Clinical trials: Polyphenols
Obesity, Diabetes
Study of the Mechanisms of Metabolic Adaptations to Overfeeding
Obesity results from complex interactions between genetic and environmental factors, and are strongly associated with metabolic complications such as type 2 diabetes mellitus.
- Trial name
- Polynut (NCT02225457)
- Testing
- Hypercaloric diet, polyphenols
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Overweight, Obesity
Efficacy of a Tea Catechin Sports Drink for Enhancing Exercise-Induced Fat Loss
The primary objective of this trial is to evaluate the influence of consuming a tea catechin containing sports beverage on body fat mass during exercise-induced weight loss among overweight and obese men and women.
- Trial name
- NCT00692731
- Testing
- 500 mL/day of a beverage providing approximately 625 mg catechins, Control beverage matched for energy and caffeine content
- Where
- 2 sites in United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Provident Clinical Research
Body Weight
Effect of Polyphenol-rich Dark Chocolate on Body Weight in Overweight and Obese Adults
The aim of this study is to investigate if dark chocolate rich in polyphenols decreases body weight/ body fat in the overweight and obese adult population.
- Trial name
- NCT01749852
- Testing
- Polyphenol-rich Dark chocolate
- Where
- United Kingdom
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Queen Margaret University
Healthy
Acute Effect of a Proprietary Botanical Blend Rich in Polyphenols on Flow-mediated Dilation in Healthy Subjects
It is well established that endothelial dysfunction is an early predictor of cardiovascular events in at-risk patients. Finding safe and effective product able to improve endothelial function is of public health interest.
- Trial name
- NCT04697589
- Testing
- Memophenol 300 mg, Memophenol 600 mg
- Where
- France
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Thalassemia, Iron Overload
Inhibitory Effect of a Polyphenol Supplement on Dietary Iron Absorption in Adults with Thalassemia
Genetic disorders, such as thalassemia, can lead to iron overload and severe adverse health outcomes. In iron-loading thalassemia, iron overload is due to increased iron absorption.
- Trial name
- NCT05326503
- Testing
- Meal matrix with polyphenol supplement (PPS), No meal matrix with PPS
- Where
- Thailand
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Obesity, Insulin Resistance
Effects of Hesperidin on Insulin Sensitivity
This study will examine whether hesperidin, a major component of citrus fruits, affects how the body responds to insulin in healthy and obese people.
- Trial name
- EHIS (NCT01773486)
- Testing
- Hesperidin
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Bioavailability
Bioavailability of Ration Items Containing Tart Cherry Extract
To determine how consuming food items containing shelf-stored tart cherry impacts your body's ability to absorb and use the compounds within tart cherry.
- Trial name
- Tart Cherry (NCT07063173)
- Testing
- Fruit Bar, Powdered Drink, Commercially available 100% tart cherry juice
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Embryo Transfer
Relationship Between Exposure to Phenols and Pregnancy Outcomes After Embryo Transfer
The goal of this observational study is to explore the association between phenol exposure and pregnancy outcome after embryo transfer.
- Trial name
- NCT06767202
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- keqin liu
Healthy Control
Metabolism of Bioactive Dietary Polyphenol Preparation (BDPP)
This study will characterize the clinical pharmacology of a select bioactive polyphenol-rich preparation (Bioactive Dietary Polyphenol Preparation, BDPP) comprised of a select Concord grape juice (CGJ), a select grape seed…
- Trial name
- NCT04421079
- Testing
- Trans-resveratrol, Concord grape juice, Grape seed polyphenol extract
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cognitive Change, Mood Change
Cognitive Effects of Sage in Healthy Humans
Extracts of sage and polyphenols have separately been reported to interact with central nervous system (CNS) mechanisms relevant to cognitive performance but, to date, no trial has combined these interventions.
- Trial name
- NCT03695003
- Testing
- Cognivia
- Where
- United Kingdom
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Northumbria University
Photoaging
Effects of Mango Intake on Skin Health and Gut Microbiome Changes in Postmenopausal Women
Mangos are a rich source of nutrients such as carotenoids, vitamin C and fiber, as well as polyphenols and phenolic acids such as mangiferin, ellagic acid, and gallotannins.
- Trial name
- NCT04869852
- Testing
- Food
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Integrative Skin Science and Research
Healthy
Interactions Between Fibre and Polyphenols on Colonic Phenolic Acid Production and Biomarkers of Health ( 6 Weeks)
The investigators have studied the acute interactions of polyphenols and NDC in a single meal in a human study containing tomatoes, lovage \& onions, with and without inulin.
- Trial name
- NCT03840746
- Testing
- Tomato, onion and lovage soup (TOL), TOL soup with inulin
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Glasgow
Borderline Hypertension
Effect of an Apple Polyphenol Extract on Brachial Artery Flow-mediated Vasodilatory Function
Effect of apple polyphenols on FMD.
- Trial name
- NCT01690676
- Testing
- Epicatechin, Microcrystalline cellulose
- Where
- Finland
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Danisco
Healthy
Gut Microbial Metabolism of Polyphenols and Cardiovascular Health (StratiPol) (Stratification Study)
There is increasing interest in the effects of various food derived polyphenols on cardiovascular health. Several studies have demonstrated improvements in vascular function after intake of polyphenol rich foods.
- Trial name
- StratiPol (NCT03573414)
- Testing
- raspberry powder, milled flaxseed and soy milk
- Where
- United Kingdom
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- King's College London
Vasodilation, Exercise
Acute Effect of Polyphenols Supplementation on Endothelial Function and Exercise Related Markers, in Physically Active Healthy Volunteers.
To evaluate the effect of acute polyphenols supplementation on vasodilation and related markers along with exercise related markers (notably performance, respiratory exchanges, perceived exertion), before, during and after a…
- Conditions
- Vasodilation, Exercise, Healthy Adults
- Trial name
- PolypOxy (NCT07518758)
- Testing
- Oral administration
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Nexira
Healthy
Acute Effect of a Standardized Botanical Blend Rich in Polyphenols on Cognitive Functions in Healthy Students
Available literature suggests that flavanols-rich foods, and more especially monomeric flavanols-rich foods such as grape, can have an acute effect on cognitive functions via different mechanisms such as cerebral blood flow…
- Trial name
- NCT03508206
- Testing
- SBRP
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Activ'inside
Cardiovascular Disease
Cranberry Juice and Cardiovascular Disease
Previous studies have shown that consumption of a low calorie cranberry beverage imparts a favorable impact on HDL cholesterol, LDL oxidation, and cell adhesion molecules in men. However, these studies were not well controlled.
- Trial name
- NCT01295684
- Testing
- Cranberry juice
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- United States Department of Agriculture (USDA)
Blood Sugar Response
Postprandial Glycemic Response to Polyphenol-fortified Snack Bars
Consuming plant chemicals (e.g., polyphenols) may have beneficial effects on human health that, if confirmed, may warrant inclusion in combat rations.
- Trial name
- NCT02763020
- Testing
- Fruit extracts high in polyphenols
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Vaginal Microbiome, Gut Microbiome
The Effect Cranberry-Based Products on the Female Microbiome
The overall objective of this clinical trial is to compare the effects of a cranberry-based product to a placebo-control product on vaginal and GI microbiome outcomes and associated participant reported outcomes in generally…
- Conditions
- Vaginal Microbiome, Gut Microbiome, Gut Health
- Trial name
- NCT07109713
- Testing
- Active
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ocean Spray Cranberries, Inc.
Healthy
Adding Polyphenol-rich Pulses to Daily Diet Improves Skin Health by Reshaping the Skin Microbiome
Skin health is influenced by the microbiome, lipids, oxidative stress, inflammation, and UV exposure. A 12-week trial with 48 women aged 45-65 will test if polyphenol-rich pulses improve skin health by affecting these factors.
- Trial name
- NCT06538415
- Testing
- Pulse Diet, Control Rice Diet
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Florida