Clinical trials: Polyphenols
Healthy
Effects of Berry Peel Intake on Glucose Metabolism in Healthy Subjects
The main objective of this study is to investigate the effect of a 4-weeks intake of berry peel powder on fasting and postprandial glucose metabolism and inflammatory markers.
- Trial name
- NCT02533986
- Testing
- Berry peel drink, Control drink
- Where
- Sweden
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Lund University
Cognitive Performance, Memory
Use Muscadine Wine Nutraceuticals to Improve Brain Health, Cognition, and Mental Health
Previous studies have shown that polyphenol-rich foods can positively affect cognitive functions, memory, and mood in humans. We hypothesize that both acute and chronic intake of muscadine wine polyphenols will improve cognitive…
- Conditions
- Cognitive Performance, Memory, Mood, Anxiety
- Trial name
- NCT05541887
- Testing
- Muscadine Wine Polyphenol
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Florida
Premenopausal Women, Overweight and Obese Women
A Pilot Study to Characterize the Bioavailability and Plasma Profile of Potato Polyphenols in Humans
Primary objective is to determine the bioavailability of and characterize the kinetic profile of target polyphenol metabolites of potatoes over 6 hour postprandial period.
- Trial name
- PPT (NCT02167607)
- Testing
- Active Comparator
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Healthy
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students
Available literature suggests that flavanols-rich foods, and more especially monomeric flavanols-rich foods such as grape, can have an acute effect on cognitive functions via different mechanisms such as cerebral blood flow…
- Trial name
- NCT03508206
- Testing
- SBRP
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Healthy
Effect of Red Grape Cells (RGC) Powder Consumption on Measures of Aerobic Fitness and Mood
This is a 3-arm double blind placebo controlled study to investigate the effect of Red Grape Cell (RGC) powder containing all the matrix of polyphenols that can be found in red grapes.
- Trial name
- NCT01832584
- Testing
- RGC
- Where
- Israel
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Fruitura Bioscience Ltd.
Healthy Men and Women
Randomized, Double-blind, Controlled Study to Evaluate the Effect of Concord Grape Extract on Vascular Function in Healthy Men and Women
Concord grape (Vitis Labrusca) is rich in polyphenols such as anthocyanins, flavanols, procyanidins and flavonols. Current reports investigating the effects of Concord grape (CG) consumption on cardiovascular disease (CVD) risk…
- Trial name
- CONCARD (NCT03553225)
- Testing
- Concord Grape extract 1, Concord Grape extract 2
- Where
- United Kingdom
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- King's College London
Iron Absorption in Presence of Polyphenols
Polyphenols in Sorghum and Iron Absorption
Iron deficiency and iron deficiency anemia are two major public health problems in developing countries. In these countries, the use of monotonous plant-based diets, low in animal source food but high in iron absorption…
- Trial name
- NCT01162616
- Testing
- labeled iron solutions
- Where
- Switzerland
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Biological Availability
Oral Bioavailability of Pterostilbene Cocrystal Compared to Its Free Form (BIOPTERO)
Oxidative stress and reactive oxygen species (ROS) can seriously affect cells, tissues and organs. The human body is capable of counteracting ROS production by stimulating antioxidant defense systems and consequently adapting to…
- Trial name
- BIOPTERO (NCT05561075)
- Testing
- Pterostilbene cocrystal, Pterostilbene free form
- Where
- Spain
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Healthy Adult Participants, ADME
Exploration of Potential Biomarkers of Polyphenol Intake From Artichoke By-product Supplements
The bioavailability study analyzes the absorption, distribution, metabolism, and excretion (ADME) processes of the polyphenols under study (HCAs).
- Conditions
- Healthy Adult Participants, ADME, Polyphenols Absorption Profile, Polyphenolic Compounds and Metabolism
- Trial name
- ARTI-UP ADME (NCT07615673)
- Testing
- Single intake of a supplement derived from artichoke by-products
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Iziar Amaia Ludwig Sanz Orrio
Healthy Subjects
Bioavailability and Pharmacokinetic Parameters of Watermelon (Rind, Flesh and Seeds) Polyphenols
The primary objectives of the study are outlined below: 1. To investigate the relative bioavailability and absorption/kinetic profile of polyphenols after consumption of watermelon rind, flesh and seeds, respectively in an acute…
- Trial name
- WM (NCT03365960)
- Testing
- Watermelon Rind, Watermelon Flesh, Watermelon Seeds
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Embryo Transfer
Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer
The goal of this observational study is to explore the association between phenol exposure and pregnancy outcome after embryo transfer.
- Trial name
- NCT06767202
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- keqin liu
Menopause
Polyphenols and Probiotics to Improve Menopausal Symptoms Via the Gut-Brain Axis
Menopause is one of the most significant lifecourse challenges for women. The decline in female sex hormones, in particular estrogen, during menopause leads to an increased risk in cardiometabolic diseases, and a decrease in…
- Trial name
- SYMPTOGUT (NCT06333223)
- Testing
- Mixture of (Poly)phenols and a probiotic supplement
- Where
- 2 sites in United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Postprandial Hyperglycemia
Effects of Fruit Extracts on Glycaemia: The GLU-FRU Study
Raised blood glucose levels can lead to adverse modifications to functional proteins within the body and eventually lead to the development of type 2 diabetes.
- Trial name
- GLU-FRU (NCT02340039)
- Testing
- Polyphenols
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- King's College London
Healthy Adults
Impact of Inulin on Production of Phenolic Acids From Tomato Onion and Lovage Soup
This is an acute human bioavailability study in self-reported healthy participants aged 20-70 years old. The investigators hypothesize that combination of polyphenolics from a soup rich in rutin and quercitin and the…
- Trial name
- NCT03577145
- Testing
- Tomato, onion & lovage soup with inulin, Tomato, onion & lovage soup, Inulin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Vascular Function
The Effect of Chocolate on Vascular Function of Endurance Runners
The aim of this study is to examine the effects of chocolate on the vascular function of endurance runners through a crossover study involving male runners consuming both dark and white chocolate.
- Trial name
- NCT06440512
- Testing
- Dark chocolate Intervention, White chocolate Intervention
- Where
- Greece
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Inflammation, Atherosclerosis
Effects of Short-term Curcumin and Multi-polyphenol Supplementation on the Anti-inflammatory Properties of HDL
Polyphenol supplements, including curcumin and resveratrol, are known to decrease inflammation, but previous polyphenol supplements were poorly absorbed and thus their effects were reduced.
- Conditions
- Inflammation, Atherosclerosis, Cardiovascular Disease
- Trial name
- PSI (NCT02998918)
- Testing
- PolyResveratrol Supplementation, Curcumin Supplementation
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of South Carolina
Hyperglycemia, Postprandial, Healthy
Effects of Enriched Fruit Juice on Blood Glucose Levels After a Meal in Healthy Subjects
Results from a large number of studies in humans have shown that diets rich in foods that give lower glucose response bring lower risk of type 2 diabetes.
- Trial name
- PolyGlucHeal (NCT03255876)
- Testing
- Enriched pomegranate juice
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Mental Energy, Physical Performance
Dose Effect of a Plant Extract on Fatigue
Test the short-term effects of the acute consumption of two separate beverages containing different concentrations of polyphenols, a beverage containing 75 mg of caffeine and a flavored placebo beverage on mental energy and…
- Trial name
- NCT03870126
- Testing
- Flavored beverage
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- PepsiCo Global R&D
Hyperglycaemia
Effects of Polyphenols Found in Pomegranate and Olives Food Supplements on Postprandial Blood Glucose in Vivo.
Consumption of carbohydrate containing foods or sugary drinks brings about changes to the blood glucose levels. After a meal or drink, blood glucose rises until it reaches a peak concentration usually after 30 minutes.
- Trial name
- NCT02486978
- Testing
- Control (109 g white bread), Dose 1, Dose 2
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Overweight or Obesity, Healthy
Berries, Inflammation, and Gut Microbiome
The primary objectives are to characterize changes in indices of systemic and gut inflammation, assess host- and microbial-derived metabolite pools, and describe and link functional metagenomics and metatranscriptomic alterations…
- Trial name
- NCT04100200
- Testing
- Mixed berries, FOS, Control
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology