Clinical trials: Polyphenols
Hypercholesterolemia, Healthy
Effects of Dietary Antioxidants to Prevent Cardiovascular Disease
Background \& Aims: The role of red wine in cardiovascular risk prevention has been documented by several epidemiological studies in patients and normocholesterolemic healthy individuals.
- Trial name
- RWTAC (NCT02409537)
- Testing
- red wine, resveratrol
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Aeromedical Center, Thessaloniki
Glycemic Index
Safety and Efficacy of a Single Dose of a Polyphenol-enriched Brown Seaweed Powder in Human
The primary endpoint of this trial will be to evaluate the safety of a single administration in human of a dose of 500 mg of a polyphenol-rich algal powder when taken 30 minutes before a test meal.
- Trial name
- ICAST (NCT00936754)
- Testing
- Brown seaweed powder
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- innoVactiv Inc.
Stroke, Ischemic Stroke
Salicornia for Neurovascular Health Improve
The purpose of this study is evaluate the effect and safety of the administration of a food supplement based on halophyte plant extracts versus placebo in the neurovascular healthy.
- Conditions
- Stroke, Ischemic Stroke, Neurovascular Injury, Brain Ischemia
- Trial name
- NCT06076122
- Testing
- Food supplement based on Salicornia extracts
- Where
- Spain
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Hypertension
The Effect of Olive Leaf Extract on Blood Pressure in Overweight Prehypertensives
Cardiovascular disease (CVD) is the leading cause of death in New Zealand (40% of all deaths). 37% of New Zealanders suffer from high blood pressure (World Health Organisation 2008 figures), a well established modifiable risk…
- Trial name
- NCT01796561
- Testing
- Olive leaf extract liquid
- Where
- New Zealand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
ADME
Absorption, Metabolism, and Excretion of (-)-[2-14C]Epicatechin in Humans
The purpose of this study is to determine the absorption, metabolism and excretion of (-)-epicatechin using the radiolabeled tracer (-)-[2-14C]epicatechin in healthy male volunteers observing a flavanol-/procyanidin-controlled…
- Trial name
- NCT01969994
- Testing
- Controlled dietary background, (-)-[2-14C]epicatechin intake
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The Institutes for Pharmaceutical Discovery, LLC
Nutrition, Absorption
Bioavailability From Chickpea Meals in Ileostomists?
The matrix of a food can significantly affect how well humans can absorb and use nutrients. Plants like fruits, vegetables, nuts, grains, and legumes have cell walls that form a network around their cells.
- Conditions
- Nutrition, Absorption, Polyphenolic Compounds and Metabolism, Polyphenols Absorption Profile
- Trial name
- NCT06921811
- Testing
- Intact chickpeas, Broken chickpeas
- Where
- United Kingdom
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Ulster
Healthy
The Effect of Meat and Food Drived Polyphenols on Oxidize LDL Level
The postprandial increase in MDA level following meat meal could cause modification to LDL particles in healthy volunteers. Co-consumption of food drived polyphenols with the meat will result in a significant decrease in LDL…
- Trial name
- NCT01389492
- Testing
- frozen meat cutlets meal, meat meals
- Where
- Israel
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Overweight and Obesity
Evaluation of Fiit-ns® in Health-related Quality of Life Improvement in Overweight and Obese Subjects
The purpose of this study is to evaluate the effects of a 16-week supplementation with a polyphenol-rich extract, Fiit-ns®, on improvement of health-related quality of life (HR-QOL) of overweight and obese volunteers, as compared…
- Trial name
- NCT03423719
- Testing
- Fiit-ns®
- Where
- Spain
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Fytexia
Healthy
De-stressing the Brain: Can Eating Grapes During Periods of Mental Stress Protect Brain and Vascular Health in Young Adults
The main aim of the current study is to investigate whether consuming grapes rich in flavonoids just before mental stress can protect cerebrovascular and peripheral vascular function, mood and cognition, from the negative effects…
- Trial name
- NCT06923722
- Testing
- High-flavonoid grape intervention, Low-flavonoid grape intervention
- Where
- United Kingdom
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Inflammation, Heart Failure
Beer, Marathon, Genetics, Inflammation and the Cardiovascular System: Be-MaGIC-Trial
The purpose of the study is to determine the myocardial function and vascular adaptation after strenuous exercise in association with consumption of polyphenols.
- Conditions
- Inflammation, Heart Failure, Sudden Cardiac Death
- Trial name
- Be-MaGIC (NCT00933218)
- Testing
- polyphenols (non-alcoholic beer), beverage without polyphenols
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Diet, Food, and Nutrition, Dietary Supplements
Bioavailability of Green Tea and Coffee Polyphenols
There is little information on the dietary intake, absorption, metabolism and bioavailability (degree to which a substance becomes available to the target tissues upon administration) of polyphenols (natural substances present in…
- Trial name
- POBAS (NCT03248115)
- Testing
- Green tea and green coffee extract tablets
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- MRC Human Nutrition Research
Polyphenol Absorption in Healthy People
Bioactivity of Olive Oils Enriched With Their Own Phenolic Compounds (VOHF1)
Hypothesis: A functional olive oil tailored to provide the best relationship between phenolic compounds (amount and type) phenolic bioavailability and bioactivity (antioxidant and anti-endothelial dysfunction) will be a useful…
- Trial name
- VOHF1 (NCT01347515)
- Testing
- olive oil
- Where
- Spain
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University Rovira i Virgili
Overweight and Obesity, Dyslipidemias
Enriched Honey With Soluble Fiber and Polyphenols on Satiety and Dyslipidemia
The aim of this trial is to evaluate the possible benefits on saciety and dyslipidemia in subjects with overweight/obesity (BMI ≥25 y <40 kg / m2) and dyslipemia after consumption of a modifed honey with soluble fiber and…
- Trial name
- SACIMIEL (NCT04153617)
- Testing
- Control honey, Modified honey with soluble fiber and polyphenols
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Cardiovascular Diseases
Combined Bioactive Therapy Effects Over Cardiovascular Markers in Statin Treated Patients
Atherosclerosis, one major cause of morbidity and mortality worldwide, is a complex and multifactorial disease triggered especially due to high level of plasma lipids and that involves three mainly conditions: chronic…
- Trial name
- NCT02732223
- Testing
- Functional treatment, Control treatment
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Instituto Dante Pazzanese de Cardiologia
Healthy Men and Women
Effects of an Organic Plant-rich Diet on Gut Microbiome and Vascular Function (ORGAMIC Pilot Study)
Previous work have shown that consumption of foods rich in polyphenols, such as berries and cocoa, led to beneficial changes in the gut microbiota composition, as well as improvements in biomarkers of cardiovascular disease risk…
- Trial name
- NCT04276974
- Testing
- Organic diet, Non-organic diet
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- King's College London
Lipid Metabolism, Diabetes
Tea Extract, Blood Lipid and Dietary Fat
There are numerous factors known to determine the relative rate of lipid metabolism at rest between and within individuals, including: biological sex, endogenous carbohydrate availability, training status and, in particular…
- Trial name
- NCT03324191
- Testing
- Tea beverage, Tea extract (medium concentration), Tea extract (high concentration)
- Where
- United Kingdom
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Bath
Healthy Aging
A Study of Biological Effects of a Polyphenol Supplement
A randomized, double-blind, placebo controlled, cross-over trial to investigate the effect of the Investigational Product "DailyColors™" (DC) on age-related pathways in adults.
- Trial name
- MIDI (NCT05829382)
- Testing
- DailyColors™
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Helse Stavanger HF
Healthy Adult Participants, ADME
Exploration of Potential Biomarkers of Polyphenol Intake From Artichoke By-product Supplements
The bioavailability study analyzes the absorption, distribution, metabolism, and excretion (ADME) processes of the polyphenols under study (HCAs).
- Conditions
- Healthy Adult Participants, ADME, Polyphenols Absorption Profile, Polyphenolic Compounds and Metabolism
- Trial name
- ARTI-UP ADME (NCT07615673)
- Testing
- Single intake of a supplement derived from artichoke by-products
- Where
- Spain
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Iziar Amaia Ludwig Sanz Orrio
Mood, Healthy
The Effect of Diet on Parents' Mental Health in the Postnatal Period
Postnatal depression (PND) is a type of depression that can occur in some parents after the birth of their baby. PND has been estimated to affect 1 in 10 new parents; mothers in particular are at an increased risk of developing…
- Conditions
- Mood, Healthy, Mothers, Fathers
- Trial name
- NCT04990622
- Testing
- Flavonoid-rich diet
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
Acute Effect of Orange Juice Mixed With Oat β-Glucan on Bioavailability of Polyphenols in Healthy Individuals
Brief summary Orange juice is the most widely consumed fruit juice, accounting for around a third of the total fruit juice market and is a rich source of vitamin C and bioactive compounds, predominantly flavonoids.
- Trial name
- NCT04867655
- Testing
- Orange Juice, Orange juice with either 6g or 3 g of β-Glucan
- Where
- United Kingdom
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Glasgow