older and have more and more non-HIV co-morbidities. These expose them to polypharmacy that increases the risk of pharmacological interaction.
- Trial name
- BICOLDER (NCT04222283)
- Testing
- BIKTARVY 50Mg-200Mg-25Mg Tablet
- Where
- 8 sites in France
- Volunteers
- 27 people
- Sponsor
- Institut de Médecine et d'Epidémiologie Appliquée - Fondation Internationale Léon M'Ba
Chronic Kidney Diseases, Polypharmacy
Effectiveness of Health Literacy Program for Polypharmacy Patients (HLP-CKD)
This study aims to evaluate the effectiveness of a health literacy promotion program in preventing chronic kidney disease (CKD) among patients who use multiple medications (polypharmacy).
- Conditions
- Chronic Kidney Diseases, Polypharmacy, Health Literacy
- Trial name
- HLP-CKD (NCT07622134)
- Testing
- Health Literacy Promotion Program (HLP-CKD)
- Where
- Thailand
- Volunteers
- 104 people
- Sponsor
- Nakhon Pathom Rajabhat University
Multimorbidity
A New Organisation of Clinic for Multimorbidity and Polypharmacy
The purpose of this study is to investigate: 1) the implementation and 2) the effects of an outpatient program for patients with complex multimorbidity.
- Trial name
- NCT06735339
- Testing
- Clinic for Multimorbidity
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- Central Jutland Regional Hospital
Heart Failure
Polypharmacy in the Heart Failure Patient: Are All Prescribed Drug Classes Required? Statin Withdrawal Study
Heart failure (cardiomyopathy) is a chronic condition in which the heart fails to function as a pump to move blood around the body.
- Trial name
- NCT01554592
- Testing
- Withdrawal of statin therapy, Statin therapy
- Where
- Australia
- Volunteers
- 13 people
- Sponsor
- The Alfred
Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More)
Prevalence of Inappropriate Prescriptions and Omitted Therapies in Hospitalized Elderly: STOPP/START Criteria Analysis
Evaluate the prevalence of potentially inappropriate prescriptions (PIPs) and potential omitted prescriptions (PPOs) in elderly patient upon admission to the acute geriatric department, based on adherence or non-adherence to the…
- Conditions
- Polypharmacy (People Under Treatment With 5 or More Drugs), Elderly (People Aged 65 or More), Deprescribing, Hospitalization
- Trial name
- SPIna (NCT07202962)
- Testing
- medication review and deprescribing
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Regione del Veneto - AULSS n. 7 Pedemontana
Polypharmacy, Elderly
Clinical and Economical Assessment of an Intervention to Reduce Potentially Inappropriate Medication in Polymedicated Elderly Patients
Objective: To evaluate the clinical and economic impact of the application of an algorithm to improve the adequacy and safety of pharmacotherapy in elderly polymedicated (receiving 8 or more medications), not institutionalized.
- Trial name
- REMEI (NCT02275572)
- Testing
- Pharmacist Intervention
- Volunteers
- 503 people
- Sponsor
- Consorci Sanitari del Maresme
Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant
Drug & Gene Interaction Risk Analysis With & Without Genetic Testing Among Patients Undergoing MTM
This randomized controlled trial will evaluate whether the use of pharmacogenetic testing through a Medication Therapy Management (MTM) program has a beneficial impact on drug therapy problems.
- Conditions
- Cytochrome P450 CYP2D6 Enzyme Deficiency, Poor Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Ultrarapid Metabolizer Due to Cytochrome P450 CYP2D6 Variant, Extensive Metabolizer Due to Cytochrome P450 CYP2D6 Variant
- Trial name
- NCT02428660
- Testing
- Pharmacogenetic testing, Software-based drug & gene interaction risk analysis, MTM
- Where
- United States
- Volunteers
- 341 people
- Sponsor
- Genelex Corporation
Healthy
Rationalisation of Polypharmacy in the Elderly by the RASP Instrument
The aim of this study is to determine whether a clinical pharmacist using the RASP list (RASP = Rationalisation of home medication by an adjusted STOPP-list in older patients; STOPP = Screening Tool of Older Persons' potentially…
- Trial name
- RASP (NCT01513265)
- Testing
- Pharmaceutical care plan, mostly based on the RASP
- Where
- Belgium
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven